Crosstalk between reactive oxygen species and pro-inflammatory markers in developing various chronic diseases: a review

Yazan Ranneh,Faisal Ali,Abdah Md Akim,Hasiah Abd. Hamid,Huzwah Khazaai,Abdulmannan Fadel 한국응용생명화학회 2017 Applied Biological Chemistry (Appl Biol Chem) Vol.60 No.3

The inflammation process in the human body plays a central role in the pathogenesis of many chronic diseases. In addition, reactive oxygen species (ROS) exert potentially a decisive role in human body, particularly in physiological and pathological process. The chronic inflammation state could generate several types of diseases such as cancer, atherosclerosis, diabetes mellitus and arthritis, especially if it is concomitant with high levels of pro-inflammatory markers and ROS. The respiratory burst of inflammatory cells during inflammation increases the production and accumulation of ROS. However, ROS regulate various types of kinases and transcription factors such nuclear factor-kappa B which is related to the activation of pro-inflammatory genes. The exact crosstalk between pro-inflammatory markers and ROS in terms of pathogenesis and development of serious diseases is still ambitious. Many studies have been attempting to determine the mechanistic mutual relationship between ROS and proinflammatory markers. Therefore hereby, we review the hypothetical relationship between ROS and pro-inflammatory markers in which they have been proposed to initiate cancer, atherosclerosis, diabetes mellitus and arthritis.

Investigation of subcooled boiling wall closures at high pressure using a two-phase CFD code

Yazan Alatrash,조윤제,송철화,윤한영 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6

This study validates the applicability of the CUPID code for simulating subcooled wall boiling under highpressure conditions against number of DEBORA tests. In addition, a new numerical technique in whichthe interfacial momentum non-drag forces are calculated at the cell faces rather than the center ispresented. This method reduced the numerical instability often triggered by calculating these terms atthe cell center. Simulation results showed good agreement against the experimental data except for thebubble sizes in the bulk. Thus, a new model to calculate the Sauter mean diameter is proposed. Next, theeffect of the relationship between the bubble departure diameter (Ddep) and the nucleation site density(N) on the performance of the Wall Heat Flux Partitioning (WHFP) model is investigated. Three correlations for Ddep and two for N are grouped into six combinations. Results by the different combinationsshow that despite the significant difference in the calculated Ddep, most combinations reasonably predictvapor distribution and liquid temperature. Analysis of the axial propagations of wall boiling parametersshows that the N term stabilizes the inconsistences in Ddep values by following a behavior reflective ofDdep to keep the total energy balance. Moreover, ratio of the heat flux components vary widely along theflow depending on the combinations. These results suggest that separate validation of Ddep correlationsmay be insufficient since its performance relies on the accompanying N correlations

Further Analysis of the Bottoming Cycle Performance in a Triple-Pressure Reheat Combined Cycle Power Plant

Yazan M. Al-Zoghool,Kyeong-Hun Park(박경훈),Seung-Jae Moon(문승재) 대한설비공학회 2015 대한설비공학회 학술발표대회논문집 Vol.2015 No.6

Optimal dynamic subcarrier allocation for dual-band OFDMA-PON supporting integrated fronthaul and backhaul in 5G networks

Yazan M. Allawi,김근영,Jungbum Cho,Ahmad G. Reza,나용수,이준구 한국통신학회 2018 ICT Express Vol.4 No.3

We propose a novel dynamic subcarrier allocation (DSCA) design for dual-band orthogonal frequency division multiple access passive optical network (DB-OFDMA-PON), supporting integrated fronthaul and backhaul services, given their stringent requirements in emerging 5G networks. An optimization problem is formulated to maximize both the bandwidth utilization and QoS guarantees. The simulation results show that our proposed DSCA achieves the desired statistical multiplexing gain and high performance in terms of throughput and delay.

The Impact of Organizational Climate on Organizational Reputation - The Mediating Role of Organizational Health: An Empirical Study from Jordan

Yazan Emnawer AL HARAISA,Ahed AL-HARAIZAH 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.10

The current study’s objective is to determine the impact of organizational climate on organizational reputation in the context of organizational health as a mediating variable, in a case study of textile enterprises in Jordan that are listed on the Industrial Qualified zones. The study population contains (12) companies, according to the industrial qualified zones, with 317 employees who are working at CEO, deputy CEO, and supervisor positions chosen through convenience sampling. While the final sample of the current study consists of 174. Furthermore, to test the current study’s hypotheses, the Smart Partial Least Square (PLS) technique was applied. Additionally, the current study concludes that there is a positive impact of organizational climate on organizational reputation. The current study shows that organizational climate has a positive impact on organizational health and organizational health has a positive impact on organizational reputation. Moreover, there is the mediation impact of organizational health on the relationship between organizational climate and organizational reputation. Based on the results of the current study, the study proposes that the level of organizational climate, organizational health, and organizational reputation in the examined companies be enhanced and increased.

An investigation into adequacy of separation gap to preclude earthquake-induced pounding

Yazan Jaradat,Pejman Sobhi,Harry Far 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.86 No.1

Pounding happens when contiguous structures with differing heights vibrate out of line caused by a seismic activity. The situation is aggravated due to the insufficient separation gap between the structures which can lead to the crashing of the buildings or total collapse of an edifice. Countries around the world have compiled building standards to address the pounding issue. One of the strategies recommended is the introduction of the separation gap between structures. AS1170.4-2007 is an Australian standard that requires 1% of the building height as a minimum separation gap between buildings to preclude pounding. This article presents experimental and numerical tests to determine the adequacy of this specification to prevent the occurrence of seismic pounding between steel frame structures under near-field and far-field earthquakes. The results indicated that the recommended minimum separation gap based on the Australian Standard is inaccurate if low-rise structure in a coupled case is utilised under both near and far field earthquakes. The standard is adequate if a tall building is involved but only when a far-field earthquake happens. The research likewise presents results derived by using the ABS and SRSS methods.

Optimum stiffness values for impact element models to determine pounding forces between adjacent buildings

Yazan Jaradat,Harry Far 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.77 No.2

Structural failure due to seismic pounding between two adjacent buildings is one of the major concerns in the context of structural damage. Pounding between adjacent structures is a commonly observed phenomenon during major earthquakes. When modelling the structural response, stiffness of impact spring elements is considered to be one of the most important parameters when the impact force during collision of adjacent buildings is calculated. Determining valid and realistic stiffness values is essential in numerical simulations of pounding forces between adjacent buildings in order to achieve reasonable results. Several impact model stiffness values have been presented by various researchers to simulate pounding forces between adjacent structures. These values were mathematically calculated or estimated. In this study, a linear spring impact element model is used to simulate the pounding forces between two adjacent structures. An experimental model reported in literature was adopted to investigate the effect of different impact element stiffness k on the force intensity and number of impacts simulated by Finite Element (FE) analysis. Several numerical analyses have been conducted using SAP2000 and the collected results were used for further mathematical evaluations. The results of this study concluded the major factors that may actualise the stiffness value for impact element models. The number of impacts and the maximum impact force were found to be the core concept for finding the optimal range of stiffness values. For the experimental model investigated, the range of optimal stiffness values has also been presented and discussed.

Validation of subcooled flow boiling model in the CUPID code

Yazan Alatrash(야잔),Yun Je Cho(조윤제),Han Young Yoon(윤한영) 한국유체기계학회 2021 유체기계 연구개발 발표회 논문집 Vol.2021 No.7

Cost-effective topology design for HSR resilient mesh networks

Allawi, Yazan M.,Dujeong Lee,Kyusang Lee,Rhee, June-Koo Kevin IEEE 2015 Journal of optical communications and networking Vol.7 No.1

<P>High-availability seamless redundancy (HSR) protocol provides a zero failover time protection applicable to any Ethernet topology. HSR is also capable of tolerating multiple simultaneous failures, which further promotes the application of packet-based Ethernet protection. Deploying HSR in mesh networks may incur a significant unnecessary cost if not designed carefully. This paper addresses the problem of minimizing the cost of HSR mesh networks given a network availability constraint. We first develop an enumeration-based method to find the optimal design. However, due to the NP-hard complexity of the problem, this is limited to only small networks. Hence, a novel two-step heuristic algorithm is proposed. The algorithm first searches a design of an initial mesh topology compliant with HSR survivability conditions, and then an evolution process takes place to find a modification of the initial topology that satisfies the required availability. The simulation results show that our heuristic algorithm achieves a comparable performance close to optimal while being computationally scalable.</P>

A Wireless Link-Up Augmentation Design for Disaster-Resilient Optical Networks

Allawi, Yazan M.,Dujeong Lee,Rhee, June-Koo Kevin IEEE 2015 Journal of Lightwave Technology Vol.33 No.17

<P>In view of the increasing frequency and damage severity of disasters, network operators have become more concerned with providing disaster-resiliency measures for their optical network infrastructure, whereas mitigating network service interruption due to the disaster region failures in the optical physical medium merely by increasing network redundancy is deemed spatially inefficient and very costly, with recent advancements, wireless technology is a potential candidate solution for efficient medium diversification. This paper addresses the challenge of efficiently designing disaster-resilient wireless-link-augmented optical network infrastructure. We formulate this problem as an optimization model of finding the subset of links in an optical network topology whose wireless augmentation maximizes postdisaster recovery of overall network availability for a given budget constraint. To overcome the computational complexity of finding the optimal design solution, a novel greedy heuristic algorithm is proposed. Performance comparisons with an exhaustive enumeration search and simple heuristics demonstrate the efficiency and scalability of our heuristic algorithm.</P>