복합성 치아종

노용관,김대범,백병주 大韓小兒齒科學會 1992 大韓小兒齒科學會誌 Vol.19 No.2

The odontomas are most common odontogenic tumors composed of various tooth-like structures : enamel, dentin, cementum, pulp tissue. The etioglogy of the odontoma is not evident but it has been suggested that local trauma or infection may produced such a lesion. Clinically, they are asymptomatic, slow growing and lesions of limited growth that show no infitration to the adjacent tissues. They are dignosed most often in the second decade of life, and have no predilection for jaws. The treatment is surgical excision and there is no expectancy of recurrence or serious complications after removal.

수치지도 및 지리정보시스템의 원리와 활용방안

이용범,이우균 고려대학교 2001 생명자원연구 Vol.9 No.-

두경부에 발생한 방선균증 3예

홍석중,주준범,김용재,이봉재 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.11

숙종대 정국구도와 왕권강화책

도동열,정용범 동의공업대학 2000 論文集 Vol.26 No.1

The system of lineage nobility in the early Ko-ryeo enjoyed the heyday under the balance and restraint. But the Lees of Injoo who had produced the queens from Lee Ja-yeon's time became then the highest lineage nobility, threated the framework of balance among the lineage nobilities, and made the royal power incompetent. The succession to throne by Suk-jong was possible owing to the interests of the lineage nobilities, and for Suk-jong the reorganization of political circles through entire exclusion of lineage nobility was difficult. Therefore, we can think that the political situation in the early reign of Suk-jong was established under the mutual restraint of meritorious retainers based on Suk-jong's power and lineage nobility. In this political situation Suk-jong promoted a set of policies such as coinage policy and construction of Namgyeong in order to consolidate the royal power. However, it was not perfectly advanced because of the objection of lineage nobility, and after Suk-jong's death was deteriorated and reduced to the existing regime. In short, the policy of consolidating royal power did not obtained the good results due to the then political situation that could not completely deny the existing political system.

알쯔하이머병 환자의 뇌혈류 장애 : Statistical Parametric Mapping을 이용한 Tc-99m ECD SPECT 분석 Statistical Parametric Mapping analysis of Tc-99m ECD SPECT

양동원,김범생,손영민,박정욱,정용안,손형선,김상윤 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.2

Background and Objectives . Alzheimer's disease (AD) is the most common cause of the dementia Pathologic and functional changes of AD are known to be unevenly distributed in the brain. This study investigates changes of cerebral blood flow (CBF) in patients with AD to determine brain regions with hypoperfusion that reflects progression of disease. Methods. Tc-99m-ECD single photon emission computed tomography (SPECT) was performed to measure regional CBF and statistical parametric mapping (SPM) 99 soft ware was used for the automated and objective approach to analyze SPECT image data. Twenty-five patients with mild to moderate dementia who met NINCDS-ADRDA critena for AD (male 11 female 14) and 17 age-matched normal control subjects were studied. The severity of AD was measured by clinical dementia rating (CDR) scale Results. SPM analysis of SPECT images revealed that CBF in the anterior cingulate gyrus left superior panetal cortex left medial frontal cortex left infenor temporal cortex. right thalamus and left hippocampus was significantly decreased in AD patients compared with normal controls (corrected p<0.05). The reduction of CBF according to CDR was localized in the left hippocampus and infenor temporal cortex right antenor and postenor ciagulate cortex and right superior panetal cortex (uncorrected p<0.01). Conclusions : Our data suggest that the cognitive dysfunction of AD is strongly related with functional abnormality in discrete brain areas 99m-Tc ECD SPECT with SPM analysis could be used as a useful functional imaging tool in AD study.

흰쥐에서의 카르복시메칠셀룰로오스나트륨과 겔란검 혼합겔의 유착방지 효과

권윤환,이시범,이정권,박용덕,박정숙,황성주 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

The aim of the present study was to investigate the efficacy of a mixed gel formulation composed of sodium carboxymethyl cellulose and gellan gum (Na-CMC gel) for the prevention of adhesions after laminectomv. The anti-adhesive effect of the Na-CMC gel was tested in a controlled randomized study using an animal model of lumbar laminectomv. The animals (60 female Sprague-Dawlev rats) were randomly allocated into two treatment groups to receive the Na-CMC gel on the injured area or no gel (control). The incidence of adhesions and their grade were blindly evaluated at 4. 8 and 12 weeks after surgery. The amount of scar tissue and tenacity were grossly reduced by the Na-CMC gel at postoperative 4. 8. and 12 weeks. The mean adhesion scores were 0.75. 125. and 1.38 at 4. 8. and 12 weeks in the gel-treated group. respectively. No significant inflammatory reaction was observed and the healing of wound was not affected by the Na-CMC gel. The Na-CMC gel reduced the amount of scar formation and tenacity in rat laminectomv model without affecting the healing of operation wound and other complications. Therefore. the Na-CMC gel may be the potential to prevent postsurgical adhesions in clinical state.

Taxol의 방사면역측정을 위한 I-125 표지화합물 합성

오옥두,최창운,금준섭,박용석,이양호,편웅범 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1997 Journal of biomedical laboratory sciences Vol.3 No.2

Taxol은 diterpenoid구조를 가진 항암제로서, 난소암과 유방암에 탁월한 효과를 보이지만 다른 항암제와 마찬가지로 독성을 가지고 있어 약물의 체내 혈중농도를 모니터링하는 것이 필요하다. 약물의 혈중농도를 모니터링하는 방법은 HPLC법, ELISA법, RIA법 등이 있으나, RIA법이 민감도 측면에서 또한 간편하다는 점에서 장점이 있다. 본 연구에서는 I-125 표지항원을 이용한 방사 면역측정법을 확립하기 위해 먼저 taxol유도체를 합성하였다. 먼저 taxol의 C-13 탄소의 곁가지에 위치한 C-2'부분의 hydroxy기를 succinic anhydride와 반응시켜 2'-hemisuccinyltaxol(Ⅰ)을 합성(반응수율:80%)하였다. 또한 tyramine을 125I로 표지하고 gel chromatography를 통해 정제된 [125I]iodotyramine(Ⅱ)(반응수율:58%)을 얻었다. (Ⅰ)과 (Ⅱ)를 반응시켜 2'-[125I]iodotyramine-hemisuccinyltaxol (Ⅲ) (반응수율:96%)을 얻어 125I 표지항원으로 사용하였다. Taxol에 대한 항체를 획득하기 위해서 (Ⅰ)을 BSA에 접합반응시켜 2'-hemisuccinyltaxol-BSA접합체를 합성하였으며, 이것을 토끼에 면역주사하여 anti-taxol serum을 얻었다. 이 항체에 대한 역가 검정실험에서 1:20의 희석비에서 B/F(%)가 약 40%를 보였다. 이와 같은 결과는 2'-[125I]iodotyramine-hemisuccinyltaxol을 표지항원으로 한 taxol의 방사면역측정 방법으로 혈청내 taxol의 농도측정이 가능함을 제시해 준다. Taxol, an anticancer drug that has diterpenoid conformation, has been used as an effctive chemotherapeutical agent in the treatment of breast and ovarian cancers. Because of its toxicity like other anticancer drugs, monitoring the taxol level in serum is important procedure during cancer therapy. The various monitoring methods using HPLC, ELISA, and RIA have been adopted, and RIA technique is known to be superior than other methods in trems of sensitivity and convenience. In this study, in order to develope taxol RIA system using 125I labelled antigen, first of all we synthesized taxol derivatives. 2'-hemisuccinyltaxol was obtained with about 80% yield by esterification of taxol at C-2' hydroxyl group on C-13 carbon with succinic anhydride. [125I]iodotyramine was prepared with 58% labelling yield by radioiodination of tyramine and purified by gel chromatography. 2'-[125I]iodotyramine-hemisuccinyltaxol, 125I labelled antigen for taxol RIA, was synthesized with 96% yield from conjugation of 2'-hemisuccinyltaxol and [125I] iodotyramine. Anti-taxol serum was produced from the rabbit immunized with 2'-hemisuccinyltaxol-BSA synthesized by 2'-hemisuccinyltaxol and BSA. The antiserum titer was determined by RIA using 2'-[125I]iodotyramine-hemisuccinyltaxol. The titer of 1:20 was obtained with about 40% of B/T. The results suggest that taxol RIA using 125I labelled antigen can be applied to monitor the taxol level in serum.

리튬-필로카르핀 경련모델의 특징 : 행동양상, 뇌파, Fos단백의 발현 및 신경병리학적 변화 Behaviors, Electroencephalography, Fos Expression, and Neuropathologic changes

김영인,이광수,김범생,김용재,천명훈,김명석 대한신경과학회 1996 대한신경과학회지 Vol.14 No.1

장기적 트립토판 결여식이 생쥐의 유해감각예민도에 미치는 영향

서영대,박제민,김명정,전명호,양구범,장세헌,강철중,김정태,김용식 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

The depressive patients can be divided into two subgroups by presence and absence of pain symptoms. Those without pain symptoms have blunted pain sensitivity whereas those with pain have normal range of pain sensitivity, and are clinically characterized by anxiety and irritability. The aim of the study is to test if these clinical profiles of the depressives with pain symptoms are related with reduced level of brain serotonin(5-HT). Forty four mice were randomly divided into two groups : one group to be bred with tryptophan free diet and the other with normal control diet, each for 4 weeks. Before the beginning of the breeding period, measured were locomotor activity by open field test, anxiety by elevated plus maze and nociceptive sensitivity by tail flick test, before and after forced swimming(FS). During each FS, duration of immobilization was also measured. The sable sets of measurements were repeated at the end of the breeding period. The brain 5-HT and 5-hydroxyindoleacetic acid(5-HIAA) were measured by high performance liquid chromatography. The results were as follows 1.Four weeks of tryptophan free diet reduced significantly body weight, brain weight, and levels of 5-HT and 5-HIAA in the whole brain. 2.Tryptophan depletion did not influence basal nociceptive sensitivity as measured by tail flick latency before FS. The normal blunting of the pain sensitivity induced by forced swimming was preserved in the tryptophan depleted group. 3.Tryptophan depletion did not influence general locomotor activity in open field. 4.Tryptophan depletion increased significantly time spent on the open arms at the elevated plus maze test done before FS. This anxiolytic-like effect was reduced by FS. 5.Tryptophan depletion did not influence duration of immobilization during FS. From these results, it is suggested that the genesis of the depression with pain symptoms is not medicated by quantitative reduction of brain serotonin

Preoperational Vibration Test of A Primary Heat Transport System of The CANDU Reactor

Yong Beum Kim,Seon Ho Song 한국소음진동공학회 1997 한국소음진동공학회 국제학술대회논문집 Vol.1997 No.1