Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Yan, Bing Chun,Park, Joon Ha,Kim, Sung Koo,Choi, Jung Hoon,Lee, Choong Hyun,Yoo, Ki-Yeon,Kwon, Young-Geun,Kim, Young-Myeong,Kim, Jong-Dai,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Cellular and molecular neurobiology Vol.32 No.8

<P>In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.</P>

고령자 (고령자) 십이지장 궤양 (궤양)

정준모(Joon Mo Chung),정극수(Keuk Soo Chung),최용환(Yong Hwan Choi),김인호(In Ho Kim),김효석(Hyo Seuk Kim),김영재(Young Jae Kim) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1

N/A Clinical studies on patients with duodenal ulcer who visited endoscopy room of Kyungpook National University Hospital since 1976 were performed. Among these patients, we compared the number of patients with gastric or duodenal ulcer yearly, and some aspects of difference between 57 cases of old age(above 60 years) and 129 cases of young age(under 30 years) patients with duodenal ulcer. The results obtained were as follows. 1) In examined cases, number of patients with duodenal ulcer was progressively increased year by year and number of gastric ulcer was more prevalent than that of duodenal ulcer unti11979 when the ratio of gastric and duodenal ulcer became nearly same, and thereafter duodenal ulcer cases were begun more predominant about 2 times that of gastric ulcer in 1981 2) Comparing the sex distribution of old and young age group, male was predominant about 12 times of female cases in young age group and about 2.5 times in old. 3) Overall complications including bleeding, perforation, obstruction and others were seen in 63. 2% of old age group and in 48.1% of young. 4) In 8 weeks follow up cases that was possible although it was least in number, 8 cases were improved or healed in old age group but 5 cases out of 18 cases in young revealed no improvement by ordinary regimen.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

Microstructure, Tensile and Fatigue Properties of Al–5 wt.%Mg Alloy Manufactured by Twin Roll Strip Casting

Joon‑Young Heo,Min‑Seok Baek,Kwang‑Jun Euh,Kee‑Ahn Lee 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.5

This study investigated the microstructure, tensile and fatigue properties of Al–5 wt.%Mg alloy manufactured by twin rollstrip casting. Strips cast as a fabricated (F) specimen and a specimen heat treated (O) at 400 °C/5 h were produced andcompared. In the F specimen, microstructural observation discovered clustered precipitates in the center area, while in theO specimen precipitates were relatively more evenly distributed. Al, Al 6 (Mn, Fe), Mg 2 Al 3 and Mg 2 Si phases were observed. However, most of the Mg 2 Al 3 phase in the heat-treated O specimen was dissolved. A room temperature tensile test measuredyield strength of 177.7 MPa, ultimate tensile strength of 286.1 MPa and elongation of 11.1% in the F specimen and167.7 MPa (YS), 301.5 MPa (UTS) and 24.6% (EL) in the O specimen. A high cycle fatigue test measured a fatigue limit of145 MPa in the F specimen and 165 MPa in the O specimen, and the O specimen achieved greater fatigue properties in allfatigue stress conditions. The tensile and fatigue fracture surfaces of the above-mentioned specimens were observed, and thisstudy attempted to investigate the tensile and fatigue deformation behavior of strip cast Al–5 wt.%Mg based on the fi ndings.

Effects of Humidity on the Microstructure and the Ferroelectric Properties of Sol-Gel grown P(VDF-TrFE) Films

Young Joon Ko,진다운,Dae Sol Kong,Jong Hoon Jung 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.4

We report the microstructure and the ferroelectric properties of poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] films grown under various humidity conditions and synthesis times by using a sol-gel method. When the synthesis time under a humid condition was short (approximately 30 min), the moisture in the environment affected only the surface morphology without any loss of ferroelectricity for the P(VDF-TrFE) films. In contrast, when the synthesis time was long (approximately 90 min), the moisture strongly affected the microstructure and the ferroelectric properties of P(VDF-TrFE). The transparent P(VDF-TrFE) film became opaque at high humidity. Scanning electron microscopy revealed numerous pores on the surface of and inside the film. The pores reduced the Young's modulus considerably from 4.15 to 0.97 GPa for the films grown at 20 and 80% relative humidity, respectively. In addition, the ferroelectric hysteresis loop disappeared at humidities above 60%. This work provides upper limits for the humidity and the synthesis time for the growth of high-quality P(VDF-TrFE) films by using a sol-gel method.

Assessment of Alcohol Level in Inebriated Victims of Sexual Assault using Ethyl Glucuronide

Young?Hoon Jo,Mia Kwon,Joon-Bae Lee,Jeong A Ko 한국분석과학회 2022 학술대회논문집 Vol.2022 No.5

소유-지배 괴리도가 경영진단의견서 공시에 미치는 영향

채수준(Chae, Soo-Joon),이아영(Lee, A-Young) 한국경영교육학회 2020 경영교육연구 Vol.35 No.4

[연구목적] 본 연구는 소유지배괴리도가 공시품질에 어떠한 영향을 미치는 지 분석하고자 하였다. 소유지배괴리도는 공정거래위원회가 ‘대규모기업집단 정보공개시스템’을 통해 제공하고 있는 지배주주의 소유권 및 지배권을 사용하여 측정하였으며, 공시품질로는 경영진단의견서(MD&A)를 고려하였다. [연구방법] 본 연구는 소유지배괴리도가 경영진단의견서 공시품질에 미치는 영향을 검증하기 위해서 2010년부터 2013년까지 유가증권시장에 상장된 1,483 기업-연도 표본을 대상으로 선형회귀분석을 실행하였다. [연구결과] 소유지배괴리도와 MD&A 공시품질 간에는 유의한 양(+)의 관련성이 존재하는 것으로 나타났다. 즉, 소유지배괴리도가 큰 기업일수록 MD&A 공시사항을 충실히 기재하고 있음을 확인하였다. 이는 상반된 두개의 해석을 가능하게 한다. 높은 소유지배괴리도로 인한 지배주주의 사익추구 가능성을 은폐하기 위한 수단으로 공시를 적극적으로 활용할 수 있다는 측면과 높은 소유지배괴리도로 인한 기업지배구조에 대한 부정적인 기업이미지를 해소하고 시장과 원활하게 소통하기 위해 공시를 활용할 수 있다는 해석이 가능하다. [연구의 시사점] 본 연구는 소유지배괴리도와 같은 기업의 소유구조가 기업의 공시품질에 영향을 미치는 요소임을 규명한다는 점에서 공헌도가 있다. 본 연구의 실증결과는 괴리도가 큰 기업일수록 MD&A와 같은 재량적 공시를 적극적으로 수행함으로써 소유구조에 따른 대리인 비용 및 정보비대칭을 완화하고자 하고 있음을 보여준다. 아울러, 대규모 기업집단 지정과 같은 규제제도가 기업들에게 스스로를 관리하게 하는 유인이 될 수 있음을 시사한다. [Purpose] The purpose of this study is to analyze how control-ownership wedge affects disclosure quality. We consider Management Discussion and Analysis(MD&A) as a proxy for disclosure quality [Methodology] This study conducted a linear regression analysis for 1,483 firm-year samples listed on the KOSPI market from the period between 2010 to 2013 to verify the effect of the ownership and control wedge on MD&A. [Findings] This paper showed that there is a significant positive (+) relationship between control-ownership wedge and MD&A disclosure quality. The results of this study verified that firms with a greater degree of control-ownership wedge faithfully described MD&A disclosure items. These results can be explained in two opposite directions. One explanation is that managers of firms with a greater degree of control-ownership wedge can actively use the MD&A disclosure as a mean to conceal the pursuit of the interests of the controlling shareholders. The other explanation is that the MD&A disclosure can be used to solve the negative corporate image of the corporate governance structure due to a high degree of control-ownership wedge and to communicate smoothly with the capital market. [Implications] This study has a contribution that the company’s ownership structure, such as the control-ownership wedge, is a factor influencing the disclosure quality of the company. The empirical results of this study show that firms with a greater degree of control-ownership wedge actively disclose the discretionary disclosure such as MD&A to alleviate agency cost and information asymmetries according to the ownership structure.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

당뇨병성 다발성 신경병증에 대한 Thioctic acid의 유효성 및 안정성에 관한 연구

박철영,김영설,오승준,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2001 임상당뇨병 Vol.2 No.1

연구배경: 당뇨병성 신경병증은 당뇨병 환자에서 흔히 나타나는 합병증으로서 임상 증상은 가볍거나 없을 수도 있지만 많은 경우에 통증, 작열감, 이감각증이나 무감각증 등의 증상을 동반하지만, 이에 대한 명확한 기전이나 뚜렷한 치료방법이 없었다. 최근에 신경세포내 산화성 스트레스의 증가로 신경세포의 손상이 발생된다는 기전이 주목을 받으면서, 당뇨병성 신경병증 환자에게 항산화제인 thiotic acid를 사용하여 좋은 효과를 관찰한 논문들이 발표되었다. 이에 저자들은 한국의 당뇨병성 다발성 신경병증 환자에서 thiotic acid를 경구 투여 후에 신경병증에 의한 효과 및 안정성을 평가하였다. 방법: 모든 대상 환자에게 Thioctic acid 600㎎ 을 1일 1회 아침 식전 30분에 8주간 투여하여 당뇨병성 다발성 신경병증에 대한 TSS의 개선여부에 대한 임상적 유효성 및 이상반응, 내약성, 실험실적 지표의 변화를 통한 안정성을 관찰하였다. 결과: 치료시작 전에 관찰한 환자가 호소하는 증상은 통증이 가장 많았으며 무감각, 작열감, 이상감각 순의 빈도를 보였다. 통증, 작열감, 이감각증, 무감각증의 평균 TSS는 1차 방문시 5.8± 1.8, 2차방문시는 4.4±1.7, 3차 방문시는 3.1±1.1로 사용기판에 따라 통계학적으로 유의한 증상의 호전이 있었다. 또한 TSS의 개선 뿐만 아니라 통증, 작열감, 이감각증 및 무감각증 각각의 증상도 치료전과 치료 4주 후 및 치료 8주 후를 비교했을 때 통계학적으로 유의한 증상의 호전이 있었다. TSS가 1차 방문 시와 비교했을 때 3차 방문시에 30% 이상 개선되었을 때(1차 방문시에 TSS 4인 환자는 2점 이상 개선되었을때) 임상적으로 의미가 있는 반응으로 간주하고 계산한 반응률은 71.3%였다. 결론: 당뇨병성 다발성 신경병중 환자에 대해 항 산화제인 thioctic acid 600㎎ 경구 투여요법은 당뇨병성 신경병증의 증상완화에 유용하며, 안전한 것으로 사료된다. Background: The study was peformed to evaluate the efficacy and safety of oral treatment with the antioxidant α-lipoic acid (Thioctcid??) in diabetic patients with peripheral polyneuropathy. Methods: Thioctacid?? 600㎎ was orally administered once a day for 8 weeks in 61 diabetic patients with peripheral polyneuropathy. Neuropathic symptom(pain, burning, paresthesia, and numbness) were scored before, and of 4 and 8 weeks after treatment. In addition, neuropathy by the physician and patients at the end of treatment. The primary endpoint was the response role after 8 weeks treatment, defined as an improvement in the total symptom score of at least more than 30%. Results: Efficacy was evaluated among forty-four patients who had completely the study according to the protocol and safety was evaluated among all of 61 patients who had taken the study medication. The response rate after 8 weeks was 77.3%. The total symptom score was significantly decreased of 4-week, and further decreased of 8-week. All the individual scores for neuropathic symptom were also significantly reduced of 4-week and further decreased at 8-week. Conclusion: These finding indicate that oral treatment with thioctacid?? at a dose of 600㎎/day for 8 weeks will improve peripheral polyneuropathy in diabetic patients, without causing any serious adverse events.