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Equivalent static wind loads for stability design of large span roof structures
Ming Gu,Youqin Huang 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.20 No.1
Wind effects on roofs are usually considered by equivalent static wind loads based on the equivalence of displacement or internal force for structural design. However, for large-span spatial structures that are prone to dynamic instability under strong winds, such equivalent static wind loads may be inapplicable. The dynamic stability of spatial structures under unsteady wind forces is therefore studied in this paper. A new concept and its corresponding method for dynamic instability-aimed equivalent static wind loads are proposed for structural engineers. The method is applied in the dynamic stability design of an actual double-layer cylindrical reticulated shell under wind actions. An experimental–numerical method is adopted to study the dynamic stability of the shell and the dynamic instability originating from critical wind velocity. The dynamic instability-aimed equivalent static wind loads of the shell are obtained.
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Meizhu Wu,Aling Shen,Youqin Chen,Liya Liu,Li Li,Senthilkumar Sankararaman,Hongwei Chen,Bin Guan,Zhixue Zhan,Shuhua Nan,Thomas J. Sferra,Jun Peng 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.1
Intestinal mucosal barrier dysfunction is involved in the pathogenesis of inflammatory bowel disease, including ulcerative colitis (UC). Xinhuang tablets (XHTs) have been prescribed for several kinds of inflammatory diseases, including UC, whereas its possible underlying molecular mechanisms had never been explored. Mouse model of UC was constructed by DSS treatment and followed by XHT treatment. Disease activity index, histopathological of colonic tissue, tumor necrosis factor-alpha (TNF-α), and serum amyloid A (SAA) levels in serum were further assessed. The underlying mechanism was further explored by determination of the expression of epithelial tight junction-related protein. XHT administration ameliorated dextran sulfate sodium (DSS)-induced clinical symptoms, colonic histological injury, and decreased the circulating levels of TNF-α and SAA. Moreover, XHT treatment significantly increased the protein levels of zona occludens (ZO)-1, whereas decreased the levels of phosphorylation of Elk-1. In conclusion, this study confirmed the therapeutic effects of XHT treatment on UC in a DSS-induced mouse model, and indicated that by increasing expression of epithelial tight junctions and decreasing phosphorylation of Elk-1 might be one of the underlying mechanisms of XHT treatment on UC.
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Equivalent static wind loads for stability design of large span roof structures
Gu, Ming,Huang, Youqin Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.20 No.1
Wind effects on roofs are usually considered by equivalent static wind loads based on the equivalence of displacement or internal force for structural design. However, for large-span spatial structures that are prone to dynamic instability under strong winds, such equivalent static wind loads may be inapplicable. The dynamic stability of spatial structures under unsteady wind forces is therefore studied in this paper. A new concept and its corresponding method for dynamic instability-aimed equivalent static wind loads are proposed for structural engineers. The method is applied in the dynamic stability design of an actual double-layer cylindrical reticulated shell under wind actions. An experimental-numerical method is adopted to study the dynamic stability of the shell and the dynamic instability originating from critical wind velocity. The dynamic instability-aimed equivalent static wind loads of the shell are obtained.
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