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고관절 치환술후 무균성 해리와 골용해 조직에서 세포사멸
김신윤,인주철,손윤경,김정완,신홍인,구경회 경북대학교 병원 2003 경북대학교병원의학연구소논문집 Vol.7 No.1
목적 : 인공 고관절 치환술 후 실패의 가장 중요한 원인이 되는 무균성 해리및 골용해와 nitric oxide(NO)에 의한 염증세포 사멸의 연관성을 규명하기 위해 본 연구를 시행하였다. 대상 및 방법 : 무균성 해리와 골용해로 인해 재치환술을 받은 18명의 환자의 조직에서 세포들의 사멸을 Terminal Deoxyribonucleotidyl Transferase-Mediated dUTP Nick End Labeing (TUNEL) 방법을 이용하여 검사하였으며, inducible nitric oxide synthase(iNOS)와 미토콘드리아 관련 세포사멸 경로를 p53, Bax, Bcl2, Ki67 항체를 이용해서 면역 염색하였다. 대조군으로 대퇴 경부 골절 환자 6명의 관절낭을 이용하였다. 결과 : 16명(89%)에서 iNOS, p53, Bax 항체에 양성 반응을 보였으며, 12명(67%)에서 Bcl2, Ki-67 항체에 양성반응을, 전례에서 TUNEL에 양성반응을 보였다. 대조군에서는 1명(17%)에서 iNOS와 Bax에, 3명(50%)에서 TUNEL에 양성반응을 보였다. 무균성 해리와 골용해 조직의 세포사멸에 대한 양성반응의 발현빈도가 대조 조직에서 보다 유의하게 높았다. 결론 : Nitric oxide에 의한 염증세포의 사멸이 인공고관절 치환술 후 생기는 무균성 해리와 골용해에 작용함을 알수 있었다. 이 결과는 해리 및 골용해의 예방과 치료방법을 개발하는데 도움을 줄 수 있다. Purpose : To evaluate the relationships between the apoptosis induced by nitric oxide(NO), aseptic loosening and osteolysis, which are the most serious causes of failure after total hip arthroplasty. Materials and Methods : Apoptosis of the inflammatory cells of interface tissues from 18 patients who underwent revision hip arthroplasty was identified by Teminal Deoxyribonucleotidyl Transferase-Mediated dUTP Nick End Labeling(TUNEL). The reaction to immunostaining of inducible nitric oxide synthase(iNOS), p59, Bax, Bcl2, and Ki-67 were evaluated. Six joint capsules obtained from six patients of femoral neck fracture were studied as controls. Results : Sixteen(89%) of 18 interface tissues were positive for iNOS, p53, and Bax monoclonal antibody and twelve(67%) for Bcl2 and Ki-67 monoclonal antibody. All tissues were positive for TUNEL. In the control group of six joint capsules, only one(17%) was positive for iNOS and Bax, and three(50%) were positive for TUNEL. The incidences of apoptiotic signals at the interfacial tissue of aseptic loosening and osteolysis were significantly greater than those of the control. Conclusion : The current study suggested that the apoptosis of inflammatory cells, due to oxidative stress by NO, might be involved in the development of implant loosening and osteolysis after total hip arthroplasty. This information might be crucial for the treatment and prevention of periprosthetic osteolysis and subsequent loosening.
A case of lichen amyloidosis in an adult
( Jee Yon Shin ),( Myeong Heon Chae ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Lichen amyloidosis is a type of primary localized cutaneous amyloidosis clinically characterized by persistent pruritic, hyperkeratotic papules commonly distributed on the shins. Histopathologically, amyloid deposition in the papillary dermis is the characteristic finding. It appears to be more common in males and most often occurs in people 50-60 years of age. A 49-year-old woman presented with brownish papuloplaques on the both lower legs. Itching sense was severe and the lesion was occurred 2 years ago. Histopatholgic findings showed amyloid deposit in the papillary dermis. D-PAS staining was negative. Based on these findings, a diagnosis of lichen amyloidosis was made. We think this case has typical chracteristics of lichen amyloidosis. Therefore we report a case of lichen amyloidosis for educational purposes.
申允植,吳得煥 金烏工科大學校 1988 論文集 Vol.9 No.-
Conceptual design의 특성과 Entity-Relationship model이 표현해야 할 사항으로부터 ER model description/manipulation language가 갖추어야 할 요소를 살펴보고 이를 바탕으로 기존의 description language를 비교 분석하고 현재의 문제점과 해결 방안을 제시한다.
申允澈 진주교육대학교 1973 論文集 Vol.8 No.-
1. Purposes I think the best way to improve the quality of education is to improve that of teachers. Accordingly, the purpose of this study is to suggest the programs nor only to improve the quality and socio-economic status of the elementary school teachers taking charge of the basic education of Korea, but also to reform the present system of teacher's college into a reasonable system fit for a current tendency. 2. Contents a) To compare a teacher-training system of elementary school of some advanced countries like America, Japan, etc, with that of Korea. b) To establish an indication of desirable education for training elementary school teachers. c) To analyze the problems and actual state of adjustment of the students of teacher's college. d) To find Gut the problems in the present system of teacher's college. e) Te research and analyze the opinions of students, teachers, educational administrators, and professors on improving the present system of teacher's college. f) To research and analyze the state of departmental system and the results front that at elementary school. g) Te research and analyze the educators' opinions on the teacher-training system of elementary school to enable them to teach a subject of specialization. 3. Methods a) Analyze of reference books b) Research on the actual condition based on questionnaire? 4. Results a) In the level of education, teacher's college training the elementary school teachers of Korea is inferior to the senior colleges of America, Japan, etc. training elementary school teachers. b) A desirable elementary school teacher is a man of abundant culture, but also must have professional knowledge and technique as an able teacher, and an excellent leadership as a reformer of commuity. c) The students' problems of teacher's college in the actual stave of adjustment are as fellows : (1) Students who considered aptitude and faith of teacher's occupation in the admission motive al·e about 17%, bolt about 50-60% of students entered a teacher's college only because of economic matters against their will. (2) About 17% of students didn't get adjusted themselves well to their school life. The main reasons why they are not adjusted well are not well matched (about 30%) in view of their individuality and adaptability. About 15% of students think they are poor at the subject matters of teacher's college. (3) About 40% of students think music is the most difficult to study and next to it is physical exercise (about 19%). 18.8% of them fetal fine arts difficult to learn. (4) About one-third of students attending teacher's college have feeling of inferiority in their attendance and about another one-third of students complain of having no chance to consult with professors with personality. (5) About one-third of students are appeared to have considerable mental complex in gaining credit nod about 72% of students feel much burdened with the tasks given. d) Problems in the present system are as follows : (1) We considering as to specialization of teacher's occupation, two-year training course is too abort to breed the quality of elementary school teachers. (2) It seems hard to improve quality and socio-economic status at the level of junior college system. (3) Under junior college system it is impossible to have students breed enough the teaching ability of the whole subjects and a subject of specialization. e) Opinions on improving the present system are as follows : (1) As to the term of school year of teacher's college, students (about 50%) and educators (about 43%) long for four-year system in their opinions. (2) Most of students (56%) wish to establish a sole departmental system for music, physical exercise, and fine arts, etc, in their opinions, but educators (75.9%) wish to have students complete net only the common course of subjects, but also one of subjects of specialization in their opinions. (3) As to departmental system at elementary school, most students (about 85%) and educators (64%) approve of it. f) Our country as well as foreign countries adopts much departmental system at elementary school. They say students gain a rapid effect of study by adopting that system. 5. Conclussion I think it is proper that the term of school year of teacher's college must be extended for four years and that to establish a subject of specialization at teacher's college, we must reform the present system of teacher's college quickly.
유산망아지에서 말herpesvirus 의 면역조직학적 및 immunogold 기법에 의한 전자현미경적 진단
신태균,이두식,진재광,임윤규,조길재 濟州大學校 農科大學 動物科學硏究所 1997 動物科學論叢 Vol.12 No.1
To investgate the causative Virus in aborbon of horse in Cheju, we examined the spleen of affected foal by immunohtochemistq and immunogold electron microscopy using EHV - specific antisera. Immunohistochemical staining revealed that a large number of EHV immunoreadive cells were deteded in the red pulp as well as in the sinudoidal cells in the affected spleen. By the immunogold electron microxopy(EM) of crude preparation of EHV culture, electron dense gold paricles were labelled along the envelope of amorphous virus parhcles with vanng sizes of 50-200nm. We suppose that immunohistochemical method is good for the diagnosis of tissues in EHV infections, and immunogold EM is recommended for the study of virus dia gnosis of fluid specimen as well as the ultrastustural study.
신오철,정수용,정윤교 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-
Recently, a damand of accuracy surface roughness about internal applied to auto-mobile, machine tool, and aerospace is increased. As a result, compared to a existing grinding system, the development of internal superfinishing system microfinishing film is expected a high efficiency for reducing time and equal surface roughness. In study, internal superfinishing system using abrasive film was developed, thus surface roughness of Ra 0.06㎛ become possible, Farther, standardization of grinding condition and selsction of abrasive film to apply real file was investigated.