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Inhibitory Lignans against NFAT Transcription Factor from Acanthopanax koreanum
Xing Fu Cai,Im Seon Lee,Nguyen Tien Dat,Guanghai Shen,강종성,Dong Hyun Kim,Young Ho Kim 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.7
Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (IC50: 36.3 ± 2.5 mM). However, the activities of 1 (IC50: > 500 mM) and 2 (IC50: 136.1 ± 9.4 mM), which possess bisaryldioxabicyclooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and (+)-syringaresinol (3) with a bisaryldioxabicyclooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.
A high-efficiency simulation method of wind field and its application on transmission line
Xing Fu,Xing-Heng Zhang,Hong-Nan Li,Gang Li,Hui-Juan Liu 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.33 No.4
Generally, the fluctuating wind is simplified as several independent one-dimensional multivariate stationary Gaussian processes in simulating a natural wind field. The correlation in the lateral, longitudinal and vertical directions should all be considered in the simulation of longitudinal wind field for the large-span spatial structures. In fact, this type of structure has lots of simulation points. The calculation amount of wind field simulation by the harmonic superposition method depends on the scale of cross-spectral density matrix, which is directly related to the number of simulated points, leading to a low efficiency when generating the time-varying wind speed. This paper innovatively proposes a high-efficiency simulation method for the longitudinal wind field based on Taylor’s hypothesis. Subsequently, the effectiveness of the proposed wind field method was verified by the numerical simulation. Finally, the dynamic responses of a transmission tower-line system under the wind loadings generated with the new method and traditional method are calculated and compared. The percentages difference of the mean and maximum axial force at the main tower members are less than 0.02% and 1%, respectively, indicating the effectiveness of the proposed time delay method. The results also show that the proposed simulation method of wind field can not only ensure the simulation accuracy, but also significantly improve the efficiency of wind speed generation, which is suitable for the wind load simulation of large-span spatial structures.
Xing Fu,Run Hu,Xiaobing Luo 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.2
Acquiring the junction temperature of light emitting diode (LED) is essential for performanceevaluation. But it is hard to get in the multipleLED applications. In this paper, an engineeringmethod is presented to estimate the junction temperatures of LEDs in multiple LED applications. This method is mainly based on an analytical model, and it can be easily applied with some simplemeasurements. Simulations and experiments were conducted to prove the feasibility of the method,and the deviations among the results obtained by the present method with those by simulationas well as experiments are less than 2% and 3%, respectively. In the final part of this study, theengineering method was used to analyze the thermal resistances of a street lamp. The materialof leadframe was found to affect the system thermal resistance mostly, and the choice of soldermaterial strongly depended on the material of the leadframe.