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Regional innovation networks and risk analysis based on Industry-University-Reserach Institution
Feng Feng,Xue Qin 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10
According to the system theory, the structure of the network determines characteristics of the network. Our paper builds a regional innovation network of Industry-University-Research Institution and analyzes the network structure variables the aggregation coefficient, average shortest path length, degree distribution by social network model. The result is obtaining the contact between network structure variables and risks, which will improve and promote the formation and development of the regional innovation networks based on Industry-University-Research Institution.
Conditional Replication of a Recombinant Adenovirus Studied Using Neomycin as a Selective Marker
( Feng Xue ),( Yi Peng Qi ),( Mallam Nock Joshua ),( Ping Lan ),( Chang Yuan Dong ) 생화학분자생물학회 2003 BMB Reports Vol.36 No.3
An E1B-defective adenovirus, named r2/Ad carrying the neo expression cassette, was constructed by homologous recombination. The construction, selection (using neomycin as a seletive marker), and propagation of the recombinant virus was performed in human embryonic kidney 293 cells (HEK 293). An in vitro study demonstrated that this recombinant virus has the ability to replicate in and lyse some p53-deficient human bladder cells (EJ), but not in some cells with functional p53, such as human adenocarcinoma cells (A549) and human fibroblast cells (MRC-5). Also, based on the cytopathic effect (CPE), it was demonstrated, under identical conditions, that the U251 cells were more sensitive to r2/Ad replication than the EJ cells. In this paper, we report that r2/Ad could be very useful in studying the in vitro selective replication of EIB-defective adenovirus and has great potential in cancer gene therapy.
Conditional Replication of a Recombinant Adenovirus Studied Using Neomycin as a Selective Marker
Xue, Feng,Qi, Yi-Peng,Joshua, Mallam Nock,Lan, Ping,Dong, Chang-Yuan Korean Society for Biochemistry and Molecular Biol 2003 Journal of biochemistry and molecular biology Vol.36 No.3
An E1B-defective adenovirus, named r2/Ad carrying the neo expression cassette, was constructed by homologous recombination. The construction, selection (using neomycin as a selective marker), and propagation of the recombinant virus was performed in human embryonic kidney 293 cells (HEK 293). An in vitro study demonstrated that this recombinant virus has the ability to replicate in and lyse some p53-deficient human tumor cells such as human glioma tumor cells (U251) and human bladder cells (EJ), but not in some cells with functional p53, such as human adenocarcinoma cells (A549) and human fibroblast cells (MRC-5). Also, based on the cytopathic effect (CPE), it was demonstrated, under identical conditions, that the U251 cells were more sensitive to r2/Ad replication than the EJ cells. In this paper, we report that r2/Ad could be very useful in studying the in vitro selective replication of E1B-defective adenovirus and has great potential in cancer gene therapy.
Entanglement Dynamics of Electron Spins in Quantum Dots Under a Nonuniform Magnetic Field
Feng-Xue Zhou,Yi-Hong Qi,Yue-Ping Niu,Shang-Qing Gong,Jun Qian,Ting Yu,Franco Nori 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.8
We investigate entanglement of two coupled electron spins in quantum dots (QDs) in the presence of an inhomogeneous magnetic field. The great effects of the inhomogeneous field are discussed for the dynamics of entanglement. It is shown that due to the system's symmetry, the inhomogeneity of the field does not affect the evolution of entanglement for Φ-type Bell state, while it plays a key role for Ψ-type Bell state. For the maximal entangled Bell states, the field is positive for the entanglement dynamics. The mean field can increase the entanglement revival for Φ-type Bell state while the inhomogeneous field can promote the entanglement revival for Ψ-type Bell state. For the unentangled initial states, the field is destructive for the entanglement generation induced by the coupling of the two spins.
Feng-Xue Jin,Xiao-Bo Xie,Shi-Dong Ji,Hong-Guang Ju,Jung-Pil Suh,Hung-Goo Hwang,Sang-Nag Ahn 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
Grain weight (GW) or grain size is the most important target not only as a major component of grain yield, but also associated with the cooking quality in rice breeding program. In a previous study, two loci for grain weight, gw8 and gw9, have been fine map to about 306.4kb and 37.4kb, respectively, in backcross populations derived from a cross between the Korean japonica cultivar Hwaseongbyeo and Oryza rufipigon (IRGC 105491). Both O.rufipogon alleles increased GW in the Hwaseongbyeo background despite the fact that O. rufipogon was the small-seeded parent. To test the effect of pyramiding the QTLs for grain weight, an F2 population consisted of 226 individuals was developed derived from the cross between the two QTLs (gw8 and gw9), and used MAS to select nearly isgenic lines for two QTLs and a pyramiding line. Molecular genotyping of F2 population revealed the existence of interaction between gw8 and gw9. Moreover, the interaction was also confirmed by phenotypic analysis of four QTL-NILs. The results suggest that epistasis interaction is important genetic basis in determining yield traits in rice.
( Xue Feng Jin ),( Hong Shan Yu ),( Dong Ming Wang ),( Ting Qiang Liu ),( Chun Ying Liu ),( Dong Shan An ),( Wan Taek Im ),( Song Gun Kim ),( Feng Xie Jin ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.3
In this paper, the kinetics of a cloned special glucosidase, named ginsenosidase type III hydrolyzing 3-O-glucoside of multi-protopanaxadiol (PPD)-type ginsenosides, were investigated. The gene (bgpA) encoding this enzyme was cloned from a Terrabacter ginsenosidimutans strain and then expressed in E. coli cells. Ginsenosidase type III was able to hydrolyze 3-O-glucoside of multi-PPD-type ginsenosides. For instance, it was able to hydrolyze the 3- O-β-D-(1→2)-glucopyranosyl of Rb1 to gypenoside XVII, and then to further hydrolyze the 3-O-β-D-glucopyranosyl of gypenoside XVII to gypenoside LXXV. Similarly, the enzyme could hydrolyze the glucopyranosyls linked to the 3-O- position of Rb2, Rc, Rd, Rb3, and Rg3. With a larger enzyme reaction Km value, there was a slower enzyme reaction speed; and the larger the enzyme reaction Vmax value, the faster the enzyme reaction speed was. The Km values from small to large were 3.85 mM for Rc, 4.08 mM for Rb1, 8.85 mM for Rb3, 9.09 mM for Rb2, 9.70 mM for Rg3(S), 11.4 mM for Rd and 12.9 mM for F2; and Vmax value from large to small was 23.2 mM/h for Rc, 16.6 mM/h for Rb1, 14.6 mM/h for Rb3, 14.3 mM/h for Rb2, 1.81mM/h for Rg3(S), 1.40 mM/h for Rd, and 0.41 mM/h for F2. According to the Vmax and Km values of the ginsenosidase type III, the hydrolysis speed of these substrates by the enzyme was Rc>Rb1>Rb3>Rb2>Rg3(S)>Rd>F2 in order.
Computer Aided Diagnosis Based on K-means Collaborative Filtering Algorithm
Feng Xue-yuan,Li Peng,Qiao Pei-li 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.4
In computer aided diagnosis (CAD) process, one of the most challenging problems is data sparsity, which leads to the diagnosis results are not reliable. This paper proposes a clustering collaborative filtering based algorithm to solve the problem of data sparsity. In this paper, we use k-means clustering algorithm to cluster the same type of patients, and then adopt collaborative filtering method to fill the missing data values for each cluster, in this way to reduce the complexity of similarity calculation of collaborative filtering. The proposed method makes full use of the information-sharing mechanism of "similar patient population" to predict and fill the missing values. A hepatitis dataset is used for evaluating the performance of the algorithm. Results indicate that the proposed algorithm has better performance for medical record data sparsity problem.