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      • SCOPUSKCI등재

        Diminazene aceturate exacerbates renal fibrosis after unilateral ureteral obstruction in female mice

        ( Yosep Kim ),( Jongwan Kim ),( Sang Jun Han ) 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.2

        Background: Diminazene aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator, exerts anti-inflammatory and antifibrotic effects in a variety of human chronic diseases. However, the role of DIZE in kidney fibrosis and the underlying mechanism remain unclear. Therefore, we investigated the effects of DIZE on the progression of renal fibrosis after unilateral ureteral obstruction (UUO), a well-established model of chronic kidney disease. Methods: C57BL/6 female or male mice were subjected to right UUO. Mice received 15 mg/kg DIZE or vehicle (saline) daily. On the 7th day after UUO, kidneys were collected for analysis of renal fibrosis (α-smooth muscle actin, phosphorylated SMAD3, transforming growth factor (TGF)-β, Masson’s trichrome, and Sirius red staining), inflammation (macrophage infiltration, proinflammatory cytokines/ chemokines), apoptosis/necrotic cell death (TUNEL and periodic acid-Schiff staining), and ACE2 activity and messenger RNA (mRNA) expression. Results: Treatment with DIZE exacerbated renal fibrosis by upregulating the profibrotic TGF-β/SMAD3 pathway, proinflammatory cytokine/chemokines (interleukin [IL]-1β, monocyte chemoattractant protein-1, IL-6, and macrophage inflammatory protein-2) levels, M2 macrophage accumulation (CD206, IL-4, IL-10, and CX3CL1), and apoptotic/necrotic cell death in the obstructed kidneys of female mice but not male mice. However, DIZE treatment had no effect on ACE2 activity or mRNA expression. Conclusion: DIZE exacerbates UUO-induced renal fibrosis by aggravating tubular damage, apoptosis, and inflammation through independent of angiotensin (1-7), angiotensin II levels, and ACE2 expression/activity, rather than protecting against renal fibrosis after UUO. DIZE also has powerful effects on recruiting macrophages, including the M2-polarized subtype, in female UUO mice.

      • A Study of the Controversy about Revision of the Westminster Confession of Faith in the Nineteenth-Century Presbyterian Church in U.S.A.

        Yosep Kim Presbyterian General Assembly Theological Seminary 2015 CHONGSHIN THEOLOGICAL JOURNAL Vol.20 No.1

        The American Presbyterian Church had upheld the authority of the Westminster Confession of Faith as the confessional standard until it faced a serious challenge of revision in the nineteenth-century. This challenge came from the motives of modern theological ideas and the rational worldview of that time. This study aims to manifest the theological motives of the revision of the Westminster Confession by analyzing Charles A. Briggs’ arguments which is based on the theological liberalism concerning some doctrines in the Confession. The response and results of the Briggs’ demand for revision will be reviewed from the perspective of reformed theology. The purpose of this examination is to evaluate the theological motives of those who called for revision of the Westminster Confession. It will be argued that although the confessional standards can be changed and revised in diverse historical situations, the Reformed Church cannot make a sound development with the beneficial heritage of the Reformed tradition without a careful and biblical consideration of the purpose of revision.

      • KCI등재

        Electrospun hydrogen manganese oxide nanofibers as effective adsorbents for Li+ recovery from seawater

        Yosep Han,Seongmin Kim,Sooyoun Yu,Nosang V. Myung,Hyunjung Kim 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.81 No.-

        Highly porous hydrogen manganese oxide (HMO) nanofibers were fabricated by combining electrospinning,calcination, and ion exchanges, and their lithium (Li) recovery performance was systematicallycompared to other adsorbent types (i.e., nanoparticles and porous microbeads with equivalentproperties). In seawater, the HMO nanofibers exhibited an excellent Li+ adsorption capacity (18.8 mg/g)with greater Li+ selectivity over other adsorbents. These might be attributed to the high number ofmacropores in the nanofiber, which facilitated the inward diffusion of Li+ and enhanced the accessibilityof activated sites. Moreover, the Li+ recovery efficiency of the nanofibers remained approximately 95%after 20 recovery cycles.

      • Significance of Calvin's Criticism of the Mass for the Reformation of the Church

        Yosep Kim Presbyterian General Assembly Theological Seminary 2020 CHONGSHIN THEOLOGICAL JOURNAL Vol.25 No.-

        Most protestant reformers in the sixteenth century had attacked the misuse of the Mass. Calvin also criticized the misuse of the Roman Mass using strong words such as impiety, blasphemy, idolatry and sacrilege. But his criticism of the Mass is essential biblical, and it is presented in the Christological perspective and with the ecclesiological intention. The purpose of this study is to review Calvin's criticism of the Mass in order to illustrate its theological implication for his idea of reforma�tion of the Church in three points: hermeneutical principle, Christological perspec�tive, and ecclesiological intention. Calvin's criticism of the Mass does not just denounce the practice of the Roman sacrament, but manifest the direction and the foundation of his idea of reforming the Church. First, God's Word is the standard by which confirmation and recovery of the identity of the Church.Secondly, it is consistently stressed that Christ is the sole highest priest whose definitive sacrifice on the cross has already redeemed every believer. Finally, Calvin wants to recover the spiritual identity of the Church as the body of Christ by rejecting papists ’ sacrilegious idea of the Mass.

      • Experimental characterization of quantum polarization of three-photon states

        Kim, Yosep,Bjö,rk, Gunnar,Kim, Yoon-Ho American Physical Society 2017 Physical Review A Vol.96 No.3

        <P>We experimentally investigate various quantum polarization features of three-photon quantum states, including product and entangled states with varying purity. The three-photon quantum states are categorized into six classes based on the rotation symmetry of mean, variance, and skewness of the polarization distribution. The representative three-photon quantum states in each category are prepared from double-pair emission from pulsed spontaneous parametric down-conversion and quantum interferometry. We demonstrate that the three-photon quantum states show interesting quantum polarization properties, such as maximum sum-uncertainty and hidden polarizations.</P>

      • KCI등재

        정치적 판단과 신앙적 결단: 저항권 사상에 나타난 녹스의 종교개혁 이해

        김요섭 ( Kim Yosep ) 한국복음주의신학회 2018 성경과신학 Vol.88 No.-

        16세기 종교개혁에 있어 당시 유럽의 급박한 정치 상황은 종교개혁자들이 맞이했던 중대한 도전들 가운에 하나였다. 스코틀랜드의 종교개혁자 존 녹스(John Knox, c.1514-1572)는 당시 스코틀랜드와 잉글랜드를 포함한 여러 나라의 급박한 정치 상황 속에서 종교개혁의 신학적 근거를 제시하고 그 실천을 추진한 대표적 인물이었다. 본 논문은 녹스의 망명 후기인 1557년부터 1559년까지 저술된 주요 작품들을 분석해 그 가운데 나타난 저항 사상을 중심으로 그가 제시했던 종교개혁 이해를 재조명하려 한다. 녹스는 당시 로마가톨릭의 우상숭배를 강요하는 독재적 군주들에 맞서 하급 관리들과 백성들의 저항의 정당성과 필요성을 주장했다. 그리고 우상숭배를 강요하는 군주들에 대한 경고만큼이나 정치적 판단에 따라 종교개혁의 의무를 타협하려 한 위선적인 정치인들과 무기력하게 우상숭배로 돌아가고 있는 백성들을 향한 경고도 멈추지 않았다. 그런 의미에서 녹스의 저항 사상은 단순한 정치적 제안이 아니라 종교개혁의 대의를 위한 신앙적 헌신의 촉구였다. 이 점을 재조명하기 위해 본 논문은 녹스가 자신의 저항 사상의 근거를 제시하기 위해 일관되게 사용했던 병행적 성경해석들을 검토하고, 그 해석의 내용과 실천적 적용 사이의 연결을 위해 그가 견지했던 언약적 관점을 분석하려 한다. 그리고 이와 같은 녹스의 성경해석과 신학적 관점을 통해 그의 저항 사상이 일관되게 지향하는 신앙적 결단으로서의 종교개혁 이해를 재확인하고 그 역사적 의의를 제안하려 한다. The sixteenth-century Reformation faced many serious challenges in practice. Political upheaval in the sixteenth-century Europe was one of most difficult challenges. John Knox(c.1514-1572), a leader of the Scottish Reformation, provided the theological foundation in the midst of the political turmoils of many countries and endeavored himself to establish presbyterianism in Scotland. This study aims to illuminate Knox’s understanding of the reformation by examining his idea of resistance insisted in his works from 1557 to 1559, the later period of his exile. In his writings, Knox argues for the legitimacy and necessity of the resistance of the less magistrates and common people against the idolatrous and tyrannous monarchs. As much as the warning against the idolatrous tyrannies, Knox did not hesitate to admonish those hypocritical leaders and impotent people concerning their duty of recovering God’s true religion. In this sense Knox idea of resistance was not merely a political proposal but rather a religious appellation for the reformation. In order to illuminate this point, this study reviews Knox’s typical parallel hermeneutics in his argument of resistance, and analyzes the perspective of covenant by which he connect the biblical cases with the current political situations. Knox consistently used the parallel hermeneutics and the perspective of covenant for the ultimate purpose of the religious reformation. He consistently urged believers to commit themselves in the political issues according only to their religious duties in the covenant with God. This review and analysis lead us to recognize the purpose of reformation as the foundation of Knox’s idea of political resistance. This recognition enables us to evaluate its historical significances properly and correctly.

      • KCI등재후보

        중세시대 개혁의 선구자 위클리프의 개혁적 교회론

        김요섭(Kim Yosep) 개혁신학회 2016 개혁논총 Vol.40 No.-

        중세 시대의 대표적인 교회 개혁 사상가 위클리프는 14세기 말 잉글랜드의 시대 상황 속에서 교회의 개혁을 위한 사상을 제시하고 그 실천을 시도한 인물이었다. 본 연구는 먼저 위클리프의 개혁적 교회론이 등장한 역사적, 사상적 배경을 검토한다. 그리고 이어서 하나님의 예정으로부터 참 교회 개념을 설명한 위클리프의 교회 이해를 평가하고 교회 개혁을 위해 그가 제시한 실천 방안을 다룬다. 위클리프의 개혁적 교회론의 가장 중요한 역사적 배경은 국내적으로는 잉글랜드에서 발생한 왕실과 교회 지도자들 사이의 정치적 갈등었으며 국외적으로는 교황청의 대분열이었다. 또 사상적 배경으로는 14세기 말 옥스포드에서 전개된 철학적 논의 가운데 위클리프가 취한 실재론과 신적 원리와 피조 세계의 원리 사이의 관계를 설명하기 위해 제안한 “지배권”개념이었다. 이와 같은 배경 위에서 위클리프는 “선택받은 사람들의 총합으로서의 참된 교회”라는 신학적 교회 이해를 제시했다. 그리고 이 이해 위에서 교황을 포함한 교회의 제도적 측면의 오류 가능성을 주장하고 부패의 실상을 지적했다. 성경을 바르게 가르치는 것과 사제들이 목회자로서의 본분을 회복하는 것, 그리고 세속 군주가 교회의 사적 재산을 몰수하는 것이 위클리프가 제시한 교회 개혁의 실천 방안들이었다. 위클리프의 교회 개념과 그 실천적 함의들이 이후 16세기 종교개혁자들이 제시했던 교회론과 여러 점에서 서로 다른 면이 있음에도 불구하고 여러 부분에서 공통점을 가지고 있다. 그것은 성경의 진리를 절대화하면서 이에 대해 교회 제도를 상대화한 점, 교황을 비롯한 사제들의 권위를 그 직임이 아닌 충실한 직무 수행에서 찾으려 한 점, 하나님의 예정과 그리스도의 머리이심을 강조함으로써 지상 교회의 영속성과 개혁의 필연성을 주장한 점들이다. 이와 같은 개혁적 교회론으로 인해 위클리프는 16세기 종교개혁을 예비한 중세 후기 종교개혁의 선구자로 평가받기에 충분하다. John Wyclif, one of the representative reformers of the middle age, presented his reformation ecclesiology in the context of the fourteenth century England. There are two most noticeable historical backgrounds: Domestically, he developed his ecclesiology in the political conflicts between the monarchy and the ecclesiastical leadership in England. Internationally, “the great schism” effected his reformation ecclesiology. Concerning philosophical backgrounds, propositional realism, endorsed by Wyclif in the metaphysical controversy of the late fourteenth century Oxford, and his concept of “dominion,” elaborated to explain the causal relationship between the divine and the created order, offered him useful theoretical grounds. For Wyclif, the true Church is “the whole congregation of the elect.” This theological idea enabled him to criticize present corruptions of the institutional church. Sincere teaching of Scripture, recovery of the ministerial role of priests, and deprivation of temporal goods of the church by secular rulers were Wyclif’s proposals for reformation. In spite of some differences, Wyclif’s reformation ecclesiology shows some significant similarities with the sixteenth-century protestant reformers: the idea of the relative nature of the church compared to the absolute truth of Scripture, the definition of the priestly office not as authoritative position but as pastoral role, and the emphasis on the perpetuity and the continuous need for reforming the Church due to the fact that “Christ is the sole head of the Church.” Those similarities are sufficient reasons for calling Wyclif “a pioneer of reformation” who prepared the way to the protestant reformers.

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