http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Silencing IL-23 expression by a small hairpin RNA protects against asthma in mice
Yanchun Li,Shucheng Hua,Jirong Lu,Meng Sun,Huanji Cheng,Shanyu Li,Li Liu,Hongmei Qiao 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.4
To determine the impact of IL-23 knockdown by RNA interference on the development and severity of ovalbumin (OVA)-induced asthmatic inflammation, and the potential mechanisms in mice, the IL-23-specific RNAi-expressing pSRZsi-IL-23p19 plasmid was constructed and inhaled into OVA-sensitized mice before each challenge, as compared with that of control mice treated with alum or budesonide. Inhalation of the pSRZsi-IL-23p19, significantly reduced the levels of OVA-challenge induced IL-23 in the lung tissues by nearly 75%, determined by RT-PCR. In addition, knockdown of IL-23 expression dramatically reduced the numbers of eosinophils and neutrophils in BALF and mitigated inflammation in the lungs of asthmatic mice. Furthermore, knockdown of IL-23 expression significantly decreased the levels of serum IgE, IL-23,IL-17, and IL-4, but not IFNγ, and its anti-inflammatory effects were similar to or better than that of treatment with budesonide in asthmatic mice. Our data support the notion that IL-23 and associated Th17 responses contribute to the pathogenic process of bronchial asthma. Knockdown of IL-23 by RNAi effectively inhibits asthmatic inflammation, which is associated with mitigating the production of IL-17 and IL-4 in asthmatic mice.
SLNR-based User Scheduling in Multi-cell networks: from Multi-antenna to Large-Scale Antenna System
( Yanchun Li ),( Guangxi Zhu ),( Hua Chen ),( Minho Jo ),( Yingzhuang Liu ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.3
In this paper, we investigate the performance of Signal to Leakage and Noise Radio (SLNR) based user scheduling in uplink of multi-cell with large-scale antenna system. Large antenna array is desired to improve the performance in future system by providing better beamforming capability. However, some studies have found that the signal channel is `hardened` (becomes invariant) when the antenna number goes extremely large, which implies that the signal channel aware user scheduling may have no gain at all. With the mathematic tool of order statistics, we analyzed the signal and interference terms of SLNR in a homogeneous multicell network. The derived distribution function of signal and interference shows that the leakage channel`s variance is much more influential than the signal channel`s variance in large-scale antenna regime. So even though the signal channel is hardened, the SLNR-based scheduling can achieve remarkable multiuser diversity (MUD) gain due to the fluctuation of the uplink leakage channel. By providing the final SINR distribution, we verify that the SLNR-based scheduling can leverage MUD in a better way than the signal channel based scheduling. The Monte Carlo simulations show that the throughput gain of SLNR-based scheduling over signal channel based scheduling is significant.
Calculation of Thermal Fields of Cracked Concrete at Elevated Temperatures
Yanchun Liu,Jijun Miao,Jialiang Liu,Guangzhong Ba,Caiwei Liu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.1
This paper analyzes the effects of cracking on the thermal field of concrete at elevated temperatures. In four concrete specimens with pre-made cracks, fire tests were performed. Then finite element analysis and theoretical analysis were conducted, which have indicated that heat conduction was the primary source of heat transfer in cracked concrete. At last mathematical software MATLAB was used to calculate the temperatures distributions of a simplified model based on theoretical analysis, which were compared with the test results. The results show that as the thermal diffusion of air is far greater than that of concrete, there is an increase in the thermal propagation through the cracked regions in comparison with undamaged regions, and the temperatures increase with the increase of cracks’ widths. The temperature of concrete farther away from a crack was less affected because concrete has a lower thermal diffusion coefficient. The water content of concrete has an impact on the temperature distributions, which should be considered at the early stage of fire when determining the concrete temperature distributions.
Effect of Graphene Oxide on Chemical Shrinkage Behavior of Cement-Based Composite Paste
Yanchun Miao,Yu Zhang,Beibei Li,Leilei Chai,Gang Ma 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.4
As a new type of nano carbon material, graphene oxide (GO) has attracted extensive attention in the academic field over recent years due to its abundant oxygen-containing functional groups and large specific surface area, which can improve the microstructure and mechanical properties of cement-based materials. However, the effect of GO on the chemical shrinkage of cement-based materials remains unclear. Therefore, in this study, to reveal the chemical shrinkage characteristics of GO/cement composite paste (GO/CP), the chemical shrinkage of cement-based composite paste with different water/cement ratios (0.32, 0.42, and 0.52), different mass fractions of GO (0 wt%, 0.01 wt%, 0.03 wt%, and 0.05 wt%), and different mass fractions of polycarboxylate superplasticizer (PC) (0 wt%, 0.02 wt%, and 0.03 wt%) were measured using the volumetric method. The results showed that the chemical shrinkage of GO/CP increases significantly with the increasing water/cement ratio. The addition of PC appeared to compound GO/CP chemical shrinkage, showing a trend of first augmenting and then reducing with the increasing PC content. For the same water/cement ratio, the chemical shrinkage of the GO/CP specimen was lower than that of the normal cement paste (NCP). When the GO content reached the range of 0.03 wt% – 0.05 wt%, the shrinkage value reached the minimum; and when the water/cement ratio was 0.42, the growth rate of chemical shrinkage of the GO/CP specimen in the middle and late hydration processes was significantly larger than that of NCP. The analysis revealed that the regulating effect of GO on cement-based materials is mainly reflected in the refinement of the pore structure and bonding behavior of the hydration product Ca(OH)2. In addition, to determine the influence of GO and PC on chemical shrinkage of GO/CP, the existing model for chemical shrinkage of NCP was modified and the functions K(ξ, t) and P(λ, t) were introduced as impact parameters, after which a suitable prediction model for chemical shrinkage of GO/CP was established by curve fitting. This study provides a theoretical basis for improving the performance of cement-based materials and clarifying the function mechanism of GO.
The Frequency Estimation of Weak Signal Based on Chaotic System Fusion Technology
Yanchun Xu,Chunling Yang,Xiaodong Qu,Mengda Yang,Quan Yang 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
in this paper we use fusion technology based on Rossler chaotic oscillator and proportional differential control technology to detect the frequency of the weak signal. The dynamic character of Rossler equation is analyzed and it is immune against the white noise and the interference signal having larger frequency difference with the intrinsicfrequency of chaotic oscillator. And proportional differential control is used to regulate the system to periodic state and the method of spectrum analysis to detect the unknown frequency. The simulation result verified that the presentedmethod is effective and it is very feasible.
Silencing IL-23 expression by a small hairpin RNA protects against asthma in mice
Li, Yanchun,Sun, Meng,Cheng, Huanji,Li, Shanyu,Liu, Li,Qiao, Hongmei,Hua, Shucheng,Lu, Jirong Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.4
To determine the impact of IL-23 knockdown by RNA interference on the development and severity of ovalbumin (OVA)-induced asthmatic inflammation, and the potential mechanisms in mice, the IL-23-specific RNAi-expressing pSRZsi-IL-23p19 plasmid was constructed and inhaled into OVA-sensitized mice before each challenge, as compared with that of control mice treated with alum or budesonide. Inhalation of the pSRZsi-IL-23p19, significantly reduced the levels of OVA-challenge induced IL-23 in the lung tissues by nearly 75%, determined by RT-PCR. In addition, knockdown of IL-23 expression dramatically reduced the numbers of eosinophils and neutrophils in BALF and mitigated inflammation in the lungs of asthmatic mice. Furthermore, knockdown of IL-23 expression significantly decreased the levels of serum IgE, IL-23, IL-17, and IL-4, but not IFN${\gamma}$, and its anti-inflammatory effects were similar to or better than that of treatment with budesonide in asthmatic mice. Our data support the notion that IL-23 and associated Th17 responses contribute to the pathogenic process of bronchial asthma. Knockdown of IL-23 by RNAi effectively inhibits asthmatic inflammation, which is associated with mitigating the production of IL-17 and IL-4 in asthmatic mice.