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        • KCI등재후보

          Effect of Acer tegmentosum Maxim. Extracts on Acute Hepatitis and Fatty Liver in Rats

          Yoonhee Seo,Davaa Bazarsad,최수영 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

          This study was performed to investigate the preventing effects to liver injury of Acer tegmentosum Maxim. extract (ATE). After oral administration ATE to SD rats, liver injuries were induced by CCl4, galactosamine or ethionine treatments. The aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride and cholesterols in blood were used as indicators of liver damage. When acute hepatitis was induced by CCl4 or galactosamine, ATE-fed rats showed low level of AST and ALT in plasma than the ATE-unfed rats. In case of ethionine-induced fatty liver, the triglyceride in plasma were shown to reduced level in ATE-fed rats than ATE-unfed rats. These results indicate that Acer tegmentosum Maxim. extract protected hepatic failure.

        • KCI등재

          Effect of Acer tegmentosum Maxim. Extracts on Acute Hepatitis and Fatty Liver in Rats

          Soo Young Choe, Yoonhee Seo, Davaa Bazarsad 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

          This study was conducted in order to investigate the effects of Acer tegmentosum Maxim. extract (ATE) in prevention of liver injury. After oral administration of ATE to SD rats, liver injuries were induced by treatment with CCl4, galactosamine, or ethionine. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride, and cholesterols in blood were used as indicators of liver damage. When acute hepatitis was induced by CCl4 or galactosamine, ATE-fed rats showed a lower level of AST and ALT in plasma than ATE-unfed rats. In the case of ethionine-induced fatty liver, triglyceride levels in plasma were reduced in ATE-fed rats, compared with ATE-unfed rats. These results indicate that Acer tegmentosum Maxim. extract protected against hepatic failure.

        • KCI등재

          Giant Intradiploic Epidermoid Cyst in the Occipital Bone: A Case Report

          ( Yoonhee Choo ),( Youngbeom Seo ),( Joonhyuk Choi ) 대한뇌종양학회 대한신경종양학회 2021 Brain Tumor Research and Treatment Vol.9 No.1

          Epidermoid cysts are uncommon intracranial tumors. As one of the extradural types of epidermoid cysts, intradiploic epidermoid cysts are even rarer tumors and occur in any part of the skull. We herein report a rare case of a giant intradiploic epidermoid cyst of the occipital bone. A 57-year-old woman presented with a 1-year history of localized headache in the occipital area. CT and MRI showed an extradural mass measuring 50×70 mm in the occipital bone with bony destruction. The patient underwent surgical resection. The tumor was completely removed with its capsule. There was no extension to the intradural space. The pathological report confirmed that the tumor was an epidermoid cyst. Follow- up MRI 24 months after the operation showed no recurrence. The headache was well controlled without any medications. We report a rare case of intradiploic epidermoid cyst with clinical and radiologic features and surgical treatment. It is important to consider this diagnosis for a patient with persistent regional headache with or without a growing scalp mass.

        • THE ELEMENTARY STUDENTS` CONCEPTIONS OF THE SIMPLE ELECTRIC CIRCUIT IN KOREA

          Seo, Sangoh,Choi, Hyukjoon,Moon, Seongsook,Hong, Yoonhee,Kwon, Jaesool 한국교원대학교 과학교육연구소 2001 청람과학교육연구논총 Vol.11 No.1

          The purpose of this study was to investigate students' conceptions of the simple electric circuit using a battery and a bulb. 19fourth grade students from a rural elementary school in Korea participated in this study. Data on the children's understandings of electric circuit were collected through three sources; prediction tests, drawing tests and individual interviews. The prediction tests were paper and pencil tests composed of 10 problems predicting whether bulbs in 10 simple circuit diagrams would light. For each prediction, the children were asked to provide a written explanation of their thinking. The drawing tests consisted of 6 problems. One was to draw the inside of the bulb base, and the others were to make the wire connections between a battery and a bulb in the diagrams to light the bulb. The interviews were conducted with seven children who showed differing degrees of understanding. No student was aware of the wire connections inside the bulb base. Many students stated whether the bulb would light or not, according to the tip of the bulb contacting the positive battery terminal and an end of wire contacting the negative battery terminal. Most of them thought that the tip of the bulb should contact the positive battery terminal so that the bulb would light. In short, students did not use a scientific conception of electric current to predict and explain the electric circuit.

        • KCI등재

          파열된 위장관 기질종양의 간 전이에 대한 동맥 색전술 치료

          장서진 ( Seo Jin Jang ),권재현 ( Jae Hyun Kwon ),한윤희 ( Yoonhee Han ) 대한소화기학회 2018 대한소화기학회지 Vol.72 No.4

          Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract and occur most frequently in the stomach. The liver is the most common metastatic site of a GIST, and spontaneous rupture of the hepatic metastasis of a malignant gastric GIST is rare. We report the case of a 70-year-old man who presented with sudden right lower quadrant abdominal pain and was diagnosed with a spontaneously ruptured hepatic metastasis of a malignant gastric GIST. The patient was successfully managed with transcatheter arterial embolization of the hepatic artery. (Korean J Gastroenterol 2018;72:205-208)

        • KCI등재

          Protective effects of Gymnaster koraiensis extract on ethanol-induced fatty liver in rats

          최수영,Yoonhee Seo,Chae Young Bang,Seok Hoon Woo,강문규 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3

          Use of chronic alcohol produces alcoholic liver disease, with relationship of the beginning of abnormal lipid metabolism. Recent studies show that abnormal cholesterol metabolism has a specific role in the pathological cause of alcoholic fatty liver disease. Gymnaster koraiensis (GK), a worthy perennial Korean wild plant has specific polyacetylene compounds. Many researches have presented that GK has many pharmacological properties, such as oxidation prevention, liver protection, and inflammation prevention. However, the conservative effect of GK on alcoholic fatty liver has not been researched so far. Male Sprague-Dawley rats were randomly separated to normal feeding (fed a normal feeding for 4 weeks) and ethanol feeding (ED) groups. Rats in the ED group were administered a Lieber-DeCarli liquid feeding (containing 6.7% ethanol) and administered GK extract (125, 250, or 500 mg/kg/day), silymarin (200 mg/kg/day), or no treatment for 4 weeks. Each treatment group contained six rats. The administration with GK decreased serum levels of triglycerides, alcohol, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase, while increased serum level of adiponectin and activity of alcohol dehydrogenase. In alcohol-triggered fatty liver, GK decreased total cholesterol and fatty acid synthase, while increased catalase and superoxide dismutase. Alterations in liver histology, as assessed by H&E staining, showed that the GK treatment decreased amass of lipids in liver. These results present that GK extract may be potential therapeutic agent for alcoholic fatty liver disease by preventing fatty acid synthesis and activating anti-oxidation enzymes, while in activating alcohol degradation in ethanol-triggered fatty liver.

        • KCI등재

          Protective effects of Gymnaster koraiensis extract on high fat diet-induced fatty liver in mice

          최수영,Seo Yoonhee,Bang Chae Young,Woo Seok Hoon,Kang Moonkyu 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.2

          Obesity produces non-alcoholic liver disease, with relationship of the beginning of abnormal lipid metabolism. Recent studies show that abnormal cholesterol metabolism has a specific role in the pathological cause of non-alcoholic fatty liver disease (NAFLD). Gymnaster koraiensis (GK), a worthy perennial Korean wild plant has specific polyacetylene compounds. Many researches have presented that GK has many pharmacological properties, such as oxidation prevention, liver protection, and inflammation prevention. However, the conservative effect of GK on non-alcoholic fatty liver has not been researched so far. Male C57/BL6J mice were randomly separated to normal feeding (ND) (fed a ND for 12 weeks) and high fat feeding (HF) groups. Mice in the HF group were administered a high fat feeding (60% kcal high fat diet) and administered GK extract (125, 250, or 500 mg/kg/day), silymarin (200 mg/kg/day), or no treatment for 12 weeks. Each treatment group contained eight mice. The administration with GK decreased serum levels of triglycerides, total cholesterol, LDL-cholesterol, alanine aminotransferase and aspartate aminotransferase, while decreased body weight, body fat and liver weight. Alterations in liver histology, as assessed by H&E and Oil-red O staining, showed that the GK treatment decreased amass of lipids and NAFLD activity scores in liver. These results present that GK extract may be potential therapeutic agent for NAFLD by preventing increases of serum lipids and increases of body weight and fat, while decreasing lipid accumulation and increase of liver weight in high fat diet-triggered fatty liver.

        • KCI등재

          Administrator Effects on Victim Rates in Workplace Bullying Surveys

          Yoojeong Nadine Seo(서유정),Yoonhee Park(박윤희) 한국비서학회 2018 비서·사무경영연구 Vol.27 No.2

          이 연구의 목적은 직장 괴롭힘 조사 결과가 조사자(administrator)에 의해 영향을 받는지 밝히는 데 있다. 이를 위해 이 연구는 한국표준산업분류의 ‘사업시설 및 사업지원’ 산업분야의 근로자들을 대상으로 세 가지 유형의 조사를 실시하여 직장내 괴롭힘을 당하는 피해자 비율을 비교 분석하였다. 이 연구에서 직장 괴롭힘은 한국에서 개발된 KICQ 조사도구를 사용하였으며, KICQ는 총 25개의 문항으로 구성되었다. 세 가지 유형의 직장 괴롭힘 조사 연구는 경영진으로부터 위임을 받은 연구자, 노조, 독립 연구자들에 의해 각각 실행되었다. 첫 번째 조사와 두 번째 조사는 동일한 기관의 다른 표본을 대상으로 약 한 달의 시간 차이를 두고 경영진의 위임을 받은 연구자 및 노조에 의해서 실시되었다. 두 조사에서 표본을 다르게 설정한 이유는 이전에 실시한 조사가 응답에 영향을 미치는 효과를 피하기 위해서이다. 그리고 세 번째 조사는 독립 연구자에 의해 시행되었으며 첫 번째 및 두 번째 조사와 동일한 업종에 종사하지만 다른 조직의 근로자들을 대상으로 실시되었다. 세 가지 조사 연구로부터 밝혀진 직장 괴롭힘 피해자 비율을 비교 분석한 결과, 다음과 같은 결과가 나타났다. 경영진의 위임을 받아 실행한 조사 연구에서는 행동척도에 따라 피해자를 조사하는 조작적 피해자 비율이 7.8%에 불과한 반면, 다른 두 개의 조사 연구(노조 및 독립 연구자에 의한 조사)에서는 조작적 피해자 비율이 25.5%로 높은 결과를 보임으로써 상이한 결과를 보였다. 한편, 응답자 스스로가 피해자라고 인식하는 주관적 피해자 비율은 세 가지 조사에서 비슷하게 5.2%~5.6%로 낮은 비율을 보였다. 조사 주체에 의한 유의미한 차이는 없었으나, 세 가지 유형의 조사 가운데 경영진의 개입으로 이루어진 조사에서 가장 낮은 직장 괴롭힘 피해자 비율(5.2%)이 나타났다. 이 연구 결과는 직장 괴롭힘 조사 주체에 의한 피해자 비율(조작적 피해율 및 주관적 피해율)을 최초로 조사하고 그 결과를 비교 분석하였다는 점에서 의의가 있다. 아울러 직장 괴롭힘 조사에서 피해자 실체를 제대로 파악하기 위해서는 경영진의 직접적 개입을 피해야 하며, 조사와 관련하여 한국인의 체면차리기 문화 및 내부고발자에 대한 부정적 태도와 한국 문화를 반영한 조사도구 사용 등을 고려해야 한다는 실무적 시사점을 제시하였다. This paper aims to examine if the result of workplace bullying investigation is influenced by the administrator. For that purposes, this paper compares three the victim rates from three surveys on the ‘Facility Administrations and Support Services’ workers. The tool used to measure workplace bullying was KICQ (Korean Interpersonal Conflict Questionnaire), which is the 25 item workplace bullying index developed in South Korea. The surveys were led by researchers commissioned by the management(Survey 1), by the union(Survey 2), and by independent researchers(Survey 3) respectively. Surveys 1 and 2 were conducted to different employees in the same organization in order to avoid the influence of the previous survey on responses. Survey 3 was carried out to employees in the same industries but working for different organizations as a control condition. The following results were obtained. Management involvement led to a significant drop in the rate of operational victims to 7.8% while the other two surveys produced equal operational victim rates of 25.0%. The rates of subjective victims were not much affected by the administrator but management involvement did produce the lowest victim rate. Several practical implications were suggested. Firstly, in order to avoid the bias caused by the administrator effect, management should not be directly involved and even the indirect involvement should be kept unknown to the respondents. Secondly, ‘face-saving’ value in South Korea should be taken into consideration. Thirdly, the reluctance to admit victimization can also be explained by the unfavourable attitudes towards ‘whistle-blowers’. Finally, the indigenous nature of organizational behavior should also be considered.

        • KCI등재

          An Investigation into the Operational and Subjective Approaches to Identify Sexual Harassment Victims

          Yoojeong Nadine Seo(서유정),Yoonhee Park(박윤희) 한국비서학회 2018 비서·사무경영연구 Vol.27 No.3

          국내에서 직장 성희롱 연구는 정기적으로 이루어져 왔다. 그간 성희롱 조사에서는 제목에 직접적으로 ‘성희롱’이라는 용어를 사용한 경우도 있고 그렇지 않은 경우도 있으며, 피해자를 찾아내기 위한 질문이나 기준도 상이하였다. 이처럼 표준화되지 않은 방법은 성희롱 조사 연구에서 표집 오류에 관한 문제를 야기할뿐만 아니라 피해자들의 성희롱 상태를 찾아내는데 있어 지장을 초래할 수 있다. 이에 따라 본 연구의 목적은 조작적 접근법 및 주관적 접근법을 적용하여 성희롱 피해 정도를 분석하고 표준화된 조사방법에 대해 논하는 것이다. 조작적(operational) 접근 방식은 행동척도에 따라 성희롱 피해자를 분류하는 방법이며, 주관적(subjective) 접근 방식은 응답자 스스로가 피해자라고 인식하는지의 여부에 따라 성희롱 피해자를 분류하는 방법이다. 이 연구에서는 ‘업무상황 조사’라는 조사 제목으로 성희롱 피해에 관한 조사를 실시하였다. 조사결과, 주관적 피해자 비율은 응답자 전체 가운데 여성이 11.6%, 남성이 6.9%인 것으로 나타났다. 한편, 조작적 피해자 비율은 여성이 34.4%, 남성이 25.0%로 드러났다. 이러한 결과는 남성 및 여성 모두 자신들의 성희롱 피해 정도를 과소평가하거나 성희롱을 당하고 있다는 사실 자체를 인지하지 못하고 있음을 보여주고 있다. 연구 결과에 기초하여 시사점을 제시하면 다음과 같다. 우선 성희롱은 여성 및 남성 모두에게 해당되는 이슈이다. 현재 국내 직장 성희롱 관련 법령 및 정책은 여성에게만 초점을 두고 있으나, 이는 지양되어야 하며 남성도 포함된 방향으로 선회되어야 한다. 이에 따라 성희롱에 대한 방지 및 지원책이 남성 및 여성 근로자 모두에게 제공될 필요가 있다. 또한 성희롱 예방 교육을 보다 적극적으로 실시함으로써 성희롱 예방에 관한 바른 태도와 이해를 정립할 필요가 있다. 이러한 행동들은 사회적 합의를 이루어 성에 관계없이 다함께 성희롱을 극복할 수 있는 기반이 될 것이다. Surveys on workplace sexual harassment have been regularly conducted in South Korea. Many of the surveys use the term ‘sexual harassment’ directly in the title and/or the questions and the criteria for identifying victims vary. The unstandardized methods raise a question over sampling bias and may interfere with uncovering the state of sexual harassment. In order to address the issue, this study applied operational and subjective approaches to identify victims. To achieve the research purpose, the survey was conducted under the neutral title ‘Work Conditions Survey’. Data analyses revealed that the rate of subjective victims were 11.6% for females and 6.9% for males. In terms of operational victims, females were 34.4% and males 25.0%. The result indicates that both genders are likely to underestimate the extent of their victimization or are unaware of being sexually harassed. A number of implications can be made. Firstly, sexual harassment is an issue that concerns both men and women. South Korean legislation and policy over sexual harassment at work have been focusing on female victims but the gender-centrism should be avoided. Protection and support should be provided for both male and female workers. In addition, preventive education should also be enhanced to establish the right attitudes towards sexual harassment. Such actions would promote societal consensus, regardless of gender, to act together to overcome sexual harassment.

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