전,후기 노인의 건강행위, 건강상태와 건강관련 삶의 질

정영해 ( Young Hae Chung ),조유향 ( Yoo Hyang Cho ) 대한보건협회 2014 대한보건연구 Vol.40 No.1

연구목적 : 본 연구는 노년 전기와 후기 노인의 건강행위, 건강상태와 건강관련 삶의 질 수준을 파악하고, 관련요인을 파악 하고자 한 것이다. 연구방법 : 2010년 국민건강영양조사 제5기 1차년도 원자료를 사용하여 65세 이상 노인 1,339명을 대상으로 교육, 경제수준, 운동, 흡연, 음주, 만성질병, 성별, 거주지역, 동거인, 주관적건강상태, BMI 및 EQ-5D를 건강설문-검진조사가중치를 사례 수에 맞추어 활용하였으며 SPSS 20.0을 이용하여 분석하였다. 노년전기군(<75세)과 노년후기군(≥75세)을 카이제곱검정과 t-검정으로 비교하였으며, 후진제거방식 회귀분석으로 두 군의 건강관련 삶의 질 관련요인을 비교하였다. 연구결과 : 여성노인이 58.4%로 많았으며, 교육수준은 초졸 이하가 3/4으로, 노년후기군은 여성노인과 초졸 이하가 더 많았고, 노년전기군에는 중졸, 고졸, 대졸이상 노인과 배우자와 함께하는 비율이 많았다. 흡연율 13.3%, 음주율 46.9%, 운동실천율 47.8%, 만성질환율 80.3%이었는데, 노년전기군의 경우 음주와 운동실천율 및 비만이 높았고, 노년후기군은 저체중, 우울증상, 자살을 생각해본 적과 주관적인 건강상태가 유의하게 높았다. 노년전기군의 삶의 질은 노년후기군에 비해 유의하게 높았으며, 삶의 질을 구성한 각 항목은 모두 노년전기군에서 유의하게 낮아 노년후기군보다 삶의 질이 더 좋았다. 노년전기군의 삶의 질 관련요인은 성별, 주관적 건강상태, BMI로 나타났고, 노년후기군에서는 경제수준, 만성질환 유무와 주관적 건강상태가 삶의 질과 관련되었다. 결론 : 노인의 삶의 질을 높이기 위하여, 노년 전기에는 체중관리에 초점을 맞추고 성별에 따라 차별화된 서비스를 제공하며 노년 후기에는 경제상태와 교육수준에 따른 서비스를 제공하고, 전·후기 노인 모두 만성질관관리, 건강관리, 및 일상생활능력 향상을 위한 서비스를 제공되어야 함을 제안한다. Objectives: The purpose of this study was to investigate the difference in quality of life and related factors among the elderly by the young and the old-old. Methods: Elderly data of 1,339 case from National Health and Nutrition Examination Survey (Korea Center for Disease Control, 2010) were analyzed with SPSS 20.0, using complex survey data analysis methods. Most of the instruments were used according to the original survey while some were re-categorized. Gender, education, living area, income status, factors considered to be related to quality of life such as exercise, smoking and drinking habits, existence of chronic diseases, perceived health, and BMI were explored for their relationship with quality of life. Significance level was set to .05. Results: In this study, 58.4% of the subject were female, and approximately 3/4 had education below elementary school. However, there were more female, more elementary school education, and fewer living with significant others among the old-old. Underweight, depression, and suicidal thoughts were more prevalent among the old-old. The old-old perceived their health worse. Quality of life scores were lower for the old-old. In terms of health behaviors, there were more drinking, exercising, and overweight among the young-old. Factors related to quality of life turned out to be gender, perceived health and BMI among the young-old and education, economic status, and perceived health among the old-old. Conclusion: We recommend differentiated health policy and health programs for the young- and the old-old.

젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구

이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.

어머니의 신경증적 성향과 완벽주의 및 심리적 통제가 유아의 내면화 문제행동에 미치는 영향

왕해경, 한세영 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.1

The purpose of this study was to examine the effects of mother's neuroticism, perfectionism and psychological control on children's internalized problem behaviors such as depression, anxiety, and withdrawal. The subjects of this study were 373 mothers of 3, 4, and 5-years-old children who were attending to 7 public kindergartens and 1 private kindergartens located in Cheongju city. The results of this study were as follows: First, it indicated that mother's neuroticism, self-oriented perfectionism, criticism, and unstable emotion had statistically significant effects on young children's depression. That is, the more neuroticism, the less self-oriented perfectionism, and the more psychological control like criticism and unstable emotion mothers showed, the higher young children's depression was. Second, it revealed that mother's neuroticism and criticism and love withdrawal had statistically significant effects on young children's anxiety. That is, children of mothers with more neuroticism and psychological control like criticism and love withdrawal showed higher anxiety. Third, it was found that only mother's neuroticism had a statistically significant effect on young children's withdrawal. That is, the more neuroticism mothers showed, the higher young children's withdrawal was.

In Vitro Fertilization and Embryo Cleavage in Canine Oocytes

Hae }ung Kim,Sang Ryeul Lee,Sin Hae Park,Sung Hyun Kim,Bong Soo Kim,Dong Hun Yoo,Sin Hae Park,Mi Jung Shin,Jae Wook Kim,Zae Young Ryoo 한국동물생명공학회(구 한국동물번식학회) 2006 Reproductive & developmental biology Vol.30 No.2

어린이집 영유아의 성장ㆍ발달에 관한 종단적 연구(Ⅱ)

고영인,임재택,조희숙,황해익,정계숙 부산대학교 영유아보육연구소 1998 영유아보육연구 Vol.4 No.-

The purpose of this study was to investigate longitudinal growth and development of young children and follow-up effects of the educare program in the PNU Day Care Center. Particularly, the first objective of this second report of study was the comparison the entire domains of development with age between the Oct. of 1995 and the Dec. of 1998. The second objective was to analyze the developmental .changes of 5 children who entered the center in 4 years old since Oct. 1995. The subjects of this study were 448 children(241 boys, 207 girls). The instruments of this study were the KISC and KEDl-WISC(for intelligence test), the Learning Readiness Test, the Social and Emotional Scale, Height Scale and Weight Scale( for physical growth). The tests were carried out 2 times per year (the early of the year and the late of the year). Results from comparsion across the 1st through 7th tests during 3 years indicated that the mean of the height was increased about 1-8cm for all of 2-5 years old children. The mean of the weight also was increased about 1.5-4.0kg except 2 years old children. The intelligence score (T score) by KISC was increased around 6-42 points except 6 years old boys and girls. In the intelligence score by KEDl, there was improvements of average 8 points for 7 years old children. In the learning Readiness Test of 5, 6 years old children, the scores all of children except 6 years old girls got were decreased. The scores of 6 years old girls were incresed 6 points in the Dec. of 1998. In the Social and Emotional Scale, there was big improvement of scores between in the 1st test and in the 7th test. These results were discussed in the view of sample size, developmental characteristics, test instruments and educare program of the PNU day care center.

Polymerase chain reaction으로 설사 영유아 대변 검체에서 adenovirus type 40, 41의 분리 동정

박혜경,서주영,정영해,김경희 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-

Adenovirus is the second leading cause of acute gastroenteritis. As the children with diarrhea by acute adenoviral gastroentertis usually require hospitalization, rapid diagnosis is necessary for proper management. Adenovirus infection can be diagnosed conventionally by the direct electron microscopic observation of the virus particle, isolation of the virus by cell culture, or enzyme immuno assay. Recently, polymerase chain reaction is applied for the detection of adenovirus. In this study, we investigated stools collected from 100 children hospitalized for diarrhea in Ewha womans University Hospital from the September of 1995 to the July of 1996 for adenovirus by polymerase chain reaction. Two oligonucleotide primers, desiginated as hexAA1885 and hexAA1913, were used for the detection of enteric adenovirus type 40 an 41 in PCR. After amplification pf 35 cycles, 300 bp fragments were detected on 1.8% Sea Kem GT agar gel in 14 samples. The stool samples were further analyzed by electron microscopy and immunoblotting. In electron microscopy, icosahedral particles of about 75nm were observed in a^7 of the 14 samples. The 14 samples were collected from children whose mean age was 1.4 years and the sex ratio was 10/4(M/F). The seasonal variation showed acute gastroenteritis by adenovirus infection was frequent in March to May and in September to October in Korea.

일반논문 : 왜 벽지불로 인해 공덕을 얻으려하는가 -벽지불에 대한 새로운 이해를 위해-

원혜영 ( Hae Young Won ) 동양철학연구회 2013 東洋哲學硏究 Vol.75 No.-

일반적으로 알고 있는 벽지불의 개념을 새롭게 정립할 필요가 있음은 초기불교 전통에서 벽지불이 ``홀로 깨달았다``란 어원적 이미지가 전혀 낯설지 않게 작용하여, 벽지불이 행한 행적들과 수행하는 모습은 대중들에게 신비적이고 존경의 대상이었다는 점을 간과하고 있기 때문이다. "홀로(eka)"는 문자적 의미가 아니라 상징적으로 종교적 삶 속으로 들어간다는 의미이다. 벽지불은 스승 없이 깨달아서 사람들에게 복과 이익을 주고 천상에 태어나게 하게 하는 이유로 존경의 대상이다. 벽지불에게 공양해서 공덕을 쌓는 에피소드는 보시와 공덕의 관계를 새로운 시각으로 바라볼 수 있게 한다. 텍스트에서 벽지불의 위상은 역사적 건축물 속에서도 실행되었기에 잊혀져가고 있는 존재를 떠올리게 한다. 현장은 인도를 방문한 7세기 동안, 많은 스뚜빠가 벽지불을 기념하여 세워진 것을 발견한다. 벽지불의 위상은 스뚜빠로 이행되어 존재감을 이어갔다. 붓다와 벽지불은 동시에 함께 존재할 수 없다. 다른 대다수의 학자들은 벽지불의 출현이 무불시대의 현상이라고 믿는다. 붓다와 아라한, 그리고 벽지불이 가진 성격들로 인해 그들 사이에 차이는 있다. 벽지불의 신통력은 텍스트에서 주목되어 그에게 공양하여 전생에 쌓은 공덕이 중요한 미래 삶을 좌우한다. 벽지불의 신통력은 붓다만큼이나 그의 위상을 대변한다. 벽지불이 가진 근본적이고 보수적 이미지를 재고하고 탈피하 게끔 만들 수 있는 치밀한 고증들이 존재하기에 ``벽지불에 대한 새로운 이해``에 관련된 논의가 가능하리라 본다. There is a need to establish a new concept we generally know as pratyekabuddha. "Self-enlightenment (or realization by self alone)" in the early Buddhist tradition is not uncommon. Just look at the mystical and performance arts of the pratyekabuddha in respect to the public as the audience. The literal meaning of "eka (or alone)," is to enter into religious life symbolically. Hae-Young, Won This is special because in pratyekabuddha, there is no teacher and the enlightenment comes to the self without guidance from a teacher. This is the reason to give blessing and benefit to the people born in the heaves in respect to pratyekabuddha. Building merits as offerings were a clearly professed practice in pratyekabuddha. As recorded in the Buddhist text, Hsuan-tsang, he visited India during the seventh century and visited numerous pratyekabuddha stupas. Pratyekabuddha and Buddha cannot exist simultaneously in a single era. Many scholars believe that the emergence of pratyekabuddha was during the period where ``Non-Buddha`` phenomenon prevailed. The magical powers of pratyekabuddha were noted in the early Buddhist texts. The merit gained in one``s previous life is important to the future life. The magical powers that are taught by pratyekabuddha are a distinct characteristic of the practice. Stock images are fundamentally about pratyekabuddha and tend to be conservative. In this manner, his images can be newly reestablished. And this is possible through the careful historical research of the past and even present.

Nifedipine 투여가 선천성 고혈압 쥐의 CYP1A1과 2B1 유도에 미치는 영향

홍영숙,김형래,박혜영,배영숙,박상신 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.3

Cytochrome P-450(CYP) enzymes are important in catalyzing the hiotransffrmation on manyendogeneous compounds and xenobiotics, including drugs and carcinogens. In the presentstudy, effect of nifedipine a voltage dependent calcium channel blocker on the induction ofCYP1A1 and 2B1 was investigated. Change of CYP1A1 and 2B1 activities were measuredby using specific enzyme activities and Western blot analysis. CYP1A1, as quantified by ethoxyresorufin-0-deethylase activity and Western blot with monoclonal antibody 1-7-1, increasedin liver microsome of nifedipine-treated spontaneous hypertensive rat(SHR. 30mg/kg.b.w, twicea day for 3days) but not in kidney microsome. CYP2B1, as quantified by benzyloxyresorufin-O-dealkylase activity and Western blot wit]1 monoclonal antibody 2-66-3, markedly increasedin liver microsome of nifedipine-treated SHR but slightly in kidney microsome. The resultsdemonstrate that nifedipine is a potent inducer of CYP2B1 in SHR.

신생아의 행동반응에 대한 실무교육이 간호사와 신생아와의 유희적 상호작용에 미치는 영향

양영옥 ( Young Ok Yang ),김영혜 ( Young Hae Kim ) 부모자녀건강학회 2002 부모자녀건강학회지 Vol.5 No.1

The purpose of this study was to find out the effect of in-service education on the nurse-newborn play interaction. The research design adopted the pre-experimental design applied only for one pretest-posttest group and Barnard`s mother-infant interaction model was used as a conceptual framework. The subjects were 26 nurses who were selected from 2 nurseries in general hospital in Pusan, and 52 healthy newborns who were after 4 days from birth during data collection period at the same hospital. The data were collected from June 1st to October 5th in 2001, by video-taping for the interactive behaviors between the nurse and the newborn, played for 5 minutes in nurseries 2 weeks before and after in-service education. The in-service education consisted of the newborn`s behavior responses focused on the newborn baby`s states, behavior, cues and state modulation, 3 times per 1 week, 90 minutes per 1 time, lecture, demonstration and hand out project. The experimental tool used for this research was Ha Young-Soo`s Korean translation of the Maternal-Infant Play Interaction Scale by Thompson, Jody Baird, Sara Gordman, Bryant(1982), some parts of which were adapted to be suitable for the purpose of this research. Mother and baby scale by Wolke & James-Roberts(1987) was also modified and used as the criterion of nurse`s perception of a newborn baby. The results of this study were as follows: 1. This result supported the major hypothesis: After the intervention of in-service education, the nurse and newborn play interaction was promoted. 2. After intervention of in-service education, the nurse perception of newborn, especially the criteria of newborn`s reaction was promoted., The results of this research confirm that in-service education on the newborn`s behavior responses such as states, behavior, cues and state modulation is an effective way to improve the interaction between the nurse and the baby. It elevated the nurse`s sensitivities to the baby`s needs. Therefore, in-service education can change the conditions of current nursing practice mostly centered on physical care into a better one in which nurses consider the emotional, social, and intellectual development stages of babies. Accordingly, in-service education contributed to promoting the effective nurse-newborn play interaction so positively.

기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.