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        • KCI등재

          Royal Jelly (Honey Bee) Is a Potential Antioxidant Against Cadmium-Induced Genotoxicity and Oxidative Stress in Albino Mice

          Kültiğin,Çavuşoğlu,Kürşad,Yapar,Emine,Yalçin 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6

          Cadmium (Cd) is a highly toxic heavy metal that induces genotoxic damage in the body. Besides, Cd induces oxidative damage in various tissues by altering antioxidant defence enzymes system. In this study, we investigated the protective role of royal jelly (RJ) on Cd-induced genotoxicity and oxidative stress in mice. For this aim, the micronucleus (MN) test in erythrocytes and exfoliated cells of buccal mucosa and the chromosome aberration (CA) test in bone marrow cells were applied. In addition, the levels of reduced glutathione (GSH) and malondialdehyde (MDA) were evaluated in the liver and kidneys. Thirty-six animals were divided into six groups: the control group received distilled water alone, whereas mice in the treatment groups received RJ alone (100 and 250mg/kg of body weight), Cd alone (2mg/kg of body weight), and RJ+Cd. Cd toxicity resulted in a significant (P<.05) increase in CAs, abnormal metaphase number, and MN formation. Cd also caused a decrease in mitotic index. Oral administration of RJ at two doses (100 and 250mg/kg of body weight) showed significant (P<.05) suppression of mutagenic effects of Cd. Moreover, Cd-induced oxidative damage caused a significant decrease in GSH level and a significant increase in MDA level in the liver and kidneys. Treatment with two doses of RJ caused a significant recovery in antioxidant status of GSH and a significant inhibition of MDA production. It could be concluded that RJ has a protective role against Cd-induced genotoxicity and oxidative stress in mice, due to its antioxidant effects.

        • KCI등재

          Protective Role of Grape Seed Extract Against Doxorubicin-Induced Cardiotoxicity and Genotoxicity in Albino Mice

          Emine,Yalçin,Ertan,Oruç,Kültiğin,Çavuşoğlu,Kürşad,Yapar 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4

          In this study, the protective role of grape seed extract (GSE) against doxorubicin (DOX)-induced cardiotoxicity and genotoxicity has been evaluated in male Mus musculus var. albino mice. The micronucleus (MN) test in erythrocytes and the chromosome aberration (CA) test in bone marrow cells were used. Also, levels of reduced glutathione (GSH) and lipid peroxidation as malondialdehyde (MDA) in heart homogenates were measured, and in addition the changes in heart histology were investigated. The mice were randomly divided into six groups. Group I (negative control) received intraperitoneal injections of isotonic saline (0.02mL/g) for 6 consecutive days, Group II received intraperitoneal injections of DOX (2.5mg/kg of body weight, six doses every other day; cumulative dosage, 15mg/kg of body weight) for 6 consecutive days, Group III received GSE (50mg/kg of body weight, 21 doses every other day; cumulative dosage, 1,050mg/kg of body weight) for 21 consecutive days, Group IV received GSE (150mg/kg of body weight, 21 doses every other day; cumulative dosage, 3,150mg/kg of body weight) for 21 consecutive days, Group V received GSE (50mg/kg of body weight, 28 doses every other day; cumulative dosage, 1,400mg/kg of body weight) for 28 consecutive days plus DOX (2.5mg/kg of body weight, six doses every other day; cumulative dosage, 15mg/kg of body weight) for 6 consecutive days, and Group VI received GSE (150mg/kg of body weight, 28 doses every other day; cumulative dosage, 4,200mg/kg of body weight) for 28 consecutive days plus DOX (2.5mg/kg of body weight, six doses every other day; cumulative dosage, 15mg/kg of body weight) for 6 consecutive days. DOX induced heart damage as indicated from a pronounced change in heart histology. In the DOX-treated group, there was a significant increase in MDA content in the heart homogenate, and the level of GSH was significantly decreased. DOX induced genotoxicity by increasing the number of aberrant metaphases (AMNs), MNs, and structural chromosomal aberrations (CAs) such as chromatid breaks, dicentrics, acentric fragments, and gaps and showed a detractive effect on the mitotic index (MI) of cells. Pretreatment with GSE before treatment with DOX significantly protected the heart tissue by ameliorating its antioxidant activity. In Groups V and VI, the MDA level of heart tissue was significantly decreased, and the GSH level was increased compared to the DOX-treated group. Moreover, GSE significantly protected bone marrow chromosomes from DOX-induced genotoxicity by reducing the total AMNs and the frequency of structural CAs. GSE treatment also decreased the frequency of MNs and increased the MI values. It could be concluded that GSE acts as a potent antioxidant to prevent heart damage and genotoxicity of bone marrow cells.

        • KCI등재

          Protective Effect of Royal Jelly and Green Tea Extracts Effect Against Cisplatin-Induced Nephrotoxicity in Mice: A Comparative Study

          Kürşad,Yapar,Kültiğin,Çavuşoğlu,Ertan,Oruç,Emine,Yalçin 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.5

          The aim of the present study was to investigate the protective role of royal jelly (RJ) and green tea (GT) extracts on cisplatin (cDDP)-induced nephrotoxicity in adult albino mice. Albino mice were randomly divided into six groups: Group I (control) received a single intraperitoneal injection of isotonic saline (0.02mL/g), Group II received a single intraperitoneal injection of cDDP (7mg/kg of body weight), Group III received RJ (100mg/kg of body weight), Group IV received GT (100mg/kg of body weight), Group V received RJ (100mg/kg of body weight)+cDDP (7mg/kg of body weight), and Group VI received GT (100mg/kg of body weight)+cDDP (7mg/kg of body weight). The concentrations of blood urea nitrogen (BUN) and creatinine were evaluated. In addition, kidney samples were taken for determination of tissue malondialdehyde (MDA) and reduced glutathione (GSH) levels. In addition, histopathological changes in kidneys were investigated. The results indicated that no significant differences in MDA, GSH, BUN, and creatinine levels were observed among the control group and groups treated with RJ alone and GT alone (P>.05). However, there was a significant increase in BUN and creatinine parameters after cDDP application in Groups II, V, and VI. The mice treated with only cDDP exhibited an increase in serum BUN and creatinine levels when compared to Groups V and VI (P<.05). Moreover, cDDP-induced oxidative damage caused a significant decrease in GSH levels and a significant increase in MDA levels in kidneys (P<.05). RJ and GT supplementation attenuated cDDP-induced nephrotoxicity, which was manifested by stopping the elevation in serum creatinine and BUN levels. Moreover, RJ and GT supplementation restored GSH content and MDA production levels in the kidney tissue following cDDP treatment (P<.05). These products were also effective in protecting against cDDP-induced tissue damage in mouse kidneys. In conclusion, 100mg/kg of body weight doses of RJ and GT provided protection against cDDP-induced nephrotoxicity, and both products can act as protector agents against cDDP-induced kidney damages.

        • KCI등재

          Protective Effect of Ginkgo biloba L. Leaf Extract Against Glyphosate Toxicity in Swiss Albino Mice

          Kültiğin,Çavuşoğlu,Kürşad,Yapar,Ertan,Oruç,Emine,Yalçın 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10

          The aim of the present study was to investigate the protective role of Ginkgo biloba L. leaf extract against the active agent of Roundup^ⓡ herbicide (Monsanto, Creve Coeur, MO, USA). The Swiss Albino mice were randomly divided into six groups, with each group consisting of six animals: Group I (control) received an intraperitoneal injection of dimethyl sulfoxide (0.2 mL, once only), Group II received glyphosate at a dose of 50 mg/kg of body weight, Group III received G. biloba at a dose of 50 mg/kg of body weight, Group IV received G. biloba at a dose of 150 mg/kg of body weight, Group V received G. biloba (50 mg/kg of body weight) and glyphosate (50 mg/kg of body weight), and Group VI received G. biloba (150 mg/kg of body weight) and glyphosate (50 mg/kg of body weight). The single dose of glyphosate was given intraperitoneally. Animals from all the groups were sacrificed at the end of 72 hours, and their blood, bone marrow, and liver and kidney tissues were analyzed for aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), and glutathione (GSH) levels and the presence of micronucleus (MN), chromosomal aberrations (CAs), and pathological damages. The results indicated that serum AST, ALT, BUN, and creatinine levels significantly increased in mice treated with glyphosate alone compared with the other groups (P<.05). Besides, glyphosate-induced oxidative damage caused a significant decrease in GSH levels and a significant increase in MDA levels of the liver and kidney tissues. Moreover, glyphosate alone–treated mice presented higher frequencies of CAs, MNs, and abnormal metaphases compared with the controls (P<.05). These mice also displayed a lower mean mitotic index than the controls (P<.05). Treatment with G. biloba produced amelioration in indices of hepatotoxicity, nephrotoxicity, lipid peroxidation, and genotoxicity relative to Group II. Each dose of G. biloba provided significant protection against glyphosate-induced toxicity, and the strongest effect was observed at a dose of 150 mg/kg of body weight. Thus, in vivo results showed that G. biloba extract is a potent protector against glyphosate-induced toxicity, and its protective role is dose-dependent.

        • KCI등재SCOPUS

          Analysis of partially embedded beams in two-parameter foundation

          A.Yalçin,Akoz,Hale,Ergun 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.42 No.1

          In this study, Pasternak foundation model, which is a two parameter foundation model, is used to analyze the behavior of laterally loaded beams embedded in semi-infinite media. Total potential energy variation of the system is written to formulate the problem that yielded the required field equations and the boundary conditions. Shear force discontinuities are exposed within the boundary conditions by variational method and are validated by photo elastic experiments. Exact solution of the deflection of the beam is obtained. Both foundation parameters are obtained by self calibration for this particular problem and loading type in this study. It is shown that, like the first parameter k, the second foundation parameter G also depends not only on the material type but also on the geometry and the loading type of the system. On the other hand, surface deflection of the semi infinite media under singular loading is obtained and another method is proposed to determine the foundation parameters using the solution of this problem.

        • KCI등재

          The Protective Effect of Royal Jelly on Chronic Lambda-Cyhalothrin Toxicity: Serum Biochemical Parameters, Lipid Peroxidation, and Genotoxic and Histopathological Alterations in Swiss Albino Mice

          Kültiğin,Çavuşoğlu,Kürşad,Yapar,Ertan,Oruç,Emine,Yalçın 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10

          The present study was undertaken to investigate the protective effect of royal jelly (RJ) against toxicity induced by a synthetic pyrethroid insecticide, lambda-cyhalothrin (LCT), in Swiss albino mice. Animals were randomly divided into six groups of six animals each. The control group received distilled water alone, whereas mice in the treatment groups received RJ alone (100 or 250 mg/kg of body weight), LCT alone (668 ppm), or RJ+LCT for 21 days. All mice (100%) survived until the end of experiment and were sacrificed at the end of 24 hours. Blood, bone marrow, and liver and kidney tissues were analyzed for aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), and reduced glutathione (GSH) levels and micronucleus (MN) frequency, chromosomal aberrations (CAs), and pathological damages. Serum AST, ALT, BUN, and creatinine levels were elevated in mice treated with LCT alone compared with the other tested groups (P<.05). LCT-induced oxidative damage caused a significant decrease in GSH levels and a significant rise in MDA levels of liver and kidney tissues. LCT alone–treated mice presented higher frequencies (P<.05) of MNs, CAs, and abnormal metaphases compared with the controls; moreover, the mitotic index was lower than in controls (P<.05). Oral treatment with RJ significantly ameliorated the indices of hepatotoxicity, nephrotoxicity, lipid peroxidation, and genotoxicity induced by LCT. Both doses of RJ tested provided significant protection against LCT-induced toxicity, and its strongest effect was observed at the dose level of 250 mg/kg of body weight. In vivo results suggest that RJ is a potent antioxidant against LCT-induced toxicity, and its protective effect is dose dependent.

        • KCI등재SCOPUS

          Compartment Syndrome Following Arthroscopic Removal of a Bullet in the Knee Joint after a Low-Velocity Gunshot Injury

          Mert,Keskinbora,Sercan,Yalçin,İsmail,Oltulu,Mehmet,Emin,Erdil,Tuğrul,Örmeci 대한정형외과학회 2016 Clinics in Orthopedic Surgery Vol.8 No.1

          Gunshot injuries are getting more frequently reported while the civilian (nongovernmental) armament increases in the world. A 42-year-old male patient presented to emergency room of Istanbul Medipol University Hospital due to a low-velocity gunshot injury. We detected one entry point on the posterior aspect of the thigh, just superior to the popliteal groove. No exit wound was detected on his physical examination. There was swelling around the knee and range of motion was limited due to pain and swelling. Neurological and vascular examinations were intact. Following the initial assessment, the vascular examination was confirmed by doppler ultrasonography of the related extremity. There were no signs of compartment syndrome in the preoperative physical examination. A bullet was detected in the knee joint on the initial X-rays. Immediately after releasing the tourniquet, swelling of the anterolateral compartment of the leg and pulse deficiency was detected on foot in the dorsalis pedis artery. Although the arthroscopic removal of intra-articular bullets following gunshot injuries seems to have low morbidity rates, it should always be considered that the articular capsule may have been ruptured and the fluids used during the operation may leak into surrounding tissues and result in compartment syndrome.

        • KCI등재SCIESCOPUS

          Corrosion and Wear Behaviors of Boronized AISI 316L Stainless Steel

          Yusuf,Kayali,Aysel,Büyüksagis,Yllmaz,Yalçin 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.5

          In this study, the effects of a boronizing treatment on the corrosion and wear behaviors of AISI 316L austenitic stainless steel (AISI 316L) were examined. The corrosion behavior of the boronized samples was studied via electrochemical methods in a simulation body fluid (SBF) and the wear behavior was examined using the ball-on-disk wear method. It was observed that the boride layer that formed on the AISI 316L surface had a flat and smooth morphology. Furthermore, X-ray diffraction analyses show that the boride layer contained FeB, Fe2B, CrB, Cr2B, NiB, and Ni2B phases. Boride layer thickness increased with an increasing boronizing temperature and time. The boronizing treatment also increased the surface hardness of the AISI 316L. Although there was no positive effect of the coating on the corrosion resistance in the SBF medium. Furthermore, a decrease in the friction coefficient was recorded for the boronized AISI 316L. As the boronizing temperature increased, the wear rate decreased in both dry and wet mediums. As a result, the boronizing treatment contributed positively to the wear resistance by increasing the surface hardness and by decreasing the friction coefficient of the AISI 316L.

        • KCI등재SCOPUS

          Influence of Vitamin (B1, B6, B9, B12, C) and Ions (Cu2+, Mn2+, PO4 3−) on Kefir Grain Biomass Growth

          Elçin,Demirhan,Büşra,Gürses,Bengi,Ece,Yalçin,Dilek,Kiliç,Apar,Belma,Özbek 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.4

          The aim of the present study was to investigate the effects of additions of various vitamins (B1, B6, B9, B12,and C) and minerals (CuSO4·H2O, MnSO4·H2O, and Na3PO4·12 H2O) on the propagation of kefir grains. The activated kefir grains were inoculated into very low fat (0.1%) cows' milk under constant temperature (25oC) and impeller speed (100 rpm) for a propagation time of 24 h. After evaluation of the experimental data, the most influential mineral addition providing 39% increase of kefir grain biomass was found to be Na3PO4·12 H2O with a concentration of 0.30 g phosphate (PO43−) ion/L. At this optimal condition, a model was also derived for the kefir grain biomass concentration representing pH dependence. This study demonstrated the basis for further research in the direction of kefir grain biomass growth considering the effect of additions of vitamins and minerals to other researchers working in the same field and to dairy industry as well.

        • KCI등재SCOPUS

          On a subclass of certain convex harmonic functions

          S\.{i}bel,Yal\c{c}in,Met\.in,\ 대한수학회 2006 대한수학회지 Vol.43 No.4

          We define and investigate a subclass of complex valued harmonicconvex functions that are univalent and sense preserving in theopen unit disk. We obtain coefficient conditions, extreme points,distortion bounds, convolution conditions for the above family of

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