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( Yesim Ozguler ),( Vedat Hamuryudan ),( Gulen Hatemi ),( Ayse Selcen Pala ),( Sebahattin Yurdakul ),( Hasan Yazici ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: We surveyed the causes and outcome of hospitalisations among Behcet Syndrome (BS) patients in a dedicated center. Methods: The records of all inpatients in our clinic between 2002-2011 were retrospectively reviewed to identify patients hospitalised with a diagnosis of BS. We reviewed both the inpatient and outpatient charts to identify the demographic and clinical features, causes of hospitalisation and outcome. We also contacted the patients to determine their current condition. Results: 178 BS patients (74% men, mean age 42. 9±11. 3) had been hospitalised for a total of 211 times during the last ten years. We were able to contact 104(58%) of them. The reasons for hospitalisation were directly related to BS organ involvement in 118(56%) and to complications in 93(44%). The most common BS related reasons were vascular involvement in 74/118(63%) (including 21 patients with pulmonary artery aneurysms, 10 with peripheral artery aneurysms and 11 with serious venous thrombosis such as vena cava superior and Budd-Chiari syndrome), neurologic involvement in 14/118(12%), gastrointestinal involvement in 6/118(5%) and eye involvement in 6/118(5%). Hospitalisations caused by complications of BS were infections in 39/93(42%), and other drug related adverse events in 15/93(16%). Neoplasias were diagnosed in 5 patients. Among the 178 patients, 16(9%) had died. Most common causes of death were vascular involvement (n=5), infections (n=4) and malignancies (n=4). Conclusions: Vascular involvement is the leading cause of hospitalisation among BS patients, followed by infections related to therapy. Adverse events related to immunosuppressives are problematic. The predominance of men among hospitalized patients underlines the more severe course of BS in this sex. The relatively low frequency of gastrointestinal involvement among hospitalisations is in line with our previous observation that this type of involvement is rare in our BS patients.
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Effects of Combining of Smoking and Marinating on the Shelf Life of Anchovy Stored at 4℃
Yesim Ozogul,Fatih Ozogul,Esmeray Kuley 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.1
The quality of smoked and marinated anchovy was investigated in terms of sensory, chemical [total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), peroxide value (PV), fatty acids, free fatty acids (FFA), and pH] and microbiological parameters (total aerobic count (TVC), coliform, Escherichia coli, Salmonella,Staphylococcus aureus) during 7 months of storage. The results of sensory analyses showed that the total appearance,odor-taste, and texture scores decreased gradually during storage period. The results of the chemical analyses also correlated well with the sensory analyses apart from TVBN value. TBA significantly increased (p<0.05) from 1.9 to 4.25 MA/kg after the storage of 6 month. Peroxide value (POV) showed significant fluctuations (p<0.05) during the storage period. Initial TVC of 3.8 log CFU/g increased to 6.2 log CFU/g at the end of storage period. According to results obtained from sensory, chemical, and microbiological analyses, shelf life of this product was about 6 month.
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Yesim Cekin,Aylin Erman Daloğlu,Dilara Öğünç,Betil Özhak Baysan,Duygu Dağlar,Dilara İnan,Derya Mutlu,Gözde Öngüt,Dilek Çolak 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.5
Background: Active screening for vancomycin-resistant enterococci (VRE) using rectal specimens is recommended to limit the spread of antimicrobial resistance within certain high-risk populations. We evaluated the diagnostic performance of Vancomycin Resistance 3 Multiplexed Tandem PCR assay (AusDiagnostics, Australia), a rapid multiplex realtime PCR assay that detects vanA and/or vanB. Methods: Two-hundred-and-eleven rectal swabs from Hematology and Oncology unit were submitted for VRE surveillance via direct detection of vanA and/or vanB by culture and by using Vancomycin Resistance 3 Multiplexed Tandem PCR assay. Enterococci were identified to the species level by using standard biochemical tests and BD Phoenix Automated Microbiology System (BD Diagnostic Systems, USA). Vancomycin susceptibility of enterococci was determined using Etest (BioMerieux, France). Results: Compared to the culture method, Vancomycin Resistance 3 Multiplexed Tandem PCR assay had a sensitivity of 84.0%, specificity of 98.8%, positive predictive value (PPV)of 91.3%, and negative predictive value (NPV) of 97.6%. The assay failed to detect 18(8.5%) specimens because of the presence of PCR inhibitors; of the remaining 193 specimens,25 (12.9%) were positive, 23 for vanA, and 2 for vanB. Although both sensitivity and specificity for vanA VRE was 100% compared to the culture method, all vanB-positive specimens tested negative by VRE culture. Conclusions: Vancomycin Resistance 3 Multiplexed Tandem PCR assay is a rapid and laborsaving option for VRE surveillance for direct use on rectal swabs. However, the high rate of PCR failure owing to the inhibitors in the specimens and the low specificity for vanB should be considered when interpreting the results.
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A simple chemical method for conversion of Turritella terebra sea snail into nanobioceramics
Yesim Muge Sahin,Zeynep Orman,Sevil Yucel 한양대학교 세라믹연구소 2018 Journal of Ceramic Processing Research Vol.19 No.6
In this study, a sea shell was converted into bioceramic phases at three different sintering temperatures (450 oC, 850 oC,1000 oC). Among the obtained bioceramic phases, a valuable β-TCP was produced via mechanochemical conversion methodfrom sea snail Turritella terebra at 1000 oC sintering temperature. For this reason, only the bioceramic sintered at 1000 oC wasconcentrated on and FT-IR, SEM/EDX, BET, XRD, ICP-OES analyses were carried out for the complete characterization ofβ-TCP phase. Biodegradation test in Tris-buffer solution, bioactivity tests in simulated body fluid (SBF) and cell studies wereconducted. Bioactivity test results were promising and high rate of cell viability was observed in MTT assay after 24 hoursand 7 days incubation. Results demonstrated that the produced β-TCP bioceramic is qualified for further consideration andexperimentation with its features of pore size and ability to support bone tissue growth and cell proliferation. This studysuggests an easy, economic method of nanobioceramic production.
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Hayriye Yesim Can,Mehmet Elmalı,Alper Karagoz 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.2
The objectives of this study were: i) to detect the presence of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in raw milk, cheese, beef minced meat, and chicken meat samples; ii) to evaluate the antimicrobial susceptibility of the isolates; and iii) to determine clonal relation among the isolates by using pulsed-field gel electrophoresis (PFGE) method. Therefore, a total of 160 food samples were randomly collected between August 2014 and May 2015 in Hatay province, located in the southern Turkey. Twenty (12.5%) of the samples were found to be contaminated with S. aureus. A total of 40 isolates from the 20 positive samples were confirmed to be S. aureus by multiplex PCR based on 16S rRNA and nuc gene. The mec A gene was not detected in any of the S. aureus strains. In the present study, 39 out of 40 (97.5%) isolates were found to be resistant to one or more antibiotics. All of isolates were susceptible to gentamicin, oxacillin, and vancomycin. The highest resistance rate was detected in penicillin (95%) and ampicillin (92.5%), followed by tetracycline (30%), erythromycin (20%), ciprofloxacin (12.5%). Nine major patterns were determined by PFGE. In 6 of these patterns, thirty-six strains (90%) had identical PFGE profiles.
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Recent Trends in the Biosorption of Heavy Metals: A Review
Sag, Yesim,Kutsal, Tulin The Korean Society for Biotechnology and Bioengine 2001 Biotechnology and Bioprocess Engineering Vol.6 No.6
Considerable attention has been focused in recent years upon the field of biosorption for the removal of metal ions from aqeous effluents. Compared to other technologies, the advan-tages of biosortption are the high purity of the treated waste water and the cheap raw material. Really, the first major challenge for the biosorption field is to select the most promising types of biomass. Abundant biomass types either generated as a waste by-product of large-scale industrial fermentations particularly fungi or certain metal-binding seaweeds have gained importance in re-cent years due to their natural occurrence, low cost and, of course good performance in metal biosorption. Industrial solutions commonly contain multimetal systems or several organic and in organic substances that form complexes with metals at relatively high stability forming a very complex environment. When several components are present, interference and competition phe-nomena for sorption sites occur and lead to a more complex mathematical formulation of the process. The most optimal configuration for continuous flow-biosorption seems to the packed-bed column which gets gradually from the feed to the solution exit end. Owing to the com-petitive ion exchange taking place in the column, one or more of the metals present even at trace levels may overshot the acceptable limit in the column effluent before the breakthrough point of the trargeted metal. Occurrence of 'overshoot's and impact on havey metal removal has not been analyzed enough. New trends in biosorption are discussed in this review.
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Determination and classification of intraoral phosphor storage plate artifacts and errors
Deniz, Yesim,Kaya, Seher Korean Academy of Oral and Maxillofacial Radiology 2019 Imaging Science in Dentistry Vol.49 No.3
Purpose: The aim of this study was to determine the reasons and solutions for intraoral phosphor storage plate (PSP) image artifacts and errors, and to develop an appropriate classification of the artifacts. Materials and Methods: This study involved the retrospective examination of 5,000 intraoral images that had been obtained using a phosphor plate system. Image artifacts were examined on the radiographs and classified according to possible causative factors. Results: Artifacts were observed in 1,822 of the 5,000 images. After examination of the images, the errors were divided into 6 groups based on their causes, as follows: images with operator errors, superposition of undesirable structures, ambient light errors, plate artifacts (physical deformations and contamination), scanner artifacts, and software artifacts. The groups were then re-examined and divided into 45 subheadings. Conclusion: Identification of image artifacts can help to improve the quality of the radiographic image and control the radiation dose. Knowledge of the basic physics and technology of PSP systems could aid to reduce the need for repeated radiography.
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Adakan, Yesim,Taskoparan, Muharrem,Cekin, Ayhan Hilmi,Duman, Adil,Harmandar, Ferda,Taskin, Vildan,Yilmaz, Ustun,Yesil, Bayram Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Objective: To evaluate the implementation of screening colonoscopy amongst first-degree relatives (FDRs) of patients with colorectal cancer (CRC) in Turkey. Materials and Methods: A total of 400 first-degree relatives (mean(SD)age: 42.5(12.7) years, 55.5% were male) of 136 CRC patients were included in this cross-sectional questionnaire based survey. Data on demographic characteristics, relationship to patient and family history for malignancy other than the index case were evaluated in the FDRs of patients as were the data on knowledge about and characteristics related to the implementation of screening colonoscopy using a standardized questionnaire form. Results: The mean(SD) age at diagnosis of CRC in the index patients was 60.0(14.0) years, while mean(SD) age of first degree relatives was 42.5(12.7) years. Overall 36.3% of relatives were determined to have knowledge about colonoscopy. Physicians (66.9%) were the major source of information. Screening colonoscopy was recommended to 19.5% (n=78) of patient relatives, while 48.7% (n=38) of individuals participated in colonoscopy procedures, mostly (57.9%) one year after the index diagnosis. Screening colonoscopy revealed normal findings in 25 of 38 (65.8%) cases, while precancerous lesions were detected in 26.3% of screened individuals. In 19.0% of FDRs of patients, there was a detected risk for Lynch syndrome related cancer. Conclusions: In conclusion, our findings revealed that less than 20% of FDRs of patients had received a screening colonoscopy recommendation; only 48.7% participated in the procedure with detection of precancerous lesions in 26.3%. Rise of awareness about screening colonoscopy amongst patients with CRC and first degree relatives of patients and motivation of physicians for targeted screening would improve the participation rate in screening colonoscopy by FDRs of patients with CRC in Turkey.
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DEDE SAGSOZ, Yesim,YILMAZ, Alper Erdem,EKMEKYAPAR TORUN, Fatma,KOCADAGISTAN, Beyhan,KUL, Sinan The Korean Electrochemical Society 2022 Journal of electrochemical science and technology Vol.13 No.2
In this study, electrochemical treatment of urban wastewater with electrical conductivity of 1000 μS cm<sup>-1</sup> and chemical oxygen demand of 250 mg L<sup>-1</sup> was investigated using the variables of initial pH value, current density and flow rate. Electrocoagulation was used, in which aluminum and stainless steel were selected, as the electrochemical treatment process. The electrocoagulation process was operated in continuous mode. The data obtained in experimental studies show that the best COD removal efficiency occurred in experiments where the initial pH value was 6. The increase in current density from 5 A to 15 A decreased the removal efficiency from 79 to 67%. The increase in flow rate under constant current density also reduced the efficiency of removal as expected. In experiments in which current density and flow rate were examined together, the increase in flow rate allowed the application of higher current densities. This situation led to considerable reductions in energy consumption values, even if the COD removal efficiency did not significantly increase. The high COD removal obtained with the use of high flow rate and high current density indicates that the electrocoagulation process can be used for high flow rate municipal wastewater treatment.
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