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Everolimus-Eluting Stent Implantation for Unprotected Left Main Coronary Artery Stenosis
PRECOMBAT-2 Investigators,Kim, Y.H.,Park, D.W.,Ahn, J.M.,Yun, S.C.,Song, H.G.,Lee, J.Y.,Kim, W.J.,Kang, S.J.,Lee, S.W.,Lee, C.W.,Park, S.W.,Jang, Y.,Jeong, M.H.,Kim, H.S.,Hur, S.H.,Rha, S.W.,Lim, D.S. Elsevier 2012 JACC. Cardiovascular interventions Vol.5 No.7
Objectives: This study sought to evaluate the safety and efficacy of second-generation drug-eluting stents (DES) for patients with unprotected left main coronary artery (ULMCA) stenosis. Background: The clinical benefit of second-generation DES for ULMCA stenosis has not been determined. Methods: The authors assessed 334 consecutive patients who received everolimus-eluting stents (EES) for ULMCA stenosis between 2009 and 2010. The 18-month incidence rates of major adverse cardiac or cerebrovascular events (MACCE), including death, myocardial infarction (MI), stroke, or ischemia-driven target vessel revascularization (TVR), were compared with those of a randomized study comparing patients who received sirolimus-eluting stents (SES) (n = 327) or coronary artery bypass grafts (CABG) (n = 272). Results: EES (8.9%) showed a comparable incidence of MACCE as SES (10.8%; adjusted hazard ratio [aHR] of EES: 0.84; 95% confidence interval [CI]: 0.51 to 1.40; p = 0.51) and CABG (6.7%, aHR of EES: 1.40; 95% CI: 0.78 to 2.54; p = 0.26). The composite incidence of death, MI, or stroke also did not differ among patients receiving EES (3.3%), SES (3.7%; aHR of EES: 0.63; 95% CI: 0.27 to 1.47; p = 0.29), and CABG (4.8%; aHR of EES: 0.67; 95% CI: 0.29 to 1.54; p = 0.34). However, the incidence of ischemia-driven TVR in the EES group (6.5%) was higher than in the CABG group (2.6%, aHR of EES: 2.77; 95% CI: 1.17 to 6.58; p = 0.02), but comparable to SES (8.2%, aHR of EES: 1.14; 95% CI: 0.64 to 2.06; p = 0.65). Angiographic restenosis rates were similar in the SES and EES groups (13.8% vs. 9.2%, p = 0.16). Conclusions: Second-generation EES had a similar 18-month risk of MACCE for ULMCA stenosis as first-generation SES or CABG. (Evaluation of Outcomes of EES Implantation for Unprotected Left Main Coronary Artery Stenosis [PRECOMBAT-2]; NCT01348022)
갑상선 미세침흡인세포검사 슬라이드에서 BRAF Mutation 검출을 통한 갑상선 유두암의 진단
박원서<SUP>1<,SUP>,이규언<SUP>2<,SUP>,송정윤<SUP>1<,SUP>,정유승<SUP>3<,SUP>,김훈엽<SUP>4<,SUP>,고석환<SUP>1<,SUP>,윤여규<SUP>2,5<,SUP>,Won Seo Park,<SUP>1<,SUP>,Kyu Eun Lee,<SUP>2<,SUP>,Jeong Yoon Song,Ph,D,<SUP>1<,SUP>,Y 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.1
Purpose: The prevalence rate of the BRAF mutation in papillary thyroid cancer (PTC) is as high as about 52 to 83% in Korea. Preoperative detection of BRAF mutation on fine needle aspiration cytology (FNAC) slides may help the surgeon make better therapeutic decisions. The present study aims to assess the feasibility of the mutant allele specific amplification (MASA) and restriction fragment length polymorphism (RFLP) method with using conventional FNAC slides and we also wanted to evaluate the clinical role of preoperatively detecting BRAF mutation. Methods: We extracted the genomic DNA from 59 FNAC slides and performed direct sequencing (DS) for detecting BRAF mutation. We could use only 17 slides for the MASA method and 6 slides for the RFLP method due to the shortage of extracted DNA. Additionally, we retrospectively analyzed the cases for which a histological diagnosis could be made. Results: Genomic DNA was extracted from 23 out of the 59 FNAC slides. The BRAF mutation status could be assessed via DS in 33 out of the 59 FNAC slides. The concordance between the MASA method and DS and the RFLP method and DS was 36.3% and 66.7% respectively. The positive and negative predictive value of the 13 indeterminate nodules was 87.5% and 20%, respectively. We could not find any association between the BRAF mutations and the alleged risk factors of PTC. Conclusion: We believe that the purity and the amount of the DNA template must be increased to detect BRAF mutation with using a FNAC slide. Preoperative detection of the BRAF mutation on a FNAC slide may refine the cytological diagnosis, but the application of assessing BRAF mutation as a prognostic marker is debatable. (Korean J Endocrine Surg 2010;10:12-18)
갑상선 결절에 대한 세침흡입 세포검사에서 반복적인 비진단적 검체의 원인에 대한 분석
최영근<SUP>1<.SUP>,윤찬석,고승상,허민희,강성수,이지현,전이경<SUP>2<.SUP>,박지영<SUP>2<.SUP>,이해경,Young Gun Choi,<SUP>1<.SUP>,Chan Seok Yoon,Seung Sang Ko,Min Hee Hur,Sung Soo Kang,Jee Hyun Lee,Yi Kyeong Chun,<SUP>2<.SUP>,Ji Y 대한갑상선-내분비외과학회 2006 The Koreran journal of Endocrine Surgery Vol.6 No.1
Hyo Jeong Kim1,2,Jun Hyuek Yang,Hyun Soo Kim,Yeo Jin Kim,Wonhee Jang,Young Rok Seo,W. Jang,Y. R. Seo 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.1
I ntensive usage of electronic appliances containing lithium batteries causes an accumulation of e-trash. Environmental exposure to lithium batteries contaminates ecosystems. In air and water, the batteries form lithium hydroxide (LiOH) on their surfaces. LiOH enters the aquatic environment and contaminates the aquatic ecosystem by being absorbed into biological organisms. In this study, in order to identify meaningful potential biomarkers that appear in response to lithium, we measured significantly up- and down-regulated genes after LiOH exposure by conducting a microarray. In addition, we explored the functions of differentially expressed daphnia genes, and we conducted a comparative analysis in other species, Daphnia spp. to humans, then analyzed the signaling pathways using the human gene set derived from daphnia sequences that are differentially expressed in response to LiOH using the NCBI-BLAST tool and Pathway studio. As a result, we identified signaling pathways and suggested several potential biomarkers that are up- or down-regulated in response to lithium. This study may contribute to the development of a biomonitoring system which can detect the ecotoxicity of lithium. Furthermore, lithium toxicity in humans can be predicted, so the study may also provide potential biomarkers of lithium exposure in humans.
Jung, Chang H.,Yang, Yoo‐,Soo,Kim, Jun‐,Seob,Shin, Jae‐,Il,Jin, Yong‐,Su,Shin, Jae Y.,Lee, Jong H.,Chung, Koo M.,Hwang, Jae S.,Oh, Jung M.,Shin, Yeon‐,Kyun,Kweon, Dae2 Blackwell Publishing Ltd 2008 FEBS JOURNAL Vol.275 No.12
<P>Soluble <I>N</I>‐ethylmaleimide sensitive‐factor attachment receptor (SNARE) proteins have crucial roles in driving exocytic membrane fusion. Molecular recognition between vesicle‐associated (v)‐SNARE and target membrane (t)‐SNARE leads to the formation of a four‐helix bundle, which facilitates the merging of two apposing membranes. Synthetic peptides patterned after the SNARE motifs are predicted to block SNARE complex formation by competing with the parental SNAREs, inhibiting neuronal exocytosis. As an initial attempt to identify the peptide sequences that block SNARE assembly and membrane fusion, we created thirteen 17‐residue synthetic peptides derived from the SNARE motifs of v‐ and t‐SNAREs. The effects of these peptides on SNARE‐mediated membrane fusion were investigated using an <I>in vitro</I> lipid‐mixing assay, <I>in vivo</I> neurotransmitter release and SNARE complex formation assays in PC12 cells. Peptides derived from the N‐terminal region of SNARE motifs had significant inhibitory effects on neuroexocytosis, whereas middle‐ and C‐terminal‐mimicking peptides did not exhibit much inhibitory function. N‐terminal mimicking peptides blocked N‐terminal zippering of SNAREs, a rate‐limiting step in SNARE‐driven membrane fusion. Therefore, the results suggest that the N‐terminal regions of SNARE motifs are excellent targets for the development of drugs to block SNARE‐mediated membrane fusion and neurotransmitter release.</P>