Flocking for Multi-agent Systems with Optimally Rigid Topology Based on InformationWeighted Kalman Consensus Filter

Xiao-yuan Luo,Xiaolei Li,Shaobao Li,Zhongping Jiang,Xin-Ping Guan 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.1

This paper investigates the leader-follower flocking problem of multi-agent systems. The leader withinput noise is estimated by a proposed continuous-time information weighted Kalman consensus filter (IWKCF)for agents. A novel distributed flocking algorithm based on the IWKCF is further presented to make agents achieveflocking to the leader. It is shown that the proposed flocking algorithm based on the continuous-time IWKCFis asymptotically stable. Applying the topology optimization scheme, the communication complexity of systemtopologies of multi-agent systems is effectively reduced. Finally, simulations are provided to demonstrate theeffectiveness of the proposed results.

Research on Thymopentin Loaded Oral N-Trimethyl Chitosan Nanoparticles

Xiao-jia Yuan,Zhi-rong Zhang,Qing-guo Song,Qin He 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.9

Peptides, although high efficacy and specificity in their physiological function, usually have low therapeutical activities due to their poor bioavailability when administrated orally. Nanoparticles have been regarded as a useful vector for targeted drug delivery system because they can protect drug from being degraded quickly and pass the gastrointestinal barriers. Here we described a novel oral N-trimethyl chitosan nanoparticles formulation containing thymopentin (Tp5-TMC-NP). N-trimethyl chitosan (TMC) was synthesized and then used to prepare Tp5- TMC-NP by ionotropic gelation. A three-factor, five-level CCD (Central Composite Design) design was used in the optimization procedure, with HPLC as the analyzing method. The resulting Tp5-TMC-NP had a regular spherical surface and a narrow particle size range with a mean diameter of 110.6 nm. The average entrapment efficiency was 78.8%. The lyophilized Tp5-TMC-NP formulation was stable in 4oC or -20oC after storage of 3 months without obvious changes in morphology, particle size, pH and entrapment ratio. The results of the flow cytometer determination showed that the ratio of CD4+/CD8+ of Wistar female rat givenTp5-TMC-NP (ig) was 2.59 time that of the group given Tp5 (ig).

Peniciside, a New Triterpenoid Glycoside, from the Fungus Penicillium sp. 169

Xiao-Hong Yuan,Guo-You Li,Guo-Bo Xu,Wei-Lin Wu,Tao Yang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.2

Peniciside, a new fernene triterpenoid glycoside, was isolated from the EtOAc extract of the solid-state fermented rice culture of the fungus Penicillium sp. 169. Its structure was elucidated on the basis of spectroscopic analysis, and the absolute configuration was determined by X-ray crystallographic analysis and chemical methods. Peniciside is the first example of a fernene triterpenoid glycoside with two hydroxyls at C-19 and C-20.

Effect of luteoin in delaying cataract in STZ-induced diabetic rats

Yuan Chen,Xiao-Bo Sun,Hong-e Lu,Fang Wang,Xiao-Hui Fan 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.1

Luteolin, a flavonoid rich in many plants, hasshown various pharmacological effects including anti-inflammation,anti-oxidant, anti-tumor, cardioprotective andneuroprotective properties. At present, inflammation andoxidative stress have been recognized to be two importantcontributing factors to the development of diabetic cataract. The aim of this study is to investigate the effects ofluteolin on diabetes-induced oxidative stress and inflammationin the lens of rats. A diabetic rat model was inducedby intraperitoneally giving streptozotocin at a dosage of60 mg/kg, and then the rats were treated by orallyadministration of luteolin 25, 50 and 100 mg/kg for12 weeks. The results showed that luteolin administrationcould increase the antioxidant capacity such as glutathione(GSH) and glutathione peroxidase (GPx) activity, anddecreased malondialdehyde (MDA) level in the lens ofdiabetic rats. Luteolin also inhibited diabetes-induced elevationof interleukin-1 beta (IL-1b), vascular endothelialgrowth factor and nuclear factor-jB (NF-jB) mRNA andprotein expression in lens. Moreover, in the high dosegroup (100 mg/kg), lens GSH level was decreased to normalcompared to control group. The degree of oxidativeand inflammatory damage was significantly reduced inluteolin-treated rats. These data suggested that luteolin canbe an effective protection candidate of diabetes-inducedlens neurodegeneration by inhibiting the levels of inflammatorymediators and oxidative stress.

Canonical transient receptor potential channels and their modulators: biology, pharmacology and therapeutic potentials

Yuan-Yuan Gao,Wen Tian,Hui-Nan Zhang,Yang Sun,Jing-Ru Meng,Wei Cao,Xiao-Qiang Li 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.4

Canonical transient receptor potential channels(TRPCs) are nonselective, high calcium permeability cationicchannels. The TRPCs family includes TRPC1, TRPC2,TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7. These channelsare widely expressed in the cardiovascular and nervoussystems and exist in many other human tissues and celltypes, playing several crucial roles in the human physiologicaland pathological processes. Hence, the emergenceof TRPCs modulators can help investigate these channels’applications in health and disease. It is worth noting that theTRPCs subfamilies have structural and functional similarities,which presents a signifi cant diffi culty in screening anddiscovering of TRPCs modulators. In the past few years,only a limited number of selective modulators of TRPCswere detected; thus, additional research on more potent andmore selective TRPCs modulators is needed. The presentreview focuses on the striking desired therapeutic eff ectsof TRPCs modulators, which provides intel on the structuralmodifi cation of TRPCs modulators and further pharmacologicalresearch. Importantly, TRPCs modulators cansignifi cantly facilitate future studies of TRPCs and TRPCsrelated diseases.

Identification and characterization of CONSTANS-like genes from Curcuma alismatifolia

Yuan-Yuan Li,Xiao-Huang Chen,Hui-Wen Yu,Qi-Lin Tian,Luan-Mei Lu 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.2

The CONSTANS ( CO ) and CONSTANS - like ( COL ) genes have an important role in the regulation of fl owering in photoperiod-sensitive plants. However, information on the molecular characterization of COL genes in Curcuma alismatifoliais very limited. The objective of this study was to identify and evaluate 8 COL homologs ( CaCOLs ) in the C. alismatifoliatranscriptome. Their structures, phylogenetic relationships and expressing patterns under short-day (SD) and long-day (LD)contexts were investigated. Our results showed that CaCOLs were classifi ed into three groups: CaCOL3 and CaCOL6 in groupI were the most CO - like genes; CaCOL7 and CaCOL8 in group II contains only one B-box; CaCOL1 to 2 and CaCOL4 to 5formed the group III. Phylogenetic analysis of the CaCOLs in Arabidopsis, Rice, Barley, Malaccensis and C. alismatifoliademonstrated that both the B-box and CCT domains were conserved in dicot and monocot plants, but diff erent groups ofCOL genes evolved independently. Diff erent patterns of mRNA accumulation in C. alismatifolia leaves in response to SDand LD treatments were observed. CaCOL1 , CaCOL2 , CaCOL4 and CaCOL7 showed signifi cantly higher expressions inLD treatment than that of SD, indicating that they were potential fl owering inducers, and are candidate genes for research infl owering regulation and circadian controlling in C. alismatifolia plants. Altogether, our study facilitates successful regulationof fl owering in Curcuma species and provides insights for future molecular breeding programs.

Study on micro-scale 3D numerical modeling and droplet deposition of plain weave fabric

Yuan Xiao,Chengkun Zhang,Qian LI,Pengcheng Yang,Dan He 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.4

To define the deposition and morphology changes of the droplets on fabric medium clearly in spraying printing the electrical circuits on fabric surface. The Navier-Stokes (NS) equation and volume of fluid (VOF) boundary tracking model are adopted to set up a microscale three-dimensional (3D) numerical model for plain weave fabric. Simulation focused on the evolution process of phase field, pressure field and speed field during the droplets deposition. The results show that axial momentum controls the droplets outward spread quickly and synchronously with a ring shape at early stage. The control of unbalanced-Young driving force causes the three-phase contact line fixes on fiber cylinder, droplets are in an instantaneous stable state. Capillary pressure gradient controls the three-phase contact line pinning and slippage forward lead to differences in spreading direction. The rebound effect of droplets promotes further penetration of droplets into fabric. Experiment analysis displays the well match with the simulation results, indicating the rationality of the proposed micro-scale 3D plain weave fabric modeling method. The findings of this paper would contribute to the future works for flexible electronic devices on fabric surface research studies.

Liposome-mediated Induction of Apoptosis of Human Hepatoma Cells by C-Myc Antisense Phosphorothioate Oligodeoxynucleotide and 5-Fluorouracil

Yuan, Yuan,Cai, Hui,Yang, Xiao-Jun,Li, Wei,He, Jin,Guo, Tian-Kang,Chen, Yi-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Background: The aim of this study was to investigate the effect of a c-myc antisense oligodeoxynucleotide and 5-fluorouracil on the expression of c-myc, invasion and proliferation of HEPG-2 liver cancer cells. Materials and Methods: HEPG-2 cells were treated with lipiosome-mediated c-myc ADSON and 5-fluorouracil. The proliferation inhibition rate and invasion were measured by MTT and invasion assay, respectively. Cell apoptosis was detected by flow cytometry and expression of c-myc by RT-PCR and immunohistochemistry. Results: The proliferation inhibition rate was significantly higher in the antisense oligodeoxynucleotide added-5-fluorouracil group than single antisense oligodeoxynucleotide or 5-fluorouracil group (p<0.05). G0/G1 cells in the antisense oligodeoxynucleotide group and S cells in the 5-fluorouracil groups were significantly increased than that in the control group, respectively (P<0.01). The amplification strips of PCR products in 5-FU, ASODN and combination groups were significantly weaker than that in the control group (P<0.01). The percentage of c-myc-protein-positive cells were significantly lower in antisense oligodeoxynucleotide, 5-fluorouracil and combination groups than that in the control group (P<0.01). Conclusions: A liposome-mediated c-myc antisense oligodeoxynucleotide and 5-fluorouracil can inhibit the proliferation and invasion of liver cancer cells by reducing the expression of c-myc. A c-myc antisense oligodeoxynucleotide can increase the sensitivity of liver cancer cells to 5-fluorouracil and decrease the dosage of the agent necessary for efficacy, providing an experimental basis for the clinical therapy of liver cancer.

Control of Electrically Excited Synchronous Motors with a Low Switching Frequency

Yuan, Qing-Qing,Wu, Xiao-Jie,Dai, Peng,Fu, Xiao The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.4

The switching frequency of the power electronic devices used in large synchronous motor drives is usually kept low (less than 1 kHz) to reduce the switching losses and to improve the converter power capability. However, this results in a couple of problems, e.g. an increase in the harmonic components of the stator current, and an undesired cross-coupling between the magnetization current component ($i_m$) and the torque component ($i_t$). In this paper, a novel complex matrix model of electrically excited synchronous motors (EESM) was established with a new control scheme for coping with the low switching frequency issues. First, a hybrid observer was proposed to identify the instantaneous fundamental component of the stator current, which results in an obvious reduction of both the total harmonic distortion (THD) and the low order harmonics. Then, a novel complex current controller was designed to realize the decoupling between $i_m$ and $i_t$. Simulation and experimental results verify the effectiveness of this novel control system for EESM drives.

Relationship Between the SER Treatment Period and Prognosis of Patients with Small Cell Lung Cancer

Xiao, Xiao-Guang,Wang, Shu-Jing,Hu, Li-Ya,Chu, Qian,Wei, Yao,Li, Yang,Mei, Qi,Chen, Yuan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Purpose: To explore the relationship between SER (time between the start of any treatment and the end of radiation therapy) and the survival of patients with limited-stage small cell lung cancer. Materials and Methods: Between 2008 and 2013, 135 cases of limited-stage small cell lung cancer (LS-SCLC) treated with consecutively curative chemoradiotherapy were included in this retrospective analysis. In terms of SER, patients were divided into early radiotherapy group (SER<30 days, n=76) and late radiotherapy group ($SER{\geq}30$ days, n=59) with a cut-off of SER 30 days. Outcomes of the two groups were compared for overall survival. Results: For all analyzable patients, median follow-up time was 23.8 months and median overall survival time was 16.8 months. Although there was no significant differences in distant metastasis free survival between the two groups, patients in early radiotherapy group had a significantly better PFS (p=0.003) and OS (p=0.000). Conclusions: A short SER may be a good prognostic factor for LD-SCLC patients treated with concurrent chemoradiotherapy.