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1
Characterization of Plasmodium berghei Homologues of T-cell Immunomodulatory Protein as a New Potential Candidate for Protecting against Experimental Cerebral Malaria

Ai Cui,Yucen Li,Xia Zhou,Lin Wang,Enjie Luo 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.2
- 원문보기 3
  ScienceON
  
  KCI
  
  DBpia
The pathogenesis of cerebral malaria is biologically complex and involves multi-factorial mechanisms such as mi- crovascular congestion, immunopathology by the pro-inflammatory cytokine and endothelial dysfunction. Recent data have suggested that a pleiotropic T-cell immunomodulatory protein (TIP) could effectively mediate inflammatory cytokines of mammalian immune response against acute graft-versus-host disease in animal models. In this study, we identified a con- served homologue of TIP in Plasmodium berghei (PbTIP) as a membrane protein in Plasmodium asexual stage. Compared with PBS control group, the pathology of experimental cerebral malaria (ECM) in rPbTIP intravenous injection (i.v.) group was alleviated by the downregulation of pro-inflammatory responses, and rPbTIP i.v. group elicited an expansion of regulatory T- cell response. Therefore, rPbTIP i.v. group displayed less severe brain pathology and feverish mice in rPbTIP i.v. group died from ECM. This study suggested that PbTIP may be a novel promising target to alleviate the severity of ECM.
2
Personality Beliefs in Obsessive-Compulsive Disorder: How Are They Related to Symptom Severity?

Aysegul Kart,Bengu Yucens 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.8
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  KCI
  
  스콜라
Objective The comorbidity of obsessive-compulsive disorder (OCD) and personality disorders (PDs) is frequent but there are conflicting findings about which PDs are the most common. This study aimed to investigate the personality beliefs that exist on a more pathological level among OCD patients, to explore the association between personality beliefs and OCD severity, and to clarify the mediator effect of depression in this relationship. Methods 202 OCD patients and 76 healthy controls with similar sociodemographic features were included in the study. The Personality Belief Questionnaire-Short Form was administered to both groups. The Yale-Brown Obsessions and Compulsions Scale, Beck Depression Inventory, and the Beck Anxiety Inventory were administered only to the clinical sample. Results The dependent, histrionic, paranoid, borderline, and avoidant personality subscale scores were significantly higher in the OCD group than in the control group. There was an association only between OCD severity and narcissistic personality beliefs, also depression mediated the relationship between narcissistic personality and OCD severity. Conclusion Some personality beliefs at a pathological level are more common among OCD patients. Personality beliefs, as well as depression, should be routinely assessed, as they may affect OCD severity, help-seeking behavior, and response to treatment.
3
Analytical approximate solution for Initial post-buckling behavior of pipes in oil and gas wells

Yu, Yongping,Sun, Youhong,Han, Yucen Techno-Press 2012 Coupled systems mechanics Vol.1 No.2
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This paper presents analytical approximate solutions for the initial post-buckling deformation of the pipes in oil and gas wells. The governing differential equation with sinusoidal nonlinearity can be reduced to form a third-order-polynomial nonlinear equation, by coupling of the well-known Maclaurin series expansion and orthogonal Chebyshev polynomials. Analytical approximations to the resulting boundary condition problem are established by combining the Newton's method with the method of harmonic balance. The linearization is performed prior to proceeding with harmonic balancing thus resulting in a set of linear algebraic equations instead of one of non-linear algebraic equations, unlike the classical method of harmonic balance. We are hence able to establish analytical approximate solutions. The approximate formulae for load along axis, and periodic solution are established for derivative of the helix angle at the end of the pipe. Illustrative examples are selected and compared to "reference" solution obtained by the shooting method to substantiate the accuracy and correctness of the approximate analytical approach.