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Robotic-assisted hysterectomy : A series of the first 22 cases
( Yoon Hee Lee ),( Gun Oh Chong ),( Dae Gy Hong ),( Young Lae Cho ),( Yoon Soon Lee ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
To show the outcomes of the first 22 robotic-assisted hysterectomies in our hospital. From May 2008 to May 2012, A total of 22 patients, who underwent robotic-assisted hysterectomy for benign gynecologic diseases using the da Vinci Surgical System were included in the study. Patients` demographics, surgical procedures, operative and postoperative complications, hospital stay, conversion to laparotomy, time data including all operative times and pathological specimen`s weight were recorded. All the surgeries were performed by the same surgeon. The mean age was 44.7 years (range, 34 to 51), and the mean Quetelet index was 21.6 kg/m2 (range, 18.3 to 26.8). The mean operative time was 149.5 minutes (range, 90 to 240). The mean docking time was 5.2 minutes (range, 2 to 13), and the mean console time was 102.5 minutes (range, 51 to 189). There was no conversion to laparotomy. The mean estimated blood loss was 21.8 mL (range, 5 to 70). No patient required blood transfusion. The mean postoperative uterus weight was 421.0g (range, 143 to 1372). The mean hospital stay were 5.5 days (range 3-14 days). Only one intraoperative complication occurred : bladder injury was treated by primary suture. This patient was observed severe pelvic adhesion because of three previous cesarean section surgery. Robotic-assisted hysterectomy is feasible and safe for women with benign gynecologic diseases. In particular, reduced estimated blood loss in robotic-assisted hysterectomy was excellent.
Chromatin Interacting Factor OsVIL2 Is Required for Outgrowth of Axillary Buds in Rice
Yoon, Jinmi,Cho, Lae-Hyeon,Lee, Sichul,Pasriga, Richa,Tun, Win,Yang, Jungil,Yoon, Hyeryung,Jeong, Hee Joong,Jeon, Jong-Seong,An, Gynheung Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.12
Shoot branching is an essential agronomic trait that impacts on plant architecture and yield. Shoot branching is determined by two independent steps: axillary meristem formation and axillary bud outgrowth. Although several genes and regulatory mechanism have been studied with respect to shoot branching, the roles of chromatin-remodeling factors in the developmental process have not been reported in rice. We previously identified a chromatin-remodeling factor OsVIL2 that controls the trimethylation of histone H3 lysine 27 (H3K27me3) at target genes. In this study, we report that loss-of-function mutants in OsVIL2 showed a phenotype of reduced tiller number in rice. The reduction was due to a defect in axillary bud (tiller) outgrowth rather than axillary meristem initiation. Analysis of the expression patterns of the tiller-related genes revealed that expression of OsTB1, which is a negative regulator of bud outgrowth, was increased in osvil2 mutants. Chromatin immunoprecipitation assays showed that OsVIL2 binds to the promoter region of OsTB1 chromatin in wild-type rice, but the binding was not observed in osvil2 mutants. Tiller number of double mutant osvil2 ostb1 was similar to that of ostb1, suggesting that osvil2 is epistatic to ostb1. These observations indicate that OsVIL2 suppresses OsTB1 expression by chromatin modification, thereby inducing bud outgrowth.
Kim, Yoon Jun,Kim, Hwi Young,Lee, Jeong-Hoon,Yu, Su Jong,Yoon, Jung-Hwan,Lee, Hyo-Suk,Kim, Chung Yong,Cheong, Jae Youn,Cho, Sung Won,Park, Neung Hwa,Park, Byung Lae,Namgoong, Seok,Kim, Lyoung Hyo,Cheo Oxford University Press 2013 Human Molecular Genetics Vol.22 No.20
<P>Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, several genome-wide association studies (GWASs) of CHB identified human leukocyte antigen (HLA) loci, including HLA-DP and HLA-DQ in Asian populations, as being associated with the risk of CHB. To confirm and identify the host genetic factors related to CHB infection, we performed another GWAS using a higher-density chip in Korean CHB carriers. We analyzed 1400 samples from Korean population (400 CHB cases and 1000 population controls) using a higher-density GWAS chip [1 140 419 single nucleotide polymorphisms (SNPs)]. In subsequent replication analysis, we further analyzed in an independent study of a Korean CHB cohort consisting of 2909 Korean samples (971 cases and 1938 controls). Logistic regression methods were used for statistical analysis adjusting for age and sex as covariates. This study identified two new risk-associated loci for CHB on the HLA region of chromosome 6, e.g. rs652888 on euchromatic histone-lysine-methyltransferase 2 (EHMT2, <I>P</I> = 7.07 × 10<SUP>−13</SUP>) and rs1419881 on transcription factor 19 (TCF19, <I>P</I> = 1.26 × 10<SUP>−18</SUP>). Conditional analysis with nearby HLA CHB loci that were previously known, confirmed the independent genetic effects of these two loci on CHB.</P><P><B>Conclusion</B>: The GWAS and the subsequent validation study identified new variants associated with the risk of CHB. These findings may advance the understanding of genetic susceptibility to CHB.</P>