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Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.
Energy-aware resource allocation for OFDMA wireless networks with hybrid energy supplies
Qin, Meng,Yang, Qinghai,Yang, Jian,Park, Daeyoung,Kwak, Kyung Sup IET 2017 IET COMMUNICATIONS Vol.11 No.11
<P>In this study, the authors investigate the resource allocation for orthogonal frequency-division multiple access (OFDMA) wireless networks, where the base station is powered by renewable energy and electric grid. To fully exploit the renewable energy, the authors propose an energy-aware resource allocation (EARA) algorithm to maximise the network utility, which captures the tradeoff between the system throughput and the grid energy consumption. Specifically, the EARA algorithm only has to track the current system states (e.g. channel and queueing conditions) without requiring a relevant priori distribution knowledge, making it applicable for practical OFDMA wireless networks with unpredictable channel dynamics, renewable energy arrivals and stochastic traffics. Moreover, the performance achieved by the EARA algorithm is theoretically characterised. Most importantly, the authors develop an implementation architecture to take the EARA algorithm into practice, and also analyse the low implementation costs (e.g. low computational complexity, trivial signalling overhead etc.). Finally, simulation results verify the theoretical analysis and also demonstrate the advantages of the EARA algorithm.</P>
Throughput of QoS Guaranteed Wireless Systems With/Without Channel State Information
Qin, Meng,Yang, Qinghai,Yang, Jian,Kwak, Kyung Sup,Rao, Ramesh R. IEEE 2017 IEEE Transactions on Vehicular Technology VT Vol.66 No.7
<P>In this paper, we investigate the throughput of wireless systems in the presence of random data arrivals and quality-of-service (QoS) requirements, which are statistically characterized by the queueing-bound violation probability. By combining the concepts of effective capacity and effective bandwidth, we propose a unified analytical framework to investigate the achievable throughput. Employing the proposed unified framework, we further acquire the explicit expressions of the throughput of QoS guaranteed wireless systems with the channel state information (CSI) known/unknown at the transmitter. Specifically, the acquired throughput is characterized by the first-and second-order statistics of the random data arrivals, and it is shown that the QoS requirements affect the throughput by the second-order statistics of the random data arrivals and the random data transmissions. In addition, our theoretical analysis demonstrates that the throughput under QoS constraints is tighter than the conventional stable throughput, and that the first-order statistic of the random data arrivals is sufficient to characterize the throughput when the system can tolerate an arbitrarily long queueing delay. In particular, we prove that the queueing-bound violation probability decays exponentially with the queueing bound. Finally, simulation results corroborate the theoretical analysis.</P>
Comparison and Evaluation on the Chemical Constituents of Progeny in T-DNA Inserted Rice
Qin, Yang,Kim, Suk-Man,An, Gyn-Heung,Sohn, Jae-Keun The Korean Society of Crop Science 2008 한국작물학회지 Vol.53 No.2
With the development of diverse agricultures worldwide, biofortified rice noted for its preferable marketability and palatability plays an important role in the world's agricultural economics and rice breeding programs. In this report, several $M_5$ of T-DNA inserted lines derived from the donor cultivars, 'Hwayong' and 'Dongjin', were selected for high or low protein, high lipid and low amylose content, respectively. The coefficients and ranges of variation for the chemical constituents between $M_4$ and $M_5$ T-DNA inserted lines were evaluated in comparison with those of the donor varieties. Results indicated that T-DNA insertion might be an effective way to generate useful variations for chemical composition of rice grains which could be used for the development of biofortified rice cultivars.
Comparison and Evaluation on the Chemical Constituents of Progeny in T-DNA Inserted Rice
Yang Qin,Suk-Man Kim,Gynheung An,Jae-Keun Sohn 韓國作物學會 2008 한국작물학회지 Vol.53 No.2
With the development of diverse agricultures worldwide, biofortified rice noted for its preferable marketability and palatability plays an important role in the world's agricultural economics and rice breeding programs. In this report, several M5 of T-DNA inserted lines derived from the donor cultivars, 'Hwayong' and 'Dongjin', were selected for high or low protein, high lipid and low amylose content, respectively. The coefficients and ranges of variation for the chemical constituents between M4 and M5 T-DNA inserted lines were evaluated in comparison with those of the donor varieties. Results indicated that T-DNA insertion might be an effective way to generate useful variations for chemical composition of rice grains which could be used for the development of biofortified rice cultivars.
T-DNA Inheritance Stability of Resveratrol Rice Iksan526 over Multi-generations
Qin, Yang,Ahn, Hong-Il,Park, Su-Yoen,Lim, Myung-Ho,Woo, Hee-Jong,Shin, Kong-Sik,Lee, Jin-Hyoung,Cho, Hyun-Suk,Baek, So-Hyeon,Park, Soon-Ki,Kweon, Soon-Jong Korean Society of Breeding Science 2014 Plant Breeding and Biotechnology Vol.2 No.3
Genomic Variations of Rice Regenerants from Tissue Culture Revealed by Whole Genome Re-Sequencing
( Yang Qin ),( Kong-sik Shin ),( Hee-jong Woo ),( Myung-ho Lim ) 한국육종학회 2018 Plant Breeding and Biotechnology Vol.6 No.4
Plant tissue culture is a technique that has invariably been used for various purposes such as obtaining transgenic plants for crop improvement or functional analysis of genes. However, this process can be associated with a variety of genetic and epigenetic instabilities in regenerated plants, termed as somaclonal variation. In this study, we investigated mutation spectrum, chromosomal distributions of nucleotide substitution types of single-nucleotide polymorphisms (SNPs) and insertions/deletions (InDels) by whole genome re-sequencing between Dongjin and Nipponbare along with regenerated plants of Dongjin from different induction periods. Results indicated that molecular spectrum of mutations in regenerated rice against Dongjin genome ranged from 9.14 × 10 <sup>-5 </sup>to 1.37 × 10 <sup>-4 </sup>during one- to three-month callus inductions, while natural mutation rate between Dongjin and Nipponbare genomes was 6.97 × 10 <sup>-4 </sup>. Non-random chromosome distribution of SNP and InDel was observed in both regenerants and Dongjin genomes, with the highest densities on chromosome 11. The transition to transversion ratio was 2.25 in common SNPs of regenerants against Dongjin genome with the highest C/T transition frequency, which was similar to that of Dongjin against Nipponbare genome.
Nutritional composition analysis for beta-carotene-enhanced transgenic soybeans (Glycine max L.)
Yang Qin,박수윤,오선우,임명호,신공식,조현석,이성곤,우희종 한국응용생명화학회 2017 Applied Biological Chemistry (Appl Biol Chem) Vol.60 No.3
Nutritional composition is important for assessing the safety of genetically modified (GM) crops for human consumption. Three beta-carotene-enhanced soybean lines were developed by introducing the b-conglycinin promoter:: Phytoene synthase-2A-Carotene desaturase/t35S gene cassette into the genome of the commercial Kwangan (Glycine max L.) soybean variety. Transgenic soybeans were successfully detected on beta-carotene productions ranged from 170.47 to 213.58 lg/g. Comparative assessments of nutrition were conducted with 3 transgenic soybeans, their non-GM counterpart, and several commercial soybean varieties. Results indicated that most levels of proximate, fatty acids, amino acids, and vitamins showed non-significant differences between transgenic soybeans and their counterpart, and fit within the reference ranges established for other commercial soybeans and Organization for Economic Cooperation and Development Guidelines. However, significant differences on levels of crude fat, carbohydrate, d-tocopherol, and oleic acid of transgenic soybeans comparing to those of non-transgenic counterpart Kwangan cannot eliminate the influences of transgene insertion. Alternations on compositions should be definite by further studies, such as transcriptome and metabolome profiling.