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Xiujin Li,Xiaohong Liu,Yaosheng Chen 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.12
Objective : The Bayesian first-order antedependence models, which specified single nucleotide polymorphisms (SNP) effects as being spatially correlated in the conventional BayesA/B, had more accurate genomic prediction than their corresponding classical counterparts. Given advantages of BayesCπ over BayesA/B, we have developed hyper-BayesCπ, ante-BayesCπ, and ante-hyper-BayesCπ to evaluate influences of the antedependence model and hyperparameters for vg and on BayesCπ. Methods : Three public data (two simulated data and one mouse data) were used to validate our proposed methods. Genomic prediction performance of proposed methods was compared to traditional BayesCπ, ante-BayesA and ante-BayesB. Results : Through both simulation and real data analyses, we found that hyper-BayesCπ, ante-BayesCπ and ante-hyper-BayesCπ were comparable with BayesCπ, ante-BayesB, and ante-BayesA regarding the prediction accuracy and bias, except the situation in which ante-BayesB performed significantly worse when using a few SNPs and π = 0.95. Conclusion : Hyper-BayesCπ is recommended because it avoids pre-estimated total genetic variance of a trait compared with BayesCπ and shortens computing time compared with ante-BayesB. Although the antedependence model in BayesCπ did not show the advantages in our study, larger real data with high density chip may be used to validate it again in the future.
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Bending performance of NSTS members based on steel tube connection
Xueliang Zhang,Lianguang Wang,Bailing Chen,Yaosheng Zhang 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.41 No.1
This paper proposes a NSTS (new steel tube slab) structure by connecting the longitudinal steel tubes with small steel tubes in transverse, in order to decrease the construction difficulty and improve the bearing capacity of existing NTR (new tubular roof) or STS (steel tube slab) structures. Experimental study on the bending performance and influences of following parameters are carried out: the connection type of the steel tube, the diameter and eccentricity of the small steel tube, and the thickness of the bottom steel plate. The results show that the NSTS members present progressive ductile flexural failure under concentrated load. The connection type has important effect on the mechanical behavior, and the bolts fixed T-shaped plate (B+T) connection method, which provides much higher bending stiffness, is proved to be the most reliable connection type. The increase of small steel tube diameter enhances the bending performance as expected, which also confirms the effectiveness of the B+T connection, while the tube eccentricity presents little impact on the bearing capacity. The bottom steel plate significantly improves the bearing capacity and stiffness and reduces the mid-span deflection. Furthermore, the bending capacity calculation method is proposed and the calculated values show good agreement with the test results. Also, the effect rules of the diameter-thickness ratio of the small tube, the length-diameter ratio of the member and the thickness variety of the bottom steel plate on the bending capacity of NSTS members are further investigated based on the proposed theoretical method.
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Experimental Study on Pull-Out Behavior of Wedge-Grouted Rockbolt in Wind Turbine Tower Foundation
Haiyang Gao,Lianguang Wang,Xue Li,Yaosheng Zhang 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.6
To investigate the the pull-out behaviors of wedge-grouted rockbolts and grouted rockbolts in strongly weathered and moderately weathered rocks, the rockbolts with lengths of 8.0 m, 10.5 m and 13.0 m were tested under freeze–thaw cycle and cyclic load. The test result shows that the minimum anchoring length of wedge-grouted rockbolt is less than 3.0 m and of grouted rockbolt is less than 4.0 m in the strongly weathered or moderately weathered rock. The effect of the wedge head on restricting the deformation of the rockbolt is not obvious when the anchoring length is less than 6.0 m. Freeze–thaw cycle had little effect on the stiffness and deformation of the two kinds of rockbolts. The wedge-grouted rockbolts have better deformation performance than the grouted rockbolts. The bonding force between the rockbolt and the grout or the grout and the surrounding rock is greater than the tensile strength of the rockbolt. Furthermore, the calculation models of shear stress and axial strain can provide reasonable predictions for two kinds of rockbolts, and the development trends of strain and shear stress under different pullout loads were calculated.
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Xu Weimin,Tang Wenbo,Ding Wenjun,Hua Zhebin,Wang Yaosheng,Ge Xiaolong,Cui Long,Wu Xiaojian,Zhou Wei,Ding Zhao,Du Peng 거트앤리버 소화기연관학회협의회 2024 Gut and Liver Vol.18 No.1
Background/Aims: Total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is widely accepted as a radical surgery for refractory ulcerative colitis (UC). Definite results on the appropriate pouch length for an evaluation of the risk-to-benefit ratio regarding technical complications and long-term quality of life (QOL) are still scarce. Methods: Data on UC patients who underwent IPAA from 2008 to 2022 in four well-established pouch centers affiliated to China UC Pouch Center Union were collected. Results: A total of 208 patients with a median follow-up time of 6.0 years (interquartile range, 2.3 to 9.0 years) were enrolled. The median lengths of the patients’ short and long pouches were 14.0 cm (interquartile range, 14.0 to 15.0 cm) and 22.0 cm (interquartile range, 20.0 to 24.0 cm), respectively. Patients with a short J pouch configuration were less likely to achieve significantly improved long-term QOL (p=0.015) and were prone to develop late postoperative complications (p=0.042), such as increased defecation frequency (p=0.003) and pouchitis (p=0.035). A short ileal pouch was an independent risk factor for the development of late postoperative complications (odds ratio, 3.100; 95% confidence interval, 1.519 to 6.329; p=0.002) and impaired long-term QOL improvement (odds ratio, 2.221; 95% confidence interval, 1.218 to 4.050, p=0.009). Conclusions: The length of the J pouch was associated with the improvement in long-term QOL and the development of late post-IPAA complications. A long J pouch configuration could be a considerable surgical option for pouch construction.
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( Zu Yong He ),( Yuankai Huang ),( Yufeng Qin ),( Zhiguo Liu ),( Delin Mo ),( Peiqing Cong ),( Yaosheng Chen ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.4
The secretory efficiency of recombinant xylanase xynB from yeast Pichia pastoris between the α-factor preprosequence and a classical mammalian signal peptide derived from bovine β-casein was compared. The results showed that although the bovine β-casein signal peptide could direct highlevel secretion of recombinant xylanase, it was relatively less efficient than the α-factor preprosequence. In contrast, the bovine β-casein signal peptide caused remarkably more recombinant xylanase trapped intracellularly. Realtime RT-PCR analysis indicated that the difference in the secretory level between the two signal sequences was not due to the difference in the transcriptional efficiency.
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