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신선 고환조직 정자와 냉동보존-융해 고환조직 정자를 이용한 난자세포질내 정자주입술 결과의 비교 연구
최영식,최영민,김수웅,백재승,지병철,구승엽,서창석,김석현,김정구,문신용,Choi, Young-Sik,Choi, Young-Min,Kim, Soo-Woong,Paick, Jae-Seung,Jee, Byung-Chul,Ku, Seung-Yup,Suh, Chang-Suk,Kim, Seok-Hyun,Kim, Jung-Gu,Moon, Shin-Yong 대한생식의학회 2008 Clinical and Experimental Reproductive Medicine Vol.35 No.2
목 적: 무정자증 불임부부에서 신선 (fresh) 고환정자 (testicular spermatozoa)와 냉동보존-융해(cryopreserved-thawed) 고환정자를 사용한 난자세포질내 정자주입술 (intracytoplasmic sperm injection, ICSI)의 결과를 비교하고자 하였다. 연구방법: 신선 고환정자 및 냉동보존-융해 고환정자를 사용하여 ICSI 시술을 시행하기로 계획된 총 109주기 (66명)를 대상으로 하였고 신선 고환정자를 사용하기로 계획한 군 (신선 고환정자군, fresh group)에는 92주기 (61명)이 포함되었고 냉동보존-융해 고환정자를 사용하기로 계획한 군 (냉동보존-융해 고환정자군, cryopreserved-thawed group)에는 17주기 (13명)가 포함되었다. 양 군간에 수정률, 착상률, 임신률, 유산률 등 ICSI 시술의 결과들을 비교하였고 통계학적 분석은 Mann-Whitney U 검정 및 Fisher의 정확한 검정을 적절하게 사용하였다. 결 과: 신선 고환정자를 사용하여 ICSI 시술을 시행하기로 계획된 총 92주기 중 9주기에서 고환정자를 추출할 수 없어 시술 주기가 취소되었다. 냉동보존-융해 고환정자군과 비교하여 신선 고환정자군에서 수정률이 높은 경향을 보였고 ($58.0{\pm}27.8%$ vs. $45.9{\pm}25.0%$, p=0.076) 양질의 배아 수는 통계적으로 유의하게 높았다 ($0.9{\pm}1.2$ vs. $0.2{\pm}0.5$, p=0.002). 그러나 임상적 임신율, 착상률, 유산율은 양 군간에 통계적으로 유의한 차이가 없었다. 결 론: ICSI 시술을 위하여 냉동보존-융해 고환정자를 사용하는 경우 수정률 및 배아의 질이 감소하지만 임신율, 착상률, 유산율에는 영향을 미치지 않는 것으로 사료된다. 또한, ICSI 시술이전에 고환정자를 확보하고 냉동보존-융해 고환정자를 사용한다면 난자채취 당일 정자를 확보하지 못하여 주기를 취소하는 경우나 여성배우자의 불필요한 과배란유도를 줄일 수 있으며 반복적인 고환정자추출술로 인한 고환기능의 손상을 줄일 수 있는 유용한 방법으로 사료된다. Objective: To compare the outcomes of intracytoplasmic sperm injection (ICSI) with fresh and cryopreserved-thawed testicular spermatozoa in patients with azoospermia. Methods: One hundred and nine cycles (66 couples) where ICSI was planned with fresh or cryopreserved-thawed testicular spermatozoa were included in this study; Ninety two cycles (61 couples) with fresh testicular spermatozoa (fresh group) and seventeen cycles (13 couples) with cryopreserved-thawed testicular spermatozoa (cryopreserved-thawed group). We compared ICSI outcomes such as fertilization rate, implantation rate, pregnancy rate and miscarriage rate, which were statistically analyzed using Mann-Whitney U test or Fisher's exact test, where appropriate. Results: In 9 out of the 92 cycles where ICSI was planned with fresh testicular spermatozoa, testicular spermatozoa could not be retrieved. Fertilization rate tended to be higher in the fresh group than in the cryopreserved-thawed group ($58.0{\pm}27.8%$ vs. $45.9{\pm}25.0%$, p=0.076). The number of high quality embryos was significantly higher in the fresh group ($0.9{\pm}1.2$ vs. $0.2{\pm}0.5$, p=0.002). However, there were no significant differences in clinical pregnancy rate, implantation rate and miscarriage rate between the two groups. Conclusion: The results of this study suggest that although the use of cryopreserved-thawed testicular sperm for ICSI in patients with azoospermia may reduce fertilization capacity and embryo quality, it may not affect pregnancy rate, implantation rate and miscarriage rate. If testicular sperm can be obtained before ICSI procedure, the use of cryopreserved-thawed testicular sperm may also avoid unnecessary controlled ovarian hyperstimulation and cancellation of oocyte retrieval when spermatozoa cannot be retrieved as well as damage on testicular function by repeated TESE.
최영식(Young-Sik Choi) 한국산업융합학회 1998 한국산업융합학회 논문집 Vol.1 No.2
It is very important that we try to keep our traditional historical assets in the original form for a long time. Seoggur-Am has a very long and old history of about 1200 years. Yet, for the past several years there are many factors ruinning this historical treasure.<br/> Recently, specialist are new scientifically examining Seoggur-Am and evaluating its current condition, If you only judge these historical assets from the exterior structural environmental approach your scientific conclusion will not be complete. No one has studied Seoggur- Am from the viewpoint of indoor environmental climate. Therefore, I have surveyed and prepared a report of investigation as well as countermeasure so to understand the impact of indoor environmental climate on Seoggur-Am.<br/> The purpose of this paper is to first survey the existing research data based on exterior structural environment. Secondly, closely evaluate the new data of Seoggur-Am from the viewpoint of indoor environmental climate.<br/> <br/>
자연환경상태에서 인공석굴법당의 실내기후조절에 관한 연구
최영식(Young-Sik Choi),조영화(Young-Wha Cho) 한국산업융합학회 1999 한국산업융합학회 논문집 Vol.2 No.1
It is very important that we try to keep our traditional historical assets in the original form for a long time. Artificial grotto has a very long and old history of about 1250 years in Korea. Yet, for the past several years there are many factors ruinning this historical treasure. Recently, specialist are new scientifically examining artificial grotto and evaluating its current condition. If you only judge these historical assets from the exterior structural environmental approach your scientific conclusion will not be complete. No one has studied artificial grotto from the viewpoint of indoor climate environmental. Therefore, I have surveyed and prepared a report of investigation as well as countermeasure so to understand the impact of indoor climate environmental on artificial grotto. The purpose of this paper is to first survey the existing research data based on exterior structural environment. Secondly, closely evaluate the new data of artificial grotto from the viewpoint of indoor environmental control by a natural climate phenomenon in Korea.<br/>
바닥난방시 바닥 접촉면에 의한 한국인과 일본인의 온열감 반응에 대한 비교 연구
최영식(Young-Sik Choi) 한국산업융합학회 2002 한국산업융합학회 논문집 Vol.5 No.1
The objective of this paper is to clarify the combined effect of heat conduction, air temperature and thermal radiation on the person seated on the floor under operation of floor heating system. Experiments were conducted for summer seasons under 8 kinds of condition: combinations of air temperature 20℃, 22.5℃ and floor temperature 20℃, 22.5℃, 30℃, 35℃ and 40℃ under still air. Japanese and Koreans were adopted as subjects. To evaluate the effect of conduction operative temperature modified by heat conduction was derived from the human heat balance equation. New weighting coefficients were estimated from the modified operative temperature and modified mean skin temperature. As for thermal sensation the modified operative temperature more significantly correlated to that sensation each heat transfer processes. As the floor temperature is higher, the human conduction heat gain from floor increase and the dry heat from the human body decrease.<br/> <br/> <br/>
최영식 ( Young Sik Choi ) 대한언어학회 2014 언어학 Vol.22 No.1
I address two types of verbal concatenation constructions in Korean in the form of V-e V, which has been a topic of much controversy in the literature with regard to its structure. I argue that what I call type I is ambiguous in structure in that it is construed as either monoclausal or biclausal, whereas type II is always construed as monoclausal. I thus crucially diverge from the common view in the literature, according to which both types are uniformly biclausal or monoclausal (Lee 1976, Yang 1976, Choe 1988, Kim 1993, Lee 1993, Choi 2001). It will be shown that a variety of tests including scope of negation and manner adverbials, along with the distribution of negative polarity items in Korean lend support to the present thesis that the two types are different in their clausal structure.