Model Based on Alkaline Phosphatase and Gamma-Glutamyltransferase for Gallbladder Cancer Prognosis

Xu, Xin-Sen,Miao, Run-Chen,Zhang, Ling-Qiang,Wang, Rui-Tao,Qu, Kai,Pang, Qing,Liu, Chang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Purpose: To evaluate the prognostic value of alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT) in gallbladder cancer (GBC). Materials and Methods: Serum ALP and GGT levels and clinicopathological parameters were retrospectively evaluated in 199 GBC patients. Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off values of ALP and GGT. Then, associations with overall survival were assessed by multivariate analysis. Based on the significant factors, a prognostic score model was established. Results: By ROC curve analysis, $ALP{\geq}210U/L$ and $GGT{\geq}43U/L$ were considered elevated. Overall survival for patients with elevated ALP and GGT was significantly worse than for patients within the normal range. Multivariate analysis showed that the elevated ALP, GGT and tumor stage were independent prognostic factors. Giving each positive factor a score of 1, we established a preoperative prognostic score model. Varied outcomes would be significantly distinguished by the different score groups. By further ROC curve analysis, the simple score showed great superiority compared with the widely used TNM staging, each of the ALP or GGT alone, or traditional tumor markers such as CEA, AFP, CA125 and CA199. Conclusions: Elevated ALP and GGT levels were risk predictors in GBC patients. Our prognostic model provides infomration on varied outcomes of patients from different score groups.

FoxM1 as a Novel Therapeutic Target for Cancer Drug Therapy

Xu, Xin-Sen,Miao, Run-Chen,Wan, Yong,Zhang, Ling-Qiang,Qu, Kai,Liu, Chang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Background: Current cancer therapy mainly focuses on identifying novel targets crucial for tumorigenesis. The FoxM1 is of preference as an anticancer target, due to its significance in execution of mitosis, cell cycle progression, as well as other signal pathways leading to tumorigenesis. FoxM1 is partially regulated by oncoproteins or tumor suppressors, which are often mutated, lost, or overexpressed in human cancer. Since sustaining proliferating signaling is an important hallmark of cancer, FoxM1 is overexpressed in a series of human malignancies. Alarge-scale gene expression analysis also identified FoxM1 as a differentially-expressed gene in most solid tumors. Furthermore, overexpressed FoxM1 is correlated with the prognosis of cancer patients, as verified in a series of malignancies by Cox regression analysis. Thus, extensive studies have been conducted to explore the roles of FoxM1 in tumorigenesis, making it an attractive target for anticancer therapy. Several antitumor drugs have been reported to target or inhibit FoxM1 expression in different cancers, and down-regulation of FoxM1 also abrogates drug resistance in some cancer cell lines, highlighting a promising future for FoxM1 application in the clinic.

Self-tuning PID Controller Designs for Multivariable Systems

Xin Yang,Yasuki Kansha,Min-Sen Chiu 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

In this paper, a self-tuning decentralized PID controller is developed to multivariable and nonlinear systems, using just-in-time learning (JITL) technique. From the online process data, JITL provides a set of linear models, by which the parameters of PID controllers are adjusted by a self-tuning algorithm derived from the Lyapunov method such that the predicted tracking error converges asymptotically. Simulation results illustrate the performances of the proposed self-tuning PID controller and a comparison with its conventional counterparts is made.

First principles calculation of boron diffusion in fcc-Fe

Xin Zhang,Xianglong Li,Ping Wu,Sen Chen,Shiping Zhang,Ning Chen,Xiulan Huai 한국물리학회 2018 Current Applied Physics Vol.18 No.10

The diffusion mechanism of boron in fcc-Fe was studied by first-principles calculations. The sites where B atoms tend to occupy and the diffusion behavior were calculated. Results indicated that the main mechanism of boron diffusion in fcc-Fe was the B–monovacancy complex mechanism instead of the interstitial mechanism. The diffusion coefficient D1 of the B–monovacancy complex mechanism was calculated without considering the backward jump of the B atoms. The calculated D1=1.26×10−4×exp(–2.01eV/kBT) m2·s−1 is consistent with the reported results from experiments.

Biochar Application Effects on Humus Carbon Composition

Xin Zhou,Sen Dou,Zhubin Xie 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Nondestructive Surface Threshold Definition for Remanufacturing Disassembly of Interference Fit

Dan Zhou,Sen Lan,Xin Gao,Haihong Huang,Guang-Fu Liu 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.11

The disassembly of interference fit is a difficult process for remanufacturing engineering, which frequently causes multiple types of friction damage, such as scratches, furrow, and adhesion on the surface of parts. The form and size of surface damage directly affect the cost of remanufacturing repair. If the damage is less than a threshold, the part can be directly used for assembly without repairing. This condition represents a nondestructive disassembly, which is the goal of remanufacturing disassembly for interference fit. In this study, varying degrees of disassembly surface damage of interference fit are obtained by experiment and detected by TRIMOS-CL3 3D surface profilometer. Six surface evaluation parameters Sv, Sp, Sq, Str, Vmp, and Sa, are selected from ISO 25178 as indexes for entropy analysis to evaluate the damage comprehensively. According to the interface state, a comprehensive evaluation threshold of nondestructive disassembly is proposed. The rationality of the threshold is verified by the load-carrying capacity experiment of the interference fit.

Gallbladder Carcinoma: Analysis of Prognostic Factors in 132 Cases

Wang, Rui-Tao,Xu, Xin-Sen,Liu, Jun,Liu, Chang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Objective: To evaluate the prognostic factors of gallbladder carcinoma. Methods: Presentation, operative data, complications, and survival outcome were examined for 132 gallbladder carcinoma patients who underwent gallbladder surgery in our unit during 2002-2007, and follow-up results were obtained from every patient for univariate and multivariate survival analysis. Results: The univariate analysis showed that gallbladder lesion history, tumor cell differentiation, Nevin staging, preoperative lymph node metastasis and the surgical approach significantly correlated with the prognosis of the patients (p<0.05). The results of the multivariate analysis (Cox regression) showed that gallbladder lesion history, Nevin staging and the surgical approach were independent predicators with relative risks of 6.9, 4.4, 2.8, respectively (p=0.002, 0.003, 0.008). Conclusion: Gallbladder lesion history, Nevin staging and the surgical approach are independent prognostic factors for gallbladder carcinoma, a rapidly fatal disease. Therefore, early diagnosis, anti-infective therapy and radical surgery are greatly needed to improve the prognosis of gallbladder carcinoma.

Improved kinetics of LiNi_1/3Mn_1/3Co_1/3O₂ cathode material through reduced graphene oxide networks

Jiang, Ke-Cheng,Xin, Sen,Lee, Jong-Sook,Kim, Jaekook,Xiao, Xiao-Ling,Guo, Yu-Guo The Royal Society of Chemistry 2012 Physical chemistry chemical physics Vol.14 No.8

<P>An electronically conducting 3D network of reduced graphene oxide (RGO) was introduced into LiNi<SUB>1/3</SUB>Mn<SUB>1/3</SUB>Co<SUB>1/3</SUB>O<SUB>2</SUB> (LNMC) cathode material in a special nano/micro hierarchical structure. The rate test and cycling measurement showed that the hierarchical networks remarkably improve the high rate performance of LNMC electrode for lithium-ion batteries. The effect of RGO conducting networks on kinetic property was investigated by electrochemical impedance spectroscopy (EIS) and potentiostatic intermittent titration (PITT). The EIS results reveal that the RGO network greatly decreases the resistance of lithium batteries, especially the charge transfer resistance which can be attributed to the significantly improved conducting networks. The enhancement of apparent diffusion coefficient by the RGO conducting networks is shown by PITT. The power performance was found to be limited by the electrical conduction in the two-phase region, which can be greatly facilitated by the hierarchical RGO network together with carbon black. The as-obtained LNMC/RGO cathode exhibits an outstanding electrochemical property supporting the design idea of electronically conducting 3D networks for the high-energy and high-power lithium-ion batteries.</P> <P>Graphic Abstract</P><P>A 3D conducting network of reduced graphene oxide nanosheets is introduced into LiNi<SUB>1/3</SUB>Mn<SUB>1/3</SUB>Co<SUB>1/3</SUB>O<SUB>2</SUB> and is found to significantly promote the kinetics for Li storage. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cp23363k'> </P>

Study on an Optimal Control Method for Energy Injection Resonant AC/AC High Frequency Converters

Su, Yu-Gang,Dai, Xin,Wang, Zhi-Hui,Tang, Chun-Sen,Sun, Yue The Korean Institute of Power Electronics 2013 JOURNAL OF POWER ELECTRONICS Vol.13 No.2

In energy injection resonant AC-AC converters, due to the low frequency effect of the AC input envelope and the low energy injection losses requirement, the constant and steady control of the high frequency AC output envelope is still a problem that has not been solved very well. With the aid of system modeling, this paper analyzes the mechanism of the envelope pit on the resonant AC current. The computing methods for the critical damping point, the falling time and the bottom value of the envelope pit are presented as well. Furthermore, this paper concludes the stability precondition of the system AC output. Accordingly, an optimal control method for the AC output envelope is put forward based on the envelope prediction model. This control method can predict system responses dynamically under different series of control decisions. In addition, this control method can select best series of control decisions to make the AC output envelope stable and constant. Simulation and experimental results for a contactless power transfer system verify the control method.

Study on an Optimal Control Method for Energy Injection Resonant AC/AC High Frequency Converters

Yu-Gang Su,Xin Dai,Zhi-Hui Wang,Chun-Sen Tang,Yue Sun 전력전자학회 2013 JOURNAL OF POWER ELECTRONICS Vol.13 No.2

In energy injection resonant AC-AC converters, due to the low frequency effect of the AC input envelope and the low energy injection losses requirement, the constant and steady control of the high frequency AC output envelope is still a problem that has not been solved very well. With the aid of system modeling, this paper analyzes the mechanism of the envelope pit on the resonant AC current. The computing methods for the critical damping point, the falling time and the bottom value of the envelope pit are presented as well. Furthermore, this paper concludes the stability precondition of the system AC output. Accordingly, an optimal control method for the AC output envelope is put forward based on the envelope prediction model. This control method can predict system responses dynamically under different series of control decisions. In addition, this control method can select best series of control decisions to make the AC output envelope stable and constant. Simulation and experimental results for a contactless power transfer system verify the control method.