F. D. I. 대표 Dr. Yap 연설문

J. H. Yap 대한치과의사협회 1970 대한치과의사협회지 Vol.8 No.10

Incidental Finding of a Left-over Guide-Wire on a Positron Emission Tomography

Yap, Kok Hooi,Lee, Phong Teck,Buch, Mamta,Rammohan, Kandadai Seshadri The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.4

The Influence of Explicit Morphological Instruction on Reading Comprehension among Malaysian Primary ESL Learners

Yap Soon Li,Tan Kok Eng,Rohaya Abdullah 아시아영어교육학회 2020 The Journal of Asia TEFL Vol.17 No.3

This study aims to examine the significant difference in reading comprehension performance after explicit instruction in morphology. This quasi-experimental study investigated specifically the effect of explicit teaching on compounding, inflectional and derivational morphological awareness upon Malaysian primary school learners’ reading comprehension in the ESL context. Convenience sampling was applied in recruiting 125 pupils from two government primary schools in a suburb area. The experimental group was given the explicit instruction in morphology during their reading lessons for 12 consecutive weeks, and the control group had been taught without this intervention. After controlling for learners’ pre-test scores, ANCOVA statistical result concluded that the experimental group could achieve higher scores in their post-tests, which indicated a significant difference in reading comprehension performance. Therefore, it is essential for curriculum developers to give recognition of the importance of morphology. Educational practitioners and academics should explore further the teaching of morphology in order to improve their learners’ reading comprehension skill.

Brain metastases in Asian HER2-positive breast cancer patients: anti-HER2 treatments and their impact on survival

Yap, Y S,Cornelio, G H,Devi, B C R,Khorprasert, C,Kim, S B,Kim, T Y,Lee, S C,Park, Y H,Sohn, J H,Sutandyo, N,Wong, D W Y,Kobayashi, M,Landis, S H,Yeoh, E M,Moon, H,Ro, J Nature Publishing Group 2012 The British journal of cancer Vol.107 No.7

<P><B>Background:</B></P><P>In Asia, large-scale studies on anti-HER2 treatment in HER2-positive breast cancer patients with brain metastases are limited. We studied the treatment patterns of these patients in Asia to evaluate the impact of anti-HER2 treatment on the time to occurrence of brain metastases (TTBM) and survival after brain metastasis (BM).</P><P><B>Methods:</B></P><P>A retrospective study of HER2-positive breast cancer patients diagnosed with BM between January 2006 and December 2008 in six Asian countries was conducted. Demographics, tumour characteristics, treatment details, and events dates were collected from medical records.</P><P><B>Results:</B></P><P>Data from 280 patients were analysed. Before BM, 63% received anti-HER2 treatment. These patients had significantly longer TTBM than those without anti-HER2 treatment (median 33 <I>vs</I> 19 months; <I>P</I><0.002). After BM, 93% received radiotherapy, 57% received chemotherapy, and 41% received anti-HER2 treatment (trastuzumab and/or lapatinib). Use of both anti-HER2 agents, primarily sequentially, after BM demonstrated the longest survival after BM and was associated with a significant survival benefit over no anti-HER2 treatment (median 26 <I>vs</I> 6 months; hazard ratio 0.37; 95% CI 0.19–0.72).</P><P><B>Conclusion:</B></P><P>Anti-HER2 treatment before BM was associated with longer TTBM. Anti-HER2 treatment after BM was associated with a survival benefit, especially when both trastuzumab and lapatinib were utilised.</P>

Uncertainty estimation in diffusion MRI using the nonlocal bootstrap.

Yap, Pew-Thian,An, Hongyu,Chen, Yasheng,Shen, Dinggang Institute of Electrical and Electronics Engineers 2014 IEEE transactions on medical imaging Vol.33 No.8

<P>In this paper, we propose a new bootstrap scheme, called the nonlocal bootstrap (NLB) for uncertainty estimation. In contrast to the residual bootstrap, which relies on a data model, or the repetition bootstrap, which requires repeated signal measurements, NLB is not restricted by the data structure imposed by a data model and obviates the need for time-consuming multiple acquisitions. NLB hinges on the observation that local imaging information recurs in an image. This self-similarity implies that imaging information coming from spatially distant (nonlocal) regions can be exploited for more effective estimation of statistics of interest. Evaluations using in silico data indicate that NLB produces distribution estimates that are in closer agreement with those generated using Monte Carlo simulations, compared with the conventional residual bootstrap. Evaluations using in vivo data demonstrate that NLB produces results that are in agreement with our knowledge on white matter architecture.</P>

Exploring Chemotherapy-Induced Toxicities through Multivariate Projection of Risk Factors: Prediction of Nausea and Vomiting

Yap, Kevin Yi-Lwern,Low, Xiu Hui,Chan, Alexandre Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.2

Many risk factors exist for chemotherapy-induced nausea and vomiting (CINV). This study utilized a multivariate projection technique to identify which risk factors were predictive of CINV in clinical practice. A single-centre, prospective, observational study was conducted from January 2007~July 2010 in Singapore. Patients were on highly (HECs) and moderately emetogenic chemotherapies with/without radiotherapy. Patient demographics and CINV risk factors were documented. Daily recording of CINV events was done using a standardized diary. Principal component (PC) analysis was performed to identify which risk factors could differentiate patients with and without CINV. A total of 710 patients were recruited. Majority were females (67%) and Chinese (84%). Five risk factors were potential CINV predictors: histories of alcohol drinking, chemotherapy-induced nausea, chemotherapy-induced vomiting, fatigue and gender. Period (ex-/current drinkers) and frequency of drinking (social/chronic drinkers) differentiated the CINV endpoints in patients on HECs and anthracycline-based, and XELOX regimens, respectively. Fatigue interference and severity were predictive of CINV in anthracycline-based populations, while the former was predictive in HEC and XELOX populations. PC analysis is a potential technique in analyzing clinical population data, and can provide clinicians with an insight as to what predictors to look out for in the clinical assessment of CINV. We hope that our results will increase the awareness among clinician-scientists regarding the usefulness of this technique in the analysis of clinical data, so that appropriate preventive measures can be taken to improve patients' quality of life.

A Simplified Synchronous Reference Frame for Indirect Current Controlled Three-level Inverter-based Shunt Active Power Filters

Yap Hoon,Mohd Amran Mohd Radzi,Mohd Khair Hassan,Nashiren Farzilah Mailah,Noor Izzri Abdul Wahab 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5

This paper presents a new simplified harmonics extraction algorithm based on the synchronous reference frame (SRF) for an indirect current controlled (ICC) three-level neutral point diode clamped (NPC) inverter-based shunt active power filter (SAPF). The shunt APF is widely accepted as one of the most effective current harmonics mitigation tools due to its superior adaptability in dynamic state conditions. In its controller, the SRF algorithm which is derived based on the direct-quadrature (DQ) theory has played a significant role as a harmonics extraction algorithm due to its simple implementation features. However, it suffers from significant delays due to its dependency on a numerical filter and unnecessary computation workloads. Moreover, the algorithm is mostly implemented for the direct current controlled (DCC) based SAPF which operates based on a non-sinusoidal reference current. This degrades the mitigation performances since the DCC based operation does not possess exact information on the actual source current which suffers from switching ripples problems. Therefore, three major improvements are introduced which include the development of a mathematical based fundamental component identifier to replace the numerical filter, the removal of redundant features, and the generation of a sinusoidal reference current. The proposed algorithm is developed and evaluated in MATLAB / Simulink. A laboratory prototype utilizing a TMS320F28335 digital signal processor (DSP) is also implemented to validate effectiveness of the proposed algorithm. Both simulation and experimental results are presented. They show significant improvements in terms of total harmonic distortion (THD) and dynamic response when compared to a conventional SRF algorithm.

A Comparative Study between Islamic and Conventional Exchange-Traded Funds: Evidence from Global Market Indices

YAP, Kok-Leong,LAU, Wee-Yeap,ISMAIL, Izlin Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.2

This study investigates whether the Islamic Exchange-Traded Funds (ETFs) provide significant benefit to investors relative to conventional ETFs. Six pairs of Islamic and conventional ETFs with 10-year daily price data from 2010 to 2019 have been selected from major market indices like MSCI World Index, MSCI Emerging Markets, MyETF Dow Jones Islamic Market Malaysia, MSCI South East Asia and Wahed FTSE Shariah USA Index for this study. For ETFs that are launched after 2010, the price data from launch date to 2019 are used. Our results show: First, Islamic ETFs are more likely to trade at a premium rather than at a discount, implying the investors are willing to pay a premium. Second, it is also found that Islamic ETFs have a relatively shorter period of price deviation from the benchmark, implying more price stability. Third, conventional ETFs have higher return and lower tracking errors relative to Islamic ETFs. These new findings add to the stylized facts of Islamic ETFs in the extant literature for investors, plan sponsors and regulators as to the differences between the ETFs. As policy suggestion, asset management companies can design new investment products to bridge the gap between conventional and Islamic finance.

Clinical Prognostic Factors and Survival Outcome in Renal Cell Carcinoma Patients - A Malaysian Single Centre Perspective

Yap, Ning Yi,Ng, Keng Lim,Ong, Teng Aik,Pailoor, Jayalakshmi,Gobe, Glenda Carolyn,Ooi, Chong Chien,Razack, Azed Hassan,Dublin, Norman,Morais, Christudas,Rajandram, Retnagowri Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background: This study concerns clinical characteristics and survival of renal cell carcinoma (RCC) patients in University Malaya Medical Centre (UMMC), as well as the prognostic significance of presenting symptoms. Materials and Methods: The clinical characteristics, presenting symptoms and survival of RCC patients (n=151) treated at UMMC from 2003-2012 were analysed. Symptoms evaluated were macrohaematuria, flank pain, palpable abdominal mass, fever, lethargy, loss of weight, anaemia, elevated ALP, hypoalbuminemia and thrombocytosis. Univariate and multivariate Cox regression analyses were performed to determine the prognostic significance of these presenting symptoms. Kaplan Meier and log rank tests were employed for survival analysis. Results: The 2002 TNM staging was a prognostic factor (p<0.001) but Fuhrman grading was not significantly correlated with survival (p=0.088). At presentation, 76.8% of the patients were symptomatic. Generally, symptomatic tumours had a worse survival prognosis compared to asymptomatic cases (p=0.009; HR 4.74). All symptoms significantly affect disease specific survival except frank haematuria and loin pain on univariate Cox regression analysis. On multivariate analysis adjusted for stage, only clinically palpable abdominal mass remained statistically significant (p=0.027). The mean tumour size of palpable abdominal masses, $9.5{\pm}4.3cm$, was larger than non palpable masses, $5.3{\pm}2.7cm$ (p<0.001). Conclusions: This is the first report which includes survival information of RCC patients from Malaysia. Here the TNM stage and a palpable abdominal mass were independent predictors for survival. Further investigations using a multicentre cohort to analyse mortality and survival rates may aid in improving management of these patients.

Development of Dietary Guidelines in Singapore

Yap, Mabel Deurenberg,Ling, Annie,Deurenberg, Paul 대한영양사협회 2001 대한영양사협회 학술지 Vol.7 No.2

호주에서의 식생활 지침은 현재 국가영양정책에서 절대 필요한 부분이다. 호주가 직면하고 있는 건강과 영양 문제가 특이하지 않을지라도, 비교적 적은 인구, 다양한 문화적인 유산, 지리적인 환경을 우리들에게 공중보건영양에의 도전을 제공한다. 호주는 유럽계 12.8%, 아시아계 5.5%로 인구의 23.6%가 해외에서 태어난 다문화적인 사회이다. 다른 비슷한 나라인 캐나다와 뉴질랜드는 17%, 미국은 8%가 해외에서 태어났다. 한국계 호주인은 소수민족이다. 호주와 한국에서 살고 있는 한국여성에 관한 연구에서, 두 그룹 모두 건강에 관해 높은 가치를 두고 있으며 좋은 영양이 좋은 건강의 주요한 구성 요소가 되는 것으로 확인되었다. 호주인의 식생활 지침은 '영양권장량', '주요식품군'. 다른 영양 정책 문서에 의해 보충되는 호주의 영양 정책의 얼굴이다. 현재 호주는 성인, 어린이, 청년, 노인을 위한 식생활 지침이 있다. 게다가, '유아 식생활 지침'은 이 나이 그룹을 위한 더 상세한 정보를 제공한다. 호주인의 식품안내는 식생활 지침에 기초한 국가의 영양 교육 도구이다. 호주사회의 다문화적 성질 때문에, 모든 호주인에게 적용할 수 있는 식생활 지침이 실행되고 발전되기 위해서는 많은 주의가 필요하다. 국가의 영양조사에서 질문은 식생활 지침 실현의 지표로서 영양 습관에 관해 질문 되었다. 확실한 답변의 비율은 다음과 같다. 저지방 우유 마시기(호주출생 : 해외출생 = 41 : 43), 고기의 지방 제거(호주츨생 : 해외출생 = 74 : 76), 음식에 소금 추가하지 않기(호주출생 : 해외출생 = 58 : 62), 매일 2회 이상 과일 먹기(호주출생 : 해외출생 = 50 : 56), 매일 4회 이상 채소 먹기(호주출생 : 해외출생 = 54 : 57)이다. 각 경우에서, 해외출생 호주인이 호주출생 호주인보다 더 좋게 실행했다. 모든 민족에서, 호주인의 총체적인 식품과 영양 습관은 20세기의 지난 20년동안에 많이 개선되었다.