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침구경락 음양론의 새로운 발전, 기능적 뇌 척주요법 FCST
인창식 ( Chang Shik Yin ),고형균 ( Hyeong Gyun Koh ),이영진 ( Young Jin Lee ),전세일 ( Sae Il Chun ),이영준 ( Young Jun Lee ) 대한경락경혈학회 2005 Korean Journal of Acupuncture Vol.22 No.4
Objectives: Functional Cerebrospinal Therapy (FCST) is a new physiologic therapeutics developed in Korea as a meridian yinyang balance approach. The theory of yinyang balance has been at the core of health enhancement approach of meridian and acupuncture medicine ever since its start. Methods: Introductory overview of FCST is presented in relation with meridian yinynag balance theory. Results: As the temporomandibular joint (TMJ) and related tissues have direct interconnection with brainstem proprioceptive or motor systems and the face is where all the meridians converge, FCST applies a fine adjustment of the posture of TMJ as a treatment tool for neurologic conditions or meridian imbalances. Conclusions: Highly sophisticated diagnostic and therapeutic techniques to adjust various subset aspects of yinyang balance are developed within FCST, which is supposed to be one of major contributions to natural healing.
Yin, Jun,Kwon, Younghee,Kim, Dabin,Lee, Dayoung,Kim, Gyoungmi,Hu, Ying,Ryu, Ji-Hwan,Yoon, Juyoung American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.14
<P>Glutathione (GSH) plays a crucial role in human pathologies. Near-infrared fluorescence-based sensors capable of detecting intracellular GSH in vivo would be useful tools to understand the mechanisms of diseases. In this work, two cyanine-based fluorescent probes, <B>1</B> and <B>2</B>, containing sulfonamide groups were prepared. Evaluation of the fluorescence changes displayed by probe <B>1</B>, which contains a 2,4-dinitrobenzenesulfonamide group, shows that it is cell-membrane-permeable and can selectively detect thiols such as GSH, cysteine (Cys), and homocysteine (Hcy) in living cells. The response of <B>1</B> to thiols can be reversed by treatment with <I>N</I>-methylmaleimide (NMM). Probe <B>2</B>, which possesses a 5-(dimethylamino)naphthalenesulfonamide group, displays high selectivity for GSH over Cys and Hcy, and its response can be reversed using NMM. The potential biological utility of <B>2</B> was shown by its use in fluorescence imaging of GSH in living cells. Furthermore, probe <B>2</B> can determine changes in the intracellular levels of GSH modualated by H<SUB>2</SUB>O<SUB>2</SUB>. The properties of <B>2</B> enable its use in monitoring GSH in vivo in a mouse model. The results showed that intravenous injection of <B>2</B> into a mouse generates a dramatic image in which strong fluorescence is emitted from various tissues, including the liver, kidney, lung, and spleen. Importantly, <B>2</B> can be utilized to monitor the depletion of GSH in mouse tissue cells promoted by excessive administration of the painkiller acetaminophen. The combined results coming from this effort suggest that the new probe will serve as an efficient tool for detecting cellular GSH in animals.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-14/ja412628z/production/images/medium/ja-2013-12628z_0013.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja412628z'>ACS Electronic Supporting Info</A></P>
Yin, Shang-Jun,Zhang, Linmeng,Zhang, Lili,Wan, Jiaxin,Song, Wei,Jiang, Xiamin,Park, Yong-Doo,Si, Yue-Xiu Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.113 No.-
<P><B>Abstract</B></P> <P>The pharaoh cuttlefish <I>Sepia pharaonis</I> is particularly sensitive to environmental changes in its breeding environment. The breeding of <I>S</I>. <I>pharaonis</I> larvae was carried out in different salinities for 48h, and the changes in survival rate, histological structure, energy metabolism, and anti-oxidative stress parameters were investigated and correlated with arginine kinase (AK) expression changes in muscle and liver tissues. The suitable salinity for larvae cultivation ranged from 24 to 30‰, and the survival rate showed a significant decline at 21‰ salinity. Histological observations of muscle and liver showed that changes in salinity and osmotic pressure had an adverse effect on tissue structure. Measurements of glycogen and lactic acid levels suggested that <I>S</I>. <I>pharaonis</I> could dynamically adjust energy metabolism to provide additional energy under unsuitable salinity. The protein levels and enzyme activities of AK in muscle significantly increased at 21‰ salinity. The results were consistent with prompt replenishment of phosphoarginine stores during salinity stress to maintain a dynamic ATP balance, suggesting that AK plays an important role in the regulation of energy metabolism. This study provides insight into metabolic changes during salinity stress and sheds light on the functional role of AK in <I>S</I>. <I>pharaonis</I>.</P>
Clerodane furanoditerpenoids from the stems of Tinospora sinensis
Jun-Sheng Zhang,De-Feng Xu,Yin-Yin Wang,Ren-Fen Ma,Hua Zhang 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.5
One new clerodane-type furanoditerpenoidtinosinoid A ( 1 ) and nine new nor-clerodane analogs tinosinoids B–J ( 2 − 10 ) have been isolated from the stems ofTinospora sinensis . The structures of the new compoundswith absolute confi gurations have been elucidated by spectroscopicmeans, including MS, NMR and ECD techniques,as well as chemical correlation. Compound 1 is a rare sulfurcontainingclerodane diterpenoid incorporating a 2-mercaptoethanolunit via a thioether bond, while compounds 4 / 5and 9 represent two pairs of unusual equilibrium regioisomersthrough an interesting intramolecular transesterifi cation. Our bioassays established that 1 and 8 displayed moderateantiproliferative eff ects against two human tumor celllines, and 9 and 10 showed signifi cant α -glucosidase inhibitoryactivities. A kinetics study revealed that compound 10was a noncompetitive α -glucosidase inhibitor, and its possiblebinding mode to the enzyme was further probed bymolecular docking experiments.
A New Iridoid and other Chemical Constituents from Pedicularis kansuensis forma albiflora Li.
Jun-Gang Yin,Cheng-Shan Yuan,Zhong-Jian Jia 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
A new iridoid (1) and thirteen known compounds 2-14 were isolated from Pedicularis kansuensis forma albiflora Li., and their structures were elucidated by spectroscopic methods including 2D-NMR techniques.