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Kaori Shoji,Kaori Shoji,Masanobu Tsubaki,Yuzuru Yamazoe,Takao Satou,Tatsuki Itoh,Yasuhiro Kidera,Yoshihiro Tanimori,Masashi Yanae,Hideaki Matsuda,Atsushi Taga,Haruyuki Nakamura,Shozo Nishida 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside (C-glucosylxanthone), is a xanthone derivative that is widely distributed in higher plants. Recently, mangiferin was found to exhibit potential antitumor effects. However, the molecular mechanisms of this effect have not been elucidated. In the present study, we attempt to clarify the mechanism of mangiferininduced apoptosis in the human acute myeloid leukemia cell line HL-60; mangiferin was found to induce apoptosis. We also observed a concurrent increase in caspase-3 activity and DNA fragmentation. Furthermore, on examining the survival signals expressed during apoptotic induction, we observed that mangiferin caused a remarkable decrease in the nuclear entry of NF-κB p65. However, there were no changes in the expression of other survival signals,such as extracellular signal-regulated kinase 1/2, protein kinase B, and p38 mitogenactivated protein kinase. In addition, mangiferin suppressed the expressions of Bcl-xL and XIAP; however, we did not note any changes in the levels of Bcl-2, Bax, and Bim. These results indicate that mangiferin induces apoptosis by suppressing NF-κB activation and expressions of Bcl-xL and XAIP. These findings suggest that mangiferin may be useful as an anticancer agent and can be used in combination therapy with other anticancer drugs for the treatment of acute myeloid leukemia.
Yana Durmysheva,Aaron Kozbelt 대한사고개발학회 2010 The International Journal of Creativity & Problem Vol.20 No.2
Galenson’s (2001, 2006) ‘finder-seeker’ creator typology has promise as a unifying theory of creativity, but its statistical structure has not yet been studied in detail – in particular, the extent to which characteristics of the two types (finders versus seekers) are correlated versus independent. The main goal of this study was to test a new survey instrument, the Creative Approach Questionnaire (CAppQ), designed to quantitatively assess the nature of the typology. The 40-item CAppQ, consisting of pairs of 20 ‘finder’ items and 20 ‘seeker’ items, was administered to 696 college students. Rasch statistical analyses showed respectable internal consistency and provided refined measures of the two subscales, which showed a moderate negative correlation (r2 = .07). This suggests that the constructs of ‘finder’ and ‘seeker’ are fairly independent, rather than mutually exclusive. General implications and future directions for continued refinement and application of the CAppQ are discussed.
Yana Li,Xianhua Hou,Yajie Li,Qiang Ru,Shaofeng Wang,Shejun Hu,Kwok-ho Lam 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.5
Hierarchical CoMn2O4 microspheres assembled bynanoparticles have been successfully synthesized by afacile hydrothermal method and a subsequent annealingtreatment. XRD detection indicate the crystal structure. SEM and TEM results reveal the 3-dimensional porousand micro-/nanostructural microsphere assembled bynanoparticles with a size of 20-100 nm. The CoMn2O4electrode show initial specific discharge capacity ofapproximately 1546 mAh/g at the current rates 100 mA/gwith a coulombic efficiency of 66.7% and remarkablespecific capacities (1029-485 mAh/g) at various currentrates (100-2800 mA/g).
Yana, Rong,Zhang, Ruizhong,Zhang, Xian,Jiang, Chao,Han, Jian-Guo,Zhang, Ying-Jun Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.6
The objective of this study was to investigate the effects of different ratios of corn silage (CS): alfalfa hay (AH), and extruded soybeans (ESB) on milk yield, milk composition, blood metabolites, and fatty acids in milk fat and plasma. Ninety multiparous Holstein cows were arranged in a randomized block design experiment which lasted 14 weeks. Treatments were arranged as a $3{\times}3$ factorial with 0%, 5% or 10% ESB (dry matter basis) and three forage treatments: I) 30% CS, 10% AH and 10% Leymus chinense hay (LC); ii) 20% corn silage, 20% alfalfa hay and 10% LC; iii) 10% CS, 30% AH and 10% LC. Cows were allowed to consume a total mixed ration ad libitum. There was no change of dry matter intake when cows were fed the experimental diets. As more AH was added to the diets, milk yield, milk protein content and yield, and trans9, cis11-conjugated linoleic acids (CLA) concentrations in milk fat and plasma increased. When ESB were supplemented to the diets, milk yield, and trans9, cis11-CLA concentration in milk fat and plasma increased. When 10% ESB was added to the diet containing 30% AH the trans9, cis11-CLA content (1.46 g/100 g of total fatty acids) in milk was the highest among all treatments. These results suggests that AH could replace part of a CS diet and be a good forage source of diet for dairy cows to improve milk yield and milk composition. Meanwhile, ESB could be included in the diet with high AH to improve production performance of dairy cows.
Estimation of the Impact of Devaluation on Indonesian Aggregate Trade Performance
( Yana Van Der Meulen Rodgers ) 세종대학교 경제통합연구소 1995 Journal of Economic Integration Vol.10 No.4
This study evaluates the relationship between the real exchange rate and Indonesia`s aggregate trade performance between 1975 and 1990. I estimate structural import and export functions that are consistent with traditional empirical trade models, in which a rupiah devaluation leads rupiah import and export prices to increase relative to domestic prices. The study provides the first Indonesian import demand elasticity estimates, and it offers more precisely estimated non-oil export supply elasticities than previous work. Results add to the body of evidence that supports devaluation`s use in dampening imports and stimulating exports.
Yana Aleksieva,Georgi Ganchev,Velichka Milousheva 대한수학회 2016 대한수학회지 Vol.53 No.5
We develop an invariant local theory of Lorentz surfaces in pseudo-Euclidean 4-space by use of a linear map of Weingarten type. We find a geometrically determined moving frame field at each point of the surface and obtain a system of geometric functions. We prove a fundamental existence and uniqueness theorem in terms of these functions. On any Lorentz surface with parallel normalized mean curvature vector field we introduce special geometric (canonical) parameters and prove that any such surface is determined up to a rigid motion by three invariant functions satisfying three natural partial differential equations. In this way we minimize the number of functions and the number of partial differential equations determining the surface, which solves the Lund-Regge problem for this class of surfaces.
Heat Generation by Ion Friction in Water under an AC Electric Field
Yana Sissembayeva,Jinpho Hong,박홍열,Young Tae Kim,김문일,황윤회,김형국 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.75 No.10
In this study we investigate the theoretical background for the heat generation by ion friction for an electrode boiler by using sodium triphosphate and sodium chloride salt water solutions with different concentrations under AC electric fields. For comparisons, distilled, mineral, tap and sea water were investigated, as well. The input power and conductivity were calculated from the currents and the temperatures measured by applying different AC voltages. We compared the experimentally obtained conductivity data with the theoretical prediction. The energy efficiency was determined by calculating the enthalpy of the input heating power and the output power due to the temperature rise of the water. Applications of this electrode boiler and a heating system with a very high energy efficiency of nearly 100% at the initial stage was also proposed. This work can also be used for physics education, because its subjects are strongly related to undergraduate and graduate courses such as mechanics and electrodynamics.