젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구

이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.

모자보건사업의 관리정보 체계개발에 관한 연구 : Focusing on the Local Health Service Center 면보건지소를 중심으로

방숙,정영철,한성현,채영문,김영희,이정자,안상은 순천향대학교 1988 논문집 Vol.11 No.3

미세유화약물송달시스템을 이용한 로바스타틴의 생체이용률 향상

윤복영,강복기,정상영,이영원,이시범,황성주,육순홍,강길선,이해방,조선행 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

A self-microemulsifying drug delivery system (SMEDDS) was developed to increase the dissolution rate, solubility, and ultimately bioavailability of a poorly water soluble drug, lovastatin. SMEDDS was the mixtures of oils, surfactants, and cosurfactants, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal (GI) tract. Various types of self-emulsifying formulations were prepared using four types of oil (Capryol 90, Lauroglycol 90, Labrafil M 1944 CS and Labrafil M 2125), two surfactants (Cremophor EL and Tween 80), and three cosurfactants (Carbitol, PEG 400 and propylene glycol). The efficiency of emulsification was studied using a laser diffraction size analyzer to determine particle size distributions of the resultant emulsions. Optimized formulations selected for bioavailability assessment were Carpryol 90 (40%), Cremophor EL (30%) and Carbitol (30%). SMEDDS containing lovastatin (20 mg and 5 mg) were compared to a conventional lovastatin tablet (Mevacor^? , 20 mg/tab) by the oral administration as prefilled hard gelatin capsules to fasted beagle dogs for in vivo study. The area under the serum concentration-time curve from time zero to the last measured time in serum, AUC_0→24h, was significantly greater in SMEDDS, suggesting that bioavailability increase 130% and 192% by the SMEDDS, respectively. The self-emulsifying formulations of lovastatin afforded the improvement in absolute oral bioavailability relative to previous data of lovastatin tablet formulation. These data indicate the utility of dispersed self-emulsifying formulations for the oral delivery of lovastatin and potentially other poorly absorbed drugs.

백서 간재생중 H2B Histone 유전자 발현에 대한 Octamer Binding Transcription Factor의 역할

임규,방재웅,최두식,손미영,이영철,박청,김태동,김영래,박종일,윤완희,박승길,황병두 한국노화학회 2001 한국노화학회지 Vol.11 No.1

만선신부전 환자에서 관상동맥조영술 소견에 관한 연구

한대희,김성구,박상호,김성한,조원영,방덕원,조윤행,정의룡,은영근,권영구 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Patients with chronic renal fialure have a substantially elevated risk of death from cardiovascular diseases than do the general population. the patients with chronic renal failure are at significantly increased freqeuncy of hypertension, hyperlipidemia, and diabetes mellitus which are known to the risk factors of the coronary artery diseases, and the prevalence of the coronary artery diseases in chronic renal failure patients is highly associated with the hemodynamic disorder and metabolic abnormalities. therefore we expected that the coronary angiographic findings in patients with chronic renal failure should be different from the general population (control groups) and investigated the risk factors contributing to coronary artery diseases. Method : we have retrospectively compared the coronary angiographic findings of 44 patients with chronic renal failure on hemodialysis with that of 88 patients in the general population and investigated the factors contributing to the development and acceleration of coronary artery diseases in patients with chronic renal failure Result : Hypertension and diabetes mellitus which is risk factors for coronary artery disease is significantly increased in patients with chronic renal failure, in coronary angiographic finding the severity of the lesion is worse. the incidence of PCI or CABG of patients with chronic renal failure is more than that of control group but statistically no difference between patients with chronic renal failure and control group. the sex, the duration of disease, the duration of dialysis, serum creatinine in patients with chronic renal failure have no correlation to the prevalence of coronary artery disease and severity of lesion. hyperglycemic patients with chronic renal failure have high incidence of coronary artery disease and are worse in the severity of lesion Conclusions : There is significantly increased the pevalence and severity of involving multiple coronary artery diseses in hyperglycemic patients with CRF.

순무(Brassica campestris ssp. rapa) 뿌리로부터 지질화합물의 분리 및 동정

방면호,오영준,유종수,한민우,정해곤,정태숙,최명숙,이경태,김세영,백남인 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

순무 뿌리로부터 활성 물질을 분리 동정 하기 위하여 80% MeOH 수용액으로 추출하고 이를 여과, 감압 농축하여 MeOH추출물을 얻었다. 이를 EtOAc분획, n-BuOH분획, H_(2)O분획으로 나누었으며, EtOAc분획에 대해 silica gel column chromatography를 실시하여 3종의 지질화합물을 분리 정제하였다. ^(1)H-NMR, ^(13)C-NMR, DEPT spectrum 및 Mass spectrum등을 통하여 palmitic acid methyl ester(compound 1), linolenic acid methyl ester(compound 2), linoleic acid methyl ester(compound 3)으로 구조를 결정하였다. In order to isolate and identify the active compound from the Brassica campestris ssp rapa, the roots and the root skin were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H_(2)O. From the EtOAc fraction, three compounds were isolated through the repeated silica gel column chromatographies. From the result of spectral data including NMR and MS, the chemical structures of the compound were determined as palmitic acid methyl ester (compound 1), linolenic acid methyl ester (compound 2), linoleic acid methyl ester (compound 3).

RCGKA를 이용한 최적 퍼지 예측 시스템 설계

방영근,심재선,이철희 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.B

In the case of traditional binary encoding technique, it takes long time to converge the optimal solutions and brings about complexity of the systems due to encoding and decoding procedures. However, the ROGAs (real-coded genetic algorithms) do not require these procedures, and the k-means clustering algorithm can avoid global searching space. Thus, this paper proposes a new approach by using their advantages. The proposed method constructs the multiple predictors using the optimal differences that can reveal the patterns better and properties concealed in non- stationary time series where the k-means clustering algorithm is used for data classification to each predictor, then selects the best predictor. After selecting the best predictor, the cluster centers of the predictor are tuned finely via RCGKA in secondary tuning procedure. Therefore, performance of the predictor can be more enhanced. Finally, we verifies the prediction performance of the proposed system via simulating typical time series examples.

재고자산관리에 대한 간호사의 업무인지도와 만족도

방영숙,류규수,김문주 경산대학교 보건복지연구소 2000 保健福祉硏究 Vol.5 No.-

A study on satisfaction of nurses for inventory assets management of medical supplies The purpose of this study is to suggest an dfficient method of inventory assets management of medical supplies. This study used the data of nurses who are working at national hospitals, university hospitals, medical corporations, and private hospitals. The data were used to get the understandings and satisfactions of the nurses about inventory assets management of medical supplies. The results are as follows ; 1. Understandings(p<0.001) and satisfactions(p<0.05) of the nurses about their works grow over ages. There was a difference between a big city and a smaller one and there were also differences in each position of the nurses(p<0.001). According to a multiple comparisons test, the higher their position, the higher understandings and satisfaction of their works. In a case of the office in a hospital, the satisfaction of hardworking nurses in an operation room or emergency room was low(p<0.05). In a case of their working years, there was some difference in understandings and satisfactions by the type of a hospital is a private hospital, a university hospital, a medical corporation, and a national hospital, although not having a statistic significance. In the scale of a hospital, understandings and satisfactions were over 500, 3001-499, below 300 rooms, orderly, but this result was not significant, too. 2. The status of inventory assets management of medical supplies was 301-499, over 500, below 300, orderly, and the order by the type of a hospital was a private hospital, a medical corporation, a national hospital, a university hospital without the statistic significance. 3. Satisfactions had a strong positive correlation with understandings like satisfactions and inventory assets management of medical supplies. As well, the correlation coefficient of understandings and inventory assets management of medical supplies was positive as 0.525. and all of them were significant statistically(p<0.01). 4. Both the status of inventory assets management of medical supplies and understanding were significant, and this result show that each of inventory assets management of medical supplies and understanding had an effect on satisfactions. Key words : Satisfaction of nurses, Inventory assets management of medical supplies.

당뇨 유발쥐에서 인동초의 섭취가 혈청지질과 혈당 및 항산화효소계에 미치는 영향

방미애,조영자,김현아 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.4

The purpose of this study was to investigate the effects of dietary Indongcho(L. japonica Thunb) powder on blood glucose, serum lipid levels and antioxidative anzymes in normal and streptozotocin(STZ)-induced diabetic rats. Four groups of rats(2-week-old inbred Sprague-Dawley male rats) were normal rats fed control diet(NC), diabetic rats fed control diet(DC), normal rats fed Indongcho powder diet(NI), and diabetic rats fed Indongcho powder diet(DI). Diabetes was induced by single injection of streptozotocin(60mg/kg BOW., i.p.). The animals were fed ad libium each of the experimental diet for 5 weeks. Food and water intakes were determined everyday. Blood glucose and serum total cholesterol levels were determined every week. After 5 weeks the animals were sacrificed and activities of antioxidant enzymes and lipid peroxidation products were determined in their liver and kidney homogenates. We also determined serum concentrations of total lipid(TL), total cholesterol(TC), triglycerides(TG) and HDL-cholesterol(HEL-C).Blood sugar and water intake were higher in decreased by dietary Indongcho intake, Body weight gain and FER(feed efficiency ration) were reduced by STZ treatment. But, Final body weight was recovered by Indongcho-contained diet. LHR(LDL-cholesterol/HDL-cholesterol) of the DI group was significantly lower than the other experimental groups(NC, NI and DE groups). The hepatic glucose 6-phosphatase(G6Pase) activity of the groups fed Indongcho diet(NI and DI group) was lower than the groups fed control diet(NC and DC group) and the G6Pase activity of NI group was recovered to the normal levels(p<0.05). However, The glutathione peroxidase(GPx) and glutathione reductase(GR) activities in liver and G6Pase activity in kidney were not statistically different between the control and diabetic control groups. Renal GST activity of the DI group was recovered by Indongcho intake. In conclusion, these results confirm oxidative stress in the liver and kidney of rats with STZ diabetes and antioxidative effect of Indongcho.

울진원자력발전소 주변 소나무림의 종조성과 군락 특성

방제용,전영문,변두원,류병혁,이호준 建國大學校基礎科學硏究所 1995 理學論集 Vol.20 No.-

울진원자력발전소 주변 소나무림의 종조성과 군락특성을 1994년 3월부터 95년 2월까지 조사한 결과는 다음과 같다. 소나무군락은 상수리나무하위군락과 산철쭉하위군락으로 분류되었으며, 전조사방형구 내에서 출현한 종수는 총 116종으로 상수리나무하위군락과 산철쭉하위군락에서 방형구당 출현종수는 각각 28종, 23종으로 나타났다. 소나무군락의 계층별 평균 수고와 식피율은 상수리나무하위군락에서 교목층이 각각 13.5m와 78.8%, 아교목층이 6m와 37.5%, 관목층이 1.9m와 53.6%, 초본층이 0.4m와 64.4%, 산철쭉하위군락에서는 교목층이 13m와 83.8%, 아교목층이 5.5m와 52.5%, 관목층이 1.9m와 57.5%, 초본층이 0.6m와 69.4%로 나타났다. 피복지수에 의한 계층별 우점순위는 교목층과 아교목층에서 각각 소나무가 8437.5, 1111.3으로 나타났고 관목층에서 진달래(2638.5), 초본층에서 큰기름새(1048.2)가 가장 높게 나타났다. 소나무의 DBH별 분포를 보면 11-15cm급이 상수리나무하위군락과 산철쭉하위군락에서 각각 29.1%(4.2 individuals/a), 26.7%(4.5 individual/a)로 가장 높게 나타났다. 현존식생도에 따른 각 식생형의 분포면적은 소나무림이 133.1k㎡(80.5%), 경작지와 주거지 28.7k㎡(16.2%), 곰솔림 1.8k㎡(1.1%) 순으로 나타났다. 녹지자연도의 등급별 분포는 7등급(이차림)이 70.4%, 2등급(경작지와 주거지) 17.4%, 8등급(이차림) 11.6%, 4등급(벌목지) 0.2%, 6등급(인공조림지) 0.1% 순으로 나타났다. Montreal model에 의한 소나무림의 식물현존량은 3,077,327.8ton으로 산정되었다. The floristic composition and community characteristics of Pinus densiflora forest in vicinity of Ulchin Atomic Power Plant were surveyed from March, 1994 through February, 1995. The results obtained are summarized as follows: The Pinus densiflora community was classified into the subcommunity of Quercus acutissima and Rhododendron yedoence var. poukhanense. The total number of species appearing in the entire surveyed quadrats was 116 sepcies, then 28 and 23 species per quadrat in Quercus acutissima subcommunity and Rhododendron yedoence var. poukhanense subcommunity, respectively. Tree height and vegetation cover by the layer of the Pinus densiflora community were 5m and 78.8% in tree layer, in subtree layer(6m, 37.5%), in shrub layer(1.9m, 53.8%) and in herb layer(0.4m, 64.4%) in Quercus acutissima subcommunity, and in tree layer(13m, 83.8%), in subtree layer(5.5m, 52.5%), in shrub layer(1.9m, 57.5%) and in herb layer(0.6m, 69.4%) in Rhododendron yedoence var. poukhanense subcommunity. The dominance sequences on each stratum determined by the coverage index showed that Pinus densiflora was most dominant in tree layer with 8437.5 and in subtree layer with 1111.3, Rhododendron yedoence var. poukhanense in shrub layer with 2638.5, and Spodiopogon sibiricus in herb layer with 1048.2 value. The highest value of diameter breast height(DBH) distritued in the range of 11~15cm in Quercus acutissima subcommunity(29.1%, 4.2 individuals/a) and Rhododendron yedoence var. poukhanense subcommunity(26.7%, 4.5 individuals/a), respectively. The distribution area of each vegetation type in the actual vegetation map was 80.5% in Pinus densiflora forest, 16.2% in cultivated land and residential section, and 1.1% in Pinus thunbergii forest. The distribution of the degree of green naturality(DGN) was 70.4% in the 7th grade(second forest), 17.4% in the 2nd grade(cultivated land and residential section), 11.6% in the 7th grade(second forest), 0.2% in the 4th grade(cutted area), and 0.1% in the 6th grade(afforestation). It was estimated that phytomass of Pinus densiflora in the study sites, which was calculated by Montreal model, was 3,077,327.8ton.