Effectiveness of renal denervation in the treatment of hypertension: a literature review

Riya Tejas Shah,Brian Xiangzhi Wang 대한고혈압학회 2022 Clinical Hypertension Vol.28 No.-

Catheter-based renal denervation has been studied as a potential therapeutic option to reduce high blood pressure (BP). Preclinical studies in some experimental models have demonstrated an antihypertensive effect of renal denervation but reports from clinical trials have been mixedWe performed a literature search using combinations of the key terms ‘Cardiovascular diseases, Clinical trial, Pre-clinical trials, Resistant hypertension, Renal denervation, Ablation technique, Radiofrequency ablation, Ultrasound ablation, RADIANCE SOLO, SYMPLICITY HTN, SYPRAL HTN’. The databases searched were PubMed and OVID Medline.The initial SYMPLICITY HTN-1 AND HTN-2 clinical trials reported significant decreases in office BP but results from the more robustly designed SYMPLICITY HTN-3 trial, which included sham controls and ambulatory BP monitoring, showed no significant antihypertensive effect. Interest in the use of renal denervation in hypertension was once again sparked by favourable results from the SPYRAL HTN-OFF Med trialWe provide a thorough, critical analysis of key preclinical and clinical studies investigating the efficacy of catheter-based renal denervation as a treatment for hypertension and highlight future areas for research to allow better translation into clinical practice

The complete chloroplast genome of the green algae Hariotina reticulata (Scenedesmaceae, Sphaeropleales, Chlorophyta)

Lijuan He,Zhaokai Wang,Sulin Lou,Xiangzhi Lin,Fan Hu 한국유전학회 2018 Genes & Genomics Vol.40 No.5

In this study, the chloroplast genome of Hariotina reticulata was fully sequenced and compared to other Sphaeropleales chloroplast genomes. It is 210,757 bp larger than most Sphaeropleales cpDNAs. It presents a traditional chloroplast structure, and contains 103 genes, including 68 protein-coding genes, six rRNA genes and 29 tRNA genes. The coding region constitutes of 43% of the whole cpDNA. Eighteen introns are found in 11 genes and six introns are unique for Hariotina. 11 open reading frames are identified among these introns. The synteny between Hariotina and Acutodesmus cpDNAs is in general identical, while within Sphaeropleales order, high variability in cpDNA architecture is indicated by general high DCJ distances. Ankyra judayi exhibits the greatest dissimilarity in gene synteny to the others and share some unique gene clusters with Treubaria triappendiculata. The phylogenomic analyses show that A. judayi is clustered with Treubariaceae species and sister to Chlorophyceae incertae sedis and other Sphaeropleales species. The monophyly of Sphaeropleales is rejected.

Gene expression analysis of “green tide” alga Ulva prolifera (Chlorophyta) in China

Shangang Jia,Xumin Wang,Guiming Liu,Dan Luo,Jing Zhang,Yan Liu,Xiangzhi Lin,Tao Liu 한국유전학회 2011 Genes & Genomics Vol.33 No.2

Ulva prolifera (Ulvophyceae, Chlorophyta) is the causative species of the annual “green tides” in the Bohai Gulf of Northern China. In order to gain some more insight into the transcriptome of this fast-growing species of algae, we acquired 6,203 high-quality expressed-sequence-tags (ESTs),which were clustered into 4,080 unique sequences (UniSeqs). Functional classification revealed that most of the acquired transcripts were related to metabolic and biosynthetic processes,nucleotide binding, and cell part that might contribute to the organism’s rapid growth. Using 39 EST pools, 28 mitochondria genomes, and 18 chloroplast genomes from algae and land plants, we constructed three phylogenetic trees. These trees provided evidence that U. prolifera was in a sister position to Ulva linza, and shared a similar chloroplast origin with Pseudendoclonium akinetum. The findings of this study will improve our knowledge of the transcriptome and taxonomic position of U. prolifera.

Innovative utilization of red mud through co-roasting with coal gangue for separation of iron and aluminum minerals

Jianping Jin,Xiao Liu,Shuai Yuan,Peng Gao,Yanjun Li,Hao Zhang,Xiangzhi Meng 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.98 No.-

Red mud and coal gangue are industrial solid wastes discharged during alumina extraction and coalmining, respectively. As these are hazardous materials, their disposal leads to serious environmentalissues. In this study, an innovative utilization of red mud through co-roasting with coal gangue forseparation and recycling of iron and aluminum minerals is presented. Under optimum co-roastingconditions (550 C for 50 min), an iron concentrate containing 57.25% TFe (total iron content) with therecovery of 65.22%, and an aluminum-rich product containing 27.26% Al2O3 with the recovery of 71.37%were obtained after magnetic separation. The characteristics of mixed raw material and products allindicated that the goethite and hematite phases in the mixed raw material were transformed into amagnetite phase after co-roasting, although some of the magnetite generated during co-roasting wasoxidized to hematite again. This study demonstrates that co-roasting of coal gangue and red mud is apromising technology for the reduction of iron and activation of aluminum to realize resource recyclingwithout additional materials

Deficiency of Follistatin-Like Protein 1 Accelerates the Growth of Breast Cancer Cells at Lung Metastatic Sites

Ying Zhang,Xiaozhou Xu,Ying Yang,Jie Ma,Lulu Wang,Xiangzhi Meng,Bing Chen,Ling Qin,Tao Lu,Yan Gao 한국유방암학회 2018 Journal of breast cancer Vol.21 No.3

Purpose: Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein that has been shown to play a role in various types of cancer. However, the clinical significance and function of FSTL1 in breast cancer have not been reported. We investigated the role of FSTL1 in breast cancer in this study. Methods: Enzyme-linked immunosorbent assays, western blot analysis, and reverse transcription polymerase chain reaction were used to monitor the expression of FSTL1 in breast cancer tissue and in serum samples from breast cancer patients. We employed a 4T1 breast cancer model and Fstl1+/− mice for in vivo studies. Hematoxylin and eosin staining, western blot analysis, and RNA sequencing were used to analyze the effect of FSTL1 on primary tumor growth and lung metastasis. Results: We demonstrated that the expression of FSTL1 is reduced in both the breast cancer tissue and the serum of breast cancer patients. We showed that reduced levels of FSTL1 in serum correlate with elevated expression of Ki-67 and epidermal growth factor receptor (EGFR) in cancer tissues. Moreover, lowered expression of FSTL1 was associated with decreased survival in breast cancer patients. Experiments on the Fstl1+/− mouse model established that FSTL1 deficiency had no effect on primary tumor growth, but increased the lung metastases of breast cancer cells, resulting in reduced survival of tumor-bearing mice. RNA sequencing found significantly reduced expression of Egln3 and increased expression of EGFR in Fstl1+/− mice. Thus, our results suggest that FSTL1 may affect the expression of EGFR through Egln3, inhibiting the proliferation of breast cancer cells at lung metastatic sites. Conclusion: In conclusion, we suggest a suppressor role of FSTL1 in breast cancer lung metastasis. Furthermore, FSTL1 may represent a potential prognostic biomarker and a candidate therapeutic target in breast cancer patients.

Direct Position Determination of Coherently Distributed Sources based on Compressed Sensing with a Moving Nested Array

( Zhang Yankui ),( Xu Haiyun ),( Ba Bin ),( Zong Rong ),( Wang Daming ),( Li Xiangzhi ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.5

The existing direct position determinations(DPD) for coherently distributed(CD) sources are mostly applicable for uniform linear array(ULA), which result in a low degree of freedom(DOF), and it is difficult for them to realize the effective positioning in underdetermined condition. In this paper, a novel DPD algorithm for coherently distributed sources based on compressed sensing with a moving nested array is present. In this algorithm, the nested array is introduced to DPD firstly, and a positioning model of signal moving station based on nested array is constructed. Owing to the features of coherently distributed sources, the cost function of compressed sensing is established based on vectorization. For the sake of convenience, unconstrained transformation and convex transformation of cost functions are carried out. Finally, the position coordinates of the distribution source signals are obtained according to the theory of optimization. At the same time, the complexity is analyzed, and the simulation results show that, in comparison with two-step positioning algorithms and subspace-based algorithms, the proposed algorithm effectively solves the positioning problem in underdetermined condition with the same physical element number.

One-Step Hydrothermal Deposition of Ag-Doped g-C3N4-TiO2 Nanocomposites on Cotton Fabric Surface with Enhanced Photocatalytic Activity

Wenjun Li,Hui Zhang,Pei Chen,Jiale Yao,Xiangzhi Dong 한국섬유공학회 2023 Fibers and polymers Vol.24 No.2

In this study, Ag-doped g-C3N4-TiO2 nanocomposite photocatalysts were deposited on the surface of cotton fabric by a simpleone-step hydrothermal method. The structure features of as-modified cotton fabric were examined by a series of characterizationtechniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction(XRD) spectroscopy, X-ray photoelectron spectroscopy (XPS), UV–Vis diffuse reflectance spectroscopy (DRS) andphotoluminescence spectroscopy (PL). The experimental results showed that highly dispersed Ag nanoparticles were dopedinto g-C3N4-TiO2 nanocomposites which were evenly coated on the fabric surface. The introduction of Ag nanoparticles intog-C3N4-TiO2 composites could significantly improve the photodegradation rate of methyl orange (MO) dye under visiblelight irradiation. Importantly, the doping site of Ag nanoparticles had a significant influence on the photocatalytic activityof Ag-doped g-C3N4-TiO2 nanocomposites. Compared with the g-C3N4-TiO2 coated cotton fabric, the Ag-doped g-C3N4-TiO2 coated cotton fabric displayed excellent photocatalytic properties for the photodegradation of MO dyes because of thenarrowed band gap and the faster separation and transfer of photoinduced charge carriers. The substrate of cotton fabric hadlittle influence on the active radicals produced by the Ag-doped g-C3N4-TiO2 nanocomposites. In addition, the as-modifiedcotton fabric exhibited good reusability and stability after five recycles for the photodegradation of MO dyes.