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LSTM Android Malicious Behavior Analysis Based on Feature Weighting
( Qing Yang ),( Xiaoliang Wang ),( Jing Zheng ),( Wenqi Ge ),( Ming Bai ),( Frank Jiang ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.6
With the rapid development of mobile Internet, smart phones have been widely popularized, among which Android platform dominates. Due to it is open source, malware on the Android platform is rampant. In order to improve the efficiency of malware detection, this paper proposes deep learning Android malicious detection system based on behavior features. First of all, the detection system adopts the static analysis method to extract different types of behavior features from Android applications, and extract sensitive behavior features through Term frequency-inverse Document Frequency algorithm for each extracted behavior feature to construct detection features through unified abstract expression. Secondly, Long Short-Term Memory neural network model is established to select and learn from the extracted attributes and the learned attributes are used to detect Android malicious applications, Analysis and further optimization of the application behavior parameters, so as to build a deep learning Android malicious detection method based on feature analysis. We use different types of features to evaluate our method and compare it with various machine learning-based methods. Study shows that it outperforms most existing machine learning based approaches and detects 95.31% of the malware.
First records of two species of the genus Brachionycha H?ner (Lepidoptera: Noctuidae) in China
Qing-Yin YANG,Cheng-De LI,Hui-Lin HAN 한국곤충학회 2007 Entomological Research Vol.37 No.4
Two species of the genus Brachionycha Hbner -B. nubeculosa (Esper) and B. albicilia Sugi - are recorded for the first time from China. The adults and genital characteristics of the species are briefly redescribed with illustrations, and their distributions are given.
Qing-Zhu Yang,Che Wang,Lei Lang,Yang Zhou,He Wang,De-Jing Shang 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.11
Recent advances in the search for novel anticanceragents have indicated that the positively chargedantimicrobial peptides have emerged as promising agentsoffering several advantages over the conventional anticancerdrugs. As a naturally occurring, cationic, a-helicalantimicrobial peptide, temproin-1CEa has been proved toexhibit a potent anticancer effect and a moderate hemolyticactivity. In order to reduce the hemolytic activity of temporin-1CEa and improve its anticancer potency towards arange of human breast cancer cells, in the present study, sixanalogs of temporin-1CEa were rationally designed andsynthesized. The amphipathicity levels and a-helicalstructural patterns of peptides were reserved, while theircationic property and hydrophobicity were changed. Theresults of MTT and hemolysis assay indicated that theanalog peptides displayed an improved anticancer activityand showed an overall optimized therapeutic index. Thehydrophobicity of peptides was positively correlated withtheir hemolytic and antitumor activities. Moreover, the datasuggest a strategy of increasing the cationicity whilemaintaining the moderate hydrophobicity of naturallyoccurring amphipathic a-helical peptides to generate analogswith improved cytotoxicity against tumor cells butdecreased activity against non-neoplastic cells such ashuman erythrocytes. This work highlights the potential forrational design and synthesis of improved antimicrobialpeptides that have the capability to be used therapeuticallyfor treatment of cancers.
Yang, Hyo Hee,Oh, Kyung-Eon,Jo, Yang Hee,Ahn, Jong Hoon,Liu, Qing,Turk, Ayman,Jang, Jae Young,Hwang, Bang Yeon,Lee, Ki Yong,Lee, Mi Kyeong Pergamon 2018 Bioorganic & medicinal chemistry Vol.26 No.2
<P><B>Abstract</B></P> <P>In the screening of natural products for the development as cosmetic ingredients, the EtOAc-soluble fraction of <I>Humulus japonicus</I> showed tyrosinase inhibitory activity. HPLC-MS/MS coupled online tyrosinase assay of EtOAc-soluble fraction of <I>H. japonicus</I> characterized the twenty-eight constituents including two unknown ones and their tyrosinase inhibitory activity. Fractionation of <I>H. japonicus</I> using various chromatographic techniques yielded thirty-eight compounds. The chemical structures of isolated compounds were identified by spectroscopic analysis. As characterized by HPLC-MS/MS analysis, we isolated twenty-four predicted compounds and further identified two unknown ones, named humulusides A (<B>1</B>) and B (<B>2</B>). Additional ten compounds were also identified by purification. Tyrosinase inhibitory activity of isolated compounds were evaluated, which was closely correlated with the results from HPLC-MS/MS coupled online tyrosinase assay. Consistent with predicted data, two major compounds, <I>trans</I>-<I>N</I>-coumaroyltyramine (<B>14</B>) and <I>cis</I>-<I>N</I>-coumaroyltyramine (<B>15</B>) showed tyrosinase inhibition with IC<SUB>50</SUB> values of 40.6 and 36.4 μM. Taken together, <I>H. japonicus</I> is suggested as whitening ingredient in cosmetic products. In addition, HPLC-MS/MS coupled tyrosinase assay is powerful tool for predicting active compounds with short time and limited amounts, although identification of new compounds and verification of predicted data are also needs to be demonstrated by further experiment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The aerial parts of <I>Humulus japonicus</I> showed tyrosinase inhibitory activity. </LI> <LI> HPLC-MS/MS coupled online tyrosinase assay of <I>H. japonicus</I> was performed<I>.</I> </LI> <LI> Twenty-eight constituents and their tyrosinase inhibitory activity were predicted. </LI> <LI> Fractionation of <I>H. japonicus</I> yielded thirty-eight compounds including two new compounds. </LI> <LI> Constituents and tyrosinase inhibition were well matched with HPLC-MS/MS coupled assay. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Yang, Guo-Qing,Wan, Fang-Hao,Guo, Jian-Ying,Liu, Wan-Xue The Korean Society of Weed Science and The Turfgra 2011 Weed Biology and Management Vol.11 No.3
Two sesquiterpene-derivative compounds, 4,7-dimethyl-1-(propan-2-ylidene)-1,4,4a,8atetrahydronaphthalene-2,6(1H, 7H)-dione (DTD) and 6-hydroxy-5-isopropyl-3,8-dimethyl-4a,5,6,7,8,8a-hexahydronaphthalen-2(1H)-one (HHO), are the major putative allelochemicals of the aqueous leachates of Ageratina adenophora.A laboratory experiment was conducted, using the hydroponic method, to evaluate the cellular and ultrastructural changes in the seedling roots of upland rice under the stress of DTD and HHO. The subsequent changes were observed in the treated upland rice roots in comparison with their controls. The scanning electron microscopy results showed that the DTD-treated root tip cells turned into an irregular arrangement and shape and that most of them were wizened, with a poor cytoplasm. In the HHO treatment, the root tips had many irregularly shaped cells, with a greater number of sloughing cells, as well as short, wide cells that resulted in spherical and wider, but shorter, roots. At the ultrastructural level, DTD and HHO induced irregularly shaped and lobed nuclei, increased cytoplasmic vacuolation, reduced ribosome density and dictyosomes, and a reduced number of mitochondria in the cells, which indicated limited protein transportation and a reduced capability to export substances for cell development and growth in the upland rice seedling roots. The overall effect of HHO on the upland rice seedlings was more pronounced than that of DTD.
Estimation of extreme wind pressure coefficient in a zone by multivariate extreme value theory
Qing-shan Yang,Danyu Li,Yi Hui,Siu-Seong Law 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.31 No.3
Knowledge on the design value of extreme wind pressure coefficients (EWPC) of a specific zone of buildings is essential for the wind-resistant capacity of claddings. This paper presents a method to estimate the representative EWPC introducing the multivariate extreme value model. The spatial correlations of the extreme wind pressures at different locations can be consider through the multivariate extreme value. The moving average method is also adopted in this method, so that the measured point pressure can be converted to wind pressure of an area. The proposed method is applied to wind tunnel test results of a large flat roof building. Comparison with existing methods shows that it can give a good estimation for all target zones with different sizes.
Qing Zhong Li,Qing Xian Huang,Shu Cui Li,Mei Zi Yang,Bin Rao 대한생리학회-대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.15 No.5
A simple, sensitive and reproducible high-performance liquid chromatography (HPLC) method has been validated for determining concentrations of glutamate, glycine, and alanine in human plasma. Proteins in plasma were precipitated with perchloric acid, followed by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC). Simultaneous analysis of glutamate, glycine, and alanine is achieved using reversed-phase HPLC conditions and ultraviolet detection. Excellent linearity was observed for these three amino acids over their concentration ranges with correlation coefficients (r)>0.999. The intra- and inter-day precision were below 10%. This method utilizes quality control samples and demonstrates excellent plasma recovery and accuracy. The developed method has been successfully applied to measure plasma glutamate, glycine, and alanine in twenty volunteers.
Qing-Mei Quan,Qing-Xia Wang,Xue-Li Zhou,Shan Li,Xiao-Ling Yang,Yun-Guo Zhu,Zhou Cheng 한국미생물학회 2014 The journal of microbiology Vol.52 No.2
Ophiocordyceps sinensis (Ascomycota: Ophiocordycipitaceae)is a native fungal parasite of Hepialidae caterpillars and oneof the most economically important medicinal caterpillarfungi in China. However, little is known about the phylogeneticand evolutionary relationships between O. sinensis andits host insects. In this study, nuclear ITS and β-tubulin sequencesfrom O. sinensis and mitochondrial COI, COII, andCytb sequences from its hosts were analyzed across 33 populationssampled from five regions in China. Phylogenetically,both O. sinensis and its hosts were divided into three geographicallycorrelated clades, and their phylogenies were congruent. Analysis of molecular variance and calculated coefficientsof genetic differentiation revealed significant geneticdivergence among the clades within both O. sinensis (FST=0.878, NST=0.842) and its hosts (FST=0.861, NST=0.816). Estimatedgene flow was very low for O. sinensis (Nm=0.04) andthe host insects (Nm=0.04) among these three clades. Manteltests demonstrated a significant correlation (P<0.01) betweenthe genetic distances for O. sinensis and its hosts, as well as asignificant association (P<0.05) between geographic and geneticdistances in both. The similar phylogenetic relationships,geographic distributions, and genetic structure and differentiationbetween O. sinensis and its hosts imply that they have coevolved.