치주조직 재생을 위한 칼슘 포스페이트 글라스 분말이 백서 두개골 결손부의 골조직 재생에 미치는 영향

이용근,문현주,이상배,김광만,김경남,최성호 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.2

The treatment of the tone defects resulting from trauma, neoplasm, surgery, or infection is one of the major concern in dentistry. The major goal is the functional, esthetical regeneration of supporting structures already destructed by disease. Transplantation technique have been used to provide a scaffold for bone regeneration, to augment bony defects resulting from trauma or surgery, to restore bone loss caused by dental disease, to prevent the collapse the alveolar ridge in recent extraction sites, to replace bone loss by periodontal disease, to augment the alveolar ridge in implant surgery. There are autogeneous, allogenic, xenogenic and alloplastic bone-grafts in transplantation. Among the alloplastic bone-graft materials, calcium phosphates have been received the most attention. In this study, the critical size defects were surgically produced in the calvarial bone of Sprague-Dawley rats using the 8 ㎜ trephine bur. Calcium phosphate glass powders with mean diameter 400 ㎛ transplanted onto the produced detects in the experimental group, while sutured without grafting anything in the control group. Histomorphometric as well as radiodensitometric analyses were performed after sacrifice at 2, 4 and 8 weeks following operation. The prepared calcium phosphate glass powder with average size 400 ㎛ in CaO-CaF_2-P_2O_5-MgO-Al_2O_3 promoted new bone formation in the calvarial defects in the Sprague-Dawley rats. New bone was formed in the upper side of the detects as well as the defect margin and dura mater. Experimental group always exhibited higher values in the length, area and density of the newly formed bone than that of the control group. There were significant differences between the experimental and the control groups, except the density after 4 weeks (p<0.05).

鼻閉塞환자에서 수술전후 Rhinomanometry에 의한 총 비저항치의 변화

김용기,문문만,최봉남 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

For over 100 years, the interest has been shown in evaluation of the nasal airway. As a nasal obstruction can be a subjective complaint, there is wide variation in the interpretation of the nasal symptoms. Rhinomanometry is objective, reliable, easily quantitated and a reproducible method to evaluate the nasal obstruction. 51 patients with nasal obstruction were evaluated with the active anterior rhinomanometry before and after nasal surgery and 60 patients with nomal rhinoscopic findings were evaluated with same methods as a control group. The results were as follows. 1) The mean total nasal resistance was : 1.386CmH_(2)O/LPS in control group. 2.523CmH_(2)O/LPS in patient group(p<0.05). 2) The preoperative total nasal resistance by rhinomanometry was highly correlated with subjective assessment of nasal obstruction, especially for the patient with moderate to severe symptoms of nasal obstruction. 3) In the comparison of preoperative with postoperative total nasal resistance during inspiration according to the different surgical procedure, the total nasal resistance after polypectomy was significantly decreased and the obstructive symptoms were more improved in patients who have recieved polypectomy. 4) The total nasal resistance after nasal surgery was significantly decreased from the preoperative 2.523CmH_(2)O/LPS down to the postoperative 1.512CmH_(2)O/LPS(p<0.05). 5) Therefore rhinomanometry is objectively reliable in evaluation of the nasal obstruction and the effect of nasal surgery.

資産性 投資事業의 效果的 管理를 위한 經營情報시스템의 設計

崔德圓,崔相萬,洪永植 成均館大學校 1980 論文集 Vol.28 No.-

Most industries have several projects to undertake which fall into the category of capital investments. But the general tendency of their economic analysis has been confined to a project by project basis. This tendency made it very difficult to configurate overall possible impacts upon the value of a firm, and upon the future financial structure that may be produced from the performance of a certain set of selected project alternatives. This thesis attempts to resolve these shortcomings by adopting the concept of integrated management information system. For this purpose a data base schema was constructed to facilitate the systematic processing of capital investment information. From the cash flow information a desirable debt ratio (DDR) was determined to find the amount of debt that can be financed to each project under specified risk level. The DDR model, when applied with the 0-1 integer programming model, plays an important role in the selection of optimum project-mix that will keep the firm in healthy financial position throughout its planning horizon. Another important achievement from this study is that it was made possible to derive various kinds of expected financial ratios over the forthcoming time domain of top management's concern, while the conventional financial ratio analysis has been restricted to the past.

분무 열분해에 의한 Ba1-xSrxFe12O19계 자성 미립자의 제조 및 특성 변화

김동현,김광만,김경남,최세영,심인보,이용근 大韓齒科器材學會 2004 대한치과재료학회지 Vol.31 No.1

Magnetic particles with alternating magnetic field are expected to be useful as thermoseeds in hyperthermic cancer treatment, since they can be targeted and confined to the cancer site. Hard magnetic ferrites such as barium ferrite and strontium ferrite are good candidates for thermoseeds of hyperthermia because of their great hysteresis loss. In order to verify the effect of Sr-substitution to Ba-site, synthesized Ba1-xSrxFe12O19 microspheres with various compositions through spray pyrolysis followed by sol synthesis using barium nitrate, strontium acetate and iron nitrate. Coercive force was increased with increasing substitution amount of Sr whereas magnetic saturation was almost constant. Spherical microspheres with average diameter of 11.7~17.0 ㎛ were produced by spray pyrolysis at 400~1000℃. The mean size was dependent on the pyrolysis temperature and flow rate of carrier gas. In order to obtain a single phase of SrFe12O19 crystal, the spray pyrolyzed spheres were undertaken subsequent heat-treatment above 1000℃. During the subsequent heat-treatment, however, spherical microspheres were agglomerated because of necking between particles. Further study has to be continued working on synthesis of pure SrFe12O19 crystal by means of improvement of pyrolysis temperature scheme and extend the heating period.

초내식성 스테인리스강의 교정용 브라켓에의 적용

추성욱,김경남,김광만,이원유,박용수,이상배 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.3

Esthetic has become an indispensable factors to consider when choosing a orthodontic fixed appliances. However, most of the brackets used on orthodontics are made of metallic materials because those esthetic alternatives showed several controversies like brittleness, deformation and discoloration. The AISI austenitic classes, 303, 304, 316 and 317 type of stainless steels are frequently used for orthodontic metallic brackets fabrication. The composition of this type of alloy is 18 wt% of chrome, 8 wt% of nickel, 2 to 3 wt% of molybdenum and low carbon contents. They seemed to show relatively good characteristics to fabricate the orthodontic brackets in previous study. But in hostile condition such as low pH containing chlorine ion like saliva they might to be attacked by localized corrosion. The purposes of this study were to evaluate the microstructure, microhardness, corrosion resistance, frictional resistance and cytotoxocity of 316L(MD), AISI 304(AC) and experimentally produced super stainless stell bracket(SS). The results from this study were as follows; 1. MD and AC showed (Cr, Fe)23C6 precipitating in austenite matrix. SS showed small ferrite island forming in matrix. 2. SS showed the highest polarization resistance(Rp). SS seemed to have the highest corrosion resistance since SS showed 0.9 ×10-3 MPY, MD showed 3.7 ×10-3 MPY and AC showed 7.4×10-3 MPY. 3. The friction resistance decreased from 3 days to 4 weeks for SS(p<0.05). MD showed significant differences for the measurement of 3 days, 2 weeks and 4 weeks. AD did not showed significant differences to 3 days but increased at 2 weeks(p<0.05). 4. SS seemed to have the best biocompatibility since SS showed response index of 0/1 (mild), AC showed 1/2 (mild+) at cytotoxicity test. According to these results, SS seemed to have sufficient characteristics to fabricate the orthodontic brackets and superior corrosion resistance compare to AISI 300 type stainless steel which could lower the chance of nickel allergic reaction.

바륨 페라이트를 함유한 알지네이트 자성 복합 입자의 제조

이덕연,오영일,김동현,김광만,김경남,이용근 大韓齒科器材學會 2004 대한치과재료학회지 Vol.31 No.1

Magnetic polymer composite materials with high coercivity have potential applications in medical diagnostic technologies, magnetic drug delivery, and hyperthermic cancer treatment. The purpose of this study was to prepare the magnetic composite particles by encapsulating barium ferrite powders with alginate and to investigate their physical and biological properties. 0.4 g of sodium alginate was dissolved in 20 ml of distilled water and different amount (0.4~4 g) of barium ferrite powder was dispersed in alginate solution using an ultrasonication method. The resulting barium ferrite-alginate slurry was added dropwise to a CaCl2 solution to form magnetic Ca-alginate composite beads. They were separated by filtration and washed several times with water and ethanol. The final product was then completely dried at 40℃ under vacuum to obtain brownish black powders (0.1~1 mm in size) with a high magnetic response when submitted to a small magnet. Average size of magnetic composite particles was dependent on the amount of barium ferrite and the viscosity of slurry . The morphological and dimensional analyses of magnetic composite particles were performed by optical microscopy and scanning electron microscopy. Magnetic polymer composite particle was found to maintain the high coercivity. The saturation magnetization value for magnetic Ca-alginate composites increased with the increase of the barium ferrite/alginate ratio. The amount of self-heating induced by hysteresis under an alternating magnetic field was measured as a function of barium ferrite/alginate ratio in distilled water. According to the results, the encapsulated magnetic composite is expected to be useful for hyperthermia and chemotherapy remarkably.

한국재래흑염소에서 발정 및 과배란 유도와 외래유전자 주입에 적합한 1세포기 수정란의 채취

신상태,이두환,김명철,이운규,이철상,한용만,이경광 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

Three different treatments for induction of estrus in Korean native black goats were compared: follicle stimulating hormone(FSH, FSH-p^TM), FSH combined with MAP(intravaginal impregnated sponges, Veramix^ⓡ, containing 60 ㎎ medroxy progesterone acetate for 14 days), and FSH combined with progesterone(Ovaron^ⓡ, 10 ㎎ IM for 10 days) and PGF_2α(Lutalyse^ⓡ, 3 ㎎ IM at first FSH injection). FSH for inducing estrus and superovulation was given a total 20 ㎎ intramuscularilly in decreasing dosage injections twice daily over 4 days. The MAPs were withdrawn at the 3rd day of FSH injection. Estrus observations were conducted every 6 hours from last FSH injection for 24 hours by placing the does with fertile male goats. Estrus and superovulation were more successfully induced with treatment of MAP + FSH than other treatments(FSH only, or progesterone + PGF_2α + FSH) (estrus induction; 100 vs 42.8 and 71.4%, ovulation points; 11.4 vs 5.4 and 4.4, respectively). The effect of gonadotropin releasing hormone(GnRH) on the ovulation rate was also examined. However, no difference was observed for inducing ovulation with treatment or dosage(100 ㎍ 200 ㎍) of GnRH. Low midline laparotomies were performed, and then ovarian responses (ovulations and follicular development) were examined by exteriorization of the reproductive tracts. Ova were recovered from oviducts by retrograde flushing 60-146 hours after MAP removal, and were classified the developmental stages. Overall 66.1% (236/357) of recovery rate was obtained from 30 superovulated does. The optimal recovery time of microinjectable 1-cell zygotes was approximately 72-76 hours after MAP removal.

CLONING OF HUMAN LACTOFERRIN GENE AND ITS POLYMORPHISM IN NORMAL AND CANCER CELLS

Yong Yeon Cho,Soo Kyung Bae,Yong Mahn Han,Sang Gi Paik,Kyung Kwang Lee,Dae Yeul Yu 생화학분자생물학회 1993 생화학분자생물학회 춘계학술발표논문집 Vol.- No.-

Deletion of oadGAB Operon in Mannheimia succiniciproducens

Yong J CHOI,Yong Jae JEON,Ji Mahn KIM,Sang Yup LEE 한국생물공학회 2009 한국생물공학회 학술대회 Vol.2009 No.4

G-5. Transgenic Mice Carrying Human Gastrin/SV40 Large T Antigen Fusion Genes

Yong-Mahn Han,Jung-Sun Park,Sun-Jung Kim,Chul-Sang Lee,Dae-Yeul Yu,Kyung-Kwang Lee,Ook-Joon Yoo 한국실험동물학회 1993 한국실험동물학회 학술발표대회 논문집 Vol.1993 No.-