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Jih-Yang Chang,Han-Ping Yang,Chau-Shin Jang,Hsin-Tien Yeh,Tsu-Min Liu 제어로봇시스템학회 2016 제어로봇시스템학회 국제학술대회 논문집 Vol.2016 No.10
Traditional elastic actuator is the flexible structure which needed to connected to the output shaft of the brake. Besides, according to the principle of the state of the connection, it could be divided into series elastic actuators (SEA), as well as parallel elastic actuator (PEA) [3]. Therefore, the brake output has a certain flexibility, providing compliance or shock absorption, and other functions. However, since the spring constant is a fixed value, it only could be decided in the design. Namely, it is hard to adjust by following the different user’s requirement. Thus, we propose a flexible structure design which driven by electromagnetic force, by varying the magnitude of the electromagnetic force that can actively adjust the stiffness change and improve the flexibility of the traditional spring immutable problem. Then, one of the most important thing is that we do not need the extra mechanism which in order to adjust the stiffness, and even increasing the structural complexity. In other words, in the meanwhile, achieving actuator without real spring (no loss), reducing the size and simplify the structure, high response adjusting in stiffness modulation. Therefore, for the exoskeleton robot for compliance and simplify the size of demand, this research has significant innovative and progressive.
Zhao-Yang Fu,Feili Lo Yang,Hsin-Wen Hsu,Yi-Fa Lu 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.6
Drinking deep seawater (DSW) with high levels of magnesium (Mg) decreased serum lipids in animal studies. Therefore the effects of drinking DSW on blood lipids and its antioxidant capacity in hypercholesterolemic subjects were investigated. DSW was first prepared by a process of filtration and reverse osmosis, and then the concentrated DSW with high levels of Mg was diluted as drinking DSW. Forty-two hypercholesterolemic volunteers were randomly divided into three groups: reverse osmotic (RO) water, DSW (Mg: 395 mg/L, hardness 1410 ppm), and magnesium-chloride fortified (MCF)water (Mg: 386 mg/L, hardness 1430 ppm). The subjects drank 1050mL of water daily for 6 weeks, and blood samples were collected and analyzed on weeks 0, 3, and 6. Drinking DSW caused a decrease in blood total cholesterol levels and this effect was progressively enhanced with time. Serum low-density lipoprotein–cholesterol (LDL-C) was also decreased by DSW. Further, total cholesterol levels of subjects in the DSW group were significantly lower than those in the MCF water or RO water groups. Compared with week 0, the DSW group had higher blood Mg level on weeks 3 and 6, but the Mg levels were within the normal range in all three groups. DSW consumption also lowered thiobarbituric acid-reactive substances (TBARS)values in serum. In conclusion, DSW was apparently effective in reducing blood total cholesterol and LDL-C, and also in decreasing lipid peroxidation in hypercholesterolemic subjects.
James Chin-Hsin Yang,안명주,Kazuhiko Nakagawa,Tomohide Tamura,Helen Barraclough,Sotaro Enatsu,Rebecca Cheng,Mauro Orlando 대한암학회 2015 Cancer Research and Treatment Vol.47 No.3
Purpose A recent phase III study (PARAMOUNT) demonstrated that pemetrexed continuation maintenance therapy is a new treatment paradigm for advanced nonsquamous non-small cell lung cancer (NSCLC). The majority of patients enrolled in PARAMOUNT were Caucasian (94%). We reviewed efficacy and safety data from two clinical trials, which enrolled East Asian (EA) patients, to supplement data from PARAMOUNT on pemetrexed continuation maintenance therapy in patients with nonsquamous NSCLC. Materials and Methods Study S110 was a phase II, multicenter, randomized, controlled, open-label trial in never-smoker, chemonaïve, EA patients (n=31) with locally advanced or metastatic nonsquamous NSCLC (n=27). Study JMII was a multicenter, open-label, single-arm, postmarketing, clinical trial in Japanese patients (n=109) with advanced nonsquamous NSCLC. PARAMOUNT was a multicenter, randomized, double-blind, placebo-controlled trial in patients with advanced nonsquamous NSCLC. Results In EA patients with nonsquamous NSCLC, the median progression-free survival (PFS) for pemetrexed continuation maintenance therapy was 4.04 months (95% confidence interval [CI], 3.22 to 5.29 months) in study S110 and 3.9 months (95% CI, 3.2 to 5.2 months) in study JMII. The median PFS for pemetrexed continuation maintenance therapy in PARAMOUNT was 4.1 months (95% CI, 3.2 to 4.6 months). Pemetrexed continuation maintenance therapy in EA patients in studies S110 and JMII did not lead to any unexpected safety events, and was consistent with PARAMOUNT’s safety profile. Conclusion The efficacy and safety data in the EA trials were similar to those in PARAMOUNT despite differences in patient populations and study designs. These data represent consistent evidence for pemetrexed continuation maintenance therapy in EA patients with advanced nonsquamous NSCLC.
Modeling and Optimization in Precise Boring Processes for Aluminum Alloy 6061T6 Components
Rong-Tai Yang,Yung-Kuang Yang,Hsin-Te Liao,Show-Shyan Lin 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.
This investigation applies a Taguchi orthogonal table, integrating response surface methodology (RSM) to optimize parameters of a precise boring process using a computer numerical control (CNC) machine operation for the production of aluminum alloy 6061T6 components. By applying RSM analysis, the predictive mathematical model of the roughness average and roundness were developed in terms of the cutting speed, feed rate, and depth of cut. The error analysis and experimental results indicate that the proposed predictive mathematical models could adequately describe the performance indicators within the limits of the factors that are being investigated. In addition, the analysis of variance (ANOVA) was implemented to identify the significant factors and the response surface contours were constructed for determining the optimum conditions of precise boring processes using CNC machine operations.
Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis
Yang, Yoon Mee,Noureddin, Mazen,Liu, Cheng,Ohashi, Koichiro,Kim, So Yeon,Ramnath, Divya,Powell, Elizabeth E.,Sweet, Matthew J.,Roh, Yoon Seok,Hsin, I-Fang,Deng, Nan,Liu, Zhenqiu,Liang, Jiurong,Mena, E American Association for the Advancement of Scienc 2019 Science Translational Medicine Vol.11 No.496
<P>Hyaluronan (HA), a major extracellular matrix glycosaminoglycan, is a biomarker for cirrhosis. However, little is known about the regulatory and downstream mechanisms of HA overproduction in liver fibrosis. Hepatic HA and HA synthase 2 (HAS2) expression was elevated in both human and murine liver fibrosis. HA production and liver fibrosis were reduced in mice lacking HAS2 in hepatic stellate cells (HSCs), whereas mice overexpressing HAS2 had exacerbated liver fibrosis. HAS2 was transcriptionally up-regulated by transforming growth factor–β through Wilms tumor 1 to promote fibrogenic, proliferative, and invasive properties of HSCs via CD44, Toll-like receptor 4 (TLR4), and newly identified downstream effector Notch1. Inhibition of HA synthesis by 4-methylumbelliferone reduced HSC activation and liver fibrosis in mice. Our study provides evidence that HAS2 actively synthesizes HA in HSCs and that it promotes HSC activation and liver fibrosis through Notch1. Targeted HA inhibition may have potential to be an effective therapy for liver fibrosis.</P>