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      • Magnetocaloric effect in La<sub>1-x</sub>Sr<sub>x</sub>CoO<sub>3</sub> undergoing a second-order phase transition

        Long, Phan The,Manh, T.V.,Ho, T.A.,Dongquoc, Viet,Zhang, P.,Yu, S.C. Elsevier 2018 CERAMICS INTERNATIONAL Vol.44 No.13

        <P><B>Abstract</B></P> <P>We have prepared rhombohedral La<SUB>1-x</SUB>Sr<SUB>x</SUB>CoO<SUB>3-δ</SUB> (<I>x</I> = 0.2–0.5) compounds with a mass density <I>ρ</I> ≈ 5.5 g/cm<SUP>3</SUP>. Their magnetocaloric (MC) effect is studied via the magnetic-entropy change (Δ<I>S</I> <SUB>m</SUB>) and relative cooling power (<I>RCP</I>), which are calculated from initial magnetization data recorded at different temperatures. Results reveal that the Δ<I>S</I> <SUB>m</SUB> magnitude is maximum (Δ<I>S</I> <SUB>max</SUB>) around the ferromagnetic-paramagnetic phase transition and dependent on both the applied-field (<I>H</I>) magnitude and Sr content (<I>x</I>). For <I>H</I> = 50 kOe, |Δ<I>S</I> <SUB>max</SUB>| can be tuned in the range of 1.6–2.7 J/kg K, corresponding to <I>RCP</I> values of 89–141 J/kg. Among the studied La<SUB>1-x</SUB>Sr<SUB>x</SUB>CoO<SUB>3-δ</SUB> samples, the samples with <I>x</I> = 0.3–0.5 have the largest |Δ<I>S</I> <SUB>max</SUB>| values. If combining these samples as MC blocks in refrigeration application, the working temperature range of a cooling device could range from 204 to ~280 K, with |Δ<I>S</I> <SUB>max</SUB>| stable at ~2.6 J/kg K and <I>RCP</I> ≈ 198 J/kg. We have also assessed the phase-transition type and magnetic order and found La<SUB>1-x</SUB>Sr<SUB>x</SUB>CoO<SUB>3-δ</SUB> undergoing a second-order phase transition. Magnetic order tends to change from the long-range type to the short-range one when <I>x</I> varies from 0.2 to 0.5. This is in good agreement with the results obtained from the analysis of critical behavior.</P>

      • KCI등재

        MALICIOUS URL RECOGNITION AND DETECTION USING ATTENTION-BASED CNN-LSTM

        ( Yongfang Peng ),( Shengwei Tian ),( Long Yu ),( Yalong Lv ),( Ruijin Wang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.11

        A malicious Uniform Resource Locator (URL) recognition and detection method based on the combination of Attention mechanism with Convolutional Neural Network and Long Short-Term Memory Network (Attention-Based CNN-LSTM), is proposed. Firstly, the WHOIS check method is used to extract and filter features, including the URL texture information, the URL string statistical information of attributes and the WHOIS information, and the features are subsequently encoded and pre-processed followed by inputting them to the constructed Convolutional Neural Network (CNN) convolution layer to extract local features. Secondly, in accordance with the weights from the Attention mechanism, the generated local features are input into the Long-Short Term Memory (LSTM) model, and subsequently pooled to calculate the global features of the URLs. Finally, the URLs are detected and classified by the SoftMax function using global features. The results demonstrate that compared with the existing methods, the Attention-based CNN-LSTM mechanism has higher accuracy for malicious URL detection.

      • KCI등재

        Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

        An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

        Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.

      • KCI등재

        Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate

        Xiang Wei,Peng Yongbo,Zeng Hongliang,Yu Chunping,Zhang Qun,Liu Biao,Liu Jiahao,Hu Xing,Wei Wensu,Deng Minhua,Wang Ning,Liu Xuewen,Xie Jianfei,Hou Weibin,Tang Jin,Long Zhi,Wang Long,Liu Jianye 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

        Gemcitabine (GEM) is one of the first-line chemotherapies for bladder cancer (BC), but the GEMs cannot recognize cancer cells and have a low long-term response rate and high recurrence rate with side effects during the treatment of BC. Targeted transport of GEMs to mediate cytotoxicity to tumor and avoid the systemic side effects remains a challenge in the treatment of BC.Based on a firstly confirmed biomarker in BC-protein tyrosine kinase 7 (PTK7), which is overexpressed on the cell membrane surface in BC cells, a novel targeting system protein tyrosine kinase 7 aptamer-Gemcitabine conjugate (PTK7-GEMs) was designed and synthesized using a specific PTK7 aptamer and GEM through auto-synthesis method to deliver GEM against BC. In addition, the antitumor effects and safety evaluation of PTK7-GEMs was assessed with a series of in vitro and in vivo assays.PTK7-GEMs can specifically bind and enter to BC cells dependent on the expression levels of PTK7 and via the macropinocytosis pathway, which induced cytotoxicity after GEM cleavage from PTK7-GEMs respond to the intracellular phosphatase. Moreover, PTK7-GEMs showed stronger anti-tumor efficacy and excellent biosafety in three types of tumor xenograft mice models.These results demonstrated that PTK7-GEMs is a successful targeted aptamer-drug conjugates strategy (APDCs) to treat BC, which will provide new directions for the precision treatment of BC in the field of biomarker-oriented tumor targeted therapy.

      • SCISCIESCOPUS
      • KCI등재후보

        Experiment of an ABS-type control strategy for semi-active friction isolation systems

        Lyan-Ywan Lu,Ging-Long Lin,Chen-Yu Lin 국제구조공학회 2011 Smart Structures and Systems, An International Jou Vol.8 No.5

        Recent studies have discovered that a conventional passive isolation system may suffer from an excessive isolator displacement when subjected to a near-fault earthquake that usually has a long-period velocity pulse waveform. Semi-active isolation using variable friction dampers (VFD), which requires a suitable control law, may provide a solution to this problem. To control the VFD in a semi-active isolation system more efficiently, this paper investigates experimentally the possible use of a control law whose control logic is similar to that of the anti-lock braking systems (ABS) widely used in the automobile industry. This ABS-type controller has the advantages of being simple and easily implemented, because it only requires the measurement of the isolation-layer velocity and does not require system modeling for gain design. Most importantly, it does not interfere with the isolation period, which usually decides the isolation efficiency. In order to verify its feasibility and effectiveness, the ABS-type controller was implemented on a variable-friction isolation system whose slip force is regulated by an embedded piezoelectric actuator, and a seismic simulation test was conducted for this isolation system. The experimental results demonstrate that, as compared to a passive isolation system with various levels of added damping, the semi-active isolation system using the ABS-type controller has the better overall performance when both the far-field and the near-fault earthquakes with different PGA levels are considered.

      • Changes in Markers of Liver Function in HCV 1b Patients with Compensated Cirrhosis Treated with Ombitasvir/Paritaprevir/ Ritonavir plus Dasabuvir with Ribavirin

        ( Jeong Heo ),( Yan Luo ),( Wan-long Chuang ),( Jidong Jia ),( Kwang-hyub Han ),( Ming-lung Yu ),( Hong Tang ),( Young-suk Lim ),( Cheng-yuan Peng ),( Min Xu ),( Maorong Wang ),( Bo Fu ),( Niloufar Mo 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

        Aims: Patients chronically infected with HCV are at risk of developing extrahepatic manifestations of HCV as well as progressing to compensated or decompensated cirrhosis and HCC. Although current treatments have high rates of SVR, relatively little is known about possible regression of liver fibrosis after achieving an SVR. The ONYX-II trial examined the efficacy and safety of ombitasvir/paritaprevir/ritonavir plus dasabuvir + ribavirin (RBV) in Asian patients with HCV genotype 1b infection and compensated cirrhosis. Here we report changes in key markers of liver fibrosis and function. Methods: Patients with chronic HCV GT1b infection and compensated cirrhosis were enrolled in China, South Korea and Taiwan and received 12 weeks of OBV/PTV/r (25 mg/150 mg/100 mg once daily) and DSV (250 mg twice daily) with weight-based RBV. The primary objective of ONYX-II was to assess efficacy (SVR12) and safety of the regimen. Changes in markers of liver fibrosis and function between baseline (BL) and post-treatment week (PTW) 12 are presented. Results: Overall, 104 patients were enrolled and treated in ONYX-II. All patients (104/104, 100%) achieved SVR12. BL and PTW12 data for FibroTest score, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, albumin, platelet count and alpha fetoprotein (AFP) are shown in Table 1. All selected parameters showed numerical improvements between BL and PTW12. Mean ALT and AST levels returned to within normal range and FibroTest scores demonstrated a numerical improvement, suggesting improvement in liver status. The complete set of data between BL and PTW12 will be presented for these parameters and other liver composite parameters at the conference. Conclusions: Measurement of key liver function markers during the ONYX-II trial showed a numerical improvement within 12 weeks of completion of treatment in HCV GT1b-infected patients with compensated cirrhosis. Further follow-up of these patients will determine the long-term durability of these changes.

      • SCIESCOPUS

        Experiment of an ABS-type control strategy for semi-active friction isolation systems

        Lu, Lyan-Ywan,Lin, Ging-Long,Lin, Chen-Yu Techno-Press 2011 Smart Structures and Systems, An International Jou Vol.8 No.5

        Recent studies have discovered that a conventional passive isolation system may suffer from an excessive isolator displacement when subjected to a near-fault earthquake that usually has a long-period velocity pulse waveform. Semi-active isolation using variable friction dampers (VFD), which requires a suitable control law, may provide a solution to this problem. To control the VFD in a semi-active isolation system more efficiently, this paper investigates experimentally the possible use of a control law whose control logic is similar to that of the anti-lock braking systems (ABS) widely used in the automobile industry. This ABS-type controller has the advantages of being simple and easily implemented, because it only requires the measurement of the isolation-layer velocity and does not require system modeling for gain design. Most importantly, it does not interfere with the isolation period, which usually decides the isolation efficiency. In order to verify its feasibility and effectiveness, the ABS-type controller was implemented on a variable-friction isolation system whose slip force is regulated by an embedded piezoelectric actuator, and a seismic simulation test was conducted for this isolation system. The experimental results demonstrate that, as compared to a passive isolation system with various levels of added damping, the semi-active isolation system using the ABS-type controller has the better overall performance when both the far-field and the near-fault earthquakes with different PGA levels are considered.

      • KCI등재

        체외 충격파를 이용한 만성 근위부 족저 근막염의 치료

        김병수,이근배,최진,박유복,백룡빈,Kim, Byung-Soo,Lee, Keun-Bae,Choi, Jin,Park, Yu-Bok,Baik, Long-Bin 대한족부족관절학회 2006 대한족부족관절학회지 Vol.10 No.2

        Purpose: To evaluate the results of extracorporeal shock wave therapy (ESWT) for patients with chronic proximal plantar fascitis. Materials and Methods: Between April 2005 and April 2006, 35 cases (24 patients) who were followed more than 6 months were evaluated. By $EvoTron^{(R)}$, 2 sessions of ESWT (Group 1: 1200 and Group 2: 1500 shock waves / session of $0.12\;mJ/mm^2$) were performed at 2 weeks interval. The mean age was 40.0 (range, 15-59) years. 13 patients were male and 11 patients were female. Visual analogue scale (VAS) on daily activity and a 100-point scoring system including 70 points for pain and 30 points for function were used. The clinical outcomes were rated as follows: excellent, no pain on daily activity; good, less than 50% of previous VAS; fair, 50-75% of previous VAS; or poor, more than 75% of previous VAS. Excellent and good were graded as satisfactory results. We compare clinical results between groups and evaluate the relationships between clinical results and duration of symptom, fascial thickening and previous steroid injection were evaluated. Results: Overall satisfactory rate were 71.4%. There was no significant difference of clinical results between groups. And there were no significant difference between clinical results and duration of symtom, preoperative fascial thickening and previous steroid injection. Conclusions: ESWT for recalcitrant chronic proximal plantar fascitis is useful treatment method with high patient satisfaction and pain relief, but more long-term study must be needed.

      • Influence of Crystallite Size on Magnetocaloric Effect and Critical Behavior La<sub>0.7</sub>Sr<sub>0.3</sub>Mn<sub>0.92</sub>Co<sub>0.08</sub>O<sub>3</sub> Nanoparticles

        Tran Dang Thanh,Dinh Chi Linh,Le Viet Bau,Thi Anh Ho,Tien Van Manh,The-Long Phan,Seong-Cho Yu IEEE 2015 IEEE transactions on magnetics Vol.51 No.1

        <P>Four samples of La<SUB>0.7</SUB>Sr<SUB>0.3</SUB>Mn<SUB>0.92</SUB>Co<SUB>0.08</SUB>O<SUB>3</SUB> (LSMCO) with different crystallite sizes were prepared by the combination of solid-state reaction and mechanical milling methods. Based on isothermal magnetization data, M(H), temperature dependences of magnetic entropy change, ΔS<SUB>m</SUB>T, of the samples under a magnetic field change of 10 kOe were calculated. The maximum values of magnetic entropy change (|ΔS<SUB>max</SUB>|) at room temperature are in the range of 0.9-1.4 J · kg<SUP>-1</SUP> · K<SUP>-1</SUP>, corresponding to ferromagnetic (FM)-paramagnetic phase transition. In addition, M<SUP>2</SUP> versus H/M curves at temperatures around TC prove the samples exhibiting a second-order magnetic phase transition. The critical exponents β, γ, and δ were determined using the modified Arrott plot method and critical isotherm analysis. Here, these exponent values are located in between those expected for the mean-field theory and 3-D Heisenberg model. It means the coexistence of short-range and long-range FM interactions in LSMCO nanoparticles.</P>

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