Life Science : Pinusolide Isolated from Biotu orientalis Inhibits 5-Lipoxygenase Dependent Leukotriene C4 Generation by Blocking c-Jun N-Terminal Kinase Pathway in Mast Cells

( Ye Jin ),( Hyun Ok Yang ),( Jong Keun Son ),( Hyeun Wook Chang ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

Pinusolide, an herbal medicine isolated from Biota orientalis L. (B. orientalis), inhibited 5-lipoxygenase(5-LO)-dependent leukotriene C4 (LTC4) generation in immunoglobulin E (IgE)/Ag-induced bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To clarify the action mechanism of pinusolide on the inhibition of LTC4 generation, we examined the effect of pinusolide on phosphorylation of cytosolic phospholipase A2 (cPLA2), as well as translocation phospho-cPLA2 and 5-LO to nucleus. Inhibition of LTC4 generation by pinusolide was accompanied by a decrease in cPLA2 phosphorylation which occurred via a decrease in intracellular Ca2+ influx and blocking the c-Jun N-terminal kinase (JNK) pathways. However, pinusolide had no effect on extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein (MAP) kinas phosphorylation. Taken together, the present results suggest that potent inhibition of 5-LO dependent LTC4 generation bypinusolide requires both suppression of calcium influx and JNK phosphorylation.

퍼놀로지 기반 디지털 캠페인 참여형 UI 디자인 연구

신예진 ( Sin¸ Ye-jin ),김성훈 ( Kim¸ Sung-hoon ) 커뮤니케이션디자인학회 2021 커뮤니케이션 디자인학연구 Vol.77 No.-

현대 사회는 기술의 발전으로 일상생활에서 접하는 모든 것들이 디지털화되고 이와 연대적으로 현대 사회의 사용자들은 정서적 감정에 민감하게 반응하고 있다. 이러한 시대의 퍼놀로지 기반의 디지털 캠페인은 신속하게 진보하는 기술과 펀(Fun) 아이디어의 융합으로 다양한 디지털 공간에서 감각적인 서비스를 원하는 사용자들의 니즈와 가치를 충족시키는 마케팅으로 적합하며 디지털 공간에서 사용자들의 원활한 상호작용을 위해서는 참여형 UI 디자인이 요구된다. 따라서 본 연구에서는 사용자들이 퍼놀로지 기반 디지털 캠페인에 참여할 때 디지털 공간에서 유희적 감성 유발과 적극적 참여를 위한 퍼놀로지 기반의 디지털 캠페인의 참여형 UI 디자인 발전 방안을 제시하는 것이 목적이다. 먼저 퍼놀로지의 이론적 배경과 개념에 대해 고찰하고 디지털 캠페인의 정의와 유형에 대해 살펴보았다. 또한 선행연구를 통해 참여형 UI디자인의 요소들을 정리하고 공통된 요소를 도출하였다. 이를 통해 연구에 적용할 퍼놀로지 기반 디지털 캠페인을 사용자 체험유형(수용적 체험/참여적 체험/주도적 체험)으로 나누어 참여형 UI디자인 3가지 요소로 디자인 요소(레이아웃/컬러/그래픽/텍스트), 기술 요소(일관성/가시성/단순성), 사용자 요소(흥미성/정보성/관계성)를 분석유형을 도출하였다. 도출된 내용을 통해 사용자 체험유형에 따른 국내외 실시된 퍼놀로지 기반 디지털 캠페인의 3개 사례를 선정하여 분석하였으며 그 결과는 다음과 같다. 첫 번째, 모든 체험유형에서 디자인 요소인 ‘텍스트’를 이용하여 참여 독려와 행동을 유도하였고 캠페인 체험 시 사용방법, 맥락에 있어서 일관되게 나타나는 기술 요소인 ‘일관성’, 캠페인의 의도나 아이덴티티의 구축하는 사용자 요소인 ‘정보성’이 강하게 나타났다. 두 번째, 사용자가 캠페인을 수용적 체험일수록 디자인 요소가 강하게 나타났고 반면에 사용자 요소는 약하게 나타난 것을 확인할 수 있었다. 특히 수용적 체험에서 사용자 요소인 ‘관계성’과 주도적 체험에서 ‘레이아웃’이 가장 낮게 나타났다. 세 번째, 디자인과 기술의 질(quality)과 보상(Feedback)을 나타내는 ‘가시성’이 모든 유형에서 미미하게 나타났다. 따라서 디지털 공간에서 사용자의 능동적이고 자발적인 참여와 다양한 체험을 제공하고 사용자의 유희적 감성을 유발시키고 의미 있는 경험을 창출을 위해선 퍼놀로지 기반 디지털 캠페인의 활용성 향상을 위한 참여형 UI디자인에 대한 지속적인 연구가 진행되어야 한다. With the development of technology in modern society, everything we encounter in our daily life is being digitalized, and users in modern society respond sensitively to how they feel emotionally. The funology-based digital campaign of that era is suitable as a marketing that meets the needs and values of users who want to receive a sensible service in a variety of digital spaces due to the convergence of the rapidly advancing technology and the fun idea, and the participatory UI design is required for smooth interaction of users in those digital spaces. Therefore, this study aimed to suggest a development plan for the funology-based digital campaign’s participatory UI design to induce users’ enjoyable emotions and encourage their active participation in the digital spaces when they participate in the funology-based digital campaign. First of all, it considered the theoretical background and concept of funology and examined the definitions and types of the digital campaign. In addition, it derived common elements by organizing the elements of the participatory UI design. Based on this, it divided the funology-based digital campaign to be applied in the study into some user experience types (receptive experience/ participatory experience/ proactive experience) and derived analysis types such as design elements (layout/ color/ graphic/ text), descriptive elements (consistency/ visibility/ simplicity), and user elements (interest/ informativeness/ relatedness) as three elements of the participatory UI design. Based on the derived contents, it selected and analyzed three cases of the funology-based digital campaign performed both in the country and abroad according to the user experience types, and the results were as follows. First, it encouraged participation and induced actions by using the ‘text’, one of the design elements, among all experience types, and ‘consistency’, one of the descriptive elements, that is consistent in terms of the usage and context at the time of experiencing the campaign, and ‘informativeness’, one of the user elements that builds the intention or identity of the campaign, were strongly observed. Second, the more receptive the users’ experiences with the campaign, the stronger the design elements and the weaker the user elements. In particular, ‘relatedness’, a user element in the receptive experience, and ‘layout’ in the proactive experience were found to be the lowest. Third, it was confirmed that ‘visibility’, which represents the quality and feedback of the design and technology, appeared insignificantly in all the types. Therefore, a study on the participatory UI design to improve the usability of the funology-based digital campaign should continue to be carried out in order to attract active and voluntary participation of users, provide them with various experiences, induce their enjoyable emotions, and create meaningful experiences for them in digital spaces.

A bio-inspired superhydrophobic electrospun Silicon nanofiber coating for Improvement of oil Purification

Yejin Liang(LIANG YEJIN),Heechul Choi(최희철),Minbeom Kim(김민범),Eunmok Yang(양은목),Soyoung Kim(김소영) 대한환경공학회 2021 대한환경공학회 학술발표논문집 Vol.2021 No.11

Effect of Flow Rate on Smoke Control System for Railway Tunnel Fire

Yejin Ha(Yejin Ha),Joonho Jeon(Joonho Jeon) 한국화재소방학회 2023 International Journal of Fire Science and Engineer Vol.37 No.2

Tunnel is a semi-closed structure with a high risk of fire becuse of difficulty of smoke exhaust and restricted evacuation route in fire. No specific guidelines on smoke control systems have been developed for railway tunnels. Therefore, in the railway tunnel design, an average airflow velocity of 2.5 m/s inside a tunnel for the entry and exit of workers has been used as a reference. In this study, a fire simulation conducted to examine whether the average flow velocity can sufficiently apply on smoke control system in railway tunnel design. An 870-m-long railway tunnel with a single track and double track was modeled, and fire scenarios for light rail cars were simulated. It was found that the reference flow velocity showed sufficient smoke control performance, even at a maximum fire source of 60 MW. However, evacuees might be exposed to smoke due to the backlayer formed immediately. Furthermore, the smoke control performance for the reference velocity does not reflect the influence of the tunnel length. It is necessary to conduct a study on standard for appropriate smoke control performance to reduce fire risk in a railway tunnel fire.

Effects of protease supplementation on growth performance, blood constituents, and carcass characteristics of growing-finishing pigs

( Yejin Min ),( Yohan Choi ),( Younghwa Kim ),( Yongdae Jeong ),( Doowan Kim ),( Joeun Kim ),( Hyunjung Jung ),( Minho Song ) 한국축산학회 2019 한국축산학회지 Vol.61 No.4

This experiment was conducted to evaluate the effects of dietary protease on growth performance, blood constituents, and carcass characteristics of growing-finishing pigs. A total of 48 growing pigs (initial body weight, 34.8 ± 0.62 kg) were randomly assigned to 2 dietary treatments (6 pigs/pen; 4 replicates/treatment). The treatments were a diet based on corn and soybean meal (CON) and CON supplemented with 0.01 % of protease (PRO). Pigs were fed respective dietary treatments with a 2-phase feeding program for 12 weeks. Pigs fed PRO had higher average daily gain (ADG; phase I, 866.38 vs. 821.75 g/d; overall, 910.96 vs. 866.30 g/d; p < 0.05) and gain to feed ratio (G:F; phase I, 0.345 vs. 0.363 g/g; p < 0.05) than those fed CON. However, there were no differences on blood constituents and carcass characteristics between CON and PRO of growing-finishing pigs. In conclusion, dietary protease supplementation in the typical diet for growing-finishing pigs improved growth rate.

All Sky Particulate Matter Retrieval using Himawari-8 Aerosol Optical Depth Based on Machine Learning

Yejin Kim,Saman Malik,Eunjin Kang,Dongjin Cho,Jungho Im 한국대기환경학회 2023 한국대기환경학회 학술대회논문집 Vol.2023 No.10

Oils from Tenebrio molitor and Hermetia illucens Prevent Binge Alcohol-induced Gut Leakiness and Hepatic Inflammation

Yejin Sim,Dongha Kim,Su-Jin Pyo,Ho-Yong Sohn,Chuleui Jung,Young-Eun Cho 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

Comparison of organic and non-organic doenjang from physiochemical, antioxidant activities and sensorial perspectives

Yejin Shin,Mina K. Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

The aim of this study was to compare organic and non-organic doenjang from physiochemical, antioxidant activities and sensorial perspectives. Two doenjang samples were included: Traditional doenjang made with non-GMO soybeans and organic doenjang using certified organic soybeans. Two samples were produced from same manufacturers at similar time frame. The physiochemical properties of doenjang were determined, and the antioxidant activity of doenjang was determined including total polyphenol, DPPH and ABTS. Descriptive sensory analysis using highly trained panel (n=6) was also conducted. There were no significant differences in pH, moisture content and °brix. Salinity, viscosity, and color between two samples. As for antioxidant activities, total polyphenol, DPPH, and ABTS values were higher in organic doenjang. Traditional doenjang showed sensory characteristics of fish sauce, chocolate, pear and organic doenjang showed pineapple, dried plum, and balsamic aromatics. This study suggests that the quality of doenjang that has undergone the same fermentation process may vary depending on the raw materials used.

Regression Model to Predict Nitrogen Mineralization Using Soil Parameters for Pepper Upland

Yejin Lee,Seulbi Lee,Jwakyung Sung 한국토양비료학회 2020 한국토양비료학회지 Vol.53 No.4

One of the most important practices for nitrogen (N) management in arable lands is to minimize N loss using soil-customized N supply. Despite that N mineralization of soils is an useful parameter to manage N fertilization, it requires a lot of analysis. To predict N mineralization rate of upland soils, we performed regression analysis between N mineralization parameters (Mineralized N, N0, k) and soil properties. Experimental soils were randomly sampled from 40 pepper cultivation fields before fertilization. The rate of soil N mineralization was analyzed through incubation for 16 weeks at 27℃. N mineralization parameters of soils were estimated from first-order kinetic model, and a stepwise regression was conducted to predict the mineralized N, N0 and k using soil properties. Mineralized N was linearly correlated with EC (R²=0.745) which meant a good indicator to predict N mineralization rate. N0 as potentially mineralizable N was positively correlated with soil organic matter (SOM) and total N, and those represented a linear relationship (y=0.0682x, R²=0.729). SOM, sand, clay and C/N ratio were selected as parameters for prediction of N0 (R²=0.448). In addition, a regression equation for estimation of k was composed of EC, CEC, sand and clay (R²=0.508). In conclusion, we suggest that N mineralization rate by combination with soil properties could be determined with a regression equation. However, model equation represented in this study should be validated and improved through field experiments with different levels of N application and different types of soil property.

The Effects on Nutrients Uptake and Soil Chemical Properties according to Fertigation Ratio of Green Onion (Allium fistulosum L.) in Open Field

Yejin Lee,Jwakyung Sung,Yosung Song,Yangmin Kim,Byunggun Hyun 한국토양비료학회 2022 한국토양비료학회지 Vol.55 No.2

In order to apply the fertilization manual to the open-field fertigation system, it is necessary to verify the crop productivity. This study was carried out to assess an appropriate nutrient supply ratio for fertigation in open-field green onion (Allium fistulosum L.) cultivation. In this study, we compared the crop nutrient uptake and soil chemical properties according to the type of basal fertilizer (inorganic fertilizer, organic fertilizer, compost) and the ratio of fertigation (A: N60%, K40%; B: N70%, K50%; C: N80%, K80%) through field experiment. All treatment plots were treated with the same amount of fertilizer, and it was applied according to soil test results. When the fertigation ratio was increased during the crop cultivation period, there was little change in soil EC, NO₃-N, Ex. K, and there was no statistically significant difference in crop yield regardless of the types of basal fertilizer and fertigation ratio. However, the nitrogen uptake of green onions tended to decrease with the increase of the fertigation ratio. In soils with a low nutrient content, if the basal fertilization amount is reduced, the nutrient deficiency in the early stage of crop growth may reduce crop productivity. Therefore, it is recommended to fertigation ratio of A (N60%, K40%) for green onion cultivation in the open-field.