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Karaogˇuz, Meral Yirmibes¸,O¨nen, I˙lke,Cos¸ar, Behc¸et,ArKan, Zehra,S¸ahin, Feride I˙ffet,Menevs¸e, Adnan 한국유전학회 2004 Genes & Genomics Vol.26 No.2
The D2 dopamine receptor (DRD2) gene is the first candidate gene that has shown promise of an association with alcoholism. A correlation between alcoholism and Al and A2 alleles of this gene has been under research. In this study, in order to determine the frequencies of allele polymorphisms in 52 unrelated type Ⅱ alcoholics and in 93 unrelated controls, extraction of DNA was performed and appropriate condition of polymerase chain reaction (PCR) was established before TaqI enzyme digestion. To determine the significant difference in genotypes and allelic frequencies between the two groups, Fisher's exact test and Yates' corrected chi-square test were performed, respectively. No significant differences were found between the alcoholics and the controls in the current study in genotypes (p = 0.1600) and in the frequency of the Al allele (p = 0.7513). As a result, the data from the study do not support the hypothesis that the Al allele of the DRD2 gene has an association with alcoholism but it could have put additive effect on the determination of the racial differences in the allele frequencies of the TaIA polymorphism.
The Relationship between Apolipoprotein E Genotypes and Alcoholism in Type Ⅱ Alcoholics
Karaog˘uz, Meral Yirmibes¸,O¨nen, I˙lke,Cos¸ar, Behc¸et 한국유전학회 2005 Genes & Genomics Vol.27 No.1
Apolipoprotein E (Apo E) is important in plasma lipid metabolism and has three major isoforms which are encoded by three allelic forms, ε2, ε3, ε4. To explore the involment of apolipoprotein E gene in alcoholism, Apo E genotypes were evaluated after the digestion with Cfol restriction enzyme in 52 type 11 alcoholics and 120 healthy controls. The frequencies of ApoE alleles in alcoholics were 13% in ε2, 81% in ε3 and 6% in ε4. The corresponding frequencies of the three alleses in control subjects were 7%, 89% and 4%, respectively. There were no significant differences in the distribution of Apo E genotypes and alleles between the alcoholics and the controls (p>0.05).