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Comparison of Microbial Diversity and Composition in the Jejunum and Colon of Alcohol-Dependent Rats
( Yang Fan ),( Zhao Ya-e ),( Wei Ji-dong ),( Lu Yu-fan ),( Zhang Ying ),( Sun Ya-lun ),( Ma Meng-yu ),( Zhang Rui-ling ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.11
Alcohol dependence is a global public health problem, yet the mechanisms of alcohol dependence are incompletely understood. The traditional view has been that ethanol alters various neurotransmitters and their receptors in the brain and causes the addiction. However, an increasing amount of experimental evidence suggests that gut microbiota also influence brain functions via gut-to-brain interactions, and may therefore induce the development of alcohol use disorders. In this study, a rat model of alcohol dependence and withdrawal was employed, the gut microbiota composition was analyzed by high-throughput 16S rRNA gene sequencing, and the metagenome function was predicted by PICRUSt software. The results suggested that chronic alcohol consumption did not significantly alter the diversity and richness of gut microbiota in the jejunum and colon, but rather markedly changed the microbiota composition structure in the colon. The phyla Bacteroidetes and eight genera including Bacteroidales S24-7, Ruminococcaceae, Parabacteroides, Butyricimonas, et al were drastically increased, however the genus Lactobacillus and gauvreauii in the colon were significantly decreased in the alcohol dependence group compared with the withdrawal and control groups. The microbial functional prediction analysis revealed that the proportions of amino acid metabolism, polyketide sugar unit biosynthesis and peroxisome were significantly increased in the AD group. This study demonstrated that chronic alcohol consumption has a dramatic effect on the microbiota composition structure in the colon but few effects on the jejunum. Inducement of colonic microbiota dysbiosis due to alcohol abuse seems to be a factor of alcohol dependence, which suggests that modulating colonic microbiota composition might be a potentially new target for treating alcohol addiction.
Yang, Fan,Li, Ya,Sheng, Xun,Liu, Yu The Korean Society of Pharmacology 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.2
Neonatal hypoxia/ischemia (H/I), injures white matter, results in neuronal loss, disturbs myelin formation, and neural network development. Neuroinflammation and oxidative stress have been reported in neonatal hypoxic brain injuries. We investigated whether Paeoniflorin treatment reduced H/I-induced inflammation and oxidative stress and improved white matter integrity in a neonatal rodent model. Seven-day old Sprague-Dawley pups were exposed to H/I. Paeoniflorin (6.25, 12.5, or 25 mg/kg body weight) was administered every day via oral gavage from postpartum day 3 (P3) to P14, and an hour before induction of H/I. Pups were sacrificed 24 h (P8) and 72 h (P10) following H/I. Paeoniflorin reduced the apoptosis of neurons and attenuated cerebral infarct volume. Elevated expression of cleaved caspase-3 and Bad were regulated. Paeoniflorin decreased oxidative stress by lowering levels of malondialdehyde and reactive oxygen species generation and while, and it enhanced glutathione content. Microglial activation and the TLR4/NF-κB signaling were significantly down-regulated. The degree of inflammatory mediators (interleukin 1β and tumor necrosis factor-α) were reduced. Paeoniflorin markedly prevented white matter injury via improving expression of myelin binding protein and increasing O1-positive olidgodendrocyte and O4-positive oligodendrocyte counts. The present investigation demonstrates the potent protective efficiency of paeoniflorin supplementation against H/I-induced brain injury by effectually preventing neuronal loss, microglial activation, and white matter injury via reducing oxidative stress and inflammatory pathways.
Deformation Analysis and Prediction of Pneumatic Probe Based on Fluid-structure Interaction
Yang Fan,Qiu Dexin,Zhao Xinwei,Sai Qingyi,Cai Xiaoshu 한국유체기계학회 2023 International journal of fluid machinery and syste Vol.16 No.1
As an essential tool for measuring flow field, pneumatic probes have gained a wide range of applications. In order to obtain the flow field parameters accurately, it is also crucial to study the deformation of the pneumatic probe structure in flow field. In this paper, the deformation of the conical probe is numerically simulated under the condition of steady incoming flow in the transonic flow field. The fluid-structure interaction and modal analysis methods are used to obtain the deformation and vibration frequency of the probe. The results show that the vibration of the probe is underdamped under the action of two-way fluid-structure interaction, and the total deformation decays exponentially, and the total deformation after stabilization is the same as the result of one-way fluid-structure interaction. For the same material probe, the total deformation changes with time in the same dimensionless expression, and the vibration frequency as well as damping factor do not change due to the variation of flow field. The accuracy of the dimensionless expressions was verified by different incoming flow conditions and the probe material. For the cases studied in this paper, the maximum total deformation, vibration frequency and damping factor of the probe in the flow field can be obtained by using one-way fluid-structure interaction, modal analysis and two-way fluid-structure interaction with a small number of cycles, respectively, so that the total deformation of the probe in the flow field can be predicted over time. The method obtained in this paper can significantly reduce the calculation time for obtaining the probe deformation data in the flow field and improve the work efficiency, which can provide a reference for the design, calibration and application of probes in engineering applications
Yang Fan,Liu Kai,Zhu Liwei,Hu Jiayuan,Wang Xiaoyu,Shen Xiaoming,Luo Hanwu,Ammad Jadoon 한국자기학회 2017 Journal of Magnetics Vol.22 No.1
In order to detect the current flowing through concealed conductor, this paper proposes a new method based on derivative method. Firstly, this paper analyzes the main peak characteristic of the derivative function of magnetic field generated by a current-carrying conductor, and a relationship between the current flowing through the conductor and the main peak of the derivative function is obtained and applied to calculate the current. Then, the method is applied to detect the conductor current flowing through grounding grids of substations. Finally, the numerical experimental and field experiment verified the feasibility and accuracy of the method, and the computing results show that the method can effectively measure the conductor current of grounding grids with low error, and the error is within 5 %.
Enforcement of South Korean Arbitral Awards in Mainland China
YANG, Fan 한국중재학회 2015 중재연구 Vol.25 No.3
This article reviews some recent decisions of the Supreme People’s Court (SPC) of the People’s Republic of China (PRC) on the recognition and enforcement of several South Korean arbitral awards. It explains the implementation of the New York Convention in the PRC and in particular the so-called Report System under the current Mainland Chinese law and judicial practice. It identifies some deficiencies in the People’s Courts’ approaches to the application and interpretation of the New York Convention and argues that the Mainland Chinese courts should adopt the pro-enforcement principle in the determination of the relevant issues under the New York Convention. It proposes further enhancement of the Report System and that the current categorization of ‘domestic, foreign-related and foreign’ in the context of arbitration agreements and arbitral awards needs to be further reviewed and clarified by the SPC. Last but not the least, it recommends some steps that South Korean parties should take to enhance the enforceability of South Korean Arbitral Awards in Mainland China.
Signaling Pathways Controlling Microglia Chemotaxis
Yang Fan,Lirui Xie,Chang Y. Chung 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.3
Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain’s innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal injury induce transformation and activation of resting microglia with ramified morphology into a motile amoeboid form and activated microglia chemotax toward lesion site. This review outlines the current research on microglial activation and chemotaxis.
Yang Fan,Wu Qian,Yan Yan,Zhang Zhang,Li Dong 아시아심장혈관영상의학회 2022 Cardiovascular Imaging Asia Vol.6 No.4
Primary pericardial liposarcomas are extremely rare. We presented a case of a 69-year-old man who presented with exertional dyspnea for more than one week. A pericardial mass was detected by echocardiography and then further investigated by computed tomography and cardiac magnetic resonance imaging. The tumor was resected completely, and the histopathological result was confirmed to be a well-differentiated liposarcoma.