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본 연구에서는 모과내의 여러 가지 기능성 유용성분을 효과적으로 추출하기 위해서, 모과나무의 익은 열매로 만든 약재인 모과를 사용 하였다. 모과의 기능성 유용성분용매 추출 공정의 최적 조건을 확립하고자 하였다. 모과를 에탄올에 추출하여 반응표면 분석법으로 모니터링하여 최적 용매 조건을 설정하였다. 중심합성계획법에 따라 시료에 대한 용매비(X1)와 추출온도(X2), 추출시간(X3)을 요인변수로 하고 추출수율(Y1), 총페놀 함량(Y2), 전자공여능(Y3), 갈색도(Y4), 환원당(Y5)을 종속변수로 하여 시행하였다. 실험 결과 추출수율은 추출 온도와 추출 시간에 유의하게 영향을 받음을 알 수 있었다. 안장점에서 추출조건은 시료에 대한 용매비는 26.38mL/g, 추출온도는 72.82oC, 추출시간은 74.86 min에서 최대값을 나타내었다. 총페놀 함량은 용매비와 시간에 영향을 거의 받지 않았고 추출시간에는 영향을 받았으며, 최대값은 20.70mg/mL 로 나타났다. 이때의 추출조건은 시료에 대한 용매비는 22.61mL/g, 추출온도는 84.49oC, 추출시간은 77.25 min으로 나타났다. 전자공여능은 추출온도에 따라 유의하게 영향을 받은 것으로 나타났다. 안장점에서의 추출조건인 시료에 대한 용매비 10.65mL/g, 추출온도 67.78oC, 추출시간 96.75 min에서 추출수율은 94.12%로 예측되었다. 갈색도에 대한 추출조건은 시료에 대한 용매비 23.77mL/g, 추출온도 87.27oC, 추출시간 96.68 min 일 때 안장점이 나타났다. 환원당은 시료에 대한 용매비 26.83mL/g, 추출온도 82.167oC, 추출시간 81.94 min에서 10.55mg/mL로 최대값을 나타내었고 추출시간에 영향을 받았다. In this study, various active functional components in Chinese Quince were extracted by solvent extraction method. A central composit design for optimization was applied to investigate the effects of independent variables such as solvent to sample ratio (X1), extraction temperature (X2), and extraction time (X3) on the soluble solid contents (Y1), total phenols (Y2), electron donating ability (Y3), browning color (Y4) and reducing sugar contents (Y5). It was found that extraction temperature and extraction time were the main effective factors in this extraction process. The maximum soluble solid contents of 35.77% was obtained at 26.38mL/g (X1), 72.82oC (X2) and 74.86 min (X3) in saddle point. Total phenols were rarely affected by solvent ratio and extraction time, but it was affected by extraction temperature. The maximum total phenols of 20.70% was obtained at 22.61mL/g (X1), 84.49oC (X2), 77.25 min (X3) in saddle point. The electron donating ability was affected by extraction time. The maximum electron donating ability of 94.12% was obtained at 10.65mL/g (X1), 67.78oC (X2), 96.75 min (X3) in saddle point. The maximum browning color of 0.32% was obtained at 23.77mL/g (X1), 87.27oC (X2), 96.68 min (X3) in saddle point. The maximum value of reducing sugar content of 10.55% was obtained at 26.83mL/g (X1), 82.167oC (X2), 81.94 min (X3). Reducing sugar content was affected by extraction time.
( Min Kyung Back ), ( Seok Hyun Kim ), ( Byung Seok Lee ), ( Eaum Seok Lee ), ( Hyuk Soo Eun ), ( Jong Seok Joo ), ( Woo Sun Rou ), ( Jae Ho Park ), ( Myung Hee Kim ), ( Min Seong Kim ), ( Deok Yeong Kim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Acute hepatitis can sometimes lead to serious complications of liver failure leading to death, and in some cases it is one of the important factors causing chronic and socioeconomic loss. This study aimed to analysis of cause, characteristics and prognosis for patients with acute hepatitis with high aminotransferase level at admission. Methods: We retrospectively reviewed the medical records of 227 patients clinically diagnosed with acute hepatitis whose aminotransferase levels were elevated 10 times or more at the time of admission between January 2013 and December 2017. The recovery time of the disease was defined as the decrease in aminotransferase level and total bilirubin level within the normal range. Results: The most common cause of acute hepatitis was toxic hepatitis(40.0%, n=93). The proportion of acute viral hepatitis A, acute viral hepatitis B, acute viral hepatitis C and acute viral hepatitis EBV were 23.3%(n=53), 5.7%(n=13), 1.3%(n=3) and 1.3%(n=3), respectively. In addition, Alcoholic hepatitis, Autoimmune hepatitis, HBV reactivation and acute hepatitis of unknown cause were 2.6%(n=6), 5.7%(n=13), 2.2%,(n=5) and 16.7%(n=38), respectively. The duration of hospitalization for acute hepatitis was within 2weeks, and the duration of recovery was within 2 to 4weeks. 5 patients progressed to fulminant hepatitis and died. Two of them died by HBV reactivation, and the remaining three patients died from acute hepatitis B, toxic hepatitis and acute hepatitis of unknown etiology, respectively. Conclusions: The cause of acute hepatitis affects disease prognosis more than aminotransferase levels at admission. However, since aminotransferase levels may affect the patient's recovery rate or duration of hospitalization, periodic follow-up of aminotransferase levels is necessary. Especially when chronic hepatitis B is reactivated, the rate of progression to fulminant hepatitis is high. Disease control and close monitoring of chronic hepatitis B is therefore necessary.
( Min Kyu Jung ), ( Seong Woo Jeon ), ( Se Young Lee ), ( Young Dae Park ), ( Yun Jin Chung ), ( Seok Jin Yoon ), ( Su Yeong Park ), ( Eun Su Kim ), ( Sung Kook Kim ), ( Yong Hwan Choi ), ( Chang Min Cho ), ( Wo) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Eosinophilic esophagitis (EE) is an increasingly recognized disorder in adults characterized by intense eosinophilic infiltration of the esophageal mucosa and results in clinical signs and symptoms that may be indistinguishable from those of gastroesophageal reflux disease (GERD). This study was performed to define clinical characteristics of EE, which could be distinguishable from GERD. Methods: Pathologic examinations obtained from 22 patients after informed consent, who were previously diagnosed as esophagitis with eosinophilic infiltration, were reviewed blindly. EE was diagnosed with epithelial eosinophils≥15 in 2 high-power fields (HPF) or ≥20 in any HPF. Clinical and endoscopic findings were also obtained. Results: Of 22 patients, EE were 12 patients (male 8, female 4, mean age 60) and non-EE were 10 patients (male 8, female 2, mean age 58). Most common symptom in EE was dysphagia (5 out of 12, p=0.04), while heartburn in non-EE (7 out of 10, p=0.027). Mucosal fragility proved to be the only statistically significant endoscopic finding in EE, while other findings (erosion, ulcer, ring, stricture, white exudates, hiatal bemia) were insignificant between two groups. Conclusions: EE, often misdiagnosed as GEFD, is therefore, exposed to long-term inadequate treatment. Endoscopic esophageal biopsy is required for those who have dysphagia for a long time and mucosal fragility in endoscopic finding.
( Yeong Shil Joo ), ( Myeong A. Cheong ), ( Jae Il Park ), ( Min Ju Kang ), ( Byoung Joon Kim ), ( Kyu Jeung Ahn ), ( Sung Woon Kim ), ( Jin Woo Kim ), ( Yeong Seol Kim ), ( Young Kil Choi ) 대한내과학회 2001 대한내과학회 추계학술대회 Vol.61 No.10
Min,,Yeong-Ki,Chung,,Seok-Hee,Lee,,Jong-Soo,Kim,,Sung-Soo,Shin,,Hyun-Dae,Lim,,Baek-Vin,Shin,,Min-Chul,Jang,,Mi-Hyeon,Kim,,Ee-Hwa,Kim,,Chang-Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Red ginseng has been used as an ergogenic aid for endurance exorcise. In this study, the effect of aqueous extract of Red ginseng on the endurance in treadmill exorcise and 5-hydroxytryptamine (serotonin) synthesis and tryptophan hydroxylase expression in the dorsal raphe of rats were studied. Rats receiving Red ginseng showed increased time to exhaustion for treadmill running. and Red ginseng treatment inhibited exorcise-induced increases in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe. These results suggest that the suppressive effect of Red ginseng on serotonin level during exercise is a possible ergogenic mechanism of Red ginseng.