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Ye Zhang,Yan Zhao,Hongwei Pan,Xianzhong Lang,Huili Yang,Huiliang Zhang,Huixuan Zhang,Lisong Dong 한국고분자학회 2016 폴리머 Vol.40 No.3
Polylactide (PLA) was plasticized with poly(diethylene glycol adipate) (PDEGA). The plasticized PLA was further blended with core-shell structured particles of glycidyl methacrylate-functionalized methyl methacrylate-butyl acrylate copolymer (GACR) using a twin-screw extruder, and the extruded samples were blown using the blown thin film technique. Both PDEGA and GACR significantly influenced the physical properties of the films. Compared to neat PLA, the elongation at break and tear strength of the films were significantly improved. The shear yielding induced by cavitation of GACR particles was the major tearing mechanism. GACR could act as a tear resistance modifier for PLA blown films. The spherulite size of the PLA/PDEGA/GACR films decreased with the addition of GACR. The biodegradability of the PLA/PDEGA/GACR films decreased slightly. These findings contributed new knowledge to the additive area and gave important implications for designing and manufacturing polymer packaging materials.
ZHANG, Ye-Wang,PRABHU, Ponnandy,LEE, Jung-Kul Japan Society for Bioscience, Biotechnology, and A 2009 Bioscience, Biotechnology, and Biochemistry Vol.73 No.10
<P><I>Bacillus licheniformis</I> <SMALL>L</SMALL>-arabinose isomerase (BLAI) with a broad pH range, high substrate specificity, and high catalytic efficiency for <SMALL>L</SMALL>-arabinose was immobilized on various supports. Eupergit C, activated-carboxymethylcellulose, CNBr-activated agarose, chitosan, and alginate were tested as supports, and Eupergit C was selected as the most effective. After determination of the optimum enzyme concentration, the effects of pH and temperature were investigated using a response surface methodology. The immobilized BLAI enzyme retained 86.4% of the activity of the free enzyme. The optimal pH for the immobilized BLAI was 8.0, and immobilization improved the optimal temperature from 50 °C (free enzyme) to a range between 55 and 65 °C. The half life improved from 2 at 50 °C to 212 h at 55 °C following immobilization. The immobilized BLAI was used for semi-continuous production of <SMALL>L</SMALL>-ribulose. After 8 batch cycles, 95.1% of the BLAI activity was retained. This simple immobilization procedure and the high stability of the final immobilized BLAI on Eupergit C provide a promising solution for large-scale production of <SMALL>L</SMALL>-ribulose from an inexpensive <SMALL>L</SMALL>-arabinose precursor.</P>
Giant Volume Change of Active Gels under Continuous Flow
Zhang, Ye,Zhou, Ning,Li, Ning,Sun, Megan,Kim, Dongshin,Fraden, Seth,Epstein, Irving R.,Xu, Bing American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.20
<P>While living systems have developed highly efficient ways to convert chemical energy (e.g., ATP hydrolysis) to mechanical motion (e.g., movement of muscle), it remains a challenge to build muscle-like biomimetic systems to generate mechanical force directly from chemical reactions. Here we show that a continuous flow of reactant solution leads to by far the largest volume change to date in autonomous active gels driven by the Belousov–Zhabotinsky reaction. These results demonstrate that microfluidics offers a useful and facile experimental approach to optimize the conditions (e.g., fabrication methods, counterions, flow rates, concentrations of reagents) for chemomechanical transduction in active materials. This work thus provides much needed insights and methods for the development of chemomechanically active systems based on combining soft materials and microfluidic systems.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-20/ja503665t/production/images/medium/ja-2014-03665t_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja503665t'>ACS Electronic Supporting Info</A></P>
Risk of Treatment-related Mortality with Sorafenib in Patients with Cancer
Zhang, Xin-Ji,Zhang, Tian-Yi,Yu, Fei-Fei,Wei, Xin,Li, Ye-Sheng,Xu, Feng,Wei, Li-Xin,He, Jia Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. Methods: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. Results: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). Conclusions: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.
Ye Zhang,Li Wang,Wei Sun,Yue-hua Hu,Honghu Tang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.81 No.-
Recent years have seen rapid improvement of technology and large-scale applications of lithium-ionbatteries, which leads to an increasing market demand for lithium. Since the land lithium resources arediminishing drastically, the sources of lithium extraction have shifted to the large amount of waterresources containing salt-lake brines and seawater. Among the varieties of aqueous recovery approaches,membrane technology seems to have huge development potential and good application prospect. This isbecause the membrane technologies exhibit excellent Li/Mg separation selectivity, with low energyconsumption and green process owing to no addition of chemicals. The present work reviews the latestadvances in various membrane technologies, including nanofiltration membrane, electrodialysis,membrane capacitive deionization approaches, solid electrolyte electrolysis-based technology, etc. Therecent developments in positively charged nanofiltration membrane are discussed in terms of thepreparation methods, membrane properties, and Li/Mg separation coefficient. In addition, the effects ofseveral factors on electrodialysis for lithium extraction and relevant mechanisms in both simple andactual saline systems are discussed, including applied voltage, VC/VD, and coexisting ions. Theapplications of electrodialysis with novel selective membrane involving nanofiltration membrane as wellas solid electrolyte membrane and perspectives for further investigation are proposed.