http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Austenite Grain Growth Behavior of 30BF Steel Before Rough Rolling
Yong‑feng Chen,Jian‑bo Xie,Yan‑xin Wu,Jian‑xun Fu 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4
To investigate the eff ect of heat treatment on the grain size of austenite in 30BF steel, the comparisons of the morphologiesand sizes of austenite grains between heating samples were made with a high-temperature electric resistance furnace, andthe austenite growth models were built with method of mathematics. The results show that most grains in original specimenwith the sizes below 70 μm uniformly distributed. At a heating rate ( v ) of 10 °C/s, the grain size ( d ) value under a certain time( t ) increased by 60–100 μm with raising temperature ( T ) from 850 to 1100 °C, whereas the d value under a certain T merelyincreased by 70–120 μm with raising time to 60 min. Under v = 0.1 °C/s, T = 850 °C, and t = 0 s, the occupied ratio of grainswith sizes of 40–50 μm was 0.165, whereas at 900 °C, the occupied ratio was 0.125. The evolutions of ln (d5.8− d5.80 ) with1/ T were in negative linear correlations, whereas the ln (d5.8− d5.80 ) with ln t were in positive linear correlations. To sum up,the grain growth behavior of steel was elucidated.
Yong-Xiao Cao,Jian-Pu Zheng,Jian-Yu He,Jie Li,Cang-Bao Xu,Lars Edvinsson 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.6
The purpose of this study was to investigate the effect of atropine on peripheral vasodilation and the mechanisms involved. The isometric tension of rat mesenteric artery rings was recorded in vitro on a myograph. The results showed that atropine, at concentrations greater than 1 µM, relaxed the noradrenalin (NA)-precontracted rat mesenteric artery in a concentration-dependent manner. Atropine-induced vasodilatation was mediated, in part, by an endothelium-dependent mechanism, to which endothelium-derived hyperpolarizing factor may contribute. Atropine was able to shift the NA-induced concentration-response curve to the right, in a non-parallel manner, suggesting the mechanism of atropine was not mediated via the α1-adrenoreceptor. The β- adrenoreceptor and ATP sensitive potassium channel, a voltage dependent calcium channel, were not involved in the vasodilatation. However, atropine inhibited the contraction derived from NA and CaCl2 in Ca2+-free medium, in a concentration dependent manner, indicating the vasodilatation was related to the inhibition of extracellular Ca2+ influx through the receptoroperated calcium channels and intracellular Ca2+ release from the Ca2+ store. Atropine had no effect on the caffeine-induced contraction in the artery segments, indicating the inhibition of intracellular Ca2+ release as a result of atropine most likely occurs via the IP3 pathway rather than the ryanodine receptors. Our results suggest that atropine-induced vasodilatation is mainly from artery smooth muscle cells due to inhibition of the receptor-mediated Ca2+-influx and Ca2+- release, and partly from the endothelium mediated by EDHF.
Optimization of preparation and properties of Gardenia yellow pigment-loaded alginate beads
Yong Liu,Qing Zhou,Yan-Mei He,Xiu-Yun Ma,Lin-Na Liu,Yong-Jian Ke 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.8
Gardenia yellow pigment (GYP) loaded alginate beads were prepared by the ionic gelation technique, and the preparation parameters were optimized by response surface methodology for high encapsulation efficiency. The optimized parameters were alginate concentration of 3.3%, CaCl2 concentration of 2.4%, and GYP concentration of 3.2mg/mL, under which the encapsulation efficiency was 73.61%. The surface morphology and bead size analysis showed that the GYP-loaded alginate beads had a roughly spherical morphology with a wrinkled surface, and their average diameter was 0.87 mm. In vitro release test revealed that the GYP release had a pH-dependent release profile and a two-step release process. The Rigter-Peppas model was the most proper model to assess the GYP release from alginate beads. The release mechanism of GYP at pH 1.2 and 7.4 was non-Fickian transport and case-II transport, respectively. The 2,2-diphenyl-1-picrylhydrazyl assay indicated that the encapsulated GYP had effectively maintained 82.56% of the antioxidant activity.
The characteristics of genistin-induced inhibitory effects on intestinal motility
Yong-jian Xiong,Da-peng Chen,Bo-chao Lv,Fang-fei Liu,Li Wang,Yuan Lin 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.3
Genistin belongs to isoflavones. Based on thefacts that genistin exerts inhibitory effects on the contractilityof vascular smooth muscle,the present study wasdesigned to characterize the effects of genistin on intestinalcontractility and evaluate its potential clinical implication. Ex vivo [isolated jejunal segment (IJS) of rat], in vitro, andin vivo assays were used in the study. The results indicatedthat genistin (5–80 lmol/L) inhibited the contraction of IJSin a dose-dependent manner and inhibited the increasedcontractilityof IJS induced by acetylcholine (ACh), histamine,high Ca2?, and erythromycin, respectively. Theinhibitory effects of genistin were correlated with thestimulation of alpha adrenergic and beta adrenergicreceptors since these inhibitory effects were significantlyblocked in the presence of phentolamine and propranololrespectively. No further inhibitory effects of genistin wereobserved in the presence of verapamil or in Ca2?-freecondition, indicating genistin-induced inhibitory effects areCa2?-dependent. Genistin decreased myosin light chainkinase (MLCK) protein contents and MLCK mRNAexpression in IJS, and inhibited both phosphorylation andMg2?-ATPase activity of purified myosin, implicating thatthe decrease of MLCK contents and inhibition of MLCKactivity are involved in the genistin-induced inhibitoryeffects. The study suggests the potential clinical implicationsof genistin in relieving intestinal hypercontractility.
Yong, Jian-Ping,Lv, Qiao-Ying,Aisa, Haji Akber Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.2
19 Aromatic ring and L-amino acid ester contained rupestonic acid amide derivatives 2a~2l, 3a~3g were synthesized and preliminarily evaluated in vitro against influenza virus $A_3$,B and herpes simplex virus type 1 (HSV-1), 2(HSV-2) by the national center for drug screening of China. The rusults showed that 2i possessed the highest inhibition against both influenza virus $A_3\;(TC_{50}\;=\;120.6\;{\mu}mol/L,\;IC_{50}=\;19.2\;{\mu}$mol/L, SI = 6.3) and B (T$C_{50}\;=\;120.6\;{\mu}mol/L,\;IC_{50}=\;29.9\;{\mu}$mol/L, SI = 4.0); 2g was more active against influenza $A_3$ virus at very low cytotoxicity ($TC_{50}\;>\;2092.1\;{\mu}mol/L,\;IC_{50}=\;143.7\;{\mu}mol/L,$ SI > 14.6) than the parent compound; Compounds 2b, 2c, 2f showed higher activities both against HSV-1 and HSV-2 than that of the parent compound, and 2f was the most potent inhibitor of HSV-1 ($TC_{50}\;=\;200.0\;{\mu}mol/L,\;IC_{50}\;=\;11.3\;{\mu}mol$/L, SI = 17.7 ) and HSV-2 ($TC_{50}\;=\;200.0\;{\mu}mol/L,\;IC_{50}\;=\;20.7\;{\mu}mol$/L , SI = 9.7).
Jian-ping Yong,Haji Akber Aisa 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
To improve the biological activities of rupestonic acid, 21 new rupestonic acid fatty ester derivatives (2a-2h)and aromatic ester derivatives (2i-2u) were synthesized and preliminarily evaluated for their anti-influenza activity in vitro by the national center for drug screening of China, using the Oseltamivir and Ribavirin as reference drugs. The results showed that 2l (IC_50 = 0.5 μmol/L) exhibited potent anti-influenza A_3 viral activity among the synthesized compounds and was 10-fold more potent than that of the reference drug Oseltamivir (IC_50 = 5.1 μmol/L).
Jian-ping Yong,Qiao-ying Lv,Haji Akber Aisa 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.2
19 Aromatic ring and L-amino acid ester contained rupestonic acid amide derivatives 2a~2l, 3a~3g were synthesized and preliminarily evaluated in vitro against influenza virus A3,B and herpes simplex virus type 1 (HSV-1), 2(HSV-2) by the national center for drug screening of China. The rusults showed that 2i possessed the highest inhibition against both influenza virus A3 (TC50 = 120.6 μmol/L, IC50 = 19.2 μmol/L, SI = 6.3) and B (TC50 = 120.6 μmol/L, IC50 = 29.9 μmol/L, SI = 4.0); 2g was more active against influenza A3 virus at very low cytotoxicity (TC50 > 2092.1 μmol/L, IC50 = 143.7 μmol/L, SI > 14.6) than the parent compound; Compounds 2b, 2c, 2f showed higher activities both against HSV-1 and HSV-2 than that of the parent compound, and 2f was the most potent inhibitor of HSV-1 (TC50 = 200.0 μmol/L, IC50 = 11.3 μmol/L, SI = 17.7 ) and HSV-2 (TC50 = 200.0 μmol/L, IC50 = 20.7 μmol/L , SI = 9.7).
Minimal Redundancy Maximal Relevance Criterion-based Multi-biometric Feature Selection
Yong Jian Chin,Kian Ming Lim,Siew Chin Chong,Chin Poo Lee 한국산학기술학회 2013 SmartCR Vol.3 No.2
Multimodal biometrics are always adopted to improve the recognition performance of single modality biometric systems. Besides introducing more discriminating power to the biometric system, integrating multiple modalities also leads to the curse of dimensionality problem. In this paper, we engage the minimal redundancy maximal relevance criterion to reduce the dimensionality of the feature vector. The minimal redundancy maximal relevance criterion is a feature selection criterion that aims to retain the most relevant elements while discarding the other redundant elements. Our experiments show that, with only 15% of the original feature length, minimal redundancy maximal relevance criterion-based features are able to perform similarly well or even better than the baseline results.