도연명은거원인재탐 ( 陶淵明隱居原因再探 )

진영명 ( Ying Ming Chen ) 한국중국학회 1995 중국학보 Vol.35 No.1

朝鮮人視城中的乾隆皇帝 : 以《熱河日記》爲中心

劉广銘,金英今 中韓人文科學硏究會 2008 한중인문학연구 Vol.24 No.-

박지원 등이 창조한 건륭황제의 형상은 '객관화'됨으로써 동시대와 후세의 조선인들이 건륭황제를 묘사하는 데 있어서 원초적인 경험을 제공해주는 '기본 텍스트'로 작용하여 왔고 앞으로도 장기간에 걸쳐 건륭황제와 그 가족을 해석하는 기틀로 작용하게 될 것이다. 박지원이 묘사한 건륭황제는 조선조시기라는 역사적인 배경에서 이루어진 것인 동시에 박지원은 또한 조선조시기라는 역사적인 배경을 이루는 한 요소이기도 하다. 다시 말하면 사회집단의 상상력과 텍스트 사이의 관계는 전자가 후자를 제약하는 단선적인 영향관계가 아니라 양자가 서로 영향주는 관계, 일종의 교호적인 대화과정에 처해 있으며 부단한 대화과정에서 끊임없이 새로운 의의가 생성되고 새로운 형상이 탄생하게 되는 것이다. The objective image of Emperor Qianlong created by Pak Chi-Won is regarded as the pre-interpretation of the emperor. Such an image not only made the foundation for those Koreans in the same and following periods but also constrained the followers' interpretation of Qianlong and his family for a long time. Though the interpretation of Qianlong by Pak Chi-Won was constrained in the context of Li Dynasty, his interpretation also contributed to the creation of the context. It means the relation between virtual world of the community and text is not that the former one influences and constrains the later one but they interact with each other. They have an iterative dialogue relation. In such iterative dialogues new meanings and new images are continuously created.

Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment

Ying Xing,Jie Ming,Tao Liu,Nana Zhang,Dingjun Zha,Ying Lin 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.9

Purpose: Previous reports have shown that hyperglycemia-induced inhibition of transient receptor potential vanilloid sub type 4 (TRPV4), a transient receptor potential ion channel, affects the severity of hearing impairment (HI). In this study, we explored the role of TRPV4 in HI using HEI-OC1 cells exposed to high glucose (HG). Materials and Methods: HEI-OC1 cells were cultured in a HG environment (25 mM D-glucose) for 48 hours, and qRT-PCR and Western blotting were used to analyze the expression of TRPV4 at the mRNA and protein level. TRPV4 agonist (GSK1016790A) or antagonist (HC-067047) in cultured HEI-OC1 cells was used to obtain abnormal TRPV4 expression. Functional TRPV4 activity was assessed in cultured HEI-OC1 cells using the MTT assay and a cell death detection ELISA. Results: TRPV4 agonists exerted protective effects against HG-induced HI, as evidenced by increased MTT levels and inhibition of apoptosis in HEI-OC1 cells. TRPV4 overexpression significantly increased protein levels of phosphorylated p38 mitogen-activatedprotein kinase (p-p38 MAPK), while TRPV4 antagonists had the opposite effect. Our results indicated that TRPV4 is a hyperglycemia-related factor that can inhibit cell proliferation and promote cell apoptosis by activating the MAPK signaling pathwayin HEI-OC1 cells. Conclusion: Our results show that the overexpression of TRPV4 can attenuate cell death in HEI-OC1 cells exposed to HG.

Design and Development of Multi-treatment Flow for Salty Water of the Pickled Cabbage

( Ming-ying Chien ),( Li-cheng Hsieh ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

In the process of producing pickled food, it results in high concentration of salty water. If discharged the salty water without treatments, it would cause environmental problems. A base in Dapi Township, Yunlin County, Taiwan, processing pickled cabbage, yields high concentration of salty water of 1044.48 ㎥ to 1443.84㎥ each year. There is a project of salty water treatment, expand current processing system consist of circulating pool, and crystallizing pool. For the purpose of the expanded system easy operated and steady treating, this study is focus on the control method of treatment flow of salty water. Based on the experiment data, when the relative humidity is 55%RH and the environmental temperature is 45°C, the level of salty water drops 0.5 cm every 12 hours. Additionally, there is a linear formula fitting the result to calculate daily evaporation. In conclusion, using the same setting of environment, this system is expected to treat salty water by 1 cm daily level decline per unit area, and it would be an alternative solution for the salty water in Taiwan.

Characteristics of registered studies for Coronavirus disease 2019 (COVID-19): a systematic review

Ming Yang,Ya-xi Shang,Zi-yu Tian,Min Xiong,Chun-li Lu,Jiang Yue,Zhang Yao,Zhang Ying-ying,Jin Xin-yan,Jin Qiu-bai,Zhang Ying-ying,Willcox Merlin L.,Liu Jian-ping 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background: The World Health Organization characterized the Coronavirus disease 2019 (COVID-19) as a pandemic on March 11th. Many clinical trials on COVID-19 have been registered, and we aim to review the study characteristics and provide guidance for future trials to avoid duplicated effort. Methods: Studies on COVID-19 registered before March 3rd, 2020 on eight registry platforms worldwide were searched and the data of design, participants, interventions, and outcomes were extracted and analyzed. Results: Three hundred and ninety-three studies were identified and 380 (96.7%) were from mainland China, while 3 in Japan, 3 in France, 2 in the US, and 3 were international collaborative studies. Two hundred and sixty-six (67.7%) aimed at therapeutic effect, others were for prevention, diagnosis, prognosis, etc. Two hundred and two studies (51.4%) were randomized controlled trials. Two third of therapeutic studies tested Western medicines including antiviral drugs (17.7%), stem cell and cord blood therapy (10.2%), chloroquine and derivatives (8.3%), 16 (6.0%) on Chinese medicines, and 73 (27.4%) on integrated therapy of Western and Chinese medicines. Thirty-one studies among 266 therapeutic studies (11.7%) used mortality as primary outcome, while the most designed secondary outcomes were symptoms and signs (47.0%). Half of the studies (45.5%) had not started recruiting till March 3rd. Conclusion: Inappropriate outcome setting, delayed recruitment and insufficient numbers of new cases in China implied many studies may fail to complete. Strategies and protocols of the studies with robust and rapid data sharing are warranted for emergency public health events, helping the timely evidence-based decision-making.

Public Understanding of E-government

Ming-Ying Lee 서울행정학회 2005 서울행정학회 학술대회 발표논문집 Vol.- No.-

Zn promoted Cu–Al catalyst for hydrogenation of ethyl acetate to alcohol

Ying-ming Zhu,Li Shi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4

The additives of Zn to Cu/Al2O3 catalysts had been studied for hydrogenation of ethyl acetate to ethanol. In addition, X-ray diffraction (XRD), thermo-gravimetric analysis (TGA), H2-temperature programmed reduction (TPR) and TEM studies were performed to characterize the catalysts. The flow reactor studies demonstrated that Zn significantly enhance the reactivity of ethyl acetate in the reaction. The nature of the Cu species on the support, the influence of Zn/Al molar ratio and time-on-stream study were also studied. Pretreatment using pure H2 at different temperatures affected the performance, while the best among the conditions tested was 573 K for 2 h. Addition of Zn influenced the particle size and dispersion of Cu in the studied system. The detected conversion of ethyl acetate reached 66.3% with a 95.3% selectivity of ethanol. This investigation of the Zn promoted Cu/Al2O3 catalyst provides a recently proposed pathway for ethyl acetate hydrogenation reaction to produce ethanol over Cu catalysts.

The Seasonality of Tropical Cyclone Activity in the Western North Pacific

YING Ming,Eun-Jeong CHA 건국대학교 기후연구소 2010 기후연구 Vol.5 No.2

This study recognized five annual cycle modes of the tropical cyclone (TC) activity in the western North Pacific using the CMA-STI data by an objective-oriented K-means cluster analysis approach. The five annual cycle modes include one normal mode and four abnormal modes: a weakened mode, two enhanced modes, and an anti-seasonal mode which suggests TC activities are enhanced in early season but suppressed in peak season. The yearly storm number and storm lifespan of both the weakened mode and the anti-seasonal mode are different from those of the two enhanced modes. The annual amplitudes of TC activity seem to be closely associated with the area of TC genesis. The discrepancies are obvious in frequencies of the five modes. However, comparison with both JMA and JTWC data suggests that the seasonality of TC activity has large bias.

Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells

Ying-ying Xu,Hai-ru Yu,Jia-yi Sun,Zhao Zhao,Shuang Li,Xin-feng Zhang,Zhi-xuan Liao,Ming-ke Cui,Juan Li,Chan Li,Qiang Zhang 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2

Purpose Although the interferon  (IFN) signaling and the paired-like homeodomain transcription factor 2 (PITX2) have both been implicated in the progression of breast cancer (BCa), it remains obscure whether these two pathways act in a coordinated manner. We therefore aimed to elucidate the expression and function of PITX2 during the pathogenesis of endocrine resistance in BCa. Materials and Methods PITX2 expression was assessed in BCa tissues using quantitative reverse transcription polymerase chain reaction (RT-qPCR) and immunohistochemistry and in experimentally induced letrozole-resistant BCa cells using RT-qPCR and immunoblotting. Effects of PITX2 deregulation on BCa progression was determined by assessing MTT, apoptosis and xenograft model. Finally, using multiple assays, the transcriptional regulation of interferon-inducible transmembrane protein 1 (IFITM1) by PITX2 was studied at both molecular and functional levels. Results PITX2 expression was induced in letrozole-resistant BCa tissues and cells, and PITX2 induction by IFN signaling powerfully protected BCa cells against letrozole insult and potentiated letrozole-resistance. Mechanistically, PITX2 enhanced IFN-induced AKT activation by transactivating the transcription of IFITM1, thus rendering BCa cells unresponsive to letrozoleelicited cell death. Additionally, ablation of IFITM1 expression using siRNA substantially abolished IFN-elicited AKT phosphorylation, even in the presence of PITX2 overexpression, thus sensitizing BCa cells to letrozole treatment. Conclusion These results demonstrate that constitutive upregulation of PITX2/IFITM1 cascade is an intrinsic adaptive mechanism during the pathogenesis of letrozole-resistance, and modulation of PITX2/IFITM1 level using different genetic and pharmacological means would thus have a novel therapeutic potential against letrozole resistance in BCa.

Hydrogenation of Ethyl Acetate to Ethanol over Bimetallic Cu-Zn/SiO₂Catalysts Prepared by Means of Coprecipitation

Ying-ming Zhu,Xin Wang Li Shi 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.1

A series of bimetallic Cu-Zn/SiO 2 catalysts were prepared via thermal decomposition of the as-synthesized CuZn(OH) 4 (H 2 SiO 3 ) 2 ·nH 2 O hydroxides precursors. This highly dispersed Cu-solid base catalyst is extremely effective for hydrogenation of ethyl acetate to ethanol. The reduction and oxidation features of the precursors prepared by coprecipitation method and catalysts were extensively investigated by TGA, XRD, TPR and N 2 - adsorption techniques. Catalytic activity by ethyl acetate hydrogenation of reaction temperatures between 120 and 300 o C, different catalyst calcination and reduction temperatures, different Cu/Zn loadings have been examined extensively. The relation between the performance for hydrogenation of ethyl acetate and the structure of the Cu-solid base catalysts with Zn loading were discussed. The detected conversion of ethyl acetate reached 81.6% with a 93.8% selectivity of ethanol. This investigation of the Cu-Zn/SiO 2 catalyst provides a recently proposed pathway for ethyl acetate hydrogenation reaction to produce ethanol over Cu- solid base catalysts.