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기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고
김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2
Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.
박보림,엄영란 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1
BACKGROUND: While it was emphasized the advantages for breast-feeding and recommanded breast-feeding, it was least to solve the mother's probems in breast-feeding. To continue breast-feed, the mothers need be probided the care for the early problems. METHODS: We interviewed 62 women with questionaire during puerperium(2-31days) in Soonchunhyang Chunan Hospital OB unit. They were breast-feeding. RESULTS: The experience at early breast-feeding was very positive, which were 'the realization of role transition, the formation of attachment, the feeling of happiness. The best important problems of early breast-feeding were 'baby falls asleep, leaking breasts, and worry about insuffcient milk because of small breasts'. The maternal learning needs were significantly related with the problems that they really experienced. CONCLUSION: The education about breastfeeding and its problems should be based on the maternal learning needs and their experience. And the method of educaton should be changed from topic-oriented to problem-solving.
일개 간호학과 학생을 대상으로 자기효능감과 대처정도의 상관성 분석
조남옥,엄영란,유경희 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2
The purpose of this study was to analysis the correlation between self-efficacy and level of coping in nursing students. Subjects of the study were 134 nursing students. Self report questionnaires were used to measure the variables including self-efficacy and level of coping. Reliability coefficients of the self-efficacy and coping instruments were found Cronbach's α=.80 ~.91. In data analysis, SPSS PC 6.0 Program was utilized for descriptive statistics, Pearson's correlation, One-Way Anova. The results of Pearson's correlation and One-way Anova were as follows. 1) The self-efficacy was significant correlation with level of coping(r=.246, p<.005) and the number of year in campus life(r=.506, p<.0001). 2) There was significant difference in self-efficacy according to the number of year in campus life(F=16.52, P<.0001). 3) There was significant differences in the level of coping according to the satisfaction of campus life(F=3.02, P<.05) and self-efficacy(F=4.2621, P<.05). Based on the results obtained from this study, strategies to ptomote self-efficacy have to be developed in nursing curriculum.
이정금(Lee Jung-Geum),김영란(Kim Young-Rhan),강효정(Kang Hyo-Jung),한미라(Han Mi-Ra),임부연(Lim Boo-Yeun) 한국열린유아교육학회 2007 열린유아교육연구 Vol.12 No.1
본 연구는 유아들이 산책활동을 통해 가지게 되는 독특한 경험양식을 주의 깊은 관찰과 경청을 통해 질적으로 연구해보는 것을 목적으로 하였다. 산책활동이 일상적인 생활로 이루어지는 두 유아교육기관 만5세 유아를 대상으로 비디오 촬영과 연구일지로 자료를 수집하였다. 본 연구에서 산책활동 경험은 그동안 현대 유아교육에서 간과 해온 자연의 의미와 중요성을 다시 생각하게 하는 기회를 제공하였으며, 특히 유아들은 자연과 만나면서 그들의 몸과 마음을 매우 특별하고 창의적인 방법으로 활용하고 확장하는 능력을 보여주었다. 산책활동을 통해 유아들이 구조화된 실내외 교실에서 경험할 수 없는 독특한 몸의 감각과 인지작용을 가능하게 함으로써 보다 높은 단계로 나아가는 학습능력 그리고 자연적 능력과 사회적 능력을 동시에 보여 주었다. 이러한 점에서 본 연구는 자연이 주요한 교육적 화두로 등장하는 오늘날 유아교육기관에서 유아의 풍부한 경험세계를 확장하는 좋은 활동의 예로써 산책활동에 보다 귀 기울이고 적극적으로 활용할 것을 제안하였다. This study aims at looking closely young children's experiential world observed through San-Check, a walking activity in nature. The researcher particularly focused on how young children build experiences in nature which are totally different from their structured classroom, and their competence in dealing with many stimuli and materials found in nature. Two classes of five-year-olds which do a walking activity on a daily basis were selected. Data were collected from direct observation of children's walking activity from June 2006 to September 2006. The researcher went to each school at least once a week to participate in the walking activity which lasted 2-3 hours or almost a half day before lunch time. The study revealed that young children construct their experiences in very creative and unique ways and are extremely competent in using their bodies and thoughts in nature. Children demonstrated a striking ability to use their bodies through their sensory organs and became more sensitive and intellectual. Children also displayed diverse ways of thinking ways that are more creative, alive and intellectual than those demonstrated in structured classrooms. Children's thinking skills became more imaginative, explorative, and sympathetic towards wildlife. This study suggests that a walking activity in an early childhood institution should be viewed as an educational activity that helps young children use their somatic senses in more intellectual ways. This study suggests that a walking activity like San-Check should be more actively considered to help young children's experience become more healthy, spiritual, and intellectual.
Synthesis and cytotoxicity of 2-phenylquinazolin-4(3H)-one derivatives
Hea-Young, Park,Hee-Kyung, Rhee,Ji Hye, Yoo,Eun Young, Lee,Young Joo, Kwon,Hang-Rhan, Seo,Yun-Sil, Lee 梨花女子大學校 藥學硏究所 2012 藥學硏究論文集 Vol.- No.22
Thirty 2-phenylquinazolin-4(3H)-one derivatives were prepared and their cytotoxic activities were tested in five human tumor cell lines. Some compounds (Se, Sk, St. 6c and 6f) showed relatively high cytotoxic activity. Especially, compound 6c showed the most cytotoxicity against all cell lines tested among the synthesized derivatives, and the inhibitory activity of 6c against Hela cell was higher than that of adriamycin. The putative mechanism of antitumor action in apoptotic cell death was cell cycle arrest in the GO/Gl phase by compounds Sk, Sv, Sm. 6c, and 6f in Hela cells. These compounds showed relatively high cytotoxicity in this cell type.
Prenatal diagnosis of atrial isomerism in the Korean population
( Mi Young Lee ),( Hye Sung Won ),( Jae Yoon Shim ),( Pil Ryang Lee ),( Byong Sop Lee ),( Ellen Ai Rhan Kim ),( Young Hwue Kim ),( Jeong Jun Park ),( Tae Jin Yun ),( Ahm Kim ) 대한산부인과학회 2014 Obstetrics & Gynecology Science Vol.57 No.3
Objective To report our experiences in the prenatal diagnosis of atrial isomerism and postnatal outcomes. Methods A total of 80 fetuses prenatally diagnosed with atrial isomerism were retrospectively analyzed between 1999 and 2011 at a single institution. Results Of 43 fetuses with prenatally diagnosed right atrial isomerism (RAI), 40 cases were analyzed. The diagnostic accuracy was 93%. The main intracardiac anomalies in RAI were atrioventricular septal defect (AVSD), abnormal pulmonary venous connection, bilateral superior vena cava (BSVC), and pulmonary atresia. Among 28 live births, three infants were lost to follow up, and the overall survival rate was 60%. Of 37 fetuses with prenatally diagnosed left atrial isomerism (LAI), 35 were evaluated. The diagnostic accuracy was 97%. The main intracardiac anomalies in LAI were ventricular septal defect, BSVC, AVSD, double outlet right ventricle, and bradyarrhythmia. Among seven patients with bradyarrhythmia, only one showed a complete atrioventricular block. All fetuses had an interrupted inferior vena cava with azygous continuation. The overall survival rate was 90%. Conclusion Our study confirms the previous findings of fetal atrial isomerism. We also demonstrates a much lower prevalence of AVSD and complete heart block in LAI and a better survival rate in RAI. Although the postnatal outcomes for RAI were worse than those for LAI, successful postnatal surgery with active management improved the survival rate.