중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

ApoB/ApoA-I ratio is independently associated with carotid atherosclerosis in type 2 diabetes mellitus with well-controlled LDL cholesterol levels

( Ji Eun Jun ),( Young Ju Choi ),( Yong-ho Lee ),( Dae Jung Kim ),( Seok Won Park ),( Byung Wook Huh ),( Eun Jig Lee ),( Sun-ha Jee ),( Kyu Yeon Hur ),( Sung Hee Choi ),( Kap Bum Huh ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.1

Background/Aims: This study aimed to investigate whether the apolipoprotein (Apo) B/ApoA-I ratio is associated with carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) subjects with low density lipoprotein cholesterol (LDL-C) levels less than 100 mg/dL. Methods: This cross-sectional study included 845 subjects aged with T2DM 40 to 75 years who had visited Huh’s Diabetes Center in Seoul, Republic of Korea for CIMT measurement. Traditional fasting lipid profiles, ApoB and ApoA-I levels were examined. CIMT was measured at three points on the far wall of 1 cm long section of the common carotid artery in the proximity of the carotid bulb. The mean value of six measurements from right and left carotid arteries were used as the mean CIMT. In this study, carotid atherosclerosis was defined as having a focal plaque or diffuse thickening of the carotid wall (mean CIMT ≥ 1.0 mm) Results: The prevalence of carotid atherosclerosis increased with ApoB/ApoA-I ratio. The ApoB/ApoA-I ratio, expressed as both quartiles (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.21 to 3.79; p for trend = 0.014) and continuous values (OR, 10.05; 95% CI, 3.26 to 30.97; p < 0.001), was significantly associated with a higher risk for carotid atherosclerosis, regardless of conventional cardiovascular disease risk factors. The optimal ApoB/ApoA-I ratio cutoff value for detecting carotid atherosclerosis was 0.57, based on receiver operating characteristic curve analysis with a sensitivity of 58.0% and a specificity of 55.1%. Conclusions: A high ApoB/ApoA-I ratio was significantly associated with carotid atherosclerosis in T2DM patients with LDL-C levels less than 100 mg/dL.

제2형 당뇨병환자에서 ApoB/ApoA-I Ratio와 대사증후군 및 대사증후군 각 요소와의 관계

김정은 ( Jung Eun Kim ),김화영 ( Wha Young Kim ),이윤정 ( Yoon Jung Lee ),박지은 ( Ji Eun Park ),최영주 ( Young Ju Choi ),허갑범 ( Kap Bum Huh ),황지윤 ( Ji Yun Hwang ) 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.2

연구배경: Apolipoprotein B/apolipoprotein A-I 비율(ApoB/ApoA-I)은 대사증후군의 중요한 임상적 지표이다. 하지만, 한국인 제2형 당뇨병환자들을 대상으로 ApoB/ApoA-I과 대사증후군의 관련성을 살펴본 연구는 미미하다. 따라서 본 연구에서는 ApoB/ApoA-I과 ApoB/ApoA-I 사분위에 따른 대사증후군 및 대사증후군 각 요소별 위험도를 보았다. 방법: 대상자는 서울의 당뇨병 전문 클리닉 허내과를 방문한 제2형 당뇨병환자 812명 (남자 424명, 여자 388명)이다. 이들을 성별로 ApoB/ApoA-I의 사분위에 따라 네 군으로 나누었다(가장 낮은 군:Q1-가장 높은 군:Q4). 체위, 혈액성상 및 식품섭취 빈도조사지를 통한 식이섭취량이 측정되었다. 결과: 대사증후군의 유병률은 남자 47.9%, 여자 66.5%였다. 대사증후군과 대사증후군의 각 위험요소에 대한 OR은 남녀 모두 ApoB/ApoA-I의 Q2에서 Q4로 갈수록 유의하게 증가했다(남자: OR=5.37; 95% CI=2.98-9.65 and OR=7.41; 95% CI=4.04-13.6; 여자: OR=2.57; 95% CI=1.28-5.15 and OR=8.49; 95% CI=4.28-16.8). 이러한 경향은 남녀 모두에서 연령, 당뇨 유병기간, 공복 혈당, 대량영양소를 보정한 후에도 변하지 않았다(남자: OR=5.24; 95% CI=2.80-9.24 and OR=7.98; 95% CI=4.09-15.6; 여자: OR=3.54; 95% CI=1.84-6.81, OR=4.41; 95% CI=2.26-8.61, and OR=8.29; 95% CI=3.85-17.8). 결론: 본 연구에서는 당뇨병환자에서 가장 중요한 인자 중 하나인 다량 영양소 섭취량을 포함한 대사증후군의 위험요인을 보정하기 전과 후 모두 ApoB/ApoA-I이 증가 할수록 대사증후군 및 대사증후군 각 요소의 위험도가 증가했다. 향후, ApoB/ApoA-I 증가와 대사증후군 및 대사증후군 각 요소의 위험도에 대한 정확한 평가를 위해 ApoB/ApoA-I과 관련한 식이위험요인에 대한 전향적인 연구가 필요할 것으로 사료된다. Background: The Apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I) is a powerful clinical indicator of metabolic syndrome. However, few studies have searched for an association between ApoB/ApoA-I and metabolic syndrome in Korean patients with type 2 diabetes. We investigated the relation between ApoB/ApoA-I and the risk of metabolic syndrome and its components. Methods: Subjects were 812 (424 males and 388 females) Korean patients who were being treated for type 2 diabetes at Huh`s Diabetes Center in Seoul. The patients were classified into quartiles (lowest:Q1- highest:Q4) of ApoB/ApoA-I by gender. Anthropometric and hematological characteristics and dietary intake using a food frequency questionnaire were assessed. Results: The prevalence of metabolic syndrome in our sample was 47.9% in males and 66.5% in females. The odds ratios (OR) for metabolic syndrome and for having its components were significantly increased from Q2 to Q4 quartiles of ApoB/ApoA-I in males (OR = 5.37; 95% CI = 2.98-9.65 and OR = 7.41; 95% CI = 4.04-13.6) and females (OR = 2.57; 95% CI = 1.28-5.15 and OR = 8.49; 95% CI = 4.28-16.8). These trends withstood adjustment for age, duration of type 2 diabetes, fasting blood glucose levels, and macronutrient intake both in males (OR = 5.24; 95% CI = 2.80-9.24 and OR = 7.98; 95% CI = 4.09-15.6) and in females (OR=4.41; 95% CI = 2.26-8.61 and OR = 8.29; 95% CI = 3.85-17.8). Conclusion: ApoB/ApoA-I appeared to be independently associated with risk of having metabolic syndrome and its components in Korean patients with type 2 diabetes after adjustment for putative risk factors including macronutrient intake, a particularly important lifestyle factor for patients with type 2 diabetes. A follow-up study of this population should evaluate the mechanisms underlying the relation between ApoB/ApoA-I and metabolic syndrome and its components. (Korean Diabetes J 33:143-154, 2009)

일본 중세의 가부장제 성립과정 : 여성지위의 변천을 중심으로

허영은 대구대학교 인문과학예술문화연구소 2001 人文科學硏究 Vol.22 No.-

견관절 통증을 동반한 환자에서의 상극근 건파열에 관한 고찰

허은선,남용현,성인영 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.1

Shoulder pain is the common problem and debilitating problem. And its etiology remains poorly understood. One of the etiology is the rotator cuff tear. Arthrography has been considered standard diagnostic method for detecting cuff tear but it is invasive. So, we performed non-invasive sonographic examination on the 160 shoulders-84 painful shoulders, 76 asymptomatic shoulders-from 80 patients with painful shoulder. We grouped 80 patients into three, group one is the 20 hemiplegic patients older than 50 years, group two is the 40 non-hemiplegic patients older than 50 years, group three is the 20 non-hemiplegic patients younger than 50 years. Mean age was 61.9, 60.0 and 37.8 year old in each group The rate of the positive sonographic finding of supraspinatus tendon tear was 70%, 72.5% and 50% in each group. The pain was highly correlated with the supraspinatus tendon tear findings on the sonography(P<0.01) We checked variable factors such as aging, hemiplegic condition, limited range of motion, history of trauma whether or not affect the supraspinatus tendon tear incidence. The aging was the only possible affecting factor that increase the incidence of supraspinatus tendon tear in our study.

에타놀 攝取가 運動選手의 肺機能에 미치는 影響

허복,黃樹寬,朱永恩 慶北大學校 師範大學 1986 敎育硏究誌 Vol.28 No.-

In an effort to elucidate the effect of ethanol on the pulmonary function in athletes, 26 athletic college students were selected. Pulmonary function test was performed after administration of ethanol to the blood ethanol level of 40㎎/㎗. Results of the test were summarized as follows: Forced expiratory volumes were decreased by ethanol, and FVC and FEV_0.5, in particular, showed a significant decrease. Forced expiratory flows were decreased by ethanol. Especially, PEF, PEF_25%, FEF_(200∼1200㎖), and FEF_(25∼75%) showed a significant decrease. MVV was decreased by ethanol ingestion. Alveolar PO_2 and PCO_2 were not changed by ethanol ingestion. Blood pH, PCO_2, PO_2, bicarbonate, base excess, O_2 content and O_2 saturation showed no significant change.

Preparation and Properties of Thermoplastic Polyurethane Elastomers

허재호,김태우,김은영,김한도 釜山大學校 1996 生産技術硏究所論文集 Vol.51 No.-

Isophorone diisocyanate (IPDI), 1,4-butanediol 및 polpropylene glycol로부터 2단계 중합 방법을 통하여 일련의 폴리우레탄 탄성체를 제조하였다. 이 폴리 우레탄은 IPDI와 1,4-butanediol로 구성된 경질 시그먼트와 PPG로 구성된 경질 시그먼트로 구성되어 있으며, 경질 시그먼트의 블록 길이와 함량을 변화시켰다. 경질 시그먼트의 함량(37.8∼66.7 wt%)에 따른 전이온도, 인장강도, 인장회복력, 경도 등을 조사하였다. A series of thermoplastic polyurethane elastomer were prepared via a two-step polymerization process using isophorone diisocyanate(IPDI), 14-butanediol as hard segment, and polypropylene glycol(PPG, Mw 3000) to give a soft segment. Hard block segment length and content(37.8∼66.7 wt%) were varied. The effects of hard-segment content, heat treatment on properties such as almost plateau modulus, glass transition temperature, hardness, tensile strength, and tensile retraction were investigated.

平安時代의 혼인거주형태에 대해

허영은 대구대학교 인문과학 예술문화연구소 1999 人文科學硏究 Vol.19 No.-

비구 골절의 수술적 치료

문은선,노성만,허재영 全南大醫大 1987 전남의대학술지 Vol.24 No.2

체내 당원질 저장능력의 향상을 통한 장거리 선수의 기록 향상 방안

김영환,허복,황수관,주영은 慶北大學校 體育科學硏究所 1986 체육과학연구지 Vol.2 No.-

This study was aimed at clarifying the effect of a dietary ragime designed to enhance the body's glycogen-storaging ability on the record of long-distance runners. The subjects employed were a total of 24 male college long-distance runners aged between 19 and 21 years. As a preliminary experiment, 8 ml/㎏ BW of 20% glucose was administered and blood levels of glucose, insulin and lactate were observed. The dietary regime consisted of low-carbohydrate diet with heavey exercise for 3 days followed by high-carbohydrate diet with light exercise for 3 days. On the day after the last day of the dietary regime, 20 ㎞-running was performed and blood levels of glucose, insulin and lactate, hematocrit and body weight were measured. The measured parameters and the records were compared with those measured during 20 ㎞-running performed before the dietary regime. The results obtained are summarized as follows. After the administration of 20% glucose, blood glucose level was doubled in 30 min. Insulin was increased by 6.5 times in 60 min and was sharply decreased in 120 min but was still higher than the resting level. Blood levels of glucos(x) and insulin(y) revealed a high correlation and the regression equation was y=-16.90+0.294x. Blood lactate was somewhat increased. After 20 ㎞-running, the blood glucose, insulin and lactate were all increased. Compared with those measured before dietary regime, blood glucose and lactate levels measured after the regime were higher, while the insulin was lower. The body weight was reduced and the hematocrit was increased by the dietary regime. The record was improved by 2 min 3 sec. From the above results, it can be concluded that high-carbohydrate diet such as glucose solution is necessary in restoring the depleted blood glucose level during exercise, that meals should be taken at least 2∼3 hours before long-distance running to get the increased plasma insulin level restored and that improved endurance can be obtained by accumulating body glycogen through dietary regime.