양극성 정동장애와 혈청 Inositol-1-phosphatase 활성도 변화

조현주,김영철,우행원,연규월,조기승 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2

Objects : Several lines of possibilites have been oroposed about the etiology of bipolar attective disorder in biological, genetic and psychosocial aspect. The purpose of this study is to inspect the etiology of bipolar affective disorder in biological aspect by measuring the changes of serum inositol-1-phosphatase activity and investing a causal relationship between clinical symptoms and serum inositol-1-phosphatase activities in patients with bipolar affective disorder. Methods : The subjects were 18 inpatients who met DSM-IV diagnostic criteria for bipolar I affective disorder, manic episode and 15 normal controls. Inositol-1-phosphatase activities were measured in serum by using spectrophotometer. Clinical symptoms of patients were assessed by YMRS at admission day and after 2 weeks lithium treatment. Results : 1) Inositol-1-phosphatase activities of the patients were increased to about 2 times as compared with those of normal controls. And the activity levels were decreased gradually to the normal at 14 days. 2) Young's Mania Rating Scale(YMRS) scores were decreased significantly by lithium treatment. 3) Statistical significance could not be found between the change of YMRS scores and the levels of inositol-1-phosphatase activity. Conclusion : In this study, statistical significance could not be found between clinical improvement and inositol-1-phosphatase activities, but the fact that lithium treatment improve the clinical manifestation shown by YMRS score changes, and reverse the increased inositol-1-phosphatase activities suggests the strong association between pathophysiology of bipolar affective disorders and inositide metabolism.

미세유화약물송달시스템을 이용한 로바스타틴의 생체이용률 향상

윤복영,강복기,정상영,이영원,이시범,황성주,육순홍,강길선,이해방,조선행 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

A self-microemulsifying drug delivery system (SMEDDS) was developed to increase the dissolution rate, solubility, and ultimately bioavailability of a poorly water soluble drug, lovastatin. SMEDDS was the mixtures of oils, surfactants, and cosurfactants, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal (GI) tract. Various types of self-emulsifying formulations were prepared using four types of oil (Capryol 90, Lauroglycol 90, Labrafil M 1944 CS and Labrafil M 2125), two surfactants (Cremophor EL and Tween 80), and three cosurfactants (Carbitol, PEG 400 and propylene glycol). The efficiency of emulsification was studied using a laser diffraction size analyzer to determine particle size distributions of the resultant emulsions. Optimized formulations selected for bioavailability assessment were Carpryol 90 (40%), Cremophor EL (30%) and Carbitol (30%). SMEDDS containing lovastatin (20 mg and 5 mg) were compared to a conventional lovastatin tablet (Mevacor^? , 20 mg/tab) by the oral administration as prefilled hard gelatin capsules to fasted beagle dogs for in vivo study. The area under the serum concentration-time curve from time zero to the last measured time in serum, AUC_0→24h, was significantly greater in SMEDDS, suggesting that bioavailability increase 130% and 192% by the SMEDDS, respectively. The self-emulsifying formulations of lovastatin afforded the improvement in absolute oral bioavailability relative to previous data of lovastatin tablet formulation. These data indicate the utility of dispersed self-emulsifying formulations for the oral delivery of lovastatin and potentially other poorly absorbed drugs.

만선신부전 환자에서 관상동맥조영술 소견에 관한 연구

한대희,김성구,박상호,김성한,조원영,방덕원,조윤행,정의룡,은영근,권영구 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Patients with chronic renal fialure have a substantially elevated risk of death from cardiovascular diseases than do the general population. the patients with chronic renal failure are at significantly increased freqeuncy of hypertension, hyperlipidemia, and diabetes mellitus which are known to the risk factors of the coronary artery diseases, and the prevalence of the coronary artery diseases in chronic renal failure patients is highly associated with the hemodynamic disorder and metabolic abnormalities. therefore we expected that the coronary angiographic findings in patients with chronic renal failure should be different from the general population (control groups) and investigated the risk factors contributing to coronary artery diseases. Method : we have retrospectively compared the coronary angiographic findings of 44 patients with chronic renal failure on hemodialysis with that of 88 patients in the general population and investigated the factors contributing to the development and acceleration of coronary artery diseases in patients with chronic renal failure Result : Hypertension and diabetes mellitus which is risk factors for coronary artery disease is significantly increased in patients with chronic renal failure, in coronary angiographic finding the severity of the lesion is worse. the incidence of PCI or CABG of patients with chronic renal failure is more than that of control group but statistically no difference between patients with chronic renal failure and control group. the sex, the duration of disease, the duration of dialysis, serum creatinine in patients with chronic renal failure have no correlation to the prevalence of coronary artery disease and severity of lesion. hyperglycemic patients with chronic renal failure have high incidence of coronary artery disease and are worse in the severity of lesion Conclusions : There is significantly increased the pevalence and severity of involving multiple coronary artery diseses in hyperglycemic patients with CRF.

STS에 대한 고등학생들의 견해에 관한 평가도구 개발

임재항,강순민,공영태,최병순,남정희 한국과학교육학회 2004 한국과학교육학회지 Vol.24 No.6

이 연구의 목적은 STS에 대해서 우리 나라 고등학생들이 가지는 견해를 알아보기 위한 평가도구인 HS-VOSTS(Korean students' views on STS)를 개발하는 것이다. HS-VOSIS문항을 개발하기 위해서 다음과 같은 연구과 정을 수행하였다. 우선, 문헌과 선행 연구 고찰을 통해 4가지 범주의 10가지 하위 범주와 관련하여 23개의 논제를 포함하는 STS 범주 체계를 설정하였다. STS 범주 체계는 정의ㆍ과학의 외적 사회학ㆍ과학의 내적 사회학ㆍ인식론의 네 가지의 커다란 범주로 구성되어 있다. 다음은 91f 범주 체계를 기초로 4단계에 걸쳐 문항을 개발하였다. 1단계에서는 각 논제에 대한 짝진술문을 기초로 학생진술 문항지를 작성하여 772명의 고등학생들(16.3세)에게 투입하였다. 2단계에서는 짝진술문 중 하나를 제거하여 문항의 진술문으로 하고, 분류된 공통견해를 답지로 하여 1차 다지선다형 문항지를 구성하였다 3단계에서는 고등학생 28명(16.5세)을 대상으로 반구조화 면담을 실시하여 그 결과 분석을 통해 2차 다지선다형 문항지를 구성하였다. 4단계에서는 2차 다지선다형 문항지를 고등학생 306명에게 적용하여 낮은 반응비율을 보인 답지들을 제거하여 최종 검사도구를 완성하였다. HS-VOSTS는 학생들의 STS에 대한 신념 및 견해를 알아볼 수 있는 유용한 도구로서, 그 결과는 교사뿐만 아니라 교육과정 개발자, 교과서 저자, 교육정책 입안자들에게 많은 시사점을 줄 수 있을 것이라 생각한다. The purpose of this study was to develop HS-VOSTS(High School Students' Views On Science-Technology-Society), which is an instrument that monitors high school students' views on STS. For this study, 23 multiple-choice items were developed on four categories. First, a categorial scheme was constructed. The categorial scheme was based on many instruments that evaluate students' understanding on STS, literature review, and STS learning goal that many researchers had asserted. Second, the multiple-choice items were developed. The development of the items was carried out through four steps. In the first step, some pairs of statement on each subordinate category were formed. Next, the student statement questionaries which were based on the pairs of statement were responded by 772 students. In the second step, the response written by the students were analyzed to common viewpoints and the first multiple-choice items were constructed. In the third step, the semistructured interview with 28 high school students was implemented and the second multiple-choice items were constructed. In the fourth step, the final version of the instrument was developed through the analysis of the students' response on the second multiple-choice items. HS-VOSTS is an useful instrument for monitoring students' beliefs and viewpoints on STS topics. The results of the students' responses to HS-VOSTS items reflect the students' own thoughts directly. These results will give some implications for the curriculum developers, the authors of text books and the educational policy makers as well as the teachers.

大邱市民의 牛乳消費實態와 仁識度

朴恒均,張仁浩,權海秉,金永洪 경북대학교 교육대학원 1977 논문집 Vol.9 No.-

This survey is for getting references to establish a plan for increasing milk demands and the improvement of dairy hygiene by studing the amount of milk consumption, tendency of milk consumers and the recognition of milk in Daegu City. One hundred eighteen thousand and three hundred seventy four homes of pupils who are attending the elementary school in Daegu-City were surveyed for milk consumed or not and 1,280 homes consumed milk and 1,561 homes, non-drinking milk were studied from September 28, 1977 to October 10, 1977 as follows: 1) The annual consumption of milk is 11,497M/T, 4.65% of 247,000M/T national milk production. And dairy cattles fed in Daegu area are 4,752, 4.13% of 115,000 heads fed in Korea. 2) Daily consumption milk is 31,000㎏ and a shortage of 5,000㎏ arose in the summer while there was a 8,000-9,000㎏ over abundance in the winter. 3) Home delivered milk for 118,374 homes that have pupils was 10,560, 8.92%. 4) According to monthly income, 29.7% of 1,280 homes delivered milk was less than 100,000 Won for monthly earnings, and 43.7% for 1,561 homes not delivered milk was less than 1000,000Won for monthly earnings. The number of homes that were not delivered milk was two times as much as home consumed milk. 5) Depending on housewife's school career, middle school graduates were 33.0%, high school 66.9% while among homes that had not consumed milk, 46.37% housewife attended middle school and 49.6% high school. 6) If the price is lower than now, homes requiring more milk was 84.6% but childrens high school year. And if it was low price, 88.4% homes wanted to begin drinking milk, 35.43% by their children's high school year. This indicates that an increasing number of homes required milk. 7) The consumption of 2 bottles (360㎖) or more per homes is 79.69% and one bottle (180㎖) per home is 20.31%. 8) Homs delivered for one year more were 75.7% and less than one year 34.6%. 9) Delivered milk placed in refrigerators was 69% and others 31.4%. People who drank cold milk was 81.56% and hot milk were 18.44% 10) Milk price delivered was: A high of 45.94% and a low of 2.97% and a reasonable 51.09%. 11) The reasons for drinking milk were: Weakened body 49.6%, taste 18.04%, and instead of a rice meal 31.02%. 12) The physical effects after drinking were: Good 65.47%, bad 0.5%. 13) Homes which liked to have delivered milk in the morning were 85.31% and daily 97.19%. 14) Milk quality was: Good 27.89% and normal or of poor grade 72.8%. 15) Milk delivery systems were: Good 65.31% and not good 29.65%. 16) The mainreason for not drinking milk taste 20.88%, Yogurt used instead 20.50%, and powdered milk used instead 22.74%, and unwholesome milk 16.02%.

중등학교 교사의 역할 수행에 대한 교사-학생의 지각에 관한 연구

이항재,오영순 順天鄕大學校 人文科學硏究所 1998 순천향 인문과학논총 Vol.6 No.-

初步者를 위한 Tennis Service의 段階的인 指導方法에 關한 硏究

이영흥,홍성표 忠南大學校體育科學硏究所 1984 體育科學硏究誌 Vol.2 No.1

This research was tried to find out the effective way to teach tennis service for the beginners. The object of study was composed of 8 students of the first grade in girl's high school who have not taken special lessons for tennis but wanted to learn it, was divided them into two groups. Experimental and comparative group(each has 4 students). They have taken lesson for 2 hours a day, four times in a week through 24 weeks. The investigator divided the teaching program of slice service and top spin service into three steps, taught them he same procedure in the first and second step. In the last step the experimental group has learned ball toss, spin, ball control but the other group has learned only service. After comparing and analysising the outcome of the experimental group's development, the research reached the following conclusion. 1. In raising tole success rate of service, the experimental group which practices ball toss, spin and ball control step by step records higher meaningful level than the comparative one which repeats only service after nine weeks. 2. As the better way to coach slice service and top spin service to the beginner, we can conclude to Practice ball toss, spin and ball control step by step is more effective than simple and repeated practice at the ideal position after learning form.

公衆保健醫 및 保健診療員의 業務時間 活用에 關한 調査 硏究

李恒榮,沈雲澤 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.1

For the purpose of offering fundamental data to the development of medical delivery system, the author analysed the daily activities and time allocations of Public Health Doctors occupied Health Subcenters and Community Health Practitioners in Chungnam area, March 1 through the April 30, 1984. Data was collected from 26 Public Health Doctors and 7 Community Health Practitioners. The obtained results were as follows; 1. The average daily working hours was 6.7(range 6.9-7.6), but that was 4.2 on Saturday. 2. The average daily working hours by working place difference were own clinic 6.0, home visiting 0.5 and others clinic 0.2. Of the total 6.7 daily working hours, 3.2 was treatment activity, 2.9 was administrative activity and 0.6 was health service activity. 3. The classification of diseases being treated were disease of respiratory system, digestive system, skin & cellular tissue, muscle & skeletal system, accidentㆍ poisoning & violence, infectious & parasitic disease in that order. 4. Average number of daily health service activity were tuberculosis control 4.8, child health 4.2, health education & environmental sanitation 2.8, maternal health 2.5, but those of administrative activity were admintrative affair 10.3 and support work 9.0.

고령화 사회와 여가 레크레이션의 발전 방안

이계영,김흥태 대진대학교 1999 大眞論叢 Vol.7 No.-

The purpose of this study is firstly to try to find a development plan of leisure recreation in the aging society, and ultimately to make a contribution to a development plan of leisure recreation suited for the future society in the 21st century. The main contents consist of three aspects, and they also become conclusinos of this study. In the policy aspect of the leisure recreation of aging society, We must play great part in improvement of ability which can sensitively cope with a change of age and a turn to a form of leisure. In the actual aspect, the development plans as follows; First, expansion and supplementation of the facilities for old people's leisure recreation. Second, expansion and maximization of utilization for the public gymnasium facilities. Third, efficient reconsideration of facility management for old peoples, leisure recreation. In the program aspect, the development plans as follows; First, diversification and specialization of programs for old people's education and reinforcement of substantial old peoples education. Second, development or spread of old peoples sports programs and activation of old peoples sports activities through and industrial upbringing with chart concerned with the old.

방사선 조사가 배양된 조골세포의 apoptosis와 세포주기의 변화 및 석회화 결절 형성에 미치는 영향에 관한 연구

이영미,최항문,허민석,이삼선,최순철,박태원 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.3

Purpose : The study was aimed to detect the induction of apoptosis, cell cycle arrest and calcified nodule formation after irradiation on primarily cultured osteoblasts. Materials and Methods : Using rat calvarial osteoblasts, the effects of irradiation on apoptosis, cell cycle arrest, and calcified nodule formation were studied. The single irradiation of 10 and 20 Gy was done with 5.38 Gy/min dose rate using the 137Cs cell irradiator at 4th and 14th day of culture. Apoptosis induction and cell cycle arrest were assayed by the flowcytomtry at 1,2,3, and 4 days after irradiation. The formation of calcified nodules was observed by alizarin red staining at 1,3,10,14 days after irradiation at 4th day of culture, and at 1,4,5 days after irradiation at 14th day of culture. Results : Apoptosis was not induced by 10 or 20 Gy independent of irradiation and culture period. Irradiation did not induced Gl arrest in post-irradiated ostedblasts. After irradiation at 4th-day of culture, G2 arrest was induced but it was not statistically significant after irradiation at 14th-day of culture. In the case of irradiated cells at 4th day of culture, calcified nodules were not formed and at 14th-day of culture after irradiation, calcified nodule formation did not affected. Conclusion : Taken together, these results suggest that Irradiation at the dose of 10-20 Gy would not affect apoptosis induction of osteoblasts. Cell cycle and calcified nodule formation were influenced by the level of differentiation of osteblasts. (Korean J Oral Maxillofac Radiol 2000; 30: 189-198)