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Yu Feng,Yutao Liu,Mingming Yuan,Guilan Dong,Hongxia Zhang,Tongmei Zhang,Lianpeng Chang,Xuefeng Xia,Lifeng Li,Haohua Zhu,Puyuan Xing,Hongyu Wang,Yuankai Shi,Zhijie Wang,Xingsheng Hu 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3
Purpose To investigate the feasibility of biomarkers based on dynamic circulating tumor DNA (ctDNA) to classify small cell lung cancer (SCLC) into different subtypes. Materials and Methods Tumor and longitudinal plasma ctDNA samples were analyzed by next-generation sequencing of 1,021 genes. PyClone was used to infer the molecular tumor burden index (mTBI). Pre-treatment tumor tissues [T1] and serial plasma samples were collected (pre-treatment [B1], after two [B2], six [B3] cycles of chemotherapy and at progression [B4]). Results Overall concordance between T1 and B1 sequencing (n=30) was 66.5%, and 89.5% in the gene of <i>RB1</i>. A classification method was designed according to the changes of <i>RB1</i> mutation, named as subtype Ⅰ (both positive at B1 and B2), subtype Ⅱ (positive at B1 but negative at B2), and subtype Ⅲ (both negative at B1 and B2). The median progressive-free survival for subtype Ⅰ patients (4.5 months [95%CI: 2.6-5.8]) was inferior to subtype Ⅱ (not reached, p<0.0001) and subtype Ⅲ (10.8 months [95%CI: 6.0-14.4], p=0.002). The median overall survival for subtype Ⅰ patients (16.3 months [95%CI: 5.3-22.9]) was inferior to subtype Ⅱ (not reached, p=0.01) and subtype Ⅲ (not reached, p=0.02). Patients with a mTBI dropped to zero at B2 had longer median overall survival (not reached vs. 19.5 months, p=0.01). The changes of mTBI from B4 to B1 were sensitive to predict new metastases, with a sensitivity of 100% and a specificity of 85.7%. Conclusion Monitoring ctDNA based <i>RB1</i> mutation and mTBI provided a feasible tool to predict the prognosis of SCLC.
Approximate Clustering on Data Streams Using Discrete Cosine Transform
Yu, Feng,Oyana, Damalie,Hou, Wen-Chi,Wainer, Michael Korea Information Processing Society 2010 Journal of information processing systems Vol.6 No.1
In this study, a clustering algorithm that uses DCT transformed data is presented. The algorithm is a grid density-based clustering algorithm that can identify clusters of arbitrary shape. Streaming data are transformed and reconstructed as needed for clustering. Experimental results show that DCT is able to approximate a data distribution efficiently using only a small number of coefficients and preserve the clusters well. The grid based clustering algorithm works well with DCT transformed data, demonstrating the viability of DCT for data stream clustering applications.
Yu, Feng,Kong, Zhengyi,Li, Deguang,Vu, Quang-Viet Techno-Press 2020 Advances in concrete construction Vol.10 No.2
An experimental study on the stress-strain relation of PVC-CFRP confined reinforced concrete columns subjected to eccentric compression was carried out. Two parameters, such as the CFRP strips spacing and eccentricity of axial load, were considered. The experimental results showed that all specimens failed by compressive yield of longitudinal steel bar and rupture of CFRP strips. The bearing capacity of specimen decreases as the eccentricity or the CFRP strips spacing increases. The stress-strain relation of specimens undergoes two stages: parabolic and linear stages. In the parabolic stage, the slope of stress-strain curve decreases gradually as the eccentricity of axial loading increases while the CFRP strips spacing has little effect on the slope of stress-strain curve. For the linear stage, the slope of stress-strain curve decreases as the eccentricity of axial load or the CFRP strips spacing increases. A model for predicting the stress-strain relation of columns under eccentric compression is proposed and it agrees well with various test data.
Yufeng Zheng(Yufeng Zheng),Xue Liu(Xue Liu),Na Li(Na Li),Aimei Zhao(Aimei Zhao),Zhiqiang Sun(Zhiqiang Sun),Meihua Wang(Meihua Wang),Judong Luo(Judong Luo) 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Purpose: To analyze the gene mutation, immune infiltration and tumor growth of primary tumor and distant tumor under different treatment modes. Materials and Methods: Twenty B16 murine melanoma cells were injected subcutaneously into the of both sides of the thigh, simulating a primary tumor and a secondary tumor impacted by the abscopal effect, respectively. They were divided into blank control group, immunotherapy group, radiotherapy group, and radiotherapy combined immunotherapy group. During this period, tumor volume was measured, and RNA sequencing was performed on tumor samples after the test. R software was used to analyze differentially expressed genes, functional enrichment, and immune infiltration. Results: We found that any treatment mode could cause changes in differentially expressed genes, especially the combination treatment. The different therapeutic effects might be caused by gene expression. In addition, the proportions of infiltrating immune cells in the irradiated and abscopal tumors were different. In the combination treatment group, T-cell infiltration in the irradiated site was the most obvious. In the immunotherapy group, CD8+ T-cell infiltration in the abscopal tumor site was obvious, but immunotherapy alone might have a poor prognosis. Whether the irradiated or abscopal tumor was evaluated, radiotherapy combined with anti-programmed cell death protein 1 (anti-PD-1) therapy produced the most obvious tumor control and might have a positive impact on prognosis. Conclusion: Combination therapy not only improves the immune microenvironment but may also have a positive impact on prognosis.
Throughput and Delay of Single-Hop and Two-Hop Aeronautical Communication Networks
Yufeng Wang,Mustafa Cenk Ertürk,Jinxing Liu,나인호,산카,Salvatore Morgera 한국통신학회 2015 Journal of communications and networks Vol.17 No.1
Aeronautical communication networks (ACN) is an emerging concept in which aeronautical stations (AS) are considered as a part of multi-tier network for the future wireless communication system. An AS could be a commercial plane, helicopter, or any other low orbit station, i.e., Unmanned air vehicle, high altitude platform. The goal of ACN is to provide high throughput and cost effective communication network for aeronautical applications (i.e., Air traffic control (ATC), air traffic management (ATM) communications, and commercial in-flight Internet activities), and terrestrial networks by using aeronautical platforms as a backbone. In this paper, we investigate the issues about connectivity, throughput, and delay in ACN. First, topology of ACN is presented as a simple mobile ad hoc network and connectivity analysis is provided. Then, by using information obtained fromconnectivity analysis, we investigate two communication models, i.e., single-hop and two-hop, in which each source AS is communicating with its destination AS with or without the help of intermediate relay AS, respectively. In our throughput analysis, we use the method of finding the maximum number of concurrent successful transmissions to derive ACN throughput upper bounds for the two communication models. We conclude that the two-hop model achieves greater throughput scaling than the single-hop model for ACN and multihop models cannot achieve better throughput scaling than two-hop model. Furthermore, since delay issue is more salient in two-hop communication, we characterize the delay performance and derive the closed-form average end-to-end delay for the two-hop model. Finally, computer simulations are performed and it is shown that ACN is robust in terms of throughput and delay performances.
The Fabrication of High-Aspect-Ratio Cylindrical Nano Tool using ECM
Yufeng Wang,Ningsong Qu,Yongbin Zeng,Xiujuan Wu,Di Zhu 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.
With the miniaturization of various types of components and devices, micro- and nanometer-scale tools are increasingly in demand. Electrochemical machining (ECM) is a well-established technique for the fabrication of micro tools and nano tips. This paper presents a machining method for the fabrication of a high-aspect-ratio cylindrical nano tool using liquid membrane ECM, in which a straight reciprocating motion is applied to the anodic electrode. The method is based on periodic machining of the anodic rod within the amplitude of the straight reciprocating motion. In this process, the machining rate within amplitude varies periodically, allowing nano tools with high aspect ratios to be obtained by the presented method. Experiments were conducted to verify the proposed method. The influences of applied voltage, electrolyte concentration, amplitude and velocity of the straight reciprocating motion on the fabrication of cylindrical nano-electrode were investigated. By using this method, nano-electrodes with average diameters of several hundred nanometers and aspect ratios up to 70 were successfully fabricated.
Yufeng Chen,Xiaoqing Wang,Yao Bao 한국물리학회 2017 Current Applied Physics Vol.17 No.1
A new green phosphor Ca12Al14O32Cl2: Tb3þ derived from Tb-doped Ca-Al layered double hydroxide (Tbdoped CaAl-LDH) was prepared through phase transition route. The X-ray diffraction measurement results revealed that the Tb-doped CaAl-LDH transformed into Ca12Al14O32Cl2:Tb3þ phase at 600 『C. With temperature varying from 600, 800e1000 『C, the crystallinity of the Ca12Al14O32Cl2:Tb3þ phase gradually improved. Compositional analyses suggested the chemical formula of the Ca12Al14O32Cl2:Tb3þ phase estimated to be Ca12Al13.52Tb0.48O32Cl2. The Ca12Al13.52Tb0.48O32Cl2 phase can be efficiently excited by near ultraviolet light and show strong green emissions attributed to 5D4/7FJ (J ¼ 5, 6) transition of Tb3þ. The present Ca12Al13.52Tb0.48O32Cl2 may be a promising candidate for green phosphor applied in LED.