NR과 SBR 가황물의 경도와 강성도에 대한 온도의 영향

진현호 ( Hyun Ho Jin ),홍창국 ( Chang Kook Hong ),조동련 ( Dong Lyun Cho ),강신영 ( Shin Young Kaang ) 한국고무학회 2007 엘라스토머 및 콤포지트 Vol.42 No.3

본 연구에서는 고무제품의 수치 안정성과 성능유지에 직접적으로 영향을 미치는 중요한 특성 중 하나인 온도변화에 따른 고무재료의 경도변화를 고찰하였다. 새롭게 제작된 International Rubber Hardness Degree(IRHD, Normal type) 경도측정 시험기를 사용하여 미충전된 NR과 SBR시편의 여러 온도에서 경도변화를 측정하였으며 Young`s modulus 값과 비교하였다. NR과 SBR 모두 유리전이온도 근처에서 경도와 Young`s modulus의 급격한 변화를 보였다. 온도가 증가함에 따라 경도와 Young`s modulus 값이 증가하는 경향을 보였으며 이는 분자의 운동성과 엔트로피 영향으로 해석할 수 있다. 카본블랙과 실리카가 충전된 NR과 SBR의 경우 충전제의 함량이 증가함에 따라 경도에 미치는 온도의 영향이 감소함을 관찰하였다. Hardness of rubbery materials, which is important for dimensional stability and product performance, was investigated upon temperature change in this study. A newly developed IRHD (International Rubber Hardness Degree) tester was used to measure the hardness changes of NR and SBR specimens at various temperatures and the hardness values were compared with the Young`s modulus. The hardness and Young`s modulus of NR and SBR showed an abrupt change near the glass transition temperatures. The hardness and Young`s modulus were increased by increasing temperature due to the increased random chain conformation of molecules. The effect of temperature on hardness and Young`s modulus of NR and SBR specimens filled with carbon black and silica was decreased by increasing filler content.

유방의 관상피내암종에서의 p27_kip1, Cyclin D1 및 p53 단백의 발현

오영륜,송상용,최종순,고영혜,이회정,안긍환 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.9

융모성 질환의 임상적 연구

남상륜,손영선,이영일,노흥태,강길전 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Seventy nine cases of trophoblastic disease were analyzed at the Department of Obstetrics and Gynecology, Chungnam National University from January, 1985 to October, 1989. The results are as follows: 1. Incidence of trophoblastic disease was one per 31.8 deliveries(3.15%), and it was pathologically consisted with partial mole(27.8%), complete mole(45.6%), invasive mole (17.7%), choriocarcinoma(8.9%). 2. Age group of 26 to 30 was found most frequent(40.5%) and primipara was the most frequent group(43.0%). There was no increase for the persistent disease according to age and para. 3. Clinical manifestations were vaginal bleeding(91.1%), the most common, nausea and vomiting(20.3%), abdominal pain(10.1%) and etc. 4. Molar pregnancies with excessive uterine enlargement were found in 35.6% and were at increased risk for the persistent disease. 5. Antecedant pregnancies prior to trophoblastic disease were abortion(43.0%), term pregnancy(16.5%) and molar pregnancy(16.5%). 6.β-hCG concentration before November, 1986 was significantly lower than after ten. And the first postevacuation β-hCG level was increased in cases of the persistent disease. 7. The treatment regimens in molar pregnancies were suction curettage with prophylactic Act-D(41.4%) and without Act-D(43.1%), hysterectomy with Act-D(13.8%), and hysterotomy(1.7%). There was no difference in complication persistent disease between with and without prophylactic chemotherapy. 8. Non-metastatic and metastatic low risk patients were treated with hysterectomy with or without MTX-CF(66.7%), curettage with MTX-CF, Act-D or MAC(33.3%) to attain remission without failure. All metastatic high risk patients were treated with hysterectomy with 1-6 courses of MAC triple chemotherapy except 1 case of death from respiratory failure and 1 lost case. 9. Side effects after chemotherapy include gastrointestinal symptoms(91.1%), fever(57.8%), leukopenia(49.0%), hepatotoxicity(46.9%), stomatitis(40%), alopecia(28.9%), thrombocytopenia(15.3%) and etc, in order of frequency.

진행된 원발성 및 재발성 자궁경부암의 5-FU와 Cisplatinum 병합요법의 반응 및 독성에 관한 임상적 고찰

남상륜,손영선 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

It has been suggested that synergism between 5-FU and cisplatin could make this combination a useful regiment in treating advanced squamous cell carcinoma of uterine cervix. Between July, 1988 and October, 1989, seventeen patients with advanced or recurrent squamous cell carcinoma of cervix were treated with a chemotherapy regimen consisting of cisplatin 60㎎/㎡ IV, day 1 and 5-FU 1gm/㎡/day as a 12-hour IV infusion, days 1-5 repeated at 3-week intervals. The results are as follows: 1. Of the seventeen patients, 12 were evaluable and 5 were inevaluable because of being lost. 2. Median age of the patients was 52 years(range 34-58). 3. Overall response rate was 83% (10/12), 4 CR’s (33%) and 6 PR’s (50%). And response rates of advanced and recurrent group were 91%(10/11) and 0%(0/1). 4. Analysis of the various prognostic factors revealed that none was significantly related to response. 5. Nausea and vomiting were the most commonly encountered toxic manifestations (100%), bet were easily controlled, and were followed in frequency by alopecia (92%), leukopenia (75%), anemia (42%), diarrhea (33%), stomatitis (25%), abdominal pain (25%) and hepatotoxicity (25%). There was no treatment-related death. In conclusion, combination chemotherapy with cisplatin and continuous infusion of 5-FU seems to be a highly active regimen in the treatment of advanced squamous cell carcinoma of the cervix and deserves to do further investigation of this regimen in treating this disease as a neoadjuvant chemotherapy before surgery of radiation therapy. But more cases need to be evaluated in patients with recurrent cervical cancer.

20대와 50대 여성의 하반신에 대한 인식과 형태에 관한 연구

박옥련,이영주 慶星大學校 1998 論文集 Vol.19 No.1

Through the recognition and the satisfaction of the lower part of the women body in 20s' and 50s' we studied 303 respondents of the women to analyze what lower part shape they want. The results are as follows. 1. The recognition of the lower Part showed certain degrees of differences in thigh girth, calf girth, crotch length, weight, and stature according to the age. 2. The female of the 50s showed higher satisfaction of their lower part considering that of the 20s. 3. The cluster analysis of the lower part shape of the 20s and 50s was classified into 5 types.

부산시민의 인구이동 특성에 관한 연구

옥양련,류영달 부산대학교 사회과학대학 1994 社會科學論叢 Vol.13 No.1

This paper is to identify the major determinants of out-migration of Pusan citizens. For this purpose, first, the level of out-migration desire of Pusan citizens was investigated. Second, the reason for Pusan citizens' out-migration desire was examined which is a economic factor or suburbanizational factor. Third, the characteristics of those who are willing to leave Pusan soon were examined. For examining the above hypothese, survey data about Pusan citizens were used. The findings derived from the analyses of survey data were as follows: First, Pusan citizens consider good environmental conditions as the most important reason for out-migration. Second, education level is the most strong factor influencing the migration desire. Third, out-migration desire is stronger workers. Fourth, Pusan has also reached the stage of suburbanization as other metropolis in the advanced societies. Fifth, suburban areas surrounding Pusan are going to be the bed-town of middle class. And this kind of suburbanization will progress more rapidly in the coming years.

진행된 자궁경부암 및 재발암에서 vincristine, bleomycin, mitomycin-C 및 cisplatin의 치료성적에 관한 연구

손영선,강길전,남상륜 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

Seventeen patients with advanced or recurrent cervical cancer were treated with vincristine, bleomycin, mitomyicin-C and cisplatin between February, 1986 and January, 1989. 1. Among evaluable patients, response rate was 55.6%(patial responses in all). Response rates of advanced and recurrent group were 71% and 0%, respectively. 2. Medium survival for responders and nonresponders were 26 months and 25 months: there was no statistically significant difference(p>0.05) 3. Median survival for preoperative or preradiational chemotherapy and postoperative chemotherapy were 26 months and 23 months (p>0.05). 4. Nausea and vomiting were observed in most patients (88%), but easily controlled, and were followed in frequency by ferer, alopecia, leukopenia, stomatitis, diarrhea, but there was no serious toxicities. In addition, combination chemotherapy with vincristine, bleomycin, mitomycin-C and cisplatin in patients with advanced cervical vancer seemed to be relatively effective and well tolerable, but more cases need to be evaluated in patients with recurrent cervical cancer.

Pseudo-Gitelman씨 증후군 1예

김성렬,조영일,이해운,이정연,안해련,송종오,명승운 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Gitelman's syndrome is a rare disorder with a characteristic set of metabolic abnormalities. These include hypokalemia, metabolic alkalosis, hypocalciuria and hypomagnesemia. The clinical manifestations of Gitelman's syndrome are very similar with those of Bartter's syndrome and diuretic abuse. Gitelman' syndrome and Bartter's syndrome can be distinguished by renal clearance study after administration of furosemide and thiazide, since the primary defect in each of these disorders is an impairment in sodium reabsorption in the distal tubule and loop of Henle, respectively. Pseudo-Bartter's syndrome due to diuretic abuse can be distinguished by history of diuretic use and a positive urine assay for diuretics. We have experienced a case of pseudo-Gitelman's syndrome in 56-year old woman with unexplained hypokalemic metabolic alkalosis, hypocalciuria, and hypomagnesemia. The patient denied ingestion of diuretic medication. The results of renal clearance study using furosemide and thiazide in this case suggested the presence of the primary defect of sodium reabsorption in the distal tubule rather than in the loop of Henle. These clinical and laboratory findings were consistent with those of Gitelman's syndrome. But, this case was confirmed as pseudo-Gitelman's syndrome since diuretics were detected by a urine assay for diuretics. Furosemide and hydrochlorothiazide were contained in the pill that she had been taking due to constipation. Herein, we report the case of pseudo-Gitelman's syndrome by abuse of cathartics containig diuretics presented as Gitelman's syndrome in renal clearance study.

Novel nuclear targeting coiled-coil protein of Helicobacter pylori showing Ca2+-independent, Mg2+-dependent DNase I activity

Young Chul Kwon,김신일,Yong Seok Lee,Je Chul Lee,Myung-Je Cho,Woo-Kon Lee,Hyung-Lyun Kang,Jae-Young Song,Seung Chul Baik,Hyeon Su Ro 한국미생물학회 2016 The journal of microbiology Vol.54 No.5

HP0059, an uncharacterized gene of Helicobacter pylori, encodes a 284-aa-long protein containing a nuclear localization sequence (NLS) and multiple leucine-rich heptad repeats. Effects of HP0059 proteins in human stomach cells were assessed by incubation of recombinant HP0059 proteins with the AGS human gastric carcinoma cell line. Wild-type HP0059 proteins showed cytotoxicity in AGS cells in a concentrationdependent manner, whereas NLS mutant protein showed no effect, suggesting that the cytotoxicity is attributed to host nuclear localization. AGS cells transfected with pEGFP-HP0059 plasmid showed strong GFP signal merged to the chromosomal DNA region. The chromosome was fragmented into multiple distinct dots merged with the GFP signal after 12 h of incubation. The chromosome fragmentation was further explored by incubation of AGS chromosomal DNA with recombinant HP0059 proteins, which leaded to complete degradation of the chromosomal DNA. HP0059 protein also degraded circular plasmid DNA without consensus, being an indication of DNase I activity. The DNase was activated by MgCl2, but not by CaCl2. The activity was completely blocked by EDTA. The optimal pH and temperature for DNase activity were 7.0–8.0 and 55°C, respectively. These results indicate that HP0059 possesses a novel DNase I activity along with a role in the genomic instability of human gastric cells, which may result in the transformation of gastric cells.

친환경 가스개폐기 개폐성능 향상을 위한 유동해석 및 실험

유련(Lyun Yu),안길영(Kil-Young Ahn),김영근(Young-Geun Kim),조해용(Hae-Yong Cho) 한국기계가공학회 2022 한국기계가공학회지 Vol.21 No.9