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Gorukmez, Ozlem,Yakut, Tahsin,Gorukmez, Orhan,Sag, Sebnem Ozemri,Topak, Ali,Sahinturk, Serdar,Kanat, Ozkan Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Colorectal cancer (CRC) is reproted to be the third most common cancer worldwide and the fourth most common cause of cancer related deaths. CRC is considered to be a multifactorial disease whose risk varies due to the complex interaction between individual genetic basis and disposure to multiple endogenous factors. Glutathione S-transferases are pro-carcinogenic in CRC and are required for the conjugation between chemotherapeutics and broad spectrum xenobiotics. One hundred and eleven patients with CRC and 128 control subjects without any cancer history were enrolled in this study. Multiplex PCR was applied to determine polymorphisms for the GSTT1 and M1 genes, and PCR-RFLP was applied for the GSTP1 (Ile105Val) gene polymorphism. Values p<0.05 were defined as statistically significant. We detected a significant high correlation between predisposition for CRC and presence of the Ile/Ile genotype of the GSTP1 (IIe105Val) gene polymorphism, but we did not find a significant relationship between predisposition for CRC and GSTT1 and M1 deletion polymorphisms. In addition, we did not determine a relationship between GSTT1, M1 and P1 gene polymorphisms and any clinicopathological features of CRC. GSTT1 null/GSTM1 positive and GSTT1 null/GSTM1 positive/GSTP1 Ile/Ile genotypes were significantly higher in the patient group. Our results revealed that there is no relationship among CRC, its clinicopathologic features, and GSTT1 M1 gene polymorphisms. However, there was a significant correlation between CRC and the GSTP1 Ile/Ile genotype. Further studies with larger patient groups are required to delineate the relationships between GST gene polymorphisms and the clinicopathologic features of CRC in Turkey.
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Alli, Hasan,Yakut, Oguz Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.26 No.5
This study shows a fuzzy tuning scheme to fuzzy sliding mode controller (FSMC) for seismic isolation of earthquake-excited structures. The sliding surface can rotate in the phase plane in such a direction that the seismic isolation can be improved. Since ideal sliding mode control requires very fast switch on the input, which can not be provided by real actuators, some modifications to the conventional sliding-mode controller have been proposed based on fuzzy logic. A superior control performance has been obtained with FSMC to deal with problems of uncertainty, imprecision and time delay. Furthermore, using the fuzzy moving sliding surface, the excellent system response is obtained if comparing with the conventional sliding mode controller (SMC), as well as reducing chattering effect. For simulation validation of the proposed seismic response control, 16-floor tall building has been considered. Simulations for six different seismic events, Elcentro (1940), Hyogoken (1995), Northridge (1994), Takochi-oki (1968), the east-west acceleration component of D$\ddot{u}$zce and Bolu records of 1999 D$\ddot{u}$zce-Bolu earthquake in Turkey, have been performed for assessing the effectiveness of the proposed control approach. Then, the simulations have been presented with figures and tables. As a result, the performance of the proposed controller has been quite remarkable, compared with that of conventional SMC.
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Gumus, Bilal,Yakut, Yurdagul Bentesen The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
In agricultural systems, significant amount of energy is consumed during irrigation periods. Therefore operating irrigation systems with electrical energy produced by solar energy is very important. It is be possible to operate irrigation systems which have small-pump power like drip-irrigation with electrical energy produced by solar energy. Electrical energy produced by photovoltaic panels can vary from the estimated value due to environmental factors. Consequently analysis of a real system's performance is important. Thus, more correct projections can be made for the systems which will be designed. In this study, induction motor-pump mechanism for drip-irrigation system is operated with photovoltaic generator. Solar energy capacity of the established system is evaluated by measurements in irrigation periods. By means of simulations, power values produced by system and gained from the actual system are compared. Additionally the performance of induction motor is analyzed with the help of the driver system that increases the efficiency and controls the motor. As regards of results, design values of the drip-irrigation systems fed with solar energy in Southeastern Anatolian Regions of Turkey are obtained. Performance results of induction motor controlled with driver are also provided.
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Seismic vulnerability assessment criteria for RC ordinary highway bridges in Turkey
Avsar, O.,Yakut, A. Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.43 No.1
One of the most important and challenging steps in seismic vulnerability and performance assessment of highway bridges is the determination of the bridge component damage parameters and their corresponding limit states. These parameters are very essential for defining bridge damage state as well as determining the performance of highway bridges under a seismic event. Therefore, realistic damage limit states are required in the development of reliable fragility curves, which are employed in the seismic risk assessment packages for mitigation purposes. In this article, qualitative damage assessment criteria for ordinary highway bridges are taken into account considering the critical bridge components in terms of proper engineering demand parameters (EDPs). Seismic damage of bridges is strongly related to the deformation of bridge components as well as member internal forces imposed due to seismic actions. A simple approach is proposed for determining the acceptance criteria and damage limit states for use in seismic performance and vulnerability assessment of ordinary highway bridges in Turkey constructed after the 1990s. Physical damage of bridge components is represented by three damage limit states: serviceability, damage control, and collapse prevention. Inelastic deformation and shear force demand of the bent components (column and cap beam), and superstructure displacement are the most common causes for the seismic damage of the highway bridges. Each damage limit state is quantified with respect to the EDPs: i.e. curvature and shear force demand of RC bent components and superstructure relative displacement.
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Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients
Gorukmez, Orhan,Yakut, Tahsin,Gorukmez, Ozlem,Sag, Sebnem Ozemri,Karkucak, Mutlu,Kanat, Ozkan Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
The results of this study demonstrate the potential prognostic and predictive values of KRAS and BRAF gene mutations in patients with colorectal cancer (CRC). It has been proven that KRAS and BRAF mutations are predictive biomarkers for resistance to anti-EGFR monoclonal antibody treatment in patients with metastatic CRC (mCRC). We demonstrated the distribution of KRAS (codons 12, 13 and 61) and BRAF (codon 600) gene mutations in 50 mCRCs using direct sequencing and compared the results with clinicopathological data. KRAS and BRAF mutations were identified in 15 (30%) and 1 (2%) patients, respectively. We identified KRAS mutations in codon 12, 13 and 61 in 73.3% (11/15), 20% (3/15) and 6.67% (1/15) of the positive patients, respectively. The KRAS mutation frequency was significantly higher in tumors located in the ascending colon (p=0.043). Thus, we found that approximately 1/3 of the patients with mCRC had KRAS mutations and the only clinicopathological factor related to this mutation was tumor location. Future studies with larger patient groups should yield more accurate data regarding the molecular mechanism of CRC and the association between KRAS and BRAF mutations and clinicopathological features.
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Seismic vulnerability assessment criteria for RC ordinary highway bridges in Turkey
Ö. Avsar,A. Yakut 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.43 No.1
One of the most important and challenging steps in seismic vulnerability and performance assessment of highway bridges is the determination of the bridge component damage parameters and their corresponding limit states. These parameters are very essential for defining bridge damage state as well as determining the performance of highway bridges under a seismic event. Therefore, realistic damage limit states are required in the development of reliable fragility curves, which are employed in the seismic risk assessment packages for mitigation purposes. In this article, qualitative damage assessment criteria for ordinary highway bridges are taken into account considering the critical bridge components in terms of proper engineering demand parameters (EDPs). Seismic damage of bridges is strongly related to the deformation of bridge components as well as member internal forces imposed due to seismic actions. A simple approach is proposed for determining the acceptance criteria and damage limit states for use in seismic performance and vulnerability assessment of ordinary highway bridges in Turkey constructed after the 1990s. Physical damage of bridge components is represented by three damage limit states: serviceability,damage control, and collapse prevention. Inelastic deformation and shear force demand of the bent components (column and cap beam), and superstructure displacement are the most common causes for the seismic damage of the highway bridges. Each damage limit state is quantified with respect to the EDPs: i.e. curvature and shear force demand of RC bent components and superstructure relative displacement.
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Tahsin Atalay,Yusuf Yakut,Yavuz Köysal,Seyda Özbektaş,Hakan Bülbül,Bahattin Topaloğlu 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.2
In this study, it is aimed to determine the energy generation capability of the designed and manufactured thermoelectric system when mounted on the two-axis solar tracking system. Thus, it was possible to compare the results obtained from current study with previous study. The system used in previous study was comprised of a thermoelectric generator (TEG) for energy conversion, a linear Fresnel lens for concentrating solar rays, and a one-axis tracking system to increase the electrical and thermal efficiency of the system. In this study, a dual-axis (two-axis) tracking system was used as a tracking system to examine the change in thermal and electrical efficiency. Therefore, experimental measurements were performed again using both two-axis and one-axis solar tracking systems on 16th October 2019 and 17th October 2019, respectively, at the location which falls at 41°14′ N and 36°26′ E. Additionally, the heat transfer and electricity generation performance of TEG was theoretically analyzed using CFD model. For this purpose, a numerical model consisting TEG with heat sink was developed. It was observed that the model data obtained and the experimental data were in good agreement. The values of parameters such as temperature, solar radiation, wind speed and TEG open circuit voltage were measured instantaneously during the measurements. The maximum open circuit voltages obtained is 1.02 and 1.13 V for one-axis and dual-axis systems, respectively. The solar radiation values were measured as 464 and 472 W∕m2 , respectively when the maximum open circuit voltages value is obtained. The duration for measurements was kept about 15 min so that the average values of these parameters were used in calculations. Thus, the values of maximum output power ( P maxout) , electrical efficiency (ηe) and Seebeck coefficient ( TEG) were calculated and given in the paper.
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Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells
Mohamed Mohamed Soliman,Yakut Abdel-Fattah El-Senosi,Maysara Mahmoud Salem,Omniya Mahmoud Abdel Hamid,Kimura Kazuhiro 대한수의학회 2009 JOURNAL OF VETERINARY SCIENCE Vol.10 No.3
Treatment of AIDS (HIV) and hepatitis C virus needs protease inhibitors (PI) to prevent viral replication. Uses of PI in therapy are usually associated with a decrease in body weight and dyslipidemia. Acylation stimulating protein (ASP) is a protein synthesized in adipocytes to increase triglycerides biosynthesis, for that the relation of PI and ASP to adipogenesis is tested in this work. ASP expression was increased during 3T3-L1 differentiation and reached a peak at day 8 with cell maturation. Addition of PI during adipocytes differentiation dose dependently and significantly (p < 0.5) inhibited the degree of triglycerides (TG) accumulation. Moreover, presence of ASP (450 ng/mL) in media significantly (p < 0.5) stimulated the degree of TG accumulation and there was additive stimulation for ASP when added with insulin (10 μg/mL). Finally, when ASP in different doses (Low, 16.7; Medium, 45 and High, 450 ng/mL) incubated with a dose of ×150 PI, ASP partially inhibited the PI-inhibited adipogenesis and TG accumulation. The results in this study show that PI inhibit lipids accumulation and confirm role of ASP in TG biosynthesis and adipogenesis.
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Somali, Isil,Ustaoglu, Bahar Yakut,Tarhan, Mustafa Oktay,Yigit, Seyran Ceri,Demir, Lutfiye,Ellidokuz, Hulya,Erten, Cigdem,Alacacioglu, Ahmet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Background: To evaluate the clinicopathologic and demographic characteristics of triple-negative breast cancer (TNBC) patients and to determine differences from non-triple-negative cases. Materials and Methods: A detailed review of the medical records of 882 breast cancer (BC) patients was conducted to obtain information regarding age, menopausal status, height and weight at the time of diagnosis, presence of diabetes or hypertension, and pathologic characteristics of the tumor (tumor size, lymph node status, histologic grade, ER status, PR status, HER2 status, p53 mutation). Body mass index (BMI) was calculated and a value of ${\geq}30$ was considered as indicative of obesity. Results: 14.9% (n=132) of the patients had TNBC. There was no difference among the patients in terms of median age, comorbid conditions and menopausal status. The proportion of medullary, tubular and mucinous carcinomas was significantly higher (15.9%) in the triple-negative (TN) group, while invasive lobular histology was more frequent (8.2%) among non-triple negative (NTN) cases (p<0.001). Grade 3 (G3) tumors were more frequent in the triple-negative group (p<0.001). The rate of p53 mutation was 44.3% in TN tumors versus 28.2% in the NTN group (p<0.001). The two groups were similar in terms of LN metastasis. In the NTN group, the rate of patients with BMI ${\geq}30$ was 53% among postmenopausal patients, while it was 36% among premenopausal women, and the difference was statistically significant (p<0.001). No significant difference was observed in terms of BMI between postmenopausal and premenopausal patients in the TN group (p=0.08). Conclusions: TNBC rates and clinicopathologic characteristics of the Turkish patient population were consistent with the data from Europe and America. However, no relationship between obesity and TNBC was observed in our study. The association between TNBC and obesity needs to be evaluated in a larger patient population.
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