A novel neurofibromatosis type 1 (NF1) mutation in a patient with NF1 and pheochromocytoma

Yoorim Seo,Yeonjeong Jeong,Dong Yoon Kim,Kyueun Choi,Eun Sook Kim,Sung Dae Moon,Je Ho Han 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.1

Effect of TiO2 on the crystallization behaviors and microstructure of glazes based on MgO-Al2O3-SiO2 system

Yoorim Rho,Kangduk Kim,Jin-Ho Kim 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.S1

A MgO-Al2O3-SiO2 system was used in order to prepare glass-ceramic glazes with high-hardness applicable to ceramic tiles. The glass-ceramic glazes were prepared by adding the fluxes CaO and B2O3 and the nucleating agent TiO2 to the glaze. The crystallization behavior of the glaze was calculated by a non-isothermal thermal analysis via a Differential Thermal Analysis (DTA), and the glaze was heat treated at the crystallization temperature (Tp2). The activation energy (E) and the Avrami constant (n) of the glaze with 8wt% TiO2 substitution were 177.07 kJ/mol and 2.65, respectively. X-ray diffraction analysis (XRD) showed that the cordierite and anorthite crystal phases were formed and the karrooite crystal phases grew with increasing TiO2 substitution. The degree of crystallinity increased as the amount of TiO2 increased and the degree of crystallinity was 76.5% in the glaze with 8 wt% TiO2 substitution. In the Scanning Electron Microscope (SEM) analysis, the cordierite and anorthite crystal phases were the largest in the glaze with 8wt% TiO2 substitution and rapidly decreased in the glaze with 12 wt% TiO2 substitution. As a result, Vickers hardness of the glaze showed a high value of 7.10 GPa at the glaze with 8wt% TiO2 substitution after heat treatment at 1,010 oC.

윤리적 브랜드 초콜릿의 상업적 경쟁력을 위한 소비자 연구

김유림 ( Kim Yoorim ),김보연 ( Kim Boyeun ) 커뮤니케이션디자인학회 2022 커뮤니케이션 디자인학연구 Vol.81 No.-

윤리적 제품 및 브랜드 시장이 성장함에 따라, 본 연구는 윤리적 신념을 넘어서 소비자들의 만족감을 함양시 킬 수 있는 브랜드 경험은 어디에서 오는가를 파악하고자 한다. 이에 본 연구에서는 윤리적 초콜릿의 패키지에 서 나타나는 정보 전달 방식에 따라 소비자들의 선호도 및 구매의도가 어떤 영향을 받는지 분석하고자 하였다. 이를 위해 국내 10대에서 50대 사이의 소비자를 대상으로 온라인 설문을 수집하였으며, 회수된 샘플과 SPSS 21.0통계 프로그램을 이용하여 가설을 검증하였다. 설문 응답에 따르면, 소비자들은 윤리적 브랜드 제품에 대해 선호도와 구매의도가 높다고 응답했다. 그러나, 실제 초콜릿 패키지를 샘플을 제시하며 각각의 선호도 및 구매 의도를 평가하게 했을 때, 패키지의 타입과 소비자의 선호도 및 구매 의도는 의미있는 상관성을 갖지 못했다. 이에 따라 일반 소비자 전반이 아닌 실제 구매 경험자들의 구매동기를 분석할 필요가 대두되었다. 따라서 윤리적 브랜드 초콜릿 구매 경험자들의 구매 소구 및 구매 동기, 즉 소비 가치를 조사하는 추가 연구를 시행하였다. 그 결과, 소비자들은 초콜릿을 이성적이기보다는 감성적으로 구매하고 있었으며, Sheth et al(1991)이 제시한 다섯가지 소비 가치 중 감성적 소비 가치가 이 때의 소비 동기에서 가장 주요한 것으로 드러났다. As people’s preferences for ethical consumption grow, this study aims to understand how to satisfy consumers’ needs beyond ethical fulfillment in the process of purchasing chocolate of ethical brand. Thus, this study intends to investigate and analyze how chocolates of ethical brands deliver information via their packages and how consumers build their motivation of purchase and preferences. The study researched Korean consumers between the ages of people under 18 to over 50 via online survey. The survey was analyzed and investigated using SPSS 21.0. According to the survey, consumers answered that they have higher preference and motivation of purchase on ethically conscious brand products. However, when actual package samples are provided, their preference and motivation of purchase did not have significant correlation with the type of packages provided. Therefore, additional research was conducted to observe what appeals and motivates customers in the process of purchasing chocolate of ethical brand. The result suggests that consumers purchase chocolate more emotionally than rationally. In addition, emotional value is turned out to be the most significant factor among five consumer values suggested by Shet et al (1991) when it comes to purchasing chocolates of ethical brands.

The combination of DHEA, histamine, and insulin increases adipogenic differentiation and enhances tissue transplantation outcome in mice.

Park, Yoorim,Jung, Min Kyung,Yoon, Sun Young,Lee, Ha-Reum,Hur, Dae Young,Kim, Daejin,Yang, Yoolhee,Kim, Tae Sung,Kim, Seonghan,Yoon, Suk Ran,Park, Hyun Jeong,Bang, Sa Ik,Cho, Dae Ho Published for the International Union of Biochemis 2013 Biotechnology and applied biochemistry Vol.60 No.3

<P>Adipose stem cells (ASCs) are pluripotent cells that can generate pure fat tissue for regeneration. Differentiated adipose cells have been generated by a common inducer cocktail composed of dexamethasone, insulin, and isobutylmethylxanthine (DIM). The major drawbacks of adipose cells are their tendency to float on the culture media and their cost. To overcome some of these disadvantages, a new inducer cocktail that includes insulin, dehydroepiandrosterone, and histamine (DH IH) was tested. As a result, lipid accumulation was elevated more than twofold with DH IH than with DIM. Cell adhesion and viability, which are important factors for stable differentiation, were increased with DH IH and were proven through measurement of mRNA expression levels of adhesion marker genes, N-cadherin and vascular cell adhesion molecule, as well as through an alamar blue assay. The expression of adipogenesis-related genes, adiponectin, and glucose transporter type 4 lasted for a long time. To improve the efficiency of grafting, cell adhesion and neovascularization need to be increased. Neovascularization was observed around the transplanted adipose cells, which showed a higher number of vessel formation in DH IH than in DIM. The above results suggest that DH IH can produce pure differentiated adipose cells effectively and enhance their adhesion onto the target location when these differentiated adipose cells were applied as a clinical resource.</P>

Synergistic Action of IL-8 and Bone Marrow Concentrate on Cartilage Regeneration Through Upregulation of Chondrogenic Transcription Factors

Yoon, Dong Suk,Lee, Kyoung-Mi,Kim, Sung-Hwan,Kim, Su Hee,Jung, Youngmee,Kim, Soo Hyun,Park, Kwang Hwan,Choi, Yoorim,Ryu, Hyun Aae,Choi, Woo Jin,Lee, Jin Woo Mary Ann Liebert 2016 Tissue engineering. Part A Vol.22 No.3

<P>The objective of this study was to determine whether a biphasic scaffold loaded with a combination of a chemokine and bone marrow concentrate (BMC) could improve tissue regeneration in knee articular cartilage of beagles with cylindrical osteochondral defects. For this investigation, an osteochondral defect (6mm in diameter and 8mm deep) was created in the weight-bearing articular surface of the femoral medial condyle in beagles. Bone marrow was aspirated from the posterior iliac crests of beagles to obtain mesenchymal stem cells (MSCs) for in vitro assay. Hematoxylin and eosin (HE), Masson's trichrome (MT), safranin O/fast green staining, and immunohistochemistry were performed for histological analysis. Quantitative real-time polymerase chain reaction was performed to understand the roles of BMC in chondrogenic differentiation of MSCs. At 12 weeks after transplantation of biphasic scaffolds, we observed that interleukin-8 (IL-8) or the combination of IL-8 and BMC induced massive bone regeneration compared to saline, BMC only, and MSCs. In gross appearance, the osteochondral defect site was nearly completely filled with repair tissue in the group that received the combination of IL-8 and BMC but not in the other groups. Moreover, histological analysis showed obvious differences in cartilage regeneration among groups. HE and MT staining showed that the cartilage defect sites of the group receiving the combination of IL-8 and BMC were regenerated with cartilage-like tissues showing chondrocyte morphology. Safranin O staining showed hyaline cartilage regeneration in the group receiving IL-8 and BMC, whereas fibrous-like tissues were formed in the other groups. Furthermore, immunostaining revealed the presence of type II collagen and aggrecan in regenerated cartilage tissue of the group receiving IL-8 and BMC, whereas regenerated cartilage tissues of the other groups weakly expressed type II collagen and aggrecan. These results indicate that the combination of a chemokine IL-8 and BMC has significant positive effects on osteochondral regeneration in a beagle model through enhancing expression of the chondrogenic transcription factors and markers such as Sox9 and type II collagen.</P>

Thymosin β4 expression correlates with lymph node metastasis through hypoxia inducible factor- α induction in breast cancer

YOON, SUN YOUNG;LEE, HA REUM;PARK, YOORIM;KIM, JOO HEON;KIM, SOO YOUNG;YOON, SUK RAN;LEE, WANG JAE;CHO, BYUNG JOO;MIN, HYEYOUNG;BANG, JUNG-WOOK;PARK, HYUNJEONG;BANG, SA IK;CHO, DAEHO Sookmyung Women's University Research Institute of 2011 여성과 건강 Vol.6 No.2

Intratumoral hypoxia has been correlated with distant metastatic potential. Two hypoxia inducible factors (HIFs). HIF-1α and HIF-2α, are induced by hypoxia, and high expression of these proteins has been correlated to angiogenesis and distant metastasis. Thymosin β4 (Tβ4) is frequently highly expressed in cancer, and this overexpression correlates with malignant progression. The objective of this study was to investigate the clinical correlation of HIF-α with Tβ4 and the intracellular functional roles of Tβ4 on HIF-α activation. We examined HIF-1α, HlF-2α and Tβ4 expressions in clinical human breast carcinoma (n=70) by immunohisto-chemistry. We show that high expression of HIF-1α and HIF-2α strongly correlates with Tβ4 expression (P≤0.0001) and overexpression of Tβ4 correlates significantly with patients with lymph node metastasis (P<0.05) of human breast cancer. Additionally, we demonstrate that hypoxia up-regulates intracellular Tβ4 protein, which then affects HIF-α activity, which is the key in regulating VEGF expression. We confirmed that hypoxia-induced intracellular Tβ4 and HIF-α activities were reduced by interference of TIM expression using Tβ4 shRNA lentivirus. Vascular epidermal growth factor (VEGF)-A, a well-recognized lymphangiogenic cytokine, was also down-regulated, but VEGF-C and VEGF-D expressions were not affected. These findings suggest that the overexpression of Tβ4 is strongly associated with HIF-1α and HIF-2α expression and is also clinicopathologically involved with lymph node metastatic potential of breast cancer through the modulation of HIF-a activation and induction of VEGF-A. Ultimately, these results highlight Tβ4 as a potentially therapeutic target in malignant cancers.

러셀 모델 기반 좌표계를 활용한 감정 척도에 대한 연구

박선호 ( Sunho Park ),박근형 ( Keunhyung Park ),김태현 ( Taehyeon Kim ),김유림 ( Yoorim Kim ),김영종 ( Youngjong Kim ) 한국정보처리학회 2022 한국정보처리학회 학술대회논문집 Vol.29 No.1

최근 코로나 바이러스로 인한 팬데믹이 장기화 되었고 이는 개인의 정신건강에도 많은 악영향을 미치고 있다. 이에 따른 코로나 우울감 해소 방안으로 ‘감정일기 애플리케이션’을 제안하며 감정 분석을 위해 2차원 좌표계를 사용한다. 이 애플리케이션에서는 사용자가 입력한 좌표값의 평균으로 콘텐츠를 추천하는데, 평균 좌표값이 획일화되어 한 가지 범주에 고착되는 문제가 있다. 이를 해결하고자 본 논문에서는 콘텐츠 평가 변수 및 사용자 성향 변수를 이용하여 평균 좌표값에 변화를 주었다. 이를 통해 사용자에게 보다 적합한 콘텐츠 추천을 기대한다.

Effect of thermal sensation on emotional responses as measured through brain waves

Kim, Minjung,Chong, Sang Chul,Chun, Chungyoon,Choi, Yoorim Elsevier 2017 Building and environment Vol.118 No.-

<P><B>Abstract</B></P> <P>Beyond previous research topics assessing physiological or psychological effects of an indoor environment, the present study aims to investigate the effect of thermal sensations on people's emotional responses. For achieving this purpose, chamber experiments were conducted based on three different temperatures (PMV −2, 0, +2), and results were obtained from 139 participants' brain wave data. The emotional process depending on indoor temperature was not significant; however, that depending on subjective thermal sensations were statistically significant. Since participants felt same indoor thermal condition differently, the physical indoor temperature itself had no direct significant influence to their emotions. Positivity bias was observed when participants felt neutral and slightly warm, and negativity bias was observed in all other cases. This study supports the notion that the thermal environment affects occupants' emotional responses through subjective thermal sensations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The indoor temperature itself had no direct significant influence to emotions. </LI> <LI> Emotion was significantly different depending on subjective thermal sensation. </LI> <LI> Positivity bias was observed when participants felt neutral and slightly warm. </LI> </UL> </P>

PREDICTION OF HEAVY RAINFALL USING HIGH RESOLUTION QPM OVER THE RIVER BASINS OF THE KOREA : TYPHOON "DIANMU"CASE

JiHye KIM,JaiHo OH,YooRim JUNG,MoRang HER 한국기상학회 2011 한국기상학회 학술대회 논문집 Vol.2011 No.10-2

창작 주체성 보호를 위한 인공지능 융합 수업의 설계 및 교수 전략

손유림(Yoorim Son),김주현(Juhyun Kim),지경아(Kyunga Ji) 학습자중심교과교육학회 2024 학습자중심교과교육연구 Vol.24 No.6