Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Yong Soon Kim,Min Won Baek,Jae Hyuck Sung,Hyun Youl Ryu,Jin Sik Kim,Hyun Sun Cho,Byung Gil Choi,Min Sub Song,Moon Yong Song,Eun Ju Baik,Young Kuk Choi,Jong Kyu Kim,Il Je Yu,Kyung Seuk Song 한국독성학회 2009 Toxicological Research Vol.25 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 ㎎/㎏ body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 ㎎/㎏ body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 ㎎/㎏ body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Kim, Yong-Soon,Baek, Min-Won,Sung, Jae-Hyuck,Ryu, Hyun-Youl,Kim, Jin-Sik,Cho, Hyun-Sun,Choi, Byung-Gil,Song, Min-Sub,Song, Moon-Yong,Baik, Eun-Ju,Choi, Young-Kuk,Kim, Jong-Kyu,Yu, Il-Je,Song, Kyung-Se Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Multi-mode Kernel Weight-based Object Tracking

Eun-Sub Kim(김은섭),Yong-Goo Kim(김용구),Yoo-Joo Choi(최유주) 한국컴퓨터그래픽스학회 2015 컴퓨터그래픽스학회논문지 Vol.21 No.4

최근, 감시시스템, 게임, 영화 등 다양한 분야에서 영상을 이용한 실시간 객체 추적의 필요성이 높아짐에 따라, 커널기반 mean-shift 추적 기법에 대한 관심이 높아지고 있다. 커널 기반 mean-shift 객체 추적에 있어서 주요한 몇 가지 문제점들 중, 첫 번째로 추적 목표 객체에 대한 부분 가림 혹은 전체 가림 상황에서의 객체 추적의 문제를 들 수 있다. 본 논문에서는 멀티모드 지역적 커널 가중치를 적용함으로써 부분 가림 상황에서도 안정적으로 객체를 추적할 수 있는 실시간 mean-shift 추적 기법을 제안한다. 제안기법에서는 단일 커널을 사용하는 대신 여러 개의 서브 커널들로 구성된 커널을 사용하고, 각 서브 커널의 위치에 따른 지역적 커널 가중치를 적용한다. 기존의 멀티모드 커널 기반의 방법과 비교한 실험을 통하여 본 제안 방법이 보다 안정적으로 객체를 추적할 수 있음을 보였다. As the needs of real-time visual object tracking are increasing in various kinds of application fields such as surveillance, entertainment, etc., kernel-based mean-shift tracking has received more interests. One of major issues in kernel-based mean-shift tracking is to be robust under partial or full occlusion status. This paper presents a real-time mean-shift tracking which is robust in partial occlusion by applying multi-mode local kernel weight. In the proposed method, a kernel is divided into multiple sub-kernels and each sub-kernel has a kernel weight to be determined according to the location of the sub-kernel. The experimental results show that the proposed method is more stable than the previous methods with multi-mode kernels in partial occlusion circumstance.

A sub-1-volt nanoelectromechanical switching device.

Lee, Jeong Oen,Song, Yong-Ha,Kim, Min-Wu,Kang, Min-Ho,Oh, Jae-Sub,Yang, Hyun-Ho,Yoon, Jun-Bo Nature Pub. Group 2013 Nature nanotechnology Vol.8 No.1

<P>Nanoelectromechanical (NEM) switches have received widespread attention as promising candidates in the drive to surmount the physical limitations currently faced by complementary metal oxide semiconductor technology. The NEM switch has demonstrated superior characteristics including quasi-zero leakage behaviour, excellent density capability and operation in harsh environments. However, an unacceptably high operating voltage (4-20 V) has posed a major obstacle in the practical use of the NEM switch in low-power integrated circuits. To utilize the NEM switch widely as a core device component in ultralow power applications, the operation voltage needs to be reduced to 1 V or below. However, sub-1 V actuation has not yet been demonstrated because of fabrication difficulties and irreversible switching failure caused by surface adhesion. Here, we report the sub-1 V operation of a NEM switch through the introduction of a novel pipe clip device structure and an effective air gap fabrication technique. This achievement is primarily attributed to the incorporation of a 4-nm-thick air gap, which is the smallest reported so far for a NEM switch generated using a 'top-down' approach. Our structure and process can potentially be utilized in various nanogap-related applications, including NEM switch-based ultralow-power integrated circuits, NEM resonators, nanogap electrodes for scientific research and sensors.</P>

Genome-wide transcriptome analysis of rice genes responsive to chilling stress

Cho, Hyun Yong,Hwang, Sun-Goo,Kim, Dong Sub,Jang, Cheol Seong Canadian Science Publishing 2012 Canadian journal of plant science. Revue canadienn Vol.92 No.3

<P> Cho, H. Y., Hwang, S.-G., Kim, D. S. and Jang, C. S. 2012. Genome-wide transcriptome analysis of rice genes responsive to chilling stress. Can. J. Plant Sci. 92: 447-460. Low temperature is known to be one of the major challenges to rice production. We have selected chilling-tolerant TILLING of Donganbyeo, which showed significantly vigorous growth relative to wild-type plants under chilling stress conditions (10-12°C). We performed a comparative transcriptome analysis using a chilling-tolerant line and wild-type plant with the objective to evaluate genomic responses to chilling stress and to identify chilling inducible genes. Functional enrichment analysis results demonstrated that a large proportion of chilling-inducible genes were associated with certain biological pathways, e.g., monosaccharide catabolic processes, reflecting the energy requirements necessary for adaptation to sub-optimal temperatures in plants. Extremely low correlation coefficients in a range of −0.07 to 0.04 were detected between plant responses to chilling stress and different abiotic stress conditions such as drought, salt, cold, and heat; these results imply that plants might exploit strikingly different response mechanisms against stress conditions. The largest subnetwork, which was composed of 78 chilling-specific inducible genes, was found in the tolerant plants, but not in the wild-type plants, which probably implies the existence of a delicate and harmonious signaling pathway setup in the tolerant plants. Expression patterns of 20 chilling-responsive genes were assessed via abiotic stress treatments and phytohormone treatments. About 80% of the tested chilling-inducible genes were upregulated by exogenous abscisic acid (ABA) treatment. The results of this study may prove useful in elucidating the chilling-response pathway and in the development of chilling-tolerant rice varieties. </P>

The Establishment of the International Financial Center (IFC) in Jeju Free International City

Heonkyu JEONG,Hyo KIM,Yong-Bok CHOI,Mun-Sub CHUNG 제주대학교 관광과경영경제연구소 2020 産經論集 Vol.40 No.3

Purpose: Jeju Free International City is growing around the tourism industry. However, for Jeju Free International City to grow in line with the concept of free international city, it is necessary to move away from the current industrial structure that is focused on the tourism industry. It is necessary to reorganize the industrial structure centered on the financial industry in the long term, and for this, it is necessary to develop interest and fostering the financial industry within Jeju Special Self-Governing Province. This study intends to reconsider the necessity through the academic approach to fostering the financial industry in Jeju Free International City, which has been planned from the policy perspective. To this end, this study empirically analyzed the factors necessary to build the foundation for fostering the financial industry in Jeju Free International City. The purpose of this study is to examine the necessity for the establishment of an international financial center in Jeju and to derive the necessity for each factor through analysis of sub-factors necessary for the establishment of an international financial center in Jeju. Research design, data and methodology: This study carried out IPMA for analysis of components for fostering the financial industry. Through IPMA, this study identified priorities for the need for configuration factors and sub-factors. In addition, the thesis further performed a cross-group comparison. Result: The analysis confirmed that the factors in the living environment are the highest priority. It also confirmed that the priority of institutional policy factors and infra-facility factors is high. This study found that financial and non-financial employees differed in the priorities of factors in the comparison analysis between groups. This study also confirmed that Jeju residents and non-Jeju residents have distinct differences in the priorities of factors. Conclusion: Through this study, factors necessary for Jeju Free International City were identified. In addition, it was confirmed that there was a clear difference between the factors necessary for Jeju residents and non-Jeju residents. In the future, it is necessary to seriously consider these differences in the decision on whether to introduce, how to introduce, and priorities in the introduction of international financial center.

Anti-Cancer Effect of Ginsenoside F₂ against Glioblastoma Multiforme in Xenograft Model in SD Rats

Shin, Ji-Yon,Lee, Jung-Min,Shin, Heon-Sub,Park, Sang-Yong,Yang, Jung-Eun,KimCho, So-Mi,Yi, Tae-Hoo The Korean Society of Ginseng 2012 Journal of Ginseng Research Vol.36 No.1

The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short. Therefore, this study was conducted to assess the potential of ginsenoside $F_2$ (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with $IC_{50}$ of 50 ${\mu}g/mL$ through apoptosis, confirmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1 as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 mg/kg weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced. The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.

High-throughput screening of protein variations in soybean seeds.

Vijayanand Velusamy,Kyung Jun Lee,Bo-Keun Ha,Jin Baek Kim,Sang Hoon Kim,Si-Yong Kang,Dong Sub Kim 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07

The protein in soybean seeds accounts for approximately 40% of the dry seed weight. Two major storage proteins, 7S and 11S, constitute 70-80% of the total storage proteins in the seeds. In this study, the variation of total soluble protein extracts from 1152 soybean landraces that have been collected from South Korea were studied using high-throughput screening method with HT Protein Express Labchip (Caliper Life Sciences, Inc.). Seven distinct protein band patterns - four protein sub-units of 11S and three sub-units of 7S, were taken into account and their presence or absence were analyzed. Among the 1152 landraces, 525 genotypes were identified as lacking lipoxygenase, 255 lacking α1 subunit, 680 lacking α subunit, 169 lacking β subunit, 140 lacking acidic, 114 lacking Kunitz Trypsin Inhibitor (KTi) and 199 lacking basic protein patterns. The high-throughput protein analysis is helpful in screening a large number of populations with less time and minimum labor. The selected genotypes with low amounts or lacking of anti-nutritional factors such as trypsin inhibitor, lipoxygenase and α subunit would be used for future breeding purpose of quality improvement in soybean protein.

스테로이드로 유발된 쥐의 근골격계 변화에대한 성장호르몬의 치료 효과

최기섭,박창일,정우성,이상건,박용욱 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.5

金洙暎의 「新歸去來」硏究 : 詩 「新歸去來」의 현실인식 方法

이영섭 연세대학교 국어국문학과 1985 연세어문학 Vol.18 No.-