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Approximate Clustering on Data Streams Using Discrete Cosine Transform
Yu, Feng,Oyana, Damalie,Hou, Wen-Chi,Wainer, Michael Korea Information Processing Society 2010 Journal of information processing systems Vol.6 No.1
In this study, a clustering algorithm that uses DCT transformed data is presented. The algorithm is a grid density-based clustering algorithm that can identify clusters of arbitrary shape. Streaming data are transformed and reconstructed as needed for clustering. Experimental results show that DCT is able to approximate a data distribution efficiently using only a small number of coefficients and preserve the clusters well. The grid based clustering algorithm works well with DCT transformed data, demonstrating the viability of DCT for data stream clustering applications.
Yu, Feng,Kong, Zhengyi,Li, Deguang,Vu, Quang-Viet Techno-Press 2020 Advances in concrete construction Vol.10 No.2
An experimental study on the stress-strain relation of PVC-CFRP confined reinforced concrete columns subjected to eccentric compression was carried out. Two parameters, such as the CFRP strips spacing and eccentricity of axial load, were considered. The experimental results showed that all specimens failed by compressive yield of longitudinal steel bar and rupture of CFRP strips. The bearing capacity of specimen decreases as the eccentricity or the CFRP strips spacing increases. The stress-strain relation of specimens undergoes two stages: parabolic and linear stages. In the parabolic stage, the slope of stress-strain curve decreases gradually as the eccentricity of axial loading increases while the CFRP strips spacing has little effect on the slope of stress-strain curve. For the linear stage, the slope of stress-strain curve decreases as the eccentricity of axial load or the CFRP strips spacing increases. A model for predicting the stress-strain relation of columns under eccentric compression is proposed and it agrees well with various test data.
Yu Feng,Yutao Liu,Mingming Yuan,Guilan Dong,Hongxia Zhang,Tongmei Zhang,Lianpeng Chang,Xuefeng Xia,Lifeng Li,Haohua Zhu,Puyuan Xing,Hongyu Wang,Yuankai Shi,Zhijie Wang,Xingsheng Hu 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3
Purpose To investigate the feasibility of biomarkers based on dynamic circulating tumor DNA (ctDNA) to classify small cell lung cancer (SCLC) into different subtypes. Materials and Methods Tumor and longitudinal plasma ctDNA samples were analyzed by next-generation sequencing of 1,021 genes. PyClone was used to infer the molecular tumor burden index (mTBI). Pre-treatment tumor tissues [T1] and serial plasma samples were collected (pre-treatment [B1], after two [B2], six [B3] cycles of chemotherapy and at progression [B4]). Results Overall concordance between T1 and B1 sequencing (n=30) was 66.5%, and 89.5% in the gene of <i>RB1</i>. A classification method was designed according to the changes of <i>RB1</i> mutation, named as subtype Ⅰ (both positive at B1 and B2), subtype Ⅱ (positive at B1 but negative at B2), and subtype Ⅲ (both negative at B1 and B2). The median progressive-free survival for subtype Ⅰ patients (4.5 months [95%CI: 2.6-5.8]) was inferior to subtype Ⅱ (not reached, p<0.0001) and subtype Ⅲ (10.8 months [95%CI: 6.0-14.4], p=0.002). The median overall survival for subtype Ⅰ patients (16.3 months [95%CI: 5.3-22.9]) was inferior to subtype Ⅱ (not reached, p=0.01) and subtype Ⅲ (not reached, p=0.02). Patients with a mTBI dropped to zero at B2 had longer median overall survival (not reached vs. 19.5 months, p=0.01). The changes of mTBI from B4 to B1 were sensitive to predict new metastases, with a sensitivity of 100% and a specificity of 85.7%. Conclusion Monitoring ctDNA based <i>RB1</i> mutation and mTBI provided a feasible tool to predict the prognosis of SCLC.
Yufeng Zheng(Yufeng Zheng),Xue Liu(Xue Liu),Na Li(Na Li),Aimei Zhao(Aimei Zhao),Zhiqiang Sun(Zhiqiang Sun),Meihua Wang(Meihua Wang),Judong Luo(Judong Luo) 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Purpose: To analyze the gene mutation, immune infiltration and tumor growth of primary tumor and distant tumor under different treatment modes. Materials and Methods: Twenty B16 murine melanoma cells were injected subcutaneously into the of both sides of the thigh, simulating a primary tumor and a secondary tumor impacted by the abscopal effect, respectively. They were divided into blank control group, immunotherapy group, radiotherapy group, and radiotherapy combined immunotherapy group. During this period, tumor volume was measured, and RNA sequencing was performed on tumor samples after the test. R software was used to analyze differentially expressed genes, functional enrichment, and immune infiltration. Results: We found that any treatment mode could cause changes in differentially expressed genes, especially the combination treatment. The different therapeutic effects might be caused by gene expression. In addition, the proportions of infiltrating immune cells in the irradiated and abscopal tumors were different. In the combination treatment group, T-cell infiltration in the irradiated site was the most obvious. In the immunotherapy group, CD8+ T-cell infiltration in the abscopal tumor site was obvious, but immunotherapy alone might have a poor prognosis. Whether the irradiated or abscopal tumor was evaluated, radiotherapy combined with anti-programmed cell death protein 1 (anti-PD-1) therapy produced the most obvious tumor control and might have a positive impact on prognosis. Conclusion: Combination therapy not only improves the immune microenvironment but may also have a positive impact on prognosis.
Yufeng Qi,Haodong Wu,Conghui Liu,Danni Zheng,Congzhi Yan,Wenjing Hu,Xiaohua Zhang,Xuanxuan Dai 한국유방암학회 2022 Journal of breast cancer Vol.25 No.4
Purpose: The incidence rate of breast cancer (BC) has increased annually. Downstream neighbor of son (DONSON) critically affects cell cycle progression and maintains stable genomic properties; however, its relevant effects on BC growth and progression require in-depth investigation. Methods: DONSON upregulation was validated in public databases. DONSON expression in matched BC and adjacent tissues and cell lines (MDA-MB-231, BT-549, and HS-578T) was determined using quantitative reverse transcription polymerase chain reaction. In vitro apoptosis, invasion, migration, and proliferation tests were performed to ascertain the functions of DONSON in BC cell lines. Then, using western blot analysis, the levels of DONSON downstream proteins were determined. Results: Compared to the control, DONSON was expressed at higher levels in BC tissues and cell lines. DONSON knockdown facilitated apoptosis and limited proliferation, migration, invasion, and S/G2 transition of BC cells in vitro. Furthermore, DONSON overexpression promoted BC cell proliferation and inhibited apoptosis in vitro. Moreover, DONSON knockdown reduced cyclin A1 and cyclin-dependent kinase 2 levels. Moreover, DONSON knockdown limited the progression of epithelial-mesenchymal transition. Conclusion: DONSON critically affects BC growth and serves as a possible target and marker for the efficacy of subsequent therapies.
A Reliability Location Model for New Blood Banks in Post-Disaster Reconstruction Areas in China
Yufeng Zhou 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.11
Locating blood banks is a strategic decision problem. It is necessary to consider the risk of facility disruptions in the design stage because blood banks may fail as a result of public emergencies. Taking the timeliness and reliability of blood relief as goals, a reliability P-median location model for new blood banks was developed by considering different probabilities of facility failure in different regions. According to the characteristics of the model, a linearization technique was applied to convert the model and a Lagrangian Relaxation (LR) algorithm was proposed to solve the problem. A case study was given based on one of affected areas in the Wenchuan Earthquake, i.e., Aba prefecture in Sichuan province in China. A group of numerical examples were given to test and verify the model and algorithm. The results show that the proposed algorithm is efficient.
Commutativity and hyponormality of Toeplitz operators on the weighted Bergman space
Yufeng Lu,Chaomei Liu 대한수학회 2009 대한수학회지 Vol.46 No.3
In this paper we give necessary and sufficient conditions that two Toeplitz operators with monomial symbols acting on the weighted Bergman space commute. We also present necessary and sufficient conditions for the hyponormality of Toeplitz operators with some special symbols on the weighted Bergman space. All the results are stated in terms of the Mellin transform of the symbol. In this paper we give necessary and sufficient conditions that two Toeplitz operators with monomial symbols acting on the weighted Bergman space commute. We also present necessary and sufficient conditions for the hyponormality of Toeplitz operators with some special symbols on the weighted Bergman space. All the results are stated in terms of the Mellin transform of the symbol.