Synthesis and Biological Evaluation of 2-Aminoisonicotinic Acid Analogues as HIF-1α Inhibitors

Yan Xia,원미선,Jung Eun Kang,이기호,Song-Kyu Park,Hwan-Mook Kim 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.12

Synthesis and Biological Evaluation of Decursin, Prantschimgin and Their Derivatives

Yan Xia,민경훈,Kyeong Lee 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.1

The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.

Quantum Dialogue by Using the GHZ State

Yan XIA,Shou ZHANG,Chang-Bao FU,엄정인,연규황,홍석경 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.I

We present a quantum dialogue protocol by using the Greenberger-Horne-Zeilinger (GHZ) state. In this paper, we point out that the ‘quantum dialogue’ communication scheme recently introduced by Nguyen can be eavesdropped on under an intercept-and-resend attack. We also give a revised control mode to detect this attack. Hence, within the present version two users can exchange their secret messages securely and simultaneously, and the efficiency of information transmission can be successfully increased. We present a quantum dialogue protocol by using the Greenberger-Horne-Zeilinger (GHZ) state. In this paper, we point out that the ‘quantum dialogue’ communication scheme recently introduced by Nguyen can be eavesdropped on under an intercept-and-resend attack. We also give a revised control mode to detect this attack. Hence, within the present version two users can exchange their secret messages securely and simultaneously, and the efficiency of information transmission can be successfully increased.

Innovative Teaching Via Sustainable Vocational Education with an Improved Ant Colony Algorithm

Yan Xia 대한전자공학회 2023 IEIE Transactions on Smart Processing & Computing Vol.12 No.5

Although students’ test scores provide an important reference for teaching and learning, research scholars still need to objectively analyze the scores. Under the current situation where English performance of vocational education students does not achieve satisfactory results, this research uses a clustering algorithm to improve on the ant colony optimization algorithm. This ant colony clustering analysis algorithm is improved by incorporating two optimization strategies, and the test scores of vocational education students are introduced as the original data for cluster analysis. The optimal number of ant colonies is nine, when the three error values of the two ant colony algorithms are minimized. The convergence values of the three ant colony algorithms are smallest when there are 200 training cycles or when the training batch size is 1000, resulting in upgraded ant colony clustering algorithm convergence values of 0.498 and 1.523, respectively. The performance of the student evaluation model combined with the ant colony clustering optimization algorithm improved, followed by CF, FOA, and BP. KNN had the worst performance. Data mining on student performance can be done via research that can provide specialized advice on students' issues.

Probabilistic teleportation of an arbitrary three-particle state via a partial entangled four-particle state and a three-particle GHZ state

Yan Xia,Shou Zhang,Chang-bao Fu,엄정인,연규황 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.2

We propose a scheme to teleport an arbitrary and unknown three-particle state by using a nonmaximally four-particle entangled state and a non-maximally three-particle GHZ state from a sender to either one of two receivers. We show that teleportation can be successfully realized with a certain probability by performing three Bell-states measurements on the sender’s side and by introducing a Hadamard operation on the receiver’s side conditioned on an appropriate unitary transformation on the other possible receiver’s side We propose a scheme to teleport an arbitrary and unknown three-particle state by using a nonmaximally four-particle entangled state and a non-maximally three-particle GHZ state from a sender to either one of two receivers. We show that teleportation can be successfully realized with a certain probability by performing three Bell-states measurements on the sender's side and by introducing a Hadamard operation on the receiver's side conditioned on an appropriate unitary transformation on the other possible receiver's side.

Review : Targeting Multidrug Resistance with Small Molecules for Cancer Therapy

( Yan Xia ),( Kyeong Lee ) 한국응용약물학회 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.18 No.4

Conventional cancer chemotherapy is seriously limited by tumor cells exhibiting multidrug resistance (MDR), which is caused by changes in the levels or activity of membrane transporters that mediate energy-dependent drug efflux and of proteins that affect drug metabolism and/or drug action. Cancer scientists and oncologists have worked together for some time to understand anticancer drug resistance and develop pharmacological strategies to overcome such resistance. Much focus has been on the reversal of the MDR phenotype by inhibition of ATP-binding cassette (ABC) drug transporters. ABC transporters are a family of transporter proteins that mediate drug resistance and low drug bioavailability by pumping various drugs out of cells at the expense of ATP hydrolysis. Many inhibitors of MDR transporters have been identified, and though some are currently undergoing clinical trials, none are in clinical use. Herein, we briefly review the status of MDR in human cancer, explore the pathways of MDR in chemotherapy, and outline recent advances in the design and development of MDR modulators.

Controlled Secure Direct Communication by Using GHZ Entangled State

Yan XIA,Shou ZHANG,Chang-Bao FU,엄정인,Feng-Yue LI,연규황 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.47 No.3

We present a controlled secure direct communication protocol by using Greenberger-Horne-Zeilinger (GHZ) entangled state via swapping quantum entanglement and local unitary operations. Since messages transferred only by using local operations and a public channel after entangled states are successfully distributed, this protocol can protect the communication against a destroying-travel-qubit-type attack. This scheme can also be generalized to a multi-party controlsystem.

Deep sequencing identifies conserved and novel microRNAs from antlers cartilage of Chinese red deer (Cervus elaphus)

Yanxia Chen,Xuedong Liu,Xiaoguang Yang,Yuhui Liu,Xiaomeng Pi,Qingzhen Liu,Dong Zheng 한국유전학회 2015 Genes & Genomics Vol.37 No.5

Deer antlers are the only mammalian appendages subject to an annual cycle of epimorphic regeneration. Within the rapid-growth stage, they display the fastest cartilage development in the animal kingdom. To identify microRNA (miRNA) profiling in red deer (Cervus elaphus) antler cartilage, we applied deep sequencing technology to a small RNA library constructed from pooled cartilage (three antlers from three individuals). We generated 9,520,645 mappable reads with a size distribution of between 15 and 30 nucleotides (miRNAs of 18 nucleotides were the most abundant group: 31 %). Bioinformatics data mining revealed 399 miRNAs in antler cartilage, of which 345 were highly conserved and expressed in 25 other mammals, including the cattle (Bos taurus) and in humans (Homo sapiens). The remaining 54 miRNAs we identified were novel and likely to be antler-cartilage specific, but were expressed at low levels. The identification of these known and newly identified miRNAs in antler cartilage significantly enhances our understanding of the miRNA profiling of regenerating antler cartilage. Further studies are necessary to better understand miRNAs-regulated antlerogenesis.

Proposal for a Wavelength-Independent Optical Sensor Based on an Asymmetric Mach-Zehnder Interferometer

Yanxia Luo,Rui Yin,Wei Ji,Qingjie Huang,Zisu Gong,Jingyao Li 한국광학회 2020 Current Optics and Photonics Vol.4 No.6

A wavelength-independent optical sensor based on an asymmetric Mach-Zehnder interferometer (AMZI) is proposed. The optical sensor based on an AMZI is very sensitive to wavelength, and wavelength drift will lead to measurement error. The optical sensor is compensated to reduce its dependence on wavelength. The insensitivity of the optical sensor to wavelength mainly depends on the compensation structure, which is composed of an AMZI cascaded with another AMZI and can compensate the wavelength drift. The influence of wavelength drift on the optical sensor can be counteracted by carefully designing the size parameters of the compensation structure. When the wavelength changes from 1549.9 nm to 1550.1 nm, the error after compensation can be lower than 0.066%. Furthermore, the effect of fabrication tolerance on compensation results is analyzed. The proposed compensation method can also be used to compensate the drift of other parameters such as temperature, and can be applied to the compensation of other interference-based optical devices.

Survival of Cancer Patients in Northeast China: Analysis of Sampled Cancers from Population-Based Cancer Registries

Yanxia Li,Liya Yu,Jun Na,Shuang Li,Li Liu,Huijuan Mu,Xuanjuan Bi,Xiaoxia An,Xun Li,Wen Dong,Guowei Pan 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4

Purpose The cancer survival was characterized by following up sampled subgroups of cancer cases from three population-based cancer registries in Northeast China. Materials and Methods Survival analysis was used to analyze 6,871 patients, who had one of the 21 most common cancers based on sampling from the population-based cancer registries of three cities in Liaoning Province. All patients were diagnosed between 2000 and 2002 and were followed up to the end of 2007 by active and passive methods. The 5-year age standardized relative survival rates (ASRS) were estimated for all cancers combined and each of the 21 individual cancers. Results The survival status was traced for 80.8% of 8,506 sampled cancer cases. The 5-year ASRS for all 21 cancers combined was 41.5% (95% confidence interval, 40.3 to 42.7), the highest ASRS was observed for thyroid cancer (85.2%), breast cancer (78.9%), uterine corpus cancer (75.9%), and urinary bladder cancer (70.2%); the lowest 5-year ASRS was noted in pancreatic cancer (8.8%), liver cancer (11.0%), esophageal cancer (18.8), and lung cancer (19.6%). The cancer survival rates in Liaoning cities were similar to those of urban areas in mainland China, but significantly lower than those in Hong Kong, Korea, and Japan. Conclusion The strikingly poor cancer survival rates in three cities of Liaoning Province and in other places in China highlight the need for urgent investment in cancer prevention, early detection, and standardized and centralized treatment.