http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effect of Opuntia humifusa Extract on Indomethacin-induced Gastric Ulcer in Sprague Dawley Rat
Yoo-Ri Kim,Mi-Ree Lee,Young-Hoan Kim,Bong-Jun Jang,Seung-Chun Park,Seung-Ho Han,Bok-Hyun Kim,Zae-Young Ryoo,Kil-Soo Kim 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.4
Phytogenic agents have traditionally been used by herbalists and indigenous healers for the prevention and treatment of gastric ulcers. The prickly pear (Opuntia humifusa) is a member of the Cactaceae family, and is widely distributed in all of the semiarid countries throughout the world especially in the Mediterranean area and Central America. Most of Cactaceae family is known to be therapeutic properties for arthritis, cancer, and so on. In this study, we examined the antiulcer effect of Opuntia humifusa (OH) on the indomethacin (30 ㎎/㎏, p.o)-induced gastric ulcer in Sprague-Dawley (SD) rats. Oral administration of OH (50, 100, and 200 ㎎/㎏) once a day for 7 days dose-dependently prevented the indomethacin-induced gastric mucosal injury and accelerated the gastric ulcer healing. The pH of stomach inner-surface wall in OH pretreatment group were higher than the pH value of the control group. Gastric wall mucus was significantly preserved by the OH pretreatment at doses of 100 and 200 ㎎/㎏. These results indicate that OH has potent gastric cytoprotective and ulcer healing effects.
당뇨병성 신증의 조기예측지표로서 저항계수 및 박동계수의 의의
김상훈,김시영,이화영,이영래,김향,이상종,김병익,최윤상,이규백,조윤경,김유리,조용욱 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5
Background: Diabetic nephropathy has long been known as most common culprit of ESRD. In NIDDM. histopathologically intrarenal hemodynamic changes are nonspecific, frequently with global glomerulosclerosis, interstitial fibrosis, tubular atrophy and severe arterosderosis. Duplex renal Doppler sonography is useful in the noninvasive assessment of intrarenal hemodynamic change and Doppler indices reflect increased renal vascular resistance. So we compared the values of R.I. and P.I., in NIDDM patients, with several clinical parameters to identify that R.I. and P.I. values can reflect increased renal vascular resistance and predict diabetic nephropathy as early markers. Methods: Renal Doppler US scan was performed on 40 patients with NIDDM to obtain Doppler signals from arcuate artery or interlobar artery and thereby calculate the R.I. and P.I. From every each individual, clinical and laboratory data including age, sex, morbidity period, BMW, mean blood pressure, total cholesterol, serum creatinine, BUN, HbA1c, 24 hr urine protein and creatinine clearance were analyzed. We analyzed the correlation between values of R.I. and P.I. with clinical parameters by using univariate and multiple linear regression analysis. The patients were classified as three groups on the basis of the amount of 24 hour urirne protein and value of serum creatinine: Group l(n=15) was defined as patients with 24 hr urine protein lees than 150mg/day and serum creatinine less than 1.5mg/dL, group 2(n=12) as between 150mg/day and 500mg/day and serum creatinine less than 1.5mg/dL and group 3(n=13) as more than 500mg/day or serum creatinine above 1.5mg/dL. Results: 1) R.I. values showed correlation with age, morbidity period, mean blood pressure, HbA1c, serum creatinine, BUN, creatinine clearance and 24 hour urine total protein. P.I. values showed correlation with age, morbidity period, mean blood pressure, serum creatinine, BUN, creatinine clearance and 24 hour urine total protein. 2) R.I. and P.I. values were significantly affected by creatinine clearance and age in multiple regression analysis. 3) There were statistically positive correlation between 24 hour urine protein and R.I. and P.I.. But when we divided into three groups based on their amount of 24 hour urine protein. R.I. didn't show statistical correlation but P.I, showed significant correlation in the group of patients with proteinuria over 500mg/day(p$lt;0.05). Conclusion: Renal doppler indices reflect increased renal vascular resistance in NIDDM patients and correlate with clinical parameters of diabetic nephropathy. We suggest that the R.I. and P.I. are useful marker for indicating diabetic vascular complication in NIDDM patients. However, further conative studies should be carried out to elucidate the usefulness of R.I. and P.I. as early markers or advantaging parameters in predicting diabetic nephropathy.
Monoclonal Antibody CFC - 6 , which Binds to Helix Ⅱ , Inhibits Erythropoietin - Induced Bioactivity
Kim, Suk Joon,Yoo, Ook Joon,Ha, Byung Jhip,Oh, Myung Suk,Kim, Hyun Su,Yoo, Ree Ann,Lee, Dong Eok,Park, Ji Sook,Woo, Koo 생화학분자생물학회 1998 BMB Reports Vol.30 No.5
It was discovered that monoclonal anti -erythropoietin (EPO) antibody CFC-6 can neutralize EPO-induced cell activation. To know the binding site of CFC-6, recombinant human erythropoietin (rhEPO) was digested with Glu-C. followed by a separation using high performance liquid chromato graphy (HPLC). Each HPLC fraction was blotted on the nitrocellulose membrane and the membrane was treated with anti-EPO antibody CFC-6 and anti-mouse antibody which is modified with peroxidase. Only one spot showed the color and the fraction was sequenced by Edman degradation. The results suggest that CFC-6 recognizes amino acid sequence V63-W-Q-G-L-A-L-L-S-E72 which is a part of helix II of the EPO molecule. Binding of CFC-6 to EPO may inhibit EPO binding to its receptor. which implies that the antibody binding site and the receptor binding site are close or overlapping.
이유석 ( Yoo Seock Ree ),김성희 ( Seong Hee Kim ),김승룡 ( Seung Ryong Kim ),이정한 ( Chung Han Lee ),박문일 ( Moon Il Park ),조삼현 ( Sam Hyun Cho ),정성로 ( Sung Ro Chung ) 대한주산의학회 2003 大韓周産醫學會雜誌 Vol.14 No.2
병합임신의 자연발생은 극히 드문 경우로 30,000 임신당 1예로 알려져 있으나 보조 생식술의 발달로 그 빈도가 100예 혹은 500예 중에 1예로 증가되어 왔다. 병합임신은 임상적인 특성상 조기 발견이 어렵고 진단의 지연과 부적절한 처치는 산모와 자궁내 임신의 유지가 어렵게 된다. 따라서 즉각적인 진단과 적절한 처치가 산모와 더불어 태아 손실을 줄일 수 있게 된다. 이에 저자들은 개인병원에서 체외수정 및 배아이식술 후 난관 임신 파열과 동반된 병합임신 1예를 임신 8주에 난관적출술을 시행한 후, 산전 진찰 중 특이소견 없이 자궁내 임신을 만삭까지 지속하여 건강한 여아를 분만 하였기에 보고하는 바이다. Heterotopic pregnancy is a rare event, occurring less than 1:30,000 pregnancies in natural conception cycles. With assisted reproduction techniques, however, this incidence increase to between 1:100 and 1:500. It is known to present with a variety of symptoms and signs after leading to a delay in establishing the correct diagnosis. Delay in diagnosing and surgery can jeopardize both maternal well-being and survival of the intrauterine fetus. Prompt diagnosis and appropriate surgery contribute to the favorable outcome for the mother and surviving infant. We experienced a case of heterotopic pregnancy after in vitro fertilization and embryo transfer, which carried the intrauterine pregnancy to term delivery following rupture of the tubal pregnancy, with hypovolemic shock. So we report this case with review of literatures.
동종 골수이식 후 만성 이식편대숙주반응 환자에서 발생한 폐렴구균에 의한 수막뇌염 1예
신완식,김병욱,유진홍,김동집,김춘추,박종원,이종욱,김동욱,강문원,김양리 대한감염학회 1993 감염 Vol.25 No.3
Graft-versus-host disease (GVHD) is a frequent complication after bone marrow transplantation. Infectious complications are common in GVHD patients due to defect in cell-mediated immunity. A rare case of S. pneumoniae meningoencephalitis occured in a patient with extensive form of chronic GVHD after allogeneic bone marrow transplantation. He was immediately treated with full dosage of ceftriaxone and ampicillin. He suffered from various complications such as sepsis, acute renal failure, atelectasis, and seizure. Despite of aggressive treatment, he died probably due to renal shutdown and massive subacute cerebral infarction of left cerebral hemisphere. This report showed two unusual and rare features. First, the infection site was CNS rather than respiratory system. Second, the causative organism was S. pneumoniae, which is rare cause of CNS infection in immunocompromised patients.
류마티스 관절염 환자에서 대체의학의 이용실태 및 유용성
김예리 ( Ye Ree Kim ),유태석 ( Tae Seok Yoo ),박훈기 ( Hoon Ki Park ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),유대현 ( Dae Hyun Yoo ),배상철 ( Sang Cheol Bae ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.3
Objective: The use of Complementary and Alternative Medicine (CAM) is common especially among patients with chronic conditions. The aim of this study was to investigate the percentage and characteristics of patients who make use of CAM and analyse the effect of CAM in RA. Methods: Two hundreds and twelve patients with RA were interviewed by a trained nurse according to structured questionnaire about sociodemographic features and type, effect and cost of CAM which was used. Results: Among 212 patients with RA, 73 patients had used CAM (34.4%). There was no difference in sociodemographic features between the user and non-user of CAM. The chinese medicine containing herbal medicine and acupuncture (43.8% and 24.7%) was most commonly used. There was no difference in the score of Korean Health Assessment Questionnaire (KHAQ) between the user and non-user of CAM. In the user group, the scores of the subjective effect and satisfaction for CAM were higher than those for the hospital services. The average yearly cost for CAM was 790,000 Won/person and it was about 67.5% of the one for hospital services. Conclusion: In patients with RA, the percentage of using CAM was 34.4%. Herbal medicine was most commonly used. CAM did not affect the outcome of the patients with RA. However, the scores of the subjective effect and satisfaction for CAM were higher than those for the hospital services. For the proper management of patients with RA, it is necessary to know further data about the effectiveness and side effects of CAM through experimental and clinical research.