http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
An Analysis on the Research Trends on Online Learning Engagement Using CiteSpace
( Chen¸ Yuanyuan ),( Kim¸ Gina ) 한국현대영어영문학회 2021 현대영어영문학 Vol.65 No.3
Online learning engagement is a network application that places the homepage and related materials of a course on the Web to form a shared virtual learning space, so as to achieve a face-to-face(FTF) learning effect. Based on the studies published from 2000 to 2020 in influential international and Chinese journals in the field of online learning engagement including the core databases of Web of Science, this paper conducts co-citation and co-occurrence analysis of the literature, subjects, and keywords with the use of CiteSpace. In other words, the study tries to draw the knowledge map of the international research in the field in comparison with China by using CiteSpace which is a software designed to analyze existing literature by co-citation networks. The researchers aimed to reveal the general situation and development trends of the research on online learning engagement. It was found that the number of publications in the field increased and the numbers are given according to year. The most cited journals and articles are revealed. The paper is concluded with some implications for future related research. (Hoseo University)
Enhancing the static behavior of laminated composite plates using a porous layer
Yuan Yuan,Ke Zhao,Kuo Xu 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.72 No.6
The main aim of this paper is enhancing design of traditional laminated composite plates subjected to static loads. In this regard, this paper suggests embedding a lightweight porous layer in the middle of laminated composite as the core layer of the resulted sandwich plate. The static responses of the suggested structures with uniform, symmetric and non-symmetric porosity distributions are compared to optimize their design. Using the first order shear deformation theories, the static governing equations of the suggested laminated composite plates with a porous layer (LCPPL) rested on two-parameter foundation are obtained. A finite element method is also utilized to solve the governing equations of LCPPLs. Effects of laminated composite and porosity characteristics as well as geometry dimension, edges’ boundary conditions and foundation coefficients on the static deflection and stress distribution of the suggested composite plates have been investigated. The results reveal that the use of core between the layers of laminated composites leads to a sharp reduction in the static deflections of LCPPLs. Furthermore, in compare with perfect cores, the use of porous core between the layers of laminated composite plates can offer a considerable reduction in structural weight without a significant difference in their static responses.
Clinical Research on Albumin-Bound Paclitaxel-Based Chemotherapy for Advanced Esophageal Cancer
Yuan, Yuan,Zhang, Yan,Shi, Lin,Mei, Jing-Feng,Feng, Jif-Eng,Shen, Bo Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
Background: To evaluate the efficacy and safety of albumin-bound paclitaxel-based chemotherapy in treatment for patients with advanced esophageal cancer who failed in first-line chemotherapy. Materials and Methods: We collected29 advanced esophageal cancer patients who received albumin-bound paclitaxel-based chemotherapy fromJune 2009 to September 2013, and the efficacy and safety of the compound were evaluated. These patients were treated with $100-150mg/m^2$ nab-paclitaxel on days 1,8. The cycle was repeated every 3 weeks. Clinical efficacy was evaluated every two cycles. Results: Of the 29 patients, two persons interrupted treatment because of adverse reactions, failed to evaluate efficacy effect. The rest of 27 patients who could be evaluated for short-term response, 10 patients (37%) achieved partial response, 2 (7.4%) remained stable disease, and 15 (55.6%) had progressivedisease. The objective response rate was 37%, and the disease control rate was 44.4%.The median time to progression was 6.6 months.The major adverse reactions includedalopecia (62.07%), neutropenia (65.5%), gastrointestinalreaction (10.3%) andsensory neuropathy(6.8%). Conclusions: The albumin-bound paclitaxel-based chemotherapy is efficacy and safety in treatment for patients with advanced esophageal cancer who failed in first-line chemotherapy.
Design of a DSP-Based Real-Time Control Device for Railway Vehicle Simulation
Yuan Yuan,Wenjun Meng,Jisheng Hu 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.10
A real-time control device for railway vehicle simulation is designed in this study according to the experimental requirements of a railway vehicle electric traction and electric braking system. The device uses the high-speed processing characteristic of DSP and runs on the basis of both DSP and the corresponding experimental platform. The simulation experiment for a different power grade traction system is achieved through control of the device. Full static and dynamic simulation of the operating condition of the train electric traction and braking system is attained in the case of no commissioning.
Data Fusion-based Resilient Control System under DoS Attacks: A Game Theoretic Approach
Yuan Yuan,Fuchun Sun 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.3
In this paper, the resilient control under the Denial-of-Service (DoS) attack is rebuilt within the framework of Joint Directors of Laboratories (JDL) data fusion model. The JDL data fusion process is characterized by the so-called Game-in-Game approach, where decisions are made at different layers. The interactions between different JDL levels are considered which take the form of Packet Delivery Rate of the communication channel. Some criterions to judge whether the cyber defense system is able to protect the underlying control system is provided. Finally, a numerical example is proposed to verify the validity of the proposed method.
The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells
Yuan Yuan,Caihua Xue,Qiang Wu,Mengjie Wang,Jiahua Liu,Longfei Zhang,Qianwen Xing,Jingyan Liang,Hua Wu,Zhi Chen 한국유전학회 2021 Genes & Genomics Vol.43 No.2
Background Procyanidin B2 (PCB2) can increase the levels of anti-infammatory and immune mediators. Objectives However, its molecular mechanism in human breast cancer remains unclear. This study aimed to investigate the antitumor efect of PCB2 on MCF-7 cells and to examine the underlying mechanism. Methods The fow cytometry and EdU incorporation assays were measured the PCB2-induced BMECs. The expression levels of infammatory factors and immune response genes were upregulated in MCF-7 cells, high-throughput sequencing was used to detect diferentially expressed genes in blank and PCB2-treated MCF-7 cells. Results The results showed that PCB2 induced the apoptosis of MCF-7 cells. CD36 profles were afected in MCF-7 cells. Additionally, prediction software identifed a miR-145-5p binding site in the CD36 sequence. Luciferase reporter assays and Western blot analysis were used to verify the regulatory relationships between the diferentially expressed miRNA miR145-5p and CD36. MiR-145-5p and its key target (CD36) constitute a potential miRNA-mRNA regulatory pair. Functional studies in MCF-7 cells revealed that CD36 promotes but miR-145-5p inhibits apoptosis. Conclusion Overall, these data suggest that miR-145-5p inhibits the enhancing efect of PCB2 on CD36 expression by binding CD36 and subsequently regulating apoptosis, the immune response and anti-infammatory pathways. These results provide theoretical and experimental support for the treatment of breast cancer.
Yuan, Yuan,Cai, Hui,Yang, Xiao-Jun,Li, Wei,He, Jin,Guo, Tian-Kang,Chen, Yi-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Background: The aim of this study was to investigate the effect of a c-myc antisense oligodeoxynucleotide and 5-fluorouracil on the expression of c-myc, invasion and proliferation of HEPG-2 liver cancer cells. Materials and Methods: HEPG-2 cells were treated with lipiosome-mediated c-myc ADSON and 5-fluorouracil. The proliferation inhibition rate and invasion were measured by MTT and invasion assay, respectively. Cell apoptosis was detected by flow cytometry and expression of c-myc by RT-PCR and immunohistochemistry. Results: The proliferation inhibition rate was significantly higher in the antisense oligodeoxynucleotide added-5-fluorouracil group than single antisense oligodeoxynucleotide or 5-fluorouracil group (p<0.05). G0/G1 cells in the antisense oligodeoxynucleotide group and S cells in the 5-fluorouracil groups were significantly increased than that in the control group, respectively (P<0.01). The amplification strips of PCR products in 5-FU, ASODN and combination groups were significantly weaker than that in the control group (P<0.01). The percentage of c-myc-protein-positive cells were significantly lower in antisense oligodeoxynucleotide, 5-fluorouracil and combination groups than that in the control group (P<0.01). Conclusions: A liposome-mediated c-myc antisense oligodeoxynucleotide and 5-fluorouracil can inhibit the proliferation and invasion of liver cancer cells by reducing the expression of c-myc. A c-myc antisense oligodeoxynucleotide can increase the sensitivity of liver cancer cells to 5-fluorouracil and decrease the dosage of the agent necessary for efficacy, providing an experimental basis for the clinical therapy of liver cancer.
Yuan, Yuan,Fan, Jie-Lin,Yao, Fang-Ling,Wang, Kang-Tao,Yu, Ying,Carlson, Jennifer,Li, Ming Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Objective: Interferon-${\gamma}$ (IFN-${\gamma}$) and signal transducers and activators of transcription (STATs) each play an important role in carcinogenesis associated with viral infection. Cervical cancer is almost invariably associated with infection by human papillomavirus (HPV), and previous studies suggested that dysregulation of the signal pathway involved in IFN-${\gamma}$ and STATs is associated. Our objective was to evaluate the association of SNPs in STAT2, STAT3, and IFN-${\gamma}$ with cervical cancer susceptibility in Chinese Han women in Hunan province. Materials and Methods: Genomic DNA was extracted from peripheral blood samples of 234 cervical cancer patients and 216 healthy female controls. STAT2 and STAT3 genotyping was performed using polymerase chain reaction-restriction enzyme (PCR-RE) analysis. IFN-${\gamma}$ genotyping was detected by PCR-amplification of specific allele (PASA). Results: For STAT2 rs2066807 polymorphisms, there was no significant difference of genotype distribution (P=0.827) and allele frequencies (P=0.830, OR=1.09, 95% CI: 0.51-2.31) between cases and controls. For STAT3 rs957970 polymorphisms, there was no significant difference of genotype distribution (P=0.455) and allele frequencies (P=0.560, OR=0.92, 95% CI: 0.71-1.20) between cases and controls. For IFN-${\gamma}$ +874A/T polymorphisms, there was no significant difference of genotype distribution (P=0.652) and allele frequencies (P=0.527, OR=1.12, 95% CI: 0.79-1.59) between cases and controls. Conclusion: These results suggest that polymorphisms in STAT2, STAT3 and IFN-${\gamma}$ genes are not likely to be strong predictors of cervical cancer in Han women in southern China.
The Loading–Unloading Model of Contact Between Fractal Rough Surfaces
Yuan Yuan,Kuo Xu,Ke Zhao 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.6
A loading–unloading elastic–plastic model of contact between three dimensional fractal rough surfaces has been presented in this paper. During loading process, the mechanical properties of a single asperity follow Hertzian theory. During unloading process, the load-area relationships of a single asperity are obtained by EK model. The truncation size distribution functions for diff erent levels of asperities are deduced. And total true contact area and total contact load are obtained during a loading–unloading process. The results show as the rough surface is in elastic deformation, the load-area relationships during loading and unloading process are identical. As the rough surface is in inelastic deformation, the total true contact area during unloading process is greater than that during loading process. An experiment is designed to verify the validity of the present model.