A single blind randomised placebo controlled clinical trial of a classical Ayurvedic formulationAshokarista in the treatment of menorrhagia and dysmenorrhoea

Yasmeen Akhtar,,Mahiuddin Alamgir,,Mahmud Tareq Hassan Khan,,JMA. Hannan,M Shahabuddin Kabir Choudhuri 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.4

A well known Ayurvedic formulation Ashokarista, used for menstrual disorders has been studied in a single blind randomised placebo controlled clinical trial for the treatment of menorrhagia and dysmenorrhoea. Dysmenorrhoea and menorrhagia patients who were taking Ashokarista (20 ml twice daily) for 10 menstrual cycles had an increase in haemoglobin level. Menorrhagia treated group has shown to reduce the erythrocyte sedimentation rate level that has been increased in the menorrhagia control group. The platelet count, total count and differential count were observed unchanged in the study. The Ashokarista did not affect the SGPT and SGOT level, which signify its lack of toxicity in hepatic function. The treated menorrhagic patients showed an increase in serum albumin content and decrease in blood clotting time, whereas the serum protein content was observed unchanged. There was a significant increase in both serum cholesterol and triglyceride level, which usually associated with the use of oral contraceptives. No major side effects were observed by the clinicians during the study.

Prediction of residual mechanical behavior of heat-exposed LWAC short column: a NLFE model

Yasmeen T. Obaidat,Rami H. Haddad 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.57 No.2

A NLFE model was proposed to investigate the mechanical behavior of short columns, cast using plain or fibrous lightweight aggregate concrete (LWAC), and subjected to elevated temperatures of up to 700°C. The model was validated, before its predictions were extended to study the effect of other variables, not studied experimentally. The three-dimensional NLFE model was developed using ANSYS software and involved rational simulation of thermal mechanical behavior of plain and fibrous LWAC as well as longitudinal and lateral steel reinforcement. The prediction from the NLFE model of columns' mechanical behavior, as represented by the stress-strain diagram and its characteristics, compared well with the experimental results. The predictions of the proposed models, considering wide range of lateral reinforcement ratios, confirmed the behaviors observed experimentally and stipulated the importance of steel confinement in preserving post-heating mechanical properties of plain and fibrous LWAC columns, being subjected to high temperature.

Integrated Eff ect of Plant Growth-Promoting Compost and NPK Fertilizer on Nutrient Uptake, Phenolic Content, and Antioxidant Properties of Orthosiphon stamineus and Cosmos caudatus

Yasmeen Siddiqui,Umaiyal Munusamy,Yuvarani Naidu,Khairulmazmi Ahmad 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.6

The eff ects of plant growth-promoting (PGP) compost, conventional fertilizer (NPK), and their combination on fresh anddry herb yield, nutrient uptake, total phenolic content (TPC), total fl avonoids (TF), and antioxidant activity (DPPH andFRAP) of Orthosiphon stamineus and Cosmos caudatus were determined. The highest values for each measured variableof O. stamineus and C. caudatus were obtained when both herbs were cultivated in soils supplemented with PGP compostand NPK at halved rates. Considering the eff ect of treatments on herb nutrient composition, a marginal but signifi cant risewas detected in macro- and micronutrient contents (N, P, K, Ca, Mg, Fe, Zn, and Mn) in both herbs grown in soils supplementedwith PGP compost and NPK. TPC ranged from 121–172.6 mg GAE g −1 DW, TF from 95.4–125.4 catechin CE g −1DW, FRAP from 42.2–58.3 mmol Fe 2+ equivalent g −1 DW, and DPPH from 185.1–279.4 μmol Trolox equivalent g −1 DWin O. stamineus . TPC, TF, DPPH, and FRAP activities in C. caudatus were 176.1 mg GAE g −1 FW, 152.49 catechin CE g −1FW, 174.86 μmol Trolox equivalent g −1 FW, and 154.68 mmol Fe 2+ equivalent g −1 FW, respectively. It is suggested thatthe usage of PGP compost in combination with NPK at halved rates can reduce the indiscriminate use of mineral fertilizersin greenhouse soil and that a combination treatment had better eff ects in terms of yields and phytochemical composition inboth of the herbs compared with conventional mineral fertilization and unfortifi ed or fortifi ed compost alone.

Assessment of Respiratory Problems in Workers Associated with Intensive Poultry Facilities in Pakistan

Yasmeen, Roheela,Ali, Zulfiqar,Tyrrel, Sean,Nasir, Zaheer Ahmad Occupational Safety and Health Research Institute 2020 Safety and health at work Vol.11 No.1

Background: The poultry industry in Pakistan has flourished since the 1960s; however, there are scarce data regarding the impact of occupational exposure on the pulmonary health of farm workers in terms of years working in the industry. The objective of the present study was to assess the effect of poultry environment on the health of occupationally exposed poultry farmers in countries of warm climatic regions, such as Pakistan. This study will also show the effect of exposure to poultry facilities on the health of poultry farmers in the context of low-income countries with a relatively inadequate occupational exposure risk management. Materials and methods: The lung function capacity of 79 poultry workers was measured using a spirometer. Along with spirometry, a structured questionnaire was also administrated to obtain information about age, height, weight, smokers/nonsmokers, years of working experience, and pulmonary health of farm workers. The workers who were directly involved in the care and handling of birds in these intensive facilities were considered and divided into four groups based on their years of working experience: Group I (3-10 months), Group II (1-5 years), Group III (6-10 years), and Group IV (more than 11 years). The forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and the FEV1/FVC ratio were considered to identify lung function abnormalities. Statistical analysis was carried out using independent sample t test, Chi-square test, Pearson's correlation, and linear regression. Results: Based on the performed spirometry, 68 (86 %) of workers were found normal and healthy, whereas 11 (14 %) had a mild obstruction. Of the 11 workers with mild obstruction, the highest number with respect to the total was in Group IV (more than 11 years of working experience) followed by Group III and Group II. Most of the workers were found healthy, which seems to be because of the healthy survivor effect. For the independent sample t test, a significant difference was noticed between healthy and nonhealthy farmers, whereas Chi-square test showed a significant association with height, drugs, and working experience. Linear regression that was stratified by respiratory symptoms showed for workers with symptoms, regression models for all spirometric parameters (FVC, FEV1, and FEV1/FVC) have better predictive power or R square value than those of workers without symptoms. Conclusion: These findings suggest that lung function capacity was directly related to years of working experience. With increasing number of working years, symptoms of various respiratory problems enhanced in the poultry workers. It should be noted that most of the poultry workers were healthy and young, the rationale being that there is a high turnover rate in this profession. The mobility in this job and our finding of 86% of the healthy workers in the present study also proposed healthy worker survivor effect.

Furosine induces DNA damage and cell death in selected human cell lines: a strong toxicant to kidney Hek-293 cells

Yasmeen Saeed,J. Q. Wang,N. Zheng 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.4

Ne-(2-furoylmethyl)-L-lysine (furosine) is wellknown indicator of early stage of Maillard reaction in processed food. Yet the toxicological aspects associated with its exposure remain rarely studied. Here, we investigated the effects of furosine exposure on cell viability, DNA damage, and its mutagenic potential by using MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide), TUNEL assay (Terminal deoxynucleotidyl transferase mediated dUTP Nick End Labeling assay), and Ames assay techniques on human cell lines, i.e., liver HepG-2, kidney Hek-293, neuronal SK-N-SH, and intestinal Caco-2, respectively. Our results showed that kidney Hek-293 cell line was the most sensitive to furosine exposure as significant reduction in cell viability and induction of DNA damage were observed at 50 mg/L concentration. In contrast, intestinal Caco-2 cell lines showed resistance to furosine exposure as DNA damage was only observed at 800 mg/L concentration of furosine. Ames assay indicated that furosine has no mutagenic effects on TA 100 and TA 1535 strains. Hence, this study suggests that furosine is a strong toxicant for kidney cells.

Rosa Damascene Mill. (Rose): A versatile herb in cosmetology

Ahmed, Yasmeen,Jamil, S.Shakir,Hashimi, Ayshah,Siraj, Mantasha Binth,Jahangir, Umar Cellmed Orthocellular Medicine and Pharmaceutical 2019 셀메드 (CellMed) Vol.9 No.4

With the improvement of economic status and the desire for beauty, the interest in health and skin care is increasing. For these demands, since ages medicinal plants are in vogue. A variety of plants, cosmetics and foods with novel bioactive ingredients for skin care and beauty are under constant research and development. Skin is influenced by various factors such as Ultra-violet rays, stress, hormones and aging which together lead skin to lose elasticity, changes in pigmentation and wrinkle formation. Many medicinal plants have proven effects in skin care and beauty treatment. From this list of medicinal plants, one which is famous for its beauty, flavor and fragrance is Rosa damascene. Rosa damascene has many therapeutic action and postulated pharmacological studies such as anti-arthritic, anti-microbial, cardio protective, anti-inflammatory, antioxidant, analgesic, immune-modulator, gastro-protective, and skin ameliorative effect. Research in the field of Cosmetology has proven the effect of Rosa damascene in rehydrating skin, reducing scars and stretches, acne management, lowering skin pigmentation, delaying wrinkling and is recommended as a skin vitalizing agent. In this review, the morphology, chemical constituents, and some pharmacological activity are discussed.

Decreasing CO₂ Emissions and Embodied Energy during the Construction Phase Using Sustainable Building Materials

Saadah, Yasmeen,AbuHijleh, Bassam Sustainable Building Research Center 2010 International journal of sustainable building tech Vol.1 No.2

A great quantity of $CO_2$ is emitted to the atmosphere during the different phases of a building's life cycle: in the production of materials and products, in the construction of the building itself, in the setting up of the site, in the exploitation, the renovations, the later rehabilitations, up to the final demolition. The present paper shows the possibility of reducing the embodied energy in building materials up to 55% and the $CO_2$ emissions produced up to 43% in the construction phase, through a careful selection of sustainable building materials. The purpose of this study is to quantify the total amount of $CO_2$ emissions and embodied energy that can be saved by the method presented in the particular phase of the material selection within the life cycle of a building. This material selection, as well as the bioclimatic characteristics, must be defined from the early design project phase. The research presented here has been carried out as a case study on an existing high-rise residential building in the UAE constructed in a conventional way and with no specific selection of materials. The building is compared to a hypothetically created building with similar characteristics but using sustainable building materials.

Key Areas for Agriculture and Rural Development through Development Cooperation : A Supporting Study for Agricultural Development Cooperation Strategy for India

Parmod Yasmeen Kumar,Vijay Malave 한국농촌경제연구원 2019 한국농촌경제연구원 기본연구보고서 Vol.- No.-

Comparative Analysis of Different Bioactivities of Curcuma longa, Nigella sativa Seeds, and Camellia sinensis Extracted by Four Different Methods: A Green Way to Reduce Oxidative Stress

Humaira Yasmeen,Shahida Hassnain 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.3

Medicinal use of plants is as old as human history. Curcuma longa, Nigella sativa seeds, and Camellia sinensis have been widely used in various remedies since ages. In this study, the effect of extraction method on different bioactivities and phytochemical constituents of Curcuma longa, Nigella sativa seeds, and Camellia sinensis were evaluated and compared using single solvent system (50% ethanol). Plant extracts were prepared by percolation-assisted extraction, sonication-assisted extraction, microwave-assisted extraction, and polyphenol extraction. Following phytochemical screening, extracts were screened for antioxidant activity, antihemolytic activity, osmotic tolerance, and osmotic fragility. All plant extracts showed good phytochemical content irrespective of extraction method. However, activities in vitro antioxidant assays were dependent on plant as well as on extraction methods. Promising results were observed for antihemolytic activity against hydrogen peroxidetreated erythrocytes. Overall, Camellia sinensis exhibited the highest bioactivities followed by Curcuma longa and Nigella sativa seeds.

A single blind randomised placebo controlled clinical trial of a classical Ayurvedic formulation Ashokarista in the treatment of menorrhagia and dysmenorrhoea

Akhtar, Yasmeen,Alamgir, Mahiuddin,Khan, Mahmud Tareq Hassan,Hannan, JMA.,Choudhuri, M Shahabuddin Kabir Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.4

A well known Ayurvedic formulation Ashokarista, used for menstrual disorders has been studied in a single blind randomised placebo controlled clinical trial for the treatment of menorrhagia and dysmenorrhoea. Dysmenorrhoea and menorrhagia patients who were taking Ashokarista (20 ml twice daily) for 10 menstrual cycles had an increase in haemoglobin level. Menorrhagia treated group has shown to reduce the erythrocyte sedimentation rate level that has been increased in the menorrhagia control group. The platelet count, total count and differential count were observed unchanged in the study. The Ashokarista did not affect the SGPT and SGOT level, which signify its lack of toxicity in hepatic function. The treated menorrhagic patients showed an increase in serum albumin content and decrease in blood clotting time, whereas the serum protein content was observed unchanged. There was a significant increase in both serum cholesterol and triglyceride level, which usually associated with the use of oral contraceptives. No major side effects were observed by the clinicians during the study.